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Reposted by Anupam Patgiri

RyanLab_TCD @ryanlab.bsky.social · 4h

Exciting study from @frisophagy.bsky.social in @chinnery in the Chinnery lab @mrc-mbu.bsky.social. Congratulations to all authors involved in the study! #mitochondria

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations | Science
www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

www.science.org

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Anupam Patgiri @apatgiri.bsky.social · 4h

Acidosis orchestrates adaptations of energy metabolism in tumors www.science.org/doi/10.1126/...

Acidosis orchestrates adaptations of energy metabolism in tumors

Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...

www.science.org

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Anupam Patgiri @apatgiri.bsky.social · 20h

Congratulations, Isha!

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Reposted by Anupam Patgiri

Gladstone Institutes @gladstoneinst.bsky.social · 1d

Leveraging modern scientific tools and techniques, @ishahjain.bsky.social intends to transform our understanding of the critical roles that vitamins play in health and disease.

Bringing Modern Science to Vitamin Biology: Isha Jain Wins NIH Transformative Research Award

Leveraging modern scientific tools and techniques, Jain intends to transform our understanding of the critical roles that vitamins play in health and disease.

gladstone.org

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Reposted by Anupam Patgiri

Scott Soleimanpour @soleimanpourlab.bsky.social · 1d

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔

In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

www.science.org

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Reposted by Anupam Patgiri

Michele Frison @frisophagy.bsky.social · 4d

In this week's mitophagy news 🪫🗑️

biomed.news/bims-tofagi/...

⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

Thanks to @biomednews.bsky.social

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

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Reposted by Anupam Patgiri

David Finlay @davidfinlaytcd.bsky.social · 5d

Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization. www.cmghjournal.org/article/S235...

Wonder how metformin induced LacPhe (pmc.ncbi.nlm.nih.gov/articles/PMC...) affects macrophages and gut inflammation. @immunometforum.bsky.social

Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway

Although the anti-inflammatory benefits of exercise are well-documented, the specific mechanisms responsible for these advantages remain uncertain. N-lactoyl-phenylalanine (Lac-Phe), a major metabolit...

www.cmghjournal.org

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Anupam Patgiri @apatgiri.bsky.social · 5d

NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria www.biorxiv.org/content/10.1...

NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria

Nicotinamide adenine dinucleotide plays a central role in energy metabolism, and its decline is linked to various degenerative diseases. While NAD+ restoration holds therapeutic promise, its long term...

www.biorxiv.org

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Anupam Patgiri @apatgiri.bsky.social · 10d

D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport elifesciences.org/reviewed-pre...

D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport

elifesciences.org

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Anupam Patgiri @apatgiri.bsky.social · 12d

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging www.nature.com/articles/s43...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging - Nature Aging

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

www.nature.com

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Reposted by Anupam Patgiri

Xinnan Wang Lab @xinnanwanglab.bsky.social · 14d

Our new review is out! Likely once an independent organism, mitochondria have retained a striking degree of autonomy. We discuss their capacity to sense within—a process we refer to as mitochondrial inside-out signaling. Written by talented @furkanoflaz.bsky.social @signscaztl.bsky.social

Waggoner Lab @labwaggoner.bsky.social · 14d

Review @cp-cellchembiol.bsky.social @xinnanwanglab.bsky.social @stanforduniversity.bsky.social
Sensing within: Mitochondrial inside-out signal transduction
www.cell.com/cell-chemica...

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Anupam Patgiri @apatgiri.bsky.social · 16d

Engineered prime editors with minimal genomic errors www.nature.com/articles/s41...

Engineered prime editors with minimal genomic errors - Nature

Engineered prime editor systems with reduced occurrences of unwanted insertions or deletions during genome editing are developed.

www.nature.com

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Reposted by Anupam Patgiri

RyanLab_TCD @ryanlab.bsky.social · 17d

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social 🔽🔽🔽

biomed.news/bims-imicid/...

Highlight:
Label-free metabolic imaging monitors the fitness of chimeric antigen receptor T cells
www.nature.com/articles/s41...

Label-free metabolic imaging monitors the fitness of chimeric antigen receptor T cells - Nature Biomedical Engineering

Monitoring T cell metabolism during chimeric antigen receptor T manufacturing using optical metabolic imaging enables fine-tuning of manufacturing conditions to increase T cell yield and fitness.

www.nature.com

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Reposted by Anupam Patgiri

Catalina Vasilescu, PhD @cvasilescu.bsky.social · 18d

To honour the #MitochondrialDisease #AwarenessWeek 💚 we bring a new collection of recently-published research papers related to mitochondrial disease:
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Cryo-EM of the prohibitin complex

Hong et al, Cryo-EM structure of the prohibitin complex in open conformation

https://www.pnas.org/doi/10.1073/pnas.2512430122

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Reposted by Anupam Patgiri

Keshav K Singh, PhD @mitoscientist.bsky.social · 19d

Tonight, shine a light of hope in green to support the mito community.

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Reposted by Anupam Patgiri

Keshav K Singh, PhD @mitoscientist.bsky.social · 20d

This week (Sept 15 to 21, 2025) is Mitochondrial Disease Week
-a chance to shine light on mitochondrial disorders and the people living with them.
Light up green for mito on 20th, September.

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Anupam Patgiri @apatgiri.bsky.social · 23d

Hypermetabolism and energetic constraints in mitochondrial disorders www.nature.com/articles/s42...

Hypermetabolism and energetic constraints in mitochondrial disorders - Nature Metabolism

The prevailing notion that mitochondrial diseases arise from ATP deficiency is challenged by recent evidence that oxidative phosphorylation defects trigger maladaptive stress responses consuming exces...

www.nature.com

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Anupam Patgiri @apatgiri.bsky.social · 24d

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons www.nature.com/articles/s41...

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons - Nature

Loss-of-function variants of ABCA7, associated with Alzheimer’s disease, result in disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways in the human brain.

www.nature.com

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Reposted by Anupam Patgiri

Michele Frison @frisophagy.bsky.social · 25d

In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

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Anupam Patgiri @apatgiri.bsky.social · 25d

Replication competition drives the selective mtDNA inheritance in Drosophila ovary www.cell.com/cell-reports...

Replication competition drives the selective mtDNA inheritance in Drosophila ovary

Zhang et al. report a novel imaging method that can distinguish mtDNA variants with single-nucleotide polymorphisms at single-molecule resolution in situ. Using this method, they visualized dynamics o...

www.cell.com

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Anupam Patgiri @apatgiri.bsky.social · 28d

In vivo itaconate tracing reveals degradation pathway and turnover kinetics www.nature.com/articles/s42...

In vivo itaconate tracing reveals degradation pathway and turnover kinetics - Nature Metabolism

In this study, Willenbockel et al. trace circulating itaconate in vivo to gain insight into its fate and systemic metabolism.

www.nature.com

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Anupam Patgiri @apatgiri.bsky.social · 29d

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing www.cell.com/molecular-ce...

Structural insights into DdCBE in action enable high-precision mitochondrial DNA editing

Based on cryo-EM structures of functioning DdCBE, Xiang et al. developed a model to guide TALE-recognition region and spacer length design. Application of the model and an engineered editor with a 2–3...

www.cell.com

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Reposted by Anupam Patgiri

Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · 29d

For readers interested in cancer therapies, this review discusses how metabolic dysfunction of CD8 T cells and NK cells can diminish their anticancer activity, and assesses therapeutic strategies to overcome this www.nature.com/articles/s41...
rdcu.be/eFqm2

Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer - Nature Reviews Drug Discovery

CD8 T cells and natural killer (NK) cells play a key role in cancer immunosurveillance. However, their anticancer activity is rapidly diminished in the tumour microenvironment, associated with a decli...

www.nature.com

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Reposted by Anupam Patgiri

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 29d

Macropinocytosis-Mediated Recyclable LYTACs (McR-TACs) for Membrane and Extracellular Protein Degradation https://www.biorxiv.org/content/10.1101/2025.09.08.674971v1

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Reposted by Anupam Patgiri

Kevin C Klatt, PhD, RD @kcklatt.bsky.social · Sep 10

For any #metabolism nerds looking for some indulgence (and an escapism from the news chaos), JIMDs podcast is a great listen! I enjoyed this weeks episode on Adenosine Kinase

open.spotify.com/episode/1YRs...

Adenosine Kinase

open.spotify.com

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