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Reposted by Sebastian Baumgarten

Freddy Frischknecht @freddyfrischknecht.bsky.social · 6d

Beautiful beasts: excited to see our first volume electron microscopy study on malaria parasites published: advanced.onlinelibrary.wiley.com/doi/10.1002/... revealing new insights into Plasmodium ookinete development. Thanks for great EMBL-Umea-Heidelberg collaboration.

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Sebastian Baumgarten @sebbaumgarten.bsky.social · Sep 8

Come apply with us to unravel some beautiful malaria genetics! This is a great program with plenty benefits specifically for international students

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Sep 1

🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry.

Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, [email protected], PPU-EID @upcite.bsky.social & more 🧬

Register now ✍️ www.pasteur.fr/en/education...

Pasteur-Paris University International Doctoral Programme, The call for enrollment of students in October 2026 will be open from September 1st to October 20th, 2025

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Reposted by Sebastian Baumgarten

Jessica Bryant @jessmbryant.bsky.social · Aug 10

We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity:

www.cell.com/trends/paras...

Parasite genome organization: come together, right now!

Links between genome organization and transcription have been extensively studied in model eukaryotes; however, recent application of state-of-the-art chromosome conformation capture techniques to kin...

www.cell.com

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Reposted by Sebastian Baumgarten

Maria Bernabeu @mariabernabeu.bsky.social · Aug 7

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.

First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social

rdcu.be/ezBl7

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

rdcu.be

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Reposted by Sebastian Baumgarten

Seb Besteiro @s-besteiro.bsky.social · Jul 29

🚨 2-year post-doc position available in my lab. More details below. Please repost!

acrobat.adobe.com/id/urn:aaid:...

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Reposted by Sebastian Baumgarten

Didier Mazel @amazeld.bsky.social · Jul 28

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon
research.pasteur.fr/en/job/a-two...

A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research

research.pasteur.fr

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Reposted by Sebastian Baumgarten

Cassandra Koh 🦟🔬🧪 @cassandrakoh.bsky.social · Jul 28

📣 I'm recruiting a postdoc researcher to join my team for a project on mosquito-specific viruses and host interactions. Peep the job description & how to apply below. Perfect for soon-to-be or recent PhD graduates in mosquito vector biology 🦟 or arbovirology 🦠
🗓️ Application deadline 31 August 2025

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Reposted by Sebastian Baumgarten

fra-florini.bsky.social @fra-florini.bsky.social · Jul 17

Preprint Alert 🚨 Check out the latest piece of work from the @kirkdeitsch.bsky.social lab, where we characterized the sophisticated molecular layers controlling var2csa expression and antigenic variation in P. falciparum

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Jul 17

The molecular basis of coordinated antigen switching enabling chronic infection by human malaria parasites https://www.biorxiv.org/content/10.1101/2025.07.16.665170v1

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Reposted by Sebastian Baumgarten

Maria Bernabeu @mariabernabeu.bsky.social · Jul 11

Pre-print alert 🚨: We have developed 2D and 3D stable iPSC endothelial-differentiation models through dox inducible ETS expression. We demonstrate endothelial identity and used these models for studying malaria pathogenesis research. www.biorxiv.org/content/10.1...

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Reposted by Sebastian Baumgarten

Jessica Bryant @jessmbryant.bsky.social · Jun 30

June was a productive month: brought two things into this world, both of which were great collaborative efforts and about nine months in the making. Check out where we map P. falciparum genome architecture at high resolution with Micro-C here:

www.nature.com/articles/s41...

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Sebastian Baumgarten @sebbaumgarten.bsky.social · Jun 30

Supported by @erc.europa.eu @pasteur.fr @agencerecherche.bsky.social

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Sebastian Baumgarten @sebbaumgarten.bsky.social · Jun 30

How does the malaria parasite regulate co-expression of genes? By recruiting them into transcription factories, courtesy of MORC et al. A fantastic team effort led by @jessmbryant.bsky.social with Jacques Serizay @singh-parul.bsky.social, @ju-couble.bsky.social @rkoszul.bsky.social

Nature Microbiology @natmicrobiol.nature.com · Jun 30

OUT NOW: High resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes
@jessmbryant.bsky.social sky.social @singh-parul.bsky.social
@ju-couble.bsky.social ‬ #MicroSky

www.nature.com/articles/s41...

High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes - Nature Microbiology

Micro-C provides insights into genome organization in Plasmodium falciparum and defines the machinery used to spatially coordinate antigenic variation and stage-specific genes that are crucial for inf...

www.nature.com

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Reposted by Sebastian Baumgarten

François Mayer @francoismayer.bsky.social · Jun 13

Awesome malaria study out now in Nature Microbiology:

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!

@freddyfrischknecht.bsky.social

www.nature.com/articles/s41...

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology

A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.

www.nature.com

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Reposted by Sebastian Baumgarten

LabEx ParaFrap @parafrap.bsky.social · May 14

📢 Big Announcement: Registration & abstract submission open for EMBO Workshop "Host-Parasite Relationship: From Mechanisms to Control Strategies" organized by ParaFrap @parafrap.bsky.social @embo.org

🗓️ 5-8 Oct 2025 - Les Embiez Island-France

🔚Deadline: 15 Jul 2025 meetings.embo.org/event/25-hos...

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Sebastian Baumgarten @sebbaumgarten.bsky.social · May 23

Special shout-out to the presentations from our very own Selina Mussgnung and @thebeilab.bsky.social from the Institut Pasteur network in Dakar!

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Sebastian Baumgarten @sebbaumgarten.bsky.social · May 23

As usual, fantastic science at #EMBLMalaria. Special thanks for the travel support from @pasteur.fr in the new EMBL-Pasteur initiative and the organization @lilianamancio.bsky.social @sturalph.bsky.social @events.embl.org

EMBL Events @events.embl.org · May 22

That’s a wrap on #EMBLMalaria ! 🦟🎉

From game-changing ideas to brilliant conversations, we’re heading home inspired and energised.

Huge shoutout to everyone who joined us, and big congrats to the 10 amazing poster prize winners 🏆👏

Stay tuned for 2026 dates and more info on the awarded posters!

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Reposted by Sebastian Baumgarten

Kirk Deitsch @kirkdeitsch.bsky.social · May 16

Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance

Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...

rdcu.be

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Reposted by Sebastian Baumgarten

SheinerLab @sheinerlab.bsky.social · May 19

Parasites need mitochondrial respiration to infect and spread. Effective anti-malaria and ani-toxoplasmosis drugs target respiratory complexes (e.g. atovaquone)!

But how do the parasite complexes work and how do drugs inhibit them?

Read Andrew Maclean and Alex Mühleip phenomenal work on this! 👇

Andrew Maclean @macleanlab.bsky.social · May 19

Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...

Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology

Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...

www.nature.com

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Reposted by Sebastian Baumgarten

knuepferlab.bsky.social @knuepferlab.bsky.social · May 6

The KnuepferLab is hiring!

Our team is looking for a highly motivated, experienced molecular parasitologist to expand our group as a postdoctoral researcher at the RVC.

Follow either link below for more information on the project and the job offer:
lnkd.in/eprgmaE9
www.jobs.ac.uk/job/DMY962/p...

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Reposted by Sebastian Baumgarten

Michael Delves @mjdelves.bsky.social · Apr 9

Looking forward to joining @lshtm-malaria.bsky.social’s #WorldMalariaDay event to reflect on what’s next for malaria research and how we can continue to drive change.
Details here www.lshtm.ac.uk/newsevents/e... | LSHTM
#Malaria #GlobalHealth #WorldMalariaDay

Invitiation to attend "Prioritising in a crisis: What next for malaria research?" Friday 25th April 12.30 BST
https://www.lshtm.ac.uk/newsevents/events/prioritising-crisis-what-next-malaria-research

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Sebastian Baumgarten @sebbaumgarten.bsky.social · Apr 4

@erc.europa.eu @pasteur.fr

Sebastian Baumgarten @sebbaumgarten.bsky.social · Apr 4

Ready for the most beautifully sophisticated m6A modification program out there?

It’s sex-specific, controls a developmental transition and is temperature-sensitive. Dream team led by Selina, with @ameyasinha.bsky.social @jessmbryant.bsky.social @tizvignolini.bsky.social @ju-couble.bsky.social

N6-methyladenosine primes the malaria parasite for transmission

Sudden environmental changes are a recurring challenge for unicellular organisms, but a necessity for many to progress through their lifecycle. To transmit from its human host to mosquito vector, mala...

doi.org

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Sebastian Baumgarten @sebbaumgarten.bsky.social · Apr 2

The first joint labretreat with @anarbgomes.bsky.social, @jessmbryant.bsky.social and @amtalman.bsky.social is in the books. Thank you so much for hosting us, great science and fun.
@ecoliswatchingu.cpesr.fr @tizvignolini.bsky.social
@pasteur.fr @ird-fr.bsky.social @umontpellier.bsky.social

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Reposted by Sebastian Baumgarten

ParasitesRule @parasitesrule.org · Mar 30

From Data to Insight – A Practical Introduction to Interpreting Malaria Genetics for Surveillance, a free, self-paced online course offered by the PlasmoGenEpi network and developed with funding from the Gates Foundation.
🔗plasmogenepi.org/OnlineCourse

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Sebastian Baumgarten @sebbaumgarten.bsky.social · Mar 26

And with a lot of new approaches for the parasite as well…. protein-DNA proximity labelling, quantitative ChIP-seq, microC, ….

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