Greg Hayes
@soundgmh.bsky.social
Family | Music | Film | Surfing | http://imdb.me/greghayes | aKD #MIS_C #MISC May2020 #longcovidkids
Reposted by Greg Hayes
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 10, 2025 at 5:26 PM
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
Human genetic errors of immunity illuminate an adaptive arsenal model of rapid defenses
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Human genetic errors of immunity illuminate an adaptive arsenal model of rapid defenses
New discoveries in the field of human monogenic immune diseases highlight critical
genes and pathways governing immune responses. Here, I describe how the ~500 currently
defined human inborn errors of...
www.cell.com
November 6, 2025 at 12:16 AM
Human genetic errors of immunity illuminate an adaptive arsenal model of rapid defenses
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Reposted by Greg Hayes
Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 4, 2025 at 5:36 PM
Caspase-11 Mediated Hyperinflammation Impairs CD8⁺ T Cell Immunity and Viral Clearance in Severe SARS-CoV-2 Infection @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Greg Hayes
Nirmatrelvir/ritonavir use reduces risk for long COVID in patients with immunodeficiency url: rupress.org/jhi/article/...
Nirmatrelvir/ritonavir use reduces risk for long COVID in patients with immunodeficiency | Journal of Human Immunity | Rockefeller University Press
Our retrospective study highlights that acute use of nirmatrelvir/ritonavir significantly reduces the risk of post-acute sequelae of SARS-CoV-2 infection (
rupress.org
November 4, 2025 at 3:54 PM
Nirmatrelvir/ritonavir use reduces risk for long COVID in patients with immunodeficiency url: rupress.org/jhi/article/...
This paper strongly echoes the framework I have been developing and publicly advocating for over the last five years.
#MISC #KD #LongCovidKids
#MISC #KD #LongCovidKids
Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease - Pediatric Research
Pediatric Research - Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease
www.nature.com
November 3, 2025 at 8:00 PM
This paper strongly echoes the framework I have been developing and publicly advocating for over the last five years.
#MISC #KD #LongCovidKids
#MISC #KD #LongCovidKids
Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease - Pediatric Research
Pediatric Research - Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease
www.nature.com
November 2, 2025 at 8:29 PM
Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut microbiota alterations are linked to COVID-19 severity in North African and European populations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Gut microbiota alterations are linked to COVID-19 severity in North African and European populations - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Gut microbiota alterations are linked to COVID-19 severity in North African and European populations
www.nature.com
October 8, 2025 at 4:30 AM
Gut microbiota alterations are linked to COVID-19 severity in North African and European populations
www.nature.com/articles/s41...
www.nature.com/articles/s41...
NLRP3 as a protein thermosensor !
NLRP3 is a thermosensor that is negatively regulated by high temperature https://www.biorxiv.org/content/10.1101/2025.09.29.679254v1
October 1, 2025 at 4:10 AM
NLRP3 as a protein thermosensor !
Common mechanisms across MIS-C, KD & IBD → the gut as a central driver
Great perspective from @sanchoshimizu.bsky.social — Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases
journals.biologists.com/dmm/article/...
Great perspective from @sanchoshimizu.bsky.social — Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases
journals.biologists.com/dmm/article/...
Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases
Summary: Gut immunity may play a critical role in the initiation and persistence of multisystem inflammatory syndrome in children, inflammatory bowel disease and Kawasaki disease. Understanding this c...
journals.biologists.com
September 29, 2025 at 4:57 PM
Common mechanisms across MIS-C, KD & IBD → the gut as a central driver
Great perspective from @sanchoshimizu.bsky.social — Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases
journals.biologists.com/dmm/article/...
Great perspective from @sanchoshimizu.bsky.social — Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases
journals.biologists.com/dmm/article/...
Reposted by Greg Hayes
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
September 26, 2025 at 2:02 PM
Notably, WTA is not a PAMP.
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
Rather, WTA controls the release of bacterial DNA into cells, where it can act as a PAMP for AIM2 and cGAS. How many other meta-PAMPs are out there?
@jordanjastrab.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social @harvardmicro.bsky.social
An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon | Journal of Virology
From spike to suppression: the RGD motif fuels TGF-β and disables antiviral immunity
#PASC #LONGCOVID
journals.asm.org/doi/10.1128/...
From spike to suppression: the RGD motif fuels TGF-β and disables antiviral immunity
#PASC #LONGCOVID
journals.asm.org/doi/10.1128/...
An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon | Journal of Virology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents an ongoing public
health challenge as a cause of acute illness and post-acute sequelae of COVID-19 (PASC,
or long COVID). Our stud...
journals.asm.org
September 5, 2025 at 6:51 PM
An RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon | Journal of Virology
From spike to suppression: the RGD motif fuels TGF-β and disables antiviral immunity
#PASC #LONGCOVID
journals.asm.org/doi/10.1128/...
From spike to suppression: the RGD motif fuels TGF-β and disables antiviral immunity
#PASC #LONGCOVID
journals.asm.org/doi/10.1128/...
How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease | Review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
September 4, 2025 at 5:31 AM
How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease | Review
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Auto-inflammation isn’t confined to rare syndromes. It can also be innate immune hypersensitivity / dysfunction expressed across a spectrum — from monogenic diseases like CAPS, through post-infectious syndromes like MIS-C and KD, to chronic conditions like ME/CFS and Long Covid.
September 4, 2025 at 1:42 AM
Auto-inflammation isn’t confined to rare syndromes. It can also be innate immune hypersensitivity / dysfunction expressed across a spectrum — from monogenic diseases like CAPS, through post-infectious syndromes like MIS-C and KD, to chronic conditions like ME/CFS and Long Covid.
Reposted by Greg Hayes
Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...
BioAge Labs Announces First Participant Dosed in Phase 1 Clinical Trial of BGE-102, a Novel Brain-Penetrant NLRP3 Inhibitor
First-in-human study evaluating safety, tolerability, pharmacokinetics, and pharmacodynamics of BGE-102, an orally available small molecule with potential...
www.globenewswire.com
August 15, 2025 at 3:17 PM
Very exciting to see a new NLRP3 inhibitor enter the clinic! Great work from BioAge Labs www.globenewswire.com/news-release...
Reposted by Greg Hayes
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo
A human inborn error of immunity guided discovery and development of a prophylactic, mRNA-based antiviral.
www.science.org
August 13, 2025 at 8:06 PM
Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Greg Hayes
Adding to the conversation—in the same spirit, I think this recent paper is important:
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Systemic auto-inflammatory diseases, auto-immune diseases and immune deficiencies: From independent to overlapped diseases approach
Systemic AutoInflammatory Diseases (SAIDs), AutoImmune Diseases (AIDs), and Primary Immune Deficiencies (PIDs) were formely considered independent, ev…
www.sciencedirect.com
August 7, 2025 at 11:23 PM
Adding to the conversation—in the same spirit, I think this recent paper is important:
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Reposted by Greg Hayes
#GlycoPower! @vijayrathinam.bsky.social
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 6, 2025 at 10:12 PM
#GlycoPower! @vijayrathinam.bsky.social
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
@raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!
Reposted by Greg Hayes
Ethical and equitable considerations when establishing a diagnosis of an inborn error of immunity url: rupress.org/jhi/article/...
Ethical and equitable considerations when establishing a diagnosis of an inborn error of immunity | Journal of Human Immunity | Rockefeller University Press
This article describes the ethical dilemmas encountered by clinical immunologists in the evaluation of an inborn error of immunity. Potential sources of he
rupress.org
August 7, 2025 at 6:34 PM
Ethical and equitable considerations when establishing a diagnosis of an inborn error of immunity url: rupress.org/jhi/article/...
Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin-Associated Periodic Syndrome
acrjournals.onlinelibrary.wiley.com/doi/epdf/10....
acrjournals.onlinelibrary.wiley.com/doi/epdf/10....
Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin‐Associated Periodic Syndrome
Objective Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in NLRP3. Although somatic NLRP3 mosaicism is increasingly recognized, it ...
acrjournals.onlinelibrary.wiley.com
August 4, 2025 at 7:16 PM
Longitudinal Analysis of Somatic Mosaicism and Clonal Hematopoiesis in Cryopyrin-Associated Periodic Syndrome
acrjournals.onlinelibrary.wiley.com/doi/epdf/10....
acrjournals.onlinelibrary.wiley.com/doi/epdf/10....
Reposted by Greg Hayes
Our MISC clinical trial results, just published!
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
July 30, 2025 at 8:30 PM
Our MISC clinical trial results, just published!
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
