Søren Grubb
@sorengrubb.bsky.social
Biologist👩🔬, physiologist🔬, electrophysiologist⚡, cardiovascular scientist❤️, neuroscientist🧠 #precapillarysphincters #microvasculature #meninges #neurovascularcoupling #pericytes #MICrONS #microglia #macrophages #wasteclearance #aging
Pinned
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
🎥 NAD 2025 Annual Meeting Highlights
From Oct 3–5, Neuroscience Academy Denmark hosted:
✅ 400+ participants
✅ 100 posters
✅ Keynotes on precision psychiatry, brain barriers, ultrasound treatments, brain stimulation, sleep & circadian rhythms
We look forward to next year!
#Neuroscience #NAD2025 🧪
From Oct 3–5, Neuroscience Academy Denmark hosted:
✅ 400+ participants
✅ 100 posters
✅ Keynotes on precision psychiatry, brain barriers, ultrasound treatments, brain stimulation, sleep & circadian rhythms
We look forward to next year!
#Neuroscience #NAD2025 🧪
November 14, 2025 at 12:59 PM
🎥 NAD 2025 Annual Meeting Highlights
From Oct 3–5, Neuroscience Academy Denmark hosted:
✅ 400+ participants
✅ 100 posters
✅ Keynotes on precision psychiatry, brain barriers, ultrasound treatments, brain stimulation, sleep & circadian rhythms
We look forward to next year!
#Neuroscience #NAD2025 🧪
From Oct 3–5, Neuroscience Academy Denmark hosted:
✅ 400+ participants
✅ 100 posters
✅ Keynotes on precision psychiatry, brain barriers, ultrasound treatments, brain stimulation, sleep & circadian rhythms
We look forward to next year!
#Neuroscience #NAD2025 🧪
Reposted by Søren Grubb
“Well I don’t like that study because it doesn't give me the result I want’
September 8, 2025 at 2:32 PM
“Well I don’t like that study because it doesn't give me the result I want’
Reposted by Søren Grubb
We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
July 2, 2025 at 12:13 PM
We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
The first Master’s student with me as main supervisor graduated today! I’m proud 🥹
June 24, 2025 at 5:37 PM
The first Master’s student with me as main supervisor graduated today! I’m proud 🥹
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
June 10, 2025 at 7:38 PM
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Playing around with my 3yo daughter and an antique microscope. Looked at some #dandelion petals and a stamen using a Carl Zeiss P.A. 35 microscope using reflected light. 🧪
May 2, 2025 at 4:52 PM
Playing around with my 3yo daughter and an antique microscope. Looked at some #dandelion petals and a stamen using a Carl Zeiss P.A. 35 microscope using reflected light. 🧪
@pkpd-babe.bsky.social Can I be added to the science post? My orcID: orcid.org/0000-0002-67...
ORCID
orcid.org
May 2, 2025 at 4:46 AM
@pkpd-babe.bsky.social Can I be added to the science post? My orcID: orcid.org/0000-0002-67...
Amazing work out by Hirase Lab 🤩
Vittani, Lee, Wang, Hiraoka, et al.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
KI mouse expressing red fluorescent blood
In situ SpyTag/Catcher attachment of biosensor
ECS SpyCatcher to capture BBB leak
doi.org/10.1101/2025...
We hope this method is useful to a wide range of the biology community.
March 19, 2025 at 1:18 PM
Amazing work out by Hirase Lab 🤩
Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology!
We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social
📢 Free for NorDoc PhD students, but open to all! Apply now!
lnkd.in/dU_fxqqu
We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social
📢 Free for NorDoc PhD students, but open to all! Apply now!
lnkd.in/dU_fxqqu
March 18, 2025 at 5:46 PM
Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology!
We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social
📢 Free for NorDoc PhD students, but open to all! Apply now!
lnkd.in/dU_fxqqu
We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social
📢 Free for NorDoc PhD students, but open to all! Apply now!
lnkd.in/dU_fxqqu
Reposted by Søren Grubb
Reposted by Søren Grubb
Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging.
Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social
erictopol.substack.com/p/our-sleep-... open-access
Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social
erictopol.substack.com/p/our-sleep-... open-access
Our Sleep, Brain Aging, and Waste Clearance
How sleep prevents "dirty" brains that age faster
erictopol.substack.com
January 12, 2025 at 4:20 PM
Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging.
Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social
erictopol.substack.com/p/our-sleep-... open-access
Featuring exceptional work by Nedergaard Lab and @jonykipnis.bsky.social
erictopol.substack.com/p/our-sleep-... open-access
Reposted by Søren Grubb
🤘🏻The study I have been waiting for 30 years! Only Scandinavians can pull this out let alone publish it in a Scandinavian pain journal 🤘🏻
#painscience
#physio
#painresearch
#ignobel2025
www.degruyter.com/document/doi...
#painscience
#physio
#painresearch
#ignobel2025
www.degruyter.com/document/doi...
December 25, 2024 at 10:21 AM
🤘🏻The study I have been waiting for 30 years! Only Scandinavians can pull this out let alone publish it in a Scandinavian pain journal 🤘🏻
#painscience
#physio
#painresearch
#ignobel2025
www.degruyter.com/document/doi...
#painscience
#physio
#painresearch
#ignobel2025
www.degruyter.com/document/doi...
Reposted by Søren Grubb
SERVICE UPDATE
We normally don't ask you to "share like and subscribe" but please distribute this.
You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research.
#AcademicSky #Medsky #HigherEd
We normally don't ask you to "share like and subscribe" but please distribute this.
You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research.
#AcademicSky #Medsky #HigherEd
December 11, 2024 at 3:00 PM
SERVICE UPDATE
We normally don't ask you to "share like and subscribe" but please distribute this.
You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research.
#AcademicSky #Medsky #HigherEd
We normally don't ask you to "share like and subscribe" but please distribute this.
You are now able to delete the link after it embeds on your post so you can get those precious extra characters, and we will catch your post mentioning research.
#AcademicSky #Medsky #HigherEd
Reposted by Søren Grubb
Always fascinating these links between heart and brain ilnesses academic.oup.com/brain/advanc... #HeartBrainAxis
Loss of glymphatic homeostasis in heart failure
Heart failure can lead to reduced cerebral blood flow, neurodegeneration, and cognitive decline. In a mouse model of heart failure, Kritsilis et al. show t
academic.oup.com
December 24, 2024 at 12:44 AM
Always fascinating these links between heart and brain ilnesses academic.oup.com/brain/advanc... #HeartBrainAxis
Reposted by Søren Grubb
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
December 3, 2024 at 2:58 PM
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.
Read more: e11.bio/news/roadmap
Read more: e11.bio/news/roadmap
You can generate a #podcast with two hosts discussing a research paper using notebooklm.google.com I have tried it with a couple of papers (including my own 😂), it is a nice way of getting a summary. Try it out!
Sign in - Google Accounts
notebooklm.google.com
December 1, 2024 at 10:14 AM
You can generate a #podcast with two hosts discussing a research paper using notebooklm.google.com I have tried it with a couple of papers (including my own 😂), it is a nice way of getting a summary. Try it out!
🧠NON-NEUROCENTRIC STARTER PACKS FOR BRAIN RESEARCH:
I this thread 🧵 I will post starter packs for fields of research not directly related to neurons: #meninges, #vasculature, #glia, #immunecells, #dementia, #headache, #microscopy, and resources to get started with #Bluesky.
I this thread 🧵 I will post starter packs for fields of research not directly related to neurons: #meninges, #vasculature, #glia, #immunecells, #dementia, #headache, #microscopy, and resources to get started with #Bluesky.
November 30, 2024 at 4:47 PM
🧠NON-NEUROCENTRIC STARTER PACKS FOR BRAIN RESEARCH:
I this thread 🧵 I will post starter packs for fields of research not directly related to neurons: #meninges, #vasculature, #glia, #immunecells, #dementia, #headache, #microscopy, and resources to get started with #Bluesky.
I this thread 🧵 I will post starter packs for fields of research not directly related to neurons: #meninges, #vasculature, #glia, #immunecells, #dementia, #headache, #microscopy, and resources to get started with #Bluesky.
Here we show how 🧠 #precapillarysphincters react to #CorticalSpreadingDepolarization which is associated with #migraine with #aura 🤕. #CSD has 3 phases: constriction, dilation, and a long lasting constriction that interrupts #bloodflow🩸 to #capillaries (Tinyurl.com/euasfses).
November 30, 2024 at 12:54 PM
Here we show how 🧠 #precapillarysphincters react to #CorticalSpreadingDepolarization which is associated with #migraine with #aura 🤕. #CSD has 3 phases: constriction, dilation, and a long lasting constriction that interrupts #bloodflow🩸 to #capillaries (Tinyurl.com/euasfses).
#Neurovasculature changes from the #arterial to the #venular end. Here I have tried to draw the #cell morphologies realistically. #Endothelialcells go from spindle shaped to rhombic shaped and #muralcells from #smoothmuscle to #pericytes. #Astrocytes same shape. www.sciencedirect.com/science/arti...
November 29, 2024 at 2:49 PM
#Neurovasculature changes from the #arterial to the #venular end. Here I have tried to draw the #cell morphologies realistically. #Endothelialcells go from spindle shaped to rhombic shaped and #muralcells from #smoothmuscle to #pericytes. #Astrocytes same shape. www.sciencedirect.com/science/arti...
Here is a #precapillarysphincter. As #arterioles 🟢 dive into the 🧠, they branch to smaller vessels. When larger arterioles (15-25um) branch into #capillaries, they need a #sphincter (3-4um) to reduce #RBC flow⚫️ and pressure in the #capillary. The resistance is provided by #muralcell🔴 encirclement.
November 28, 2024 at 5:05 PM
Here is a #precapillarysphincter. As #arterioles 🟢 dive into the 🧠, they branch to smaller vessels. When larger arterioles (15-25um) branch into #capillaries, they need a #sphincter (3-4um) to reduce #RBC flow⚫️ and pressure in the #capillary. The resistance is provided by #muralcell🔴 encirclement.
Here we show how #microglia contact #pericytes and #endothelialcells in the #venule end of the #capillary bed. Note also how a #primarycilium of an #interneuron invaginates the microglia. But why? 🤔 journals.sagepub.com/doi/full/10.... @gazz4science.bsky.social
November 26, 2024 at 5:44 PM
Here we show how #microglia contact #pericytes and #endothelialcells in the #venule end of the #capillary bed. Note also how a #primarycilium of an #interneuron invaginates the microglia. But why? 🤔 journals.sagepub.com/doi/full/10.... @gazz4science.bsky.social
Reposted by Søren Grubb
Three must read papers for PhD students. #scisky #PhD #science #research #academicsky
1. The importance of stupidity in scientific research
Open Access
journals.biologists.com/jcs/article/...
1. The importance of stupidity in scientific research
Open Access
journals.biologists.com/jcs/article/...
November 24, 2024 at 1:54 PM
Three must read papers for PhD students. #scisky #PhD #science #research #academicsky
1. The importance of stupidity in scientific research
Open Access
journals.biologists.com/jcs/article/...
1. The importance of stupidity in scientific research
Open Access
journals.biologists.com/jcs/article/...
Reposted by Søren Grubb
Tell me, If you want to join the Migraine @ Headache starter pack. #Migraine #Headache #neuroscience #Neurology #pain go.bsky.app/U8U8wfW
November 26, 2024 at 8:37 AM
Tell me, If you want to join the Migraine @ Headache starter pack. #Migraine #Headache #neuroscience #Neurology #pain go.bsky.app/U8U8wfW