Rangan Lab
@ranganlab.bsky.social
Germline development
@IcahnMountSinai
@CDRBSinai
https://scholar.google.com/citations?user=GZS8SS4AAAAJ&hl=en
@IcahnMountSinai
@CDRBSinai
https://scholar.google.com/citations?user=GZS8SS4AAAAJ&hl=en
Pinned
Rangan Lab
@ranganlab.bsky.social
· Mar 17
TORC1-driven translation of Nucleoporin 44A promotes chromatin remodeling and germ cell-to-maternal transition in Drosophila https://www.biorxiv.org/content/10.1101/2025.03.14.643309v1
New preprint from our lab!
Reposted by Rangan Lab
In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila
Wnt-signaling, via β-catenin or the planar cell polarity (PCP) branch, is crucial for development, tissue homeostasis, and linked to many diseases. LRP5/6, arrow ( arr ) in Drosophila , is the obligat...
www.biorxiv.org
October 21, 2025 at 2:49 PM
In the 2nd preprint from @mlodziklab.bsky.social, Weber et al. show that LRP5/6/arrow, the Wnt/bcatenin signaling specific co-receptor, is also required for Wnt/planar cell polarity establishment, a challenge and eye-opener for the Wnt field.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Rangan Lab
Two exciting preprints from @mlodziklab.bsky.social lab. In the first preprint, Vuong and Mlodzik describe a novel, essential factor for bcatenin translocation to the nucleus, a big step forward to understand nuclear bcatenin localization. www.biorxiv.org/content/10.1...
A novel conserved protein associates with the IFT-A complex to mediate nuclear translocation of β-catenin in Wg/Wnt-signaling
Wingless (Wg)/Wnt signaling is critical throughout development and tissue homeostasis and associated with many disease states. Canonical Wg/Wnt-signaling is mediated by β-catenin (Arm in Drosophila ) ...
www.biorxiv.org
October 21, 2025 at 2:45 PM
Two exciting preprints from @mlodziklab.bsky.social lab. In the first preprint, Vuong and Mlodzik describe a novel, essential factor for bcatenin translocation to the nucleus, a big step forward to understand nuclear bcatenin localization. www.biorxiv.org/content/10.1...
Reposted by Rangan Lab
The @fly-eds.bsky.social is having its general assembly this saturday at 13:30 at #EDRC2025 , please join us to discuss our society and to find out more about @flybase.bsky.social and the current funding crisis
September 24, 2025 at 3:23 PM
The @fly-eds.bsky.social is having its general assembly this saturday at 13:30 at #EDRC2025 , please join us to discuss our society and to find out more about @flybase.bsky.social and the current funding crisis
Reposted by Rangan Lab
There are only 8 days left to register to @edrc2025.bsky.social and we would like to thank all our sponsorss! We start acknowledging the support received from @biologists.bsky.social to #EDRC2025 Thank you!
September 4, 2025 at 6:46 PM
There are only 8 days left to register to @edrc2025.bsky.social and we would like to thank all our sponsorss! We start acknowledging the support received from @biologists.bsky.social to #EDRC2025 Thank you!
Registration is officially open for the 2026 EMBO Drosophila Meeting in Crete 🪰☀️. This flagship meeting brings together researchers from around the world to share discoveries, foster collaborations, and celebrate the power of Drosophila in advancing biology. Consider applying!
September 5, 2025 at 3:57 PM
Registration is officially open for the 2026 EMBO Drosophila Meeting in Crete 🪰☀️. This flagship meeting brings together researchers from around the world to share discoveries, foster collaborations, and celebrate the power of Drosophila in advancing biology. Consider applying!
Reposted by Rangan Lab
EMBO meeting on "Molecular and Developmental Biology of Drosophila" 21 – 27 June 2026
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Molecular and Developmental Biology of Drosophila
The principal theme of the EMBO Workshop is the Molecular and Developmental Biology of Drosophila. Supported by EMBO over four decades, this will be the 24th biennial “Crete meeting”.
With the a…
meetings.embo.org
September 4, 2025 at 8:01 AM
EMBO meeting on "Molecular and Developmental Biology of Drosophila" 21 – 27 June 2026
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Registration is now open!
Deadline next November 3rd!
meetings.embo.org/event/26-dro...
Reposted by Rangan Lab
Actin up: Mrtfa regulates actomyosin and apical constriction This Research Highlight showcases the work from Keiji Itoh, Olga Ossipova, Sergei Y. Sokol:
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
September 5, 2025 at 1:27 PM
Actin up: Mrtfa regulates actomyosin and apical constriction This Research Highlight showcases the work from Keiji Itoh, Olga Ossipova, Sergei Y. Sokol:
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Rangan Lab
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
May 30, 2025 at 9:52 PM
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
Reposted by Rangan Lab
The end of US leadership in science, technology, and innovation.
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
May 30, 2025 at 9:26 PM
The end of US leadership in science, technology, and innovation.
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
All in one little table.
A tremendous gift to China, courtesy of the GOP.
nsf-gov-resources.nsf.gov/files/00-NSF...
Reposted by Rangan Lab
Science is under attack. The NIH, the NSF, and our research universities.
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
A Message to Scientists
YouTube video by Sen. Adam Schiff
youtu.be
May 28, 2025 at 9:54 PM
Science is under attack. The NIH, the NSF, and our research universities.
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
So today, I have a message for America's scientists:
youtu.be/MeoZDPy5cIY?...
Reposted by Rangan Lab
“Remember that all through history, there have been tyrants and murderers, and for a time, they seem invincible. But in the end, they always fall. Always.”
—Mahatma Gandhi
—Mahatma Gandhi
May 24, 2025 at 5:32 PM
“Remember that all through history, there have been tyrants and murderers, and for a time, they seem invincible. But in the end, they always fall. Always.”
—Mahatma Gandhi
—Mahatma Gandhi
Reposted by Rangan Lab
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
May 23, 2025 at 5:56 PM
All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!
Reposted by Rangan Lab
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
May 24, 2025 at 1:13 AM
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏
youtu.be/8YhJM6zxYDw?...
youtu.be/8YhJM6zxYDw?...
Reposted by Rangan Lab
Congratulations to the next Chair of the Dept. of Molecular Biology: Elizabeth (Liz) R. Gavis, the Damon B. Pfeiffer Professor in the Life Sciences and Assoc. Faculty in the Program in Quantitative and Computational Biology. Her term begins on July 1, 2025. molbio.princeton.edu/news/2025/ga...
Gavis named next Chair
Elizabeth (Liz) R. Gavis, the Damon B. Pfeiffer Professor in the Life Sciences in the Department of Molecular Biology and Associated Faculty in the Program in Quantitative and Computational Biology, h...
molbio.princeton.edu
May 8, 2025 at 9:07 PM
Congratulations to the next Chair of the Dept. of Molecular Biology: Elizabeth (Liz) R. Gavis, the Damon B. Pfeiffer Professor in the Life Sciences and Assoc. Faculty in the Program in Quantitative and Computational Biology. Her term begins on July 1, 2025. molbio.princeton.edu/news/2025/ga...
Congrats Yukiko!
Whitehead Institute Member Yukiko Yamashita, who studies how genetic information is passed from parents to offspring, has been elected to the National Academy of Sciences. Full story on our website: wi.mit.edu/news/yukiko-...
May 5, 2025 at 8:59 PM
Congrats Yukiko!
Reposted by Rangan Lab
Drosophila folks at the @genetics-gsa.bsky.social Fly meeting please take some time to thank the amazing organizers who put in a lot of hard work:
genetics-gsa.org/drosophila-2...
Special thanks to GSA folks especially the tireless Suzy Brown (who appears to run entirely on diet Mountain Dew)
genetics-gsa.org/drosophila-2...
Special thanks to GSA folks especially the tireless Suzy Brown (who appears to run entirely on diet Mountain Dew)
Organizers - 66th Annual Drosophila Research Conference
Visit our website to learn more.
genetics-gsa.org
March 21, 2025 at 11:43 PM
Drosophila folks at the @genetics-gsa.bsky.social Fly meeting please take some time to thank the amazing organizers who put in a lot of hard work:
genetics-gsa.org/drosophila-2...
Special thanks to GSA folks especially the tireless Suzy Brown (who appears to run entirely on diet Mountain Dew)
genetics-gsa.org/drosophila-2...
Special thanks to GSA folks especially the tireless Suzy Brown (who appears to run entirely on diet Mountain Dew)
Reposted by Rangan Lab
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
Reposted by Rangan Lab
Sign up & spread the word to trainees about the 🪱C. elegans🪱 mentor match program!
They're also setting up peer-mentoring groups at ALL stages (even faculty!). Peer mentors have helped me keep my sanity & resolve in the tough times, and cheered me on in the good times. 🙌 Sign up to find your own!
They're also setting up peer-mentoring groups at ALL stages (even faculty!). Peer mentors have helped me keep my sanity & resolve in the tough times, and cheered me on in the good times. 🙌 Sign up to find your own!
Worm people: We need YOU to help recruit more mentees for the C. elegans Community Mentor Match program! 🪱✨
📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!
📢 Help us sign up more mentees by sharing this this slide with your lab in your next lab meeting!
Join the C. elegans Community Mentor Match Program!
Join the C. elegans Community Mentor Match Program! sign up for mentors sign up for mentees and to join peer-mentoring groups https://forms.gle/DpGTWRMrNGL96wHy8 https://forms.gle/pVBD5DYGXyLT4waLA
docs.google.com
March 18, 2025 at 12:52 PM
Sign up & spread the word to trainees about the 🪱C. elegans🪱 mentor match program!
They're also setting up peer-mentoring groups at ALL stages (even faculty!). Peer mentors have helped me keep my sanity & resolve in the tough times, and cheered me on in the good times. 🙌 Sign up to find your own!
They're also setting up peer-mentoring groups at ALL stages (even faculty!). Peer mentors have helped me keep my sanity & resolve in the tough times, and cheered me on in the good times. 🙌 Sign up to find your own!
Reposted by Rangan Lab
TORC1-driven translation of Nucleoporin 44A promotes chromatin remodeling and germ cell-to-maternal transition in Drosophila https://www.biorxiv.org/content/10.1101/2025.03.14.643309v1
March 17, 2025 at 3:30 AM
TORC1-driven translation of Nucleoporin 44A promotes chromatin remodeling and germ cell-to-maternal transition in Drosophila https://www.biorxiv.org/content/10.1101/2025.03.14.643309v1
New preprint from our lab!
TORC1-driven translation of Nucleoporin 44A promotes chromatin remodeling and germ cell-to-maternal transition in Drosophila https://www.biorxiv.org/content/10.1101/2025.03.14.643309v1
March 17, 2025 at 9:30 PM
New preprint from our lab!
Reposted by Rangan Lab
We are in a biotech space race, cutting off basic science via slashing NIH and NSF funding robs the US of our competitive advantage: early innovation.
China is poised to dominate biotechnology in the 21st century - The Hill
March 12, 2025 at 1:34 AM
We are in a biotech space race, cutting off basic science via slashing NIH and NSF funding robs the US of our competitive advantage: early innovation.
Reposted by Rangan Lab
THIS IS AWESOME - shame on universites and even foundations (looking at you
@hhmi.bsky.social) for your cowardly anticipatory obedience!!!! www.huffpost.com/entry/us-tru...
@hhmi.bsky.social) for your cowardly anticipatory obedience!!!! www.huffpost.com/entry/us-tru...
Judge Blocks Trump’s Executive Order Ending Federal Support For DEI Programs
A federal judge has blocked a sweeping executive order from President Donald Trump that sought to end government support for programs promoting diversity, equity and inclusion.
www.huffpost.com
February 22, 2025 at 1:09 AM
THIS IS AWESOME - shame on universites and even foundations (looking at you
@hhmi.bsky.social) for your cowardly anticipatory obedience!!!! www.huffpost.com/entry/us-tru...
@hhmi.bsky.social) for your cowardly anticipatory obedience!!!! www.huffpost.com/entry/us-tru...
Reposted by Rangan Lab
““This crisis — and I’m not exaggerating by calling it a crisis — has already consumed one funding cycle…But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.” @labonnelab.bsky.social
February 21, 2025 at 10:52 PM
““This crisis — and I’m not exaggerating by calling it a crisis — has already consumed one funding cycle…But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.” @labonnelab.bsky.social