hajimehirase.bsky.social
Hajime Hirase
@hajimehirase.bsky.social
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Jul 2
We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
pnas.org/doi/10.1073/...
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Reposted by Hajime Hirase
haoyin.bsky.social
Hao Yin @haoyin.bsky.social · 4d
Landmark revisit
Gut microbiota-Artery axis
Non-nasal Olfactory Receptor

#ShortChainFattyAcid Propionate activates Olfr78 (+GPR41 GPR43) on #SmoothMusclecell in resistance arteries ➡️Vasodilation Hypotension

Antibiotic➡️Hypertension in Olfr78 KO, not WT🐭

@pnas.org 2013
www.pnas.org/doi/full/10....
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Reposted by Hajime Hirase
jojolab.bsky.social
Josh Johansen @jojolab.bsky.social · 7d
Excited to announce that I'll be moving to the Univ of California Irvine @ucirvine.bsky.social next Spring!🌴

Happily, this is not goodbye to Japan as I'll continue my lab @RIKEN_CBS for some time.

Help spread the word: the new UCI lab will be hiring, DM or email ([email protected]) if interested!
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Reposted by Hajime Hirase
financialtimes.com
Financial Times @financialtimes.com · 10d
Denmark bans civil drones for a week after sightings over military bases on.ft.com/4mFO2sC
Denmark bans civil drones for a week after sightings over military bases
Danish government says security measures are required ahead of two summits of European leaders
on.ft.com
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Reposted by Hajime Hirase
0501-8o0.bsky.social
a__chan @0501-8o0.bsky.social · 11d
ちいかわ焼き(うさぎ)

最近の焼肉回のおかげでうさぎさんが可愛くてしゃーない💛🐰

#ちいかわ
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Reposted by Hajime Hirase
kappa555.bsky.social
かっぱ @kappa555.bsky.social · 12d
でんぶ、あれが「ちいかわ」のうさぎの懸賞旗

宇良の取組で「ウラララ」言ってる
最強だな

#青空大相撲部　#キリトリセカイ
ちいかわのうさぎが「ウララララ」と叫んでるイラストの懸賞旗が3本回る土俵を背にドアップで入り込むピンぼけシルバニア赤ちゃん（シルクネコ）ぬい撮り写真です
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · 12d
All Science Is Either Physics or Stamp Collecting
quoteinvestigator.com/2015/05/08/s...
Quote Origin: All Science Is Either Physics or Stamp Collecting – Quote Investigator®
Question for Quote Investigator: Recently, while reading about the discovery of a new species of frog I marveled at the remarkable diversity of the biosphere. But, I was also reminded of the following humorous and barbed assertion:
quoteinvestigator.com
1
Reposted by Hajime Hirase
89nekokoneko64.bsky.social
ちいかわ💜モモンガ教🍑ネココネコ՞ ̳o̴̶̷̤ ̫ o̴̶̷̤ ̳՞✧︎ @89nekokoneko64.bsky.social · Sep 5
🍚いただきまーす❣️
モモンガちゃん🍑かわいい🥹
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Reposted by Hajime Hirase
hibikirin.bsky.social
kirin @hibikirin.bsky.social · Sep 2
最近はシルバニアだけでなくフロッキー加工されてると物欲を刺激されてしまうようになってしまった。
フロッキー加工されると全体のトーンが落ち着いてかわいく見える。
フロッキー加工された人形が5つ並んだ写真。 左からシルバニアのキリンの赤ちゃん、シカの赤ちゃん、ピカチュウ、ニャンちゅう、キティちゃん。
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Reposted by Hajime Hirase
scred62.bsky.social
Wesley R. Evans @scred62.bsky.social · Sep 5
Here's a look at a field of striatal astrocytes expressing GCaMP6f-cyto from the Huda Lab for #FluorescenceFriday !
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Aug 31
Our astro-cAMP vs vasoregulation (pnas.org/doi/abs/10.1...) and GeNL O2** (science.org/doi/10.1126/...) papers have been cited in a recent review by Isabel Christie. physoc.onlinelibrary.wiley.com/doi/full/10....
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis
Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal.
physoc.onlinelibrary.wiley.com
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Reposted by Hajime Hirase
gagigagi0g.bsky.social
虚製 @gagigagi0g.bsky.social · Aug 30
SWIMMER×サンリオキャラクターズ第2弾｜サンリオ share.google/dfljEH7wkGZz...
SWIMMER×サンリオキャラクターズ第2弾｜サンリオ
コラボ第2弾☆ 「SWIMMER」のポップなデザインやキャラクターと、そのテイストで描かれたサンリオキャラクターズを用いたオリジナルデザインだよ。 「SWIMMER」の懐かしいテイストと当時の楽しげなSHOPをイメージしたラインナップ。
share.google
1
Reposted by Hajime Hirase
nikkei.com
日経電子版 @nikkei.com · Aug 31
暑すぎて…キティやちいかわも日焼け　グッズ完売連発
www.nikkei.com/article/DGXZQO...

サンリオはポムポムプリンやシナモロールなど約20体を小麦色に。背景にあるのが平成ギャルファッションのリバイバルブームです。

なかにはバッドばつ丸やハンギョドンなどわずかに「色味が濃くなった」だけのように見えなくもないキャラも。

東京・原宿の「ちいかわベーカリー」では日焼け跡のあるパンを求めて開店前から行列ができています。
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Reposted by Hajime Hirase
upfield240.bsky.social
はにわ @upfield240.bsky.social · Aug 31
近くのスーパーでサンリオのキッチンカー来てたから買ってみた😊
かわいいけど中身が紙の半分ぐらいしかなくて値段はかわいくなかった(笑)
息子は喜んでたからよしとするか😂
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Aug 25
Wow! Nice!
AAV vectors for specific and efficient gene expression in microglia: Cell Reports Methods www.cell.com/cell-reports...
AAV vectors for specific and efficient gene expression in microglia
Aoki et al. develop an AAV vector for highly specific and efficient gene expression in cortical microglia. By flanking WPRE with microRNA target sequences, they achieve >90% specificity and enable fun...
www.cell.com
1
Reposted by Hajime Hirase
yuimoon0411.bsky.social
ゆいつき @yuimoon0411.bsky.social · Aug 10
くりまんじゅう
yuimoon0411.bsky.social
ゆいつき @yuimoon0411.bsky.social · Jul 12
くりまんじゅう
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Aug 18
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium - Lin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium
INTRODUCTION Evidence points to dysregulated Ca2+ in neurons and astrocytes in models of amyloidosis. While most of these data were obtained in vitro or in vivo under anesthesia, less work has inves.....
alz-journals.onlinelibrary.wiley.com
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Aug 8
I did not realize how Baroque this interlude is, though not quite contrapuntal.
www.youtube.com/watch?v=5fvw...
The Beatles - In My Life (Piano Solo Tutorial)
YouTube video by Aldy Tutorials
www.youtube.com
Reposted by Hajime Hirase
silvia-anderle.bsky.social
Silvia Anderle @silvia-anderle.bsky.social · Aug 5
Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...
The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience
Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...
www.nature.com
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Reposted by Hajime Hirase
rasherlo.bsky.social
Rasmus Herlo @rasherlo.bsky.social · Jul 17
paper alert: Our study on the role of astrocytic cAMP-levels on neurovascular coupling has been published and can be found here:
www.pnas.org/doi/10.1073/...

Vittani spearheaded the project, and I had the pleasure of joining, initially for computational purposes, but also with single-cell 2P exps
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice | PNAS
Local neural activation drives regional increase of cerebral blood flow (CBF), in a phenomenon known as functional hyperemia. Astrocytes, which enw...
www.pnas.org
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Jul 17
Addgene plasmids now available in full!
www.addgene.org/browse/artic...
as well as
www.addgene.org/178790/
@Addgene
Addgene: Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP(3)R2-mediated Ca(2+) signaling in mice.
www.addgene.org
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Reposted by Hajime Hirase
lewisholt.bsky.social
Lewis Holt @lewisholt.bsky.social · Jul 11
Absolutely thrilled to share the first half of my PhD work! Super proud to see it finally out!
www.nature.com/articles/s41...

Thread below for a quick (10 point) recap of what we found!
🧵🧪🧠
A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice - Nature Communications
Early-life stress has lifelong impacts on neuronal function and behavior. Here, the authors show that astrocytic glucocorticoid receptor signaling drives stress-induced neuronal and behavioral change ...
www.nature.com
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Reposted by Hajime Hirase
carandinilab.net
Matteo Carandini @carandinilab.net · Jul 7
New by Agnès Landemard (@agnesland.bsky.social‬) & co

Brainwide blood volume reflects opposing neural populations

Brainwide fluctuations in blood volume arise from two populations with opposite relation to brain state and distinct relationships to blood supply

www.biorxiv.org/content/10.1...
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Reposted by Hajime Hirase
lemojam.bsky.social
lemojam @lemojam.bsky.social · Jul 11
藻のキティちゃん可愛かった🎶 ピンバッチレモン型当たったの嬉しすぎる！🍋
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Reposted by Hajime Hirase
sa9ra9ra.bsky.social
床沈のキ @sa9ra9ra.bsky.social · Jul 13
日本館は地味に凄いことしてる。建築が良い。
藻類の力により万博ゴミから生まれ変わったスツール 藻類キティちゃんとミャクミャクに侵食されたシナモロール でっかい火星の石の展示がありました。 日本館は外観がかっこいい。
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hajimehirase.bsky.social
Hajime Hirase @hajimehirase.bsky.social · Jul 13
Loss-of-function (IP3R2-KO) and gain-of-function (Astro-GqDREADD by Bonder et al. and Astro-OptoAlpha1AR by Ozawa et al. www.mdpi.com/1422-0067/24...) studies failed to show a major causal link between GPCR-induced Ca²⁺ and hyperemia. Maybe it’s not Ca²⁺; maybe astrocytic cAMP is the real driver.
www.mdpi.com
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