Hajime Hirase
@hajimehirase.bsky.social
Pinned
We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
Reposted by Hajime Hirase
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
November 20, 2025 at 9:04 PM
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
Reposted by Hajime Hirase
November 16, 2025 at 2:26 AM
Reposted by Hajime Hirase
Next Tuesday!:🧠📷 Join us for the Japan Neuroscience Global Soirée-#SfN2025 Social! 📷7–9 PM 📷 Protector Brewery: San Diego craft beer, food (free while supplies last) & lively discussions! 📷 RSVP (optional): evite.me/pAvuVkpqbK 🍻
November 16, 2025 at 4:27 PM
Next Tuesday!:🧠📷 Join us for the Japan Neuroscience Global Soirée-#SfN2025 Social! 📷7–9 PM 📷 Protector Brewery: San Diego craft beer, food (free while supplies last) & lively discussions! 📷 RSVP (optional): evite.me/pAvuVkpqbK 🍻
Reposted by Hajime Hirase
The flexible brain: How circuit excitability and plasticity shift across the day | EurekAlert! www.eurekalert.org/news-release...
doi.org/10.1016/j.ne...
doi.org/10.1016/j.ne...
The flexible brain: How circuit excitability and plasticity shift across the day
Did you know your brain might be more receptive to learning new things depending on the time of day? This study examined how a 24-hour cycle alters brain plasticity and neuronal excitability in rats.
www.eurekalert.org
November 16, 2025 at 8:31 AM
The flexible brain: How circuit excitability and plasticity shift across the day | EurekAlert! www.eurekalert.org/news-release...
doi.org/10.1016/j.ne...
doi.org/10.1016/j.ne...
Skipping KBH H?
www.euronews.com/travel/2025/...
www.euronews.com/travel/2025/...
This new night train will travel 1,400km from Switzerland to Sweden
Tickets for the EuroNight service are expected to go on sale starting 4 November.
www.euronews.com
November 2, 2025 at 10:03 PM
Skipping KBH H?
www.euronews.com/travel/2025/...
www.euronews.com/travel/2025/...
Reposted by Hajime Hirase
Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
Karel Svoboda and Jay Shendure elected to National Academy of Medicine
The honor recognizes leaders who have demonstrated outstanding achievement and made lasting contributions to the advancement of the medical sciences, health care, and public health
alleninstitute.org
October 20, 2025 at 7:15 PM
Congratulations to Karel Svoboda and @jshendure.bsky.social on their election to the National Academy of Medicine (@nam.edu)! Election to the Academy is one of the highest honors in health and medicine. #NAMmtg
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
More on their journeys to this achievement: alleninstitute.org/news/karel-s...
Reposted by Hajime Hirase
Landmark revisit
Gut microbiota-Artery axis
Non-nasal Olfactory Receptor
#ShortChainFattyAcid Propionate activates Olfr78 (+GPR41 GPR43) on #SmoothMusclecell in resistance arteries ➡️Vasodilation Hypotension
Antibiotic➡️Hypertension in Olfr78 KO, not WT🐭
@pnas.org 2013
www.pnas.org/doi/full/10....
Gut microbiota-Artery axis
Non-nasal Olfactory Receptor
#ShortChainFattyAcid Propionate activates Olfr78 (+GPR41 GPR43) on #SmoothMusclecell in resistance arteries ➡️Vasodilation Hypotension
Antibiotic➡️Hypertension in Olfr78 KO, not WT🐭
@pnas.org 2013
www.pnas.org/doi/full/10....
October 4, 2025 at 11:57 AM
Landmark revisit
Gut microbiota-Artery axis
Non-nasal Olfactory Receptor
#ShortChainFattyAcid Propionate activates Olfr78 (+GPR41 GPR43) on #SmoothMusclecell in resistance arteries ➡️Vasodilation Hypotension
Antibiotic➡️Hypertension in Olfr78 KO, not WT🐭
@pnas.org 2013
www.pnas.org/doi/full/10....
Gut microbiota-Artery axis
Non-nasal Olfactory Receptor
#ShortChainFattyAcid Propionate activates Olfr78 (+GPR41 GPR43) on #SmoothMusclecell in resistance arteries ➡️Vasodilation Hypotension
Antibiotic➡️Hypertension in Olfr78 KO, not WT🐭
@pnas.org 2013
www.pnas.org/doi/full/10....
Reposted by Hajime Hirase
Excited to announce that I'll be moving to the Univ of California Irvine @ucirvine.bsky.social next Spring!🌴
Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time.
Help spread the word: the new UCI lab will be hiring, DM or email ([email protected]) if interested!
Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time.
Help spread the word: the new UCI lab will be hiring, DM or email ([email protected]) if interested!
October 2, 2025 at 4:15 AM
Excited to announce that I'll be moving to the Univ of California Irvine @ucirvine.bsky.social next Spring!🌴
Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time.
Help spread the word: the new UCI lab will be hiring, DM or email ([email protected]) if interested!
Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time.
Help spread the word: the new UCI lab will be hiring, DM or email ([email protected]) if interested!
Reposted by Hajime Hirase
Denmark bans civil drones for a week after sightings over military bases on.ft.com/4mFO2sC
Denmark bans civil drones for a week after sightings over military bases
Danish government says security measures are required ahead of two summits of European leaders
on.ft.com
September 28, 2025 at 2:23 PM
Denmark bans civil drones for a week after sightings over military bases on.ft.com/4mFO2sC
Reposted by Hajime Hirase
September 27, 2025 at 10:54 PM
All Science Is Either Physics or Stamp Collecting
quoteinvestigator.com/2015/05/08/s...
quoteinvestigator.com/2015/05/08/s...
Quote Origin: All Science Is Either Physics or Stamp Collecting – Quote Investigator®
Question for Quote Investigator: Recently, while reading about the discovery of a new species of frog I marveled at the remarkable diversity of the biosphere. But, I was also reminded of the following humorous and barbed assertion:
quoteinvestigator.com
September 26, 2025 at 12:47 PM
All Science Is Either Physics or Stamp Collecting
quoteinvestigator.com/2015/05/08/s...
quoteinvestigator.com/2015/05/08/s...
Reposted by Hajime Hirase
🍚いただきまーす❣️
モモンガちゃん🍑かわいい🥹
モモンガちゃん🍑かわいい🥹
September 5, 2025 at 1:36 AM
🍚いただきまーす❣️
モモンガちゃん🍑かわいい🥹
モモンガちゃん🍑かわいい🥹
Reposted by Hajime Hirase
最近はシルバニアだけでなくフロッキー加工されてると物欲を刺激されてしまうようになってしまった。
フロッキー加工されると全体のトーンが落ち着いてかわいく見える。
フロッキー加工されると全体のトーンが落ち着いてかわいく見える。
September 2, 2025 at 3:34 PM
最近はシルバニアだけでなくフロッキー加工されてると物欲を刺激されてしまうようになってしまった。
フロッキー加工されると全体のトーンが落ち着いてかわいく見える。
フロッキー加工されると全体のトーンが落ち着いてかわいく見える。
Reposted by Hajime Hirase
Here's a look at a field of striatal astrocytes expressing GCaMP6f-cyto from the Huda Lab for #FluorescenceFriday !
September 5, 2025 at 6:39 PM
Here's a look at a field of striatal astrocytes expressing GCaMP6f-cyto from the Huda Lab for #FluorescenceFriday !
Our astro-cAMP vs vasoregulation (pnas.org/doi/abs/10.1...) and GeNL O2** (science.org/doi/10.1126/...) papers have been cited in a recent review by Isabel Christie. physoc.onlinelibrary.wiley.com/doi/full/10....
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal.
physoc.onlinelibrary.wiley.com
August 31, 2025 at 8:39 AM
Our astro-cAMP vs vasoregulation (pnas.org/doi/abs/10.1...) and GeNL O2** (science.org/doi/10.1126/...) papers have been cited in a recent review by Isabel Christie. physoc.onlinelibrary.wiley.com/doi/full/10....
Reposted by Hajime Hirase
SWIMMER×サンリオキャラクターズ第2弾｜サンリオ share.google/dfljEH7wkGZz...
SWIMMER×サンリオキャラクターズ第2弾｜サンリオ
コラボ第2弾☆
「SWIMMER」のポップなデザインやキャラクターと、そのテイストで描かれたサンリオキャラクターズを用いたオリジナルデザインだよ。
「SWIMMER」の懐かしいテイストと当時の楽しげなSHOPをイメージしたラインナップ。
share.google
August 30, 2025 at 6:27 AM
SWIMMER×サンリオキャラクターズ第2弾｜サンリオ share.google/dfljEH7wkGZz...
Reposted by Hajime Hirase
暑すぎて…キティやちいかわも日焼け グッズ完売連発
www.nikkei.com/article/DGXZQO...
サンリオはポムポムプリンやシナモロールなど約20体を小麦色に。背景にあるのが平成ギャルファッションのリバイバルブームです。
なかにはバッドばつ丸やハンギョドンなどわずかに「色味が濃くなった」だけのように見えなくもないキャラも。
東京・原宿の「ちいかわベーカリー」では日焼け跡のあるパンを求めて開店前から行列ができています。
www.nikkei.com/article/DGXZQO...
サンリオはポムポムプリンやシナモロールなど約20体を小麦色に。背景にあるのが平成ギャルファッションのリバイバルブームです。
なかにはバッドばつ丸やハンギョドンなどわずかに「色味が濃くなった」だけのように見えなくもないキャラも。
東京・原宿の「ちいかわベーカリー」では日焼け跡のあるパンを求めて開店前から行列ができています。
August 31, 2025 at 2:30 AM
暑すぎて…キティやちいかわも日焼け グッズ完売連発
www.nikkei.com/article/DGXZQO...
サンリオはポムポムプリンやシナモロールなど約20体を小麦色に。背景にあるのが平成ギャルファッションのリバイバルブームです。
なかにはバッドばつ丸やハンギョドンなどわずかに「色味が濃くなった」だけのように見えなくもないキャラも。
東京・原宿の「ちいかわベーカリー」では日焼け跡のあるパンを求めて開店前から行列ができています。
www.nikkei.com/article/DGXZQO...
サンリオはポムポムプリンやシナモロールなど約20体を小麦色に。背景にあるのが平成ギャルファッションのリバイバルブームです。
なかにはバッドばつ丸やハンギョドンなどわずかに「色味が濃くなった」だけのように見えなくもないキャラも。
東京・原宿の「ちいかわベーカリー」では日焼け跡のあるパンを求めて開店前から行列ができています。
Reposted by Hajime Hirase
近くのスーパーでサンリオのキッチンカー来てたから買ってみた😊
かわいいけど中身が紙の半分ぐらいしかなくて値段はかわいくなかった(笑)
息子は喜んでたからよしとするか😂
かわいいけど中身が紙の半分ぐらいしかなくて値段はかわいくなかった(笑)
息子は喜んでたからよしとするか😂
August 31, 2025 at 5:25 AM
近くのスーパーでサンリオのキッチンカー来てたから買ってみた😊
かわいいけど中身が紙の半分ぐらいしかなくて値段はかわいくなかった(笑)
息子は喜んでたからよしとするか😂
かわいいけど中身が紙の半分ぐらいしかなくて値段はかわいくなかった(笑)
息子は喜んでたからよしとするか😂
Wow! Nice!
AAV vectors for specific and efficient gene expression in microglia: Cell Reports Methods www.cell.com/cell-reports...
AAV vectors for specific and efficient gene expression in microglia: Cell Reports Methods www.cell.com/cell-reports...
AAV vectors for specific and efficient gene expression in microglia
Aoki et al. develop an AAV vector for highly specific and efficient gene expression
in cortical microglia. By flanking WPRE with microRNA target sequences, they achieve
>90% specificity and enable fun...
www.cell.com
August 25, 2025 at 9:31 PM
Wow! Nice!
AAV vectors for specific and efficient gene expression in microglia: Cell Reports Methods www.cell.com/cell-reports...
AAV vectors for specific and efficient gene expression in microglia: Cell Reports Methods www.cell.com/cell-reports...
Reposted by Hajime Hirase
くりまんじゅう
August 10, 2025 at 4:53 AM
くりまんじゅう
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium - Lin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium
INTRODUCTION
Evidence points to dysregulated Ca2+ in neurons and astrocytes in models of amyloidosis. While most of these data were obtained in vitro or in vivo under anesthesia, less work has inves.....
alz-journals.onlinelibrary.wiley.com
August 18, 2025 at 4:48 AM
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium - Lin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
I did not realize how Baroque this interlude is, though not quite contrapuntal.
www.youtube.com/watch?v=5fvw...
www.youtube.com/watch?v=5fvw...
The Beatles - In My Life (Piano Solo Tutorial)
YouTube video by Aldy Tutorials
www.youtube.com
August 8, 2025 at 3:29 PM
I did not realize how Baroque this interlude is, though not quite contrapuntal.
www.youtube.com/watch?v=5fvw...
www.youtube.com/watch?v=5fvw...
Reposted by Hajime Hirase
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience
Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...
www.nature.com
August 5, 2025 at 10:26 AM
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...