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Reposted by Mike Schumacher

Edelblum Lab @edelblumlab.bsky.social · 8d

Join me & keynote speaker Dr. Florian Rieder at #CCCongress26, Jan. 22-24 in Vegas. @ibd-flomd.bsky.social does an outstanding job bridging #IBD basic science and clinical research, so this is sure to be a great talk Register by 10/21 & SAVE: 🔗 bit.ly/4m85s1N
#IBDsky #GIsky #Gastrosky

Home 2026

Join colleagues across the entire spectrum of clinical care and science at the premier conference on inflammatory bowel disease (IBD).

bit.ly

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Eduardo Villablanca @ejvillablanca.bsky.social · Aug 20

#Bcells are emerging as key players in #IBD, far beyond a T-cell story.

From IgA protection to pro-inflammatory subsets, we highlight how understanding B cell diversity can unlock precise #Immunotherapy in #IBD.

Check Fran and Bianca's review 👇

doi.org/10.1016/j.im...

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

www.sciencedirect.com

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Mike Schumacher @schumacherama.bsky.social · Jul 24

Giggling her way into 3 months old

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Snippert lab @hugosnippert.bsky.social · Jul 23

🔊 Paper alert
1/ Tuft cells are perhaps the coolest cells in our gut orchestrating host defense, but how do they manage? @julian-buissant.bsky.social provides new insights into tuft cell differentiation, and the development of accurate in vitro models for experimental cell biology 🧫🔬🧬
rdcu.be/exou9

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Mike Schumacher @schumacherama.bsky.social · Jul 23

Immune cell stratification in the inflamed intestinal epithelium

#immunofluorescence #microscopy #ibd

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Mucosal Immunology @mucosalimmunol.bsky.social · Jun 6

Review the contributions of mucus-associated microbes who are “Living on the Edge” in the colon:
www.mucosalimmunology.org/article/S193...

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The New York Times @nytimes.com · May 15

Breaking News: A baby with a rare disorder made medical history by receiving the first custom gene-editing treatment. The technique used has the potential to help people with thousands of other uncommon genetic diseases. nyti.ms/4j49xBy

A baby surrounded by medical devices is being held up by someone with gloved hands. A headline reads: "Baby Is Healed With World's First Personalized Gene-Editing Treatment." Photo courtesy of Children's Hospital of Pennsylvania.

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Eduardo Villablanca @ejvillablanca.bsky.social · May 14

We’re excited to share our recently published story

“A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing”

in @mucosalimmunol.bsky.social

Fantastic work led by @ramoralescastro.bsky.social !

www.mucosalimmunology.org/article/S193...

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing

The intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

www.mucosalimmunology.org

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Camp Lab @graycamplab.bsky.social · May 12

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s41... Lead by @quanxu.bsky.social, in collaboration with Lennard Halle and @fabiantheis.bsky.social

An integrated transcriptomic cell atlas of human endoderm-derived organoids - Nature Genetics

The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It compares cell types and sta...

nature.com

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Journal of Experimental Medicine @jem.org · May 5

The colonic mucus barrier & sentinel goblet cells protect the distal gut from microbial challenges. Johansson, @gobletcellguy.bsky.social et al show that microbial colonization drives sequential development of both of these barrier mechanisms in the pre-weaning intestine. rupress.org/jem/article/...

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Mike Schumacher @schumacherama.bsky.social · Apr 21

Household mischief level about to double, welcome home baby two 🙃

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Edelblum Lab @edelblumlab.bsky.social · Mar 21

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

www.science.org

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Jeremy Berg @jeremymberg.bsky.social · Feb 22

Bluetorial: The path to a new pain medication with little potential for addiction

Perhaps a good story to share with folks who want to learn about how biomedical research works and where advances come from.

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

media.tenor.com

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Nature @nature.com · Feb 20

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb.

https://go.nature.com/41a7Zzj

Rare genetic disorder treated in womb for the first time

The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

go.nature.com

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Beth Popp Berman @epopppp.bsky.social · Feb 18

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”

I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

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NiceLab @nicelab.bsky.social · Feb 4

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda: Cell Reports www.cell.com/cell-reports...

Newborns lack immune memory to viral pathogens, so wouldn't it make sense to pre-emptively turn on antiviral defenses in barrier tissues such as the intestine at birth?

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda

Enteric viral infections are a major public health problem in newborns. Ramirez Reyes et al. find that the immature intestinal epithelium of newborn mice is developmentally programmed for the homeosta...

www.cell.com

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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · Jan 31

New online! Understanding the therapeutic toolkit for inflammatory bowel disease

Understanding the therapeutic toolkit for inflammatory bowel disease

Nature Reviews Gastroenterology & Hepatology, Published online: 31 January 2025; doi:10.1038/s41575-024-01035-7The management of inflammatory bowel disease (IBD) continues to evolve. This Review is a practical guide on the therapeutic toolkit for IBD,…

www.nature.com

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Journal of Experimental Medicine @jem.org · Jan 28

New: Lee et al. @harvardmed.bsky.social provide a compendium of early transcriptional responses to major inflammatory #cytokines across all major immunocyte lineages of the mouse, highlighting unappreciated relationships btwn these cytokines and with other cytokine families https://buff.ly/4gn71Fg

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Prisca Liberali @priscaliberali.bsky.social · Jan 15

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

Cell heterogeneity and fate bistability drive tissue patterning during intestinal regeneration

Tissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

biorxiv.org

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Josh Currie @joshcurrie.bsky.social · Jan 2

A little confocal time in the empty lab is the New Year's start that I needed!

Axolotl epidermis pseudo-colored for depth and artistic interpretation :-)
Cell membranes and chromatin marked by fluorescent protein fusions

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Mike Schumacher @schumacherama.bsky.social · Jan 2

Immune phenotyping of the colon in IBD
#immunofluorescence #microscopy

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Katrina Ray @heykatray.bsky.social · Dec 16

NEW Year-in-Review in #NatureReviewsGastroHep highlighting the key papers in #IBD in 2024

Biologic agents for IBD come of age as host–microbe interactions emerge
By Leolin Katsidzira & Benjamin Misselwitz
www.nature.com/articles/s41...

#IBDsky #GastroSky #Microsky 🧪

Biologic agents for IBD come of age as host–microbe interactions emerge - Nature Reviews Gastroenterology & Hepatology

In 2024, there were major advances in inflammatory bowel disease research. Treatment strategies with biologic agents for inflammatory bowel disease matured, and gut microbiota–bacteriophage–host inter...

www.nature.com

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Mike Schumacher @schumacherama.bsky.social · Dec 10

Z-stacking thru a goblet cell stained enteroid #immunofluorescence #microscopy

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