Sebastian Baumgarten
@sebbaumgarten.bsky.social
Scientist, cyclist and lover of the sea
Reposted by Sebastian Baumgarten
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
November 26, 2025 at 3:06 PM
Just uploaded our new preprint to @ecoevorxiv.bsky.social
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Multinucleate life really is everywhere...from deep sea forams to slime molds, intracellular parasites, and beyond. 🚀
We explore how scaling, ecology, & evolution intersect when many nuclei share a single cytoplasm.
doi.org/10.32942/X2M...
Reposted by Sebastian Baumgarten
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Innate immune responses to Plasmodium falciparum disrupt the blood-brain barrier
Plasmodium falciparum accumulation at the blood-brain barrier (BBB) is a hallmark of cerebral malaria, a life-threatening complication. Conversely, the contribution of the immune response to vascular ...
www.biorxiv.org
October 21, 2025 at 11:06 AM
Pre-print alert 🚨
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
We answer a longstanding question in the field. Do immune cells cause cerebral malaria?
The answer is YES!!!! And independently of P. falciparum accumulation in the brain.
www.biorxiv.org/cgi/content/...
Reposted by Sebastian Baumgarten
Beautiful beasts: excited to see our first volume electron microscopy study on malaria parasites published: advanced.onlinelibrary.wiley.com/doi/10.1002/... revealing new insights into Plasmodium ookinete development. Thanks for great EMBL-Umea-Heidelberg collaboration.
October 2, 2025 at 2:44 PM
Beautiful beasts: excited to see our first volume electron microscopy study on malaria parasites published: advanced.onlinelibrary.wiley.com/doi/10.1002/... revealing new insights into Plasmodium ookinete development. Thanks for great EMBL-Umea-Heidelberg collaboration.
Come apply with us to unravel some beautiful malaria genetics! This is a great program with plenty benefits specifically for international students
🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry.
Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬
Register now ✍️ www.pasteur.fr/en/education...
Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬
Register now ✍️ www.pasteur.fr/en/education...
September 8, 2025 at 12:07 PM
Come apply with us to unravel some beautiful malaria genetics! This is a great program with plenty benefits specifically for international students
Reposted by Sebastian Baumgarten
We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity:
www.cell.com/trends/paras...
www.cell.com/trends/paras...
Parasite genome organization: come together, right now!
Links between genome organization and transcription have been extensively studied
in model eukaryotes; however, recent application of state-of-the-art chromosome conformation
capture techniques to kin...
www.cell.com
August 10, 2025 at 8:28 AM
We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity:
www.cell.com/trends/paras...
www.cell.com/trends/paras...
Reposted by Sebastian Baumgarten
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...
rdcu.be
August 7, 2025 at 7:27 AM
We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social
rdcu.be/ezBl7
Reposted by Sebastian Baumgarten
🚨 2-year post-doc position available in my lab. More details below. Please repost!
acrobat.adobe.com/id/urn:aaid:...
acrobat.adobe.com/id/urn:aaid:...
July 29, 2025 at 7:22 AM
🚨 2-year post-doc position available in my lab. More details below. Please repost!
acrobat.adobe.com/id/urn:aaid:...
acrobat.adobe.com/id/urn:aaid:...
Reposted by Sebastian Baumgarten
A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon
research.pasteur.fr/en/job/a-two...
research.pasteur.fr/en/job/a-two...
A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research
research.pasteur.fr
July 28, 2025 at 10:30 AM
A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon
research.pasteur.fr/en/job/a-two...
research.pasteur.fr/en/job/a-two...
Reposted by Sebastian Baumgarten
📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025
🗓️ Application deadline 31 August 2025
July 28, 2025 at 9:25 AM
📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025
🗓️ Application deadline 31 August 2025
Reposted by Sebastian Baumgarten
Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites https://www.biorxiv.org/content/10.1101/2025.07.16.665170v1
July 17, 2025 at 9:38 AM
Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum
Reposted by Sebastian Baumgarten
Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...
July 11, 2025 at 7:31 PM
Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...
Reposted by Sebastian Baumgarten
June was a productive month: brought two things into this world, both of which were great collaborative efforts and about nine months in the making. Check out where we map P. falciparum genome architecture at high resolution with Micro-C here:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 30, 2025 at 3:22 PM
June was a productive month: brought two things into this world, both of which were great collaborative efforts and about nine months in the making. Check out where we map P. falciparum genome architecture at high resolution with Micro-C here:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How does the malaria parasite regulate co-expression of genes? By recruiting them into transcription factories, courtesy of MORC et al. A fantastic team effort led by @jessmbryant.bsky.social with Jacques Serizay @singh-parul.bsky.social, @ju-couble.bsky.social @rkoszul.bsky.social
OUT NOW: High resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes
@jessmbryant.bsky.social sky.social @singh-parul.bsky.social
@ju-couble.bsky.social #MicroSky
www.nature.com/articles/s41...
@jessmbryant.bsky.social sky.social @singh-parul.bsky.social
@ju-couble.bsky.social #MicroSky
www.nature.com/articles/s41...
High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes - Nature Microbiology
Micro-C provides insights into genome organization in Plasmodium falciparum and defines the machinery used to spatially coordinate antigenic variation and stage-specific genes that are crucial for inf...
www.nature.com
June 30, 2025 at 11:36 AM
How does the malaria parasite regulate co-expression of genes? By recruiting them into transcription factories, courtesy of MORC et al. A fantastic team effort led by @jessmbryant.bsky.social with Jacques Serizay @singh-parul.bsky.social, @ju-couble.bsky.social @rkoszul.bsky.social
Reposted by Sebastian Baumgarten
Awesome malaria study out now in Nature Microbiology:
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology
A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.
www.nature.com
June 13, 2025 at 10:31 AM
Awesome malaria study out now in Nature Microbiology:
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
Reposted by Sebastian Baumgarten
📢 Big Announcement: Registration & abstract submission open for EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by ParaFrap @parafrap.bsky.social @embo.org
🗓️ 5-8 Oct 2025 - Les Embiez Island-France
🔚Deadline: 15 Jul 2025 meetings.embo.org/event/25-hos...
🗓️ 5-8 Oct 2025 - Les Embiez Island-France
🔚Deadline: 15 Jul 2025 meetings.embo.org/event/25-hos...
May 14, 2025 at 7:37 AM
📢 Big Announcement: Registration & abstract submission open for EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by ParaFrap @parafrap.bsky.social @embo.org
🗓️ 5-8 Oct 2025 - Les Embiez Island-France
🔚Deadline: 15 Jul 2025 meetings.embo.org/event/25-hos...
🗓️ 5-8 Oct 2025 - Les Embiez Island-France
🔚Deadline: 15 Jul 2025 meetings.embo.org/event/25-hos...
As usual, fantastic science at #EMBLMalaria. Special thanks for the travel support from @pasteur.fr in the new EMBL-Pasteur initiative and the organization @lilianamancio.bsky.social @sturalph.bsky.social @events.embl.org
That’s a wrap on #EMBLMalaria ! 🦟🎉
From game-changing ideas to brilliant conversations, we’re heading home inspired and energised.
Huge shoutout to everyone who joined us, and big congrats to the 10 amazing poster prize winners 🏆👏
Stay tuned for 2026 dates and more info on the awarded posters!
From game-changing ideas to brilliant conversations, we’re heading home inspired and energised.
Huge shoutout to everyone who joined us, and big congrats to the 10 amazing poster prize winners 🏆👏
Stay tuned for 2026 dates and more info on the awarded posters!
May 23, 2025 at 7:53 PM
As usual, fantastic science at #EMBLMalaria. Special thanks for the travel support from @pasteur.fr in the new EMBL-Pasteur initiative and the organization @lilianamancio.bsky.social @sturalph.bsky.social @events.embl.org
Reposted by Sebastian Baumgarten
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance
Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...
rdcu.be
May 16, 2025 at 2:08 PM
Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.
Reposted by Sebastian Baumgarten
Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)!
But how do the parasite complexes work and how do drugs inhibit them?
Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇
But how do the parasite complexes work and how do drugs inhibit them?
Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇
Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology
Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...
www.nature.com
May 19, 2025 at 12:56 PM
Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)!
But how do the parasite complexes work and how do drugs inhibit them?
Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇
But how do the parasite complexes work and how do drugs inhibit them?
Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇
Reposted by Sebastian Baumgarten
The KnuepferLab is hiring!
Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC.
Follow either link below for more information on the project and the job offer:
lnkd.in/eprgmaE9
www.jobs.ac.uk/job/DMY962/p...
Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC.
Follow either link below for more information on the project and the job offer:
lnkd.in/eprgmaE9
www.jobs.ac.uk/job/DMY962/p...
May 6, 2025 at 11:41 AM
The KnuepferLab is hiring!
Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC.
Follow either link below for more information on the project and the job offer:
lnkd.in/eprgmaE9
www.jobs.ac.uk/job/DMY962/p...
Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC.
Follow either link below for more information on the project and the job offer:
lnkd.in/eprgmaE9
www.jobs.ac.uk/job/DMY962/p...
Reposted by Sebastian Baumgarten
Looking forward to joining @lshtm-malaria.bsky.social’s #WorldMalariaDay event to reflect on what’s next for malaria research and how we can continue to drive change.
Details here www.lshtm.ac.uk/newsevents/e... | LSHTM
#Malaria #GlobalHealth #WorldMalariaDay
Details here www.lshtm.ac.uk/newsevents/e... | LSHTM
#Malaria #GlobalHealth #WorldMalariaDay
April 9, 2025 at 1:58 PM
Looking forward to joining @lshtm-malaria.bsky.social’s #WorldMalariaDay event to reflect on what’s next for malaria research and how we can continue to drive change.
Details here www.lshtm.ac.uk/newsevents/e... | LSHTM
#Malaria #GlobalHealth #WorldMalariaDay
Details here www.lshtm.ac.uk/newsevents/e... | LSHTM
#Malaria #GlobalHealth #WorldMalariaDay
Ready for the most beautifully sophisticated m6A modification program out there?
It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social
It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social
N6-methyladenosine primes the malaria parasite for transmission
Sudden environmental changes are a recurring challenge for unicellular organisms, but a necessity for many to progress through their lifecycle. To transmit from its human host to mosquito vector, mala...
doi.org
April 4, 2025 at 9:32 AM
Ready for the most beautifully sophisticated m6A modification program out there?
It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social
It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social
The first joint labretreat with @anarbgomes.bsky.social, @jessmbryant.bsky.social and @amtalman.bsky.social is in the books. Thank you so much for hosting us, great science and fun.
@ecoliswatchingu.cpesr.fr @tizvignolini.bsky.social
@pasteur.fr @ird-fr.bsky.social @umontpellier.bsky.social
@ecoliswatchingu.cpesr.fr @tizvignolini.bsky.social
@pasteur.fr @ird-fr.bsky.social @umontpellier.bsky.social
April 2, 2025 at 11:46 AM
The first joint labretreat with @anarbgomes.bsky.social, @jessmbryant.bsky.social and @amtalman.bsky.social is in the books. Thank you so much for hosting us, great science and fun.
@ecoliswatchingu.cpesr.fr @tizvignolini.bsky.social
@pasteur.fr @ird-fr.bsky.social @umontpellier.bsky.social
@ecoliswatchingu.cpesr.fr @tizvignolini.bsky.social
@pasteur.fr @ird-fr.bsky.social @umontpellier.bsky.social
Reposted by Sebastian Baumgarten
From Data to Insight – A Practical Introduction to Interpreting Malaria Genetics for Surveillance, a free, self-paced online course offered by the PlasmoGenEpi network and developed with funding from the Gates Foundation.
🔗plasmogenepi.org/OnlineCourse
🔗plasmogenepi.org/OnlineCourse
March 30, 2025 at 5:50 PM
From Data to Insight – A Practical Introduction to Interpreting Malaria Genetics for Surveillance, a free, self-paced online course offered by the PlasmoGenEpi network and developed with funding from the Gates Foundation.
🔗plasmogenepi.org/OnlineCourse
🔗plasmogenepi.org/OnlineCourse
Malaria parasites are an extreme example of ribosome heterogeneity. But how do they control which ribosomal RNA to express when?
Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social
www.biorxiv.org/content/10.1...
Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 26, 2025 at 7:45 AM
Malaria parasites are an extreme example of ribosome heterogeneity. But how do they control which ribosomal RNA to express when?
Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social
www.biorxiv.org/content/10.1...
Check out this mountain of work led by @ju-couble.bsky.social with @tizvignolini.bsky.social @jessmbryant.bsky.social
www.biorxiv.org/content/10.1...
Reposted by Sebastian Baumgarten
The VEuPathDB survey asked users to estimate the impact on their lab's productivity (from 0-100) if VEuPathDB resources were to disappear altogether. We also asked them to describe the impact. ✏️The infographic lists a few key themes that emerged from nearly 1500 comments!
March 4, 2025 at 6:56 PM
The VEuPathDB survey asked users to estimate the impact on their lab's productivity (from 0-100) if VEuPathDB resources were to disappear altogether. We also asked them to describe the impact. ✏️The infographic lists a few key themes that emerged from nearly 1500 comments!