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Reposted by Parker Singleton

Esther Schindler @estherschindler.bsky.social · 1d

I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.

Parker Singleton @parkersingleton.bsky.social · 14d

Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.

Golia Shafiei @goliashf.bsky.social · 15d

Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉

📚 Read the paper: authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset: reprobrainchart.github.io

Golia Shafiei @goliashf.bsky.social · Feb 27

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025...

Funded by National Institute of Mental Health (NIMH)

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Ted Satterthwaite @ted-satterthwaite.bsky.social · Sep 7

New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇

www.biorxiv.org/cgi/content/...

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Parker Singleton @parkersingleton.bsky.social · Aug 28

my linkedin feed has become filled with psychedelic memes and I'm connected with an OG acid kingpin.

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Parker Singleton @parkersingleton.bsky.social · Aug 26

I'm near certain sLFOs are big for psychedelics.

Cole Korponay @ckorponay.bsky.social · Aug 26

An exciting 🆕 extension of our sLFO/FC inflation work (www.nature.com/articles/s41...)

Extracting the sLFO signal from BOLD data not only sharpens FC estimates..

..the sLFO itself - via links to arousal - captures variability in trait + state drug use phenotypes: tinyurl.com/msanmrnc
#neuroimaging

Systemic physiological "noise" in fMRI has clinical relevance

Functional magnetic resonance imaging (fMRI) is central to studying neurobiological mechanisms, yet fMRI has limited clinical utility, highlighting the need for novel approaches. We show that a compon...

www.medrxiv.org

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Max Planck School of Cognition @mps-cognition.bsky.social · Aug 15

Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊

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Parker Singleton @parkersingleton.bsky.social · Aug 21

"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity"

www.researchsquare.com/article/rs-7...

Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity

We investigate the spatiotemporal organization of resting-state brain activity in individuals with and without major depressive disorder (MDD), identifying stable and recurring whole-brain functional ...

www.researchsquare.com

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Arielle Keller @ariellekeller.bsky.social · Aug 19

✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level
#neuroskyence #devpsych #PsychSciSky

katesfdamme.bsky.social @katesfdamme.bsky.social · Aug 19

Timing and plasticity are critical to progress in research on stress and neurodevelopment

@ariellekeller.bsky.social
@jamapediatrics.com
@utdallas.bsky.social
jamanetwork.com/journals/jam...

Neurodevelopmental Timing Links Stress and Psychopathology

This Viewpoint discusses the importance of contextualizing stressful experiences and the neurodevelopmental trajectory to predict the risk of psychopathology.

jamanetwork.com

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Chaz Firestone @chazfirestone.bsky.social · Aug 19

Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant?

“No!”, you say.

Allow @talboger.bsky.social to show you otherwise! Now
in press @currentbiology.bsky.social

🐇🐘

tal boger @talboger.bsky.social · Aug 19

On the left is a rabbit. On the right is an elephant. But guess what: They’re the *same image*, rotated 90°!

In @currentbiology.bsky.social, @chazfirestone.bsky.social & I show how these images—known as “visual anagrams”—can help solve a longstanding problem in cognitive science. bit.ly/45BVnCZ

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Parker Singleton @parkersingleton.bsky.social · Aug 18

Thanks Parker!

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Ted Satterthwaite @ted-satterthwaite.bsky.social · Aug 18

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

Parker Singleton @parkersingleton.bsky.social · Aug 18

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...

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Parker Singleton @parkersingleton.bsky.social · Aug 18

Analiese Lahey, @pimcuijpers.bsky.social, @mathiasharrer.bsky.social, @mntj21.bsky.social, Sandeep Nayak, Eric Strain, @vandyatvandy.bsky.social, Bob Dworkin, @jcobbscott.bsky.social. @ted-satterthwaite.bsky.social, @pennlinc.bsky.social

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Parker Singleton @parkersingleton.bsky.social · Aug 18

All of this and more can be easily accessed through sypres.io

Team effort with co-first author (!!!) @bsevchik.bsky.social and the rest of the SYPRES and Metapsy team who made this happen!

SYPRES

The official website for the sypres initiative.

sypres.io

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Parker Singleton @parkersingleton.bsky.social · Aug 18

In partnership with metapsy.org we built an interactive dashboard for exploring the data. Users can:
• Filter studies by characteristics
• Test different analysis parameters
• Test moderators
• Download figures and reports

Dashboard: metapsy.org/sypres/psilo...

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Parker Singleton @parkersingleton.bsky.social · Aug 18

Our database includes 200+ effect sizes, encompassing all depression outcomes and timepoints reported by arm in each of the 12 RCTs included. This database can be downloaded from our website (sypres.io) or imported directly into R environments using the metapsyData package from metapsy.org

screenshot of the GitHub repository readme for the database

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Parker Singleton @parkersingleton.bsky.social · Aug 18

Here, psilocybin showed a greater reduction in depression scores compared to control conditions, with a pooled Hedges’ g = -0.91 (k = 9; p = 0.0013, I2 = 58.1%, n = 501). But important caveats—small studies, blinding challenges, risk of bias, and design heterogeneity, which we discuss in the paper.

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Parker Singleton @parkersingleton.bsky.social · Aug 18

sypres.io is our new initiative featuring:
📊 Regularly updated meta-analyses
🔍 User-guided sensitivity and moderation analysis
🕵️ Transparent study quality & risk-of-bias assessments
⚙️ Open code & data

screenshot of the psilocybin for depression section on sypres.io

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Parker Singleton @parkersingleton.bsky.social · Aug 18

Psychedelic science has experienced the benefits and drawbacks of hype. However, new results are rarely contextualized in the historical body of evidence in an accessible manner. We need more robust, living, evidence synthesis that is visible and accessible to all stakeholders.

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Parker Singleton @parkersingleton.bsky.social · Aug 18

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...

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Parker Singleton @parkersingleton.bsky.social · Aug 14

@audreycluo.bsky.social has had one of the most impressive graduate careers I've ever seen. Kudos!!!!

Ted Satterthwaite @ted-satterthwaite.bsky.social · Aug 14

CONGRATS TO DOCTOR @audreycluo.bsky.social !!! Last week, Dr. Luo knocked our collective socks off with a thesis defense for the ages. Her presentation on "Axes of Hierarchical Brain Development" was magnificent -- beautiful science, presented in an incredibly accessible and engaging way. WOO!!!!

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Alaina Jaster, PhD @jasteralaina.bsky.social · Jul 18

Somehow we got almost all the students and postdocs in one photo!!

Until next time #GRCPsychedelics 🫡

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Parker Singleton @parkersingleton.bsky.social · Jul 18

the wave lol

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Melissa Herman @melissaherman.bsky.social · Jul 18

So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!

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Alex Kwan @alexkwan.bsky.social · Jul 17

Great panel this morning on the human and clinical studies of psychedelics -

my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics

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Melissa Herman @melissaherman.bsky.social · Jul 15

#GRCPsychedelics 🔥🔥🔥🔥poster session and our first ever Honorary Best PI poster award to @zenbrainest.bsky.social 🤣🤣🤣

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