Genome Biology is calling for submissions to our Collection on enhancer-promoter interactions. Enhancer–promoter interactions are central to the regulation ...

Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...

A Swiss film about a nurse pushed to her limits one night is being praised for the picture it paints of treacherously underfunded healthcare. The director talks about the ‘heart-pounding’ story that i...

Research Assistant (Fixed Term) in the Department of Physiology, Development and Neuroscience at the University of Cambridge.

A chromatin accessibility peak caller with an adaptive background model - vierstralab/hotspot3

The REX element is associated with long-range enhancer–promoter interactions.

Abstract. Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effec

Transcription factor (TF) cooperativity plays a critical role in gene regulation. However, the underlying genomic rules remain unclear, calling for scalable methods to characterize the TF binding site...

Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhält sich Chromatin als Material – als Flüssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszuführen? Ohne eine Antwort auf diese Frage können wir nicht vollständig verstehen, wie Chromatin bei Krankheiten gestört wird.

Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.

imageimageHow alterations in cell metabolism translate into specific developmental gene programs remains a major question. This study shows that forcing OXPHOS metabolism reprograms mouse embryonic stem cells (ESCs) to a more inner cell mass (ICM)-...