Prof Paula Salgado
@pssalgado.bsky.social
Structural Microbiologist studies molecular details of C. difficile at Newcastle University, UK. (she/her) Interested in science, politics, theatre, and so much more. Views my own. https://salgadolab.org/
Reposted by Prof Paula Salgado
Naturally occurring CodY variants alter ligand binding, DNA target affinity, and virulence in Clostridioides difficile www.biorxiv.org/content/10.1...
Naturally occurring CodY variants alter ligand binding, DNA target affinity, and virulence in Clostridioides difficile
Clostridioides difficile is an important nosocomial pathogen that has been classified as an “urgent threat” by the CDC. Antibiotic use is the primary risk factor for the development of C. difficile -a...
www.biorxiv.org
November 25, 2025 at 4:04 PM
Naturally occurring CodY variants alter ligand binding, DNA target affinity, and virulence in Clostridioides difficile www.biorxiv.org/content/10.1...
Reposted by Prof Paula Salgado
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
November 24, 2025 at 3:17 PM
🌟 WeINSPIREBio is hosting its first event!
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
On Dec 4, we’re running a webinar:
Structures of Success: Career Journeys of Women in Structural Biology
If you work in SB, drug discovery, or just like hearing career stories from brilliant people, join us! And please share 🙏🏼
lnkd.in/ewjD5WPt
#cryoEM
Reposted by Prof Paula Salgado
November is #CdiffAwarenessMonth. Amazing work by @lizahaart.bsky.social turned my idea into a cartoon to help explain why antibiotics are a risk factor for #CDI. More to come! The English version is supported by the #ESGCD (@escmid.bsky.social). Let me know if you think these cartoons are useful!
November 24, 2025 at 1:46 PM
November is #CdiffAwarenessMonth. Amazing work by @lizahaart.bsky.social turned my idea into a cartoon to help explain why antibiotics are a risk factor for #CDI. More to come! The English version is supported by the #ESGCD (@escmid.bsky.social). Let me know if you think these cartoons are useful!
Reposted by Prof Paula Salgado
👇👇👇👇👇
Google has started automatically opting you in to let it read your stuff to train AI. You need to turn this off in SEVERAL places in your settings (not just for Gmail), if you want to maintain privacy and confidentiality.
www.malwarebytes.com/blog/news/20...
www.malwarebytes.com/blog/news/20...
Gmail can read your emails and attachments to train its AI, unless you opt out
A new Gmail update may allow Google to use your private messages and attachments for AI training. Here's how to turn it off.
www.malwarebytes.com
November 22, 2025 at 6:51 PM
👇👇👇👇👇
Protein gel is sad 🧪
November 20, 2025 at 9:57 AM
Protein gel is sad 🧪
Reposted by Prof Paula Salgado
Antimicrobial resistance (AMR) is a growing health threat, making infections harder to treat and complicating routine medical care.
EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform.
#WAAW2025 #ActOnAMR
www.ebi.ac.uk/about/news/t...
🧬💻
EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform.
#WAAW2025 #ActOnAMR
www.ebi.ac.uk/about/news/t...
🧬💻
A new gateway to global antimicrobial resistance data
New online portal connects bacterial genomes with experimental resistance data to support antimicrobial resistance research.
www.ebi.ac.uk
November 18, 2025 at 9:59 AM
Antimicrobial resistance (AMR) is a growing health threat, making infections harder to treat and complicating routine medical care.
EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform.
#WAAW2025 #ActOnAMR
www.ebi.ac.uk/about/news/t...
🧬💻
EMBL-EBI’s new AMR portal brings together laboratory resistance data and bacterial genomes in one open platform.
#WAAW2025 #ActOnAMR
www.ebi.ac.uk/about/news/t...
🧬💻
Reposted by Prof Paula Salgado
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
Great work, beautiful structures and really interesting new insights into #Cdiff toxin inhibition. Congratulations to all! #microsky
#NewResearch
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated C. difficile infection in mice.
#MicroSky 🦠💊
www.nature.com/articles/s41...
Structure-guided design of a synthetic bile acid that inhibits Clostridioides difficile TcdB toxin - Nature Microbiology
A bile acid-bound structure of toxin TcdB revealed the mechanism of inhibition and guided the design of a synthetic bile acid that alleviated Clostridioides difficile infection in mice.
www.nature.com
November 18, 2025 at 2:18 PM
Reposted by Prof Paula Salgado
Reflection as we begin #WorldAntimicrobialAwarenessWeek #WAAW
🔴 #AMR is a growing global emergency
🔴 Solutions must go beyond prescribing #diagnostics #access #prevention
🔴 No one is safe until everyone is safe, solutions must reach all
www.thelancet.com/journals/lan...
#episky #microsky @msf.ca
🔴 #AMR is a growing global emergency
🔴 Solutions must go beyond prescribing #diagnostics #access #prevention
🔴 No one is safe until everyone is safe, solutions must reach all
www.thelancet.com/journals/lan...
#episky #microsky @msf.ca
Antimicrobial resistance: a concise update
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted
and cohesive...
www.thelancet.com
November 18, 2025 at 6:09 AM
Reflection as we begin #WorldAntimicrobialAwarenessWeek #WAAW
🔴 #AMR is a growing global emergency
🔴 Solutions must go beyond prescribing #diagnostics #access #prevention
🔴 No one is safe until everyone is safe, solutions must reach all
www.thelancet.com/journals/lan...
#episky #microsky @msf.ca
🔴 #AMR is a growing global emergency
🔴 Solutions must go beyond prescribing #diagnostics #access #prevention
🔴 No one is safe until everyone is safe, solutions must reach all
www.thelancet.com/journals/lan...
#episky #microsky @msf.ca
Reposted by Prof Paula Salgado
#WAAW is here.
This year’s theme is “From Resistance to Resilience”, spotlights how healthcare workers tackle tough, #AMR infections.
Join the free online event on 18 Nov and help keep antibiotics working. #KeepAntibioticsWorking
www.ecdc.europa.eu/en/news-even...
This year’s theme is “From Resistance to Resilience”, spotlights how healthcare workers tackle tough, #AMR infections.
Join the free online event on 18 Nov and help keep antibiotics working. #KeepAntibioticsWorking
www.ecdc.europa.eu/en/news-even...
European Antibiotic Awareness Day (EAAD) 2025
European Antibiotic Awareness Day (EAAD) is a European health initiative coordinated by ECDC.
www.ecdc.europa.eu
November 18, 2025 at 8:46 AM
#WAAW is here.
This year’s theme is “From Resistance to Resilience”, spotlights how healthcare workers tackle tough, #AMR infections.
Join the free online event on 18 Nov and help keep antibiotics working. #KeepAntibioticsWorking
www.ecdc.europa.eu/en/news-even...
This year’s theme is “From Resistance to Resilience”, spotlights how healthcare workers tackle tough, #AMR infections.
Join the free online event on 18 Nov and help keep antibiotics working. #KeepAntibioticsWorking
www.ecdc.europa.eu/en/news-even...
Reposted by Prof Paula Salgado
Chris is a brilliant structural biologist and mentor. Would highly recommend applying!
🚨Attention prospective PhD students🚨
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
Are you interested in molecular mechanisms, RNA viruses, structural biology or biophysics? 🧬🦠🧪
We have THREE fully-funded PhD projects available for October 2026 entry:
www.findaphd.com/phds/?Keywor...
Please share/repost, and get in touch if you're interested
chris hill PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in chris hill. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 15, 2025 at 10:28 AM
Chris is a brilliant structural biologist and mentor. Would highly recommend applying!
Great to see S-layers get the attention they deserve! Very cool video, @tbharat-lab.bsky.social congrats to all
Assembly, architecture and functional roles of microbial surface layers
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.
S-layers are everywhere!
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 14, 2025 at 11:14 AM
Great to see S-layers get the attention they deserve! Very cool video, @tbharat-lab.bsky.social congrats to all
Very cool structures, congrats to all! #microsky
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 1:44 PM
Very cool structures, congrats to all! #microsky
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
A pleasure to have @mfwhite2.bsky.social for our first #BiosciencesInstitute seminar this year and hearing all about #bacterial #phage defences
November 12, 2025 at 1:12 PM
A pleasure to have @mfwhite2.bsky.social for our first #BiosciencesInstitute seminar this year and hearing all about #bacterial #phage defences
Reposted by Prof Paula Salgado
New Review
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
www.thelancet.com/journals/lan...
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
www.thelancet.com/journals/lan...
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
The fungal diagnostic landscape is evolving; whereas previously, traditional culture-based
methods dominated, most invasive fungal disease is now diagnosed with non-culture-based
tests, including dire...
www.thelancet.com
November 11, 2025 at 8:12 AM
New Review
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
www.thelancet.com/journals/lan...
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
www.thelancet.com/journals/lan...
Excellent work from @allostericstate.bsky.social and Douglas Ferreira from @wyattyue.bsky.social lab at @newcastleuni.bsky.social! Congratulations to all!
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 2:02 PM
Excellent work from @allostericstate.bsky.social and Douglas Ferreira from @wyattyue.bsky.social lab at @newcastleuni.bsky.social! Congratulations to all!
Reposted by Prof Paula Salgado
Poster prize to 🏆 Olivia Gittins from Durham University
November 7, 2025 at 5:19 PM
Poster prize to 🏆 Olivia Gittins from Durham University
Reposted by Prof Paula Salgado
Poster prizes to Amy Wiseman
November 7, 2025 at 5:16 PM
Poster prizes to Amy Wiseman
Reposted by Prof Paula Salgado
Poster prize to 🏆 Matthew Grobbelaar from Durham University
November 7, 2025 at 5:18 PM
Poster prize to 🏆 Matthew Grobbelaar from Durham University
Reposted by Prof Paula Salgado
A prize winning talk 🏆 congrats
November 7, 2025 at 5:15 PM
A prize winning talk 🏆 congrats
Reposted by Prof Paula Salgado
A prize winning talk 🏆 congrats
November 7, 2025 at 5:14 PM
A prize winning talk 🏆 congrats
Reposted by Prof Paula Salgado
A prize winning talk 🏆 congrats
November 7, 2025 at 5:14 PM
A prize winning talk 🏆 congrats
Reposted by Prof Paula Salgado
Ending the meeting with a careers panel. What you you do with a PhD in structural biology?
November 7, 2025 at 3:28 PM
Ending the meeting with a careers panel. What you you do with a PhD in structural biology?
Reposted by Prof Paula Salgado
Alexander Konstantinov from UKRI STFC telling us how we can optimise refinement of x-ray data
November 7, 2025 at 2:36 PM
Alexander Konstantinov from UKRI STFC telling us how we can optimise refinement of x-ray data
Reposted by Prof Paula Salgado
Wrapping up the research talks is Paola Lanzoni-Mangutchi from the @wyattyue.bsky.social group
November 7, 2025 at 2:13 PM
Wrapping up the research talks is Paola Lanzoni-Mangutchi from the @wyattyue.bsky.social group