Konstantin Sparrer
@sparrerlab.bsky.social
Neurovirology and Neuroinflammation @DZNE @uni_Ulm.
https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/sparrer/research-areas-focus/
https://www.dzne.de/en/research/research-areas/fundamental-research/research-groups/sparrer/research-areas-focus/
Pinned
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors
Nature Communications - The study shows that the HIV-1 Nef protein stabilizes actin, thereby preventing R12C release and priming of RIG-I–like receptors. HIV-1 containing a mutant Nef unable...
rdcu.be
Our story showing that HIV-1 Nef inhibits actin-mediated innate immune sensing is now out in @natcomms.nature.com. Awesome work by @alexandrelaliberte.bsky.social @caterinaprelli.bsky.social. Great collaboration with Frank Kirchhoff/Michaela Gack/Oliver Fackler. Thanks @dfg.de @bmftr!
rdcu.be/eTFJh
rdcu.be/eTFJh
Reposted by Konstantin Sparrer
🚨Job Alert🚨
Looking for a highly motivated postdoctoral researcher to join our multidisciplinary team of scientists. The postdoc will collaborate with world-class structural biologist Peijun Zhang to understand everything about HIV capsids and how they work via host interactions.
Spread the word!
Looking for a highly motivated postdoctoral researcher to join our multidisciplinary team of scientists. The postdoc will collaborate with world-class structural biologist Peijun Zhang to understand everything about HIV capsids and how they work via host interactions.
Spread the word!
Postdoctoral Research Associate (Molecular Biology of HIV Infection) - QMUL Jobs
ID: 8551. Title: Postdoctoral Research Associate (Molecular Biology of HIV Infection). Application Deadline:
qmul-jobs.tal.net
January 20, 2026 at 5:50 PM
🚨Job Alert🚨
Looking for a highly motivated postdoctoral researcher to join our multidisciplinary team of scientists. The postdoc will collaborate with world-class structural biologist Peijun Zhang to understand everything about HIV capsids and how they work via host interactions.
Spread the word!
Looking for a highly motivated postdoctoral researcher to join our multidisciplinary team of scientists. The postdoc will collaborate with world-class structural biologist Peijun Zhang to understand everything about HIV capsids and how they work via host interactions.
Spread the word!
Reposted by Konstantin Sparrer
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Poxvirus dsDNA genomes differentially activate AIM2 or NLRP3 inflammasomes in human primary cells - The EMBO Journal
The innate immune system is known for its ability to recognize cytosolic DNA as evidence of infection, but detailed studies of this process have been mostly limited to mice and cell lines. To investig...
link.springer.com
January 21, 2026 at 1:27 AM
Ever wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
@unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
Reposted by Konstantin Sparrer
This #STTT study identified that retinol-bound holo-RBP4 strongly reactivates #HIV1 in various latently infected T-cell lines via the activation of the canonical NF-κB, JAK/STAT5, and JNK signaling pathways.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
December 18, 2025 at 3:03 PM
This #STTT study identified that retinol-bound holo-RBP4 strongly reactivates #HIV1 in various latently infected T-cell lines via the activation of the canonical NF-κB, JAK/STAT5, and JNK signaling pathways.
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Reposted by Konstantin Sparrer
The 3rd Annual Meeting of the YoungPI Working Group - for Junior Profs. and Group Leaders -
will take place in Heidelberg, on the 16th and 17th March 2026, just before the start of the GfV Meeting.
Registrations are now open:
youngpi.g-f-v.org/events/
will take place in Heidelberg, on the 16th and 17th March 2026, just before the start of the GfV Meeting.
Registrations are now open:
youngpi.g-f-v.org/events/
December 16, 2025 at 1:28 PM
The 3rd Annual Meeting of the YoungPI Working Group - for Junior Profs. and Group Leaders -
will take place in Heidelberg, on the 16th and 17th March 2026, just before the start of the GfV Meeting.
Registrations are now open:
youngpi.g-f-v.org/events/
will take place in Heidelberg, on the 16th and 17th March 2026, just before the start of the GfV Meeting.
Registrations are now open:
youngpi.g-f-v.org/events/
Our story showing that HIV-1 Nef inhibits actin-mediated innate immune sensing is now out in @natcomms.nature.com. Awesome work by @alexandrelaliberte.bsky.social @caterinaprelli.bsky.social. Great collaboration with Frank Kirchhoff/Michaela Gack/Oliver Fackler. Thanks @dfg.de @bmftr!
rdcu.be/eTFJh
rdcu.be/eTFJh
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors
Nature Communications - The study shows that the HIV-1 Nef protein stabilizes actin, thereby preventing R12C release and priming of RIG-I–like receptors. HIV-1 containing a mutant Nef unable...
rdcu.be
December 12, 2025 at 3:15 PM
Our story showing that HIV-1 Nef inhibits actin-mediated innate immune sensing is now out in @natcomms.nature.com. Awesome work by @alexandrelaliberte.bsky.social @caterinaprelli.bsky.social. Great collaboration with Frank Kirchhoff/Michaela Gack/Oliver Fackler. Thanks @dfg.de @bmftr!
rdcu.be/eTFJh
rdcu.be/eTFJh
Reposted by Konstantin Sparrer
Excited to share our new paper and a new Nef function !
rdcu.be/eTFJh
Thanks to everyone involved!
@caterinaprelli.bsky.social
@sparrerlab.bsky.social
#hiv #Nef #innateimmunity #sensing #rlr #research
rdcu.be/eTFJh
Thanks to everyone involved!
@caterinaprelli.bsky.social
@sparrerlab.bsky.social
#hiv #Nef #innateimmunity #sensing #rlr #research
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors
Nature Communications - The study shows that the HIV-1 Nef protein stabilizes actin, thereby preventing R12C release and priming of RIG-I–like receptors. HIV-1 containing a mutant Nef unable...
rdcu.be
December 12, 2025 at 11:29 AM
Excited to share our new paper and a new Nef function !
rdcu.be/eTFJh
Thanks to everyone involved!
@caterinaprelli.bsky.social
@sparrerlab.bsky.social
#hiv #Nef #innateimmunity #sensing #rlr #research
rdcu.be/eTFJh
Thanks to everyone involved!
@caterinaprelli.bsky.social
@sparrerlab.bsky.social
#hiv #Nef #innateimmunity #sensing #rlr #research
Reposted by Konstantin Sparrer
Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures https://www.biorxiv.org/content/10.64898/2025.12.10.693424v1
December 11, 2025 at 3:17 PM
Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface cultures https://www.biorxiv.org/content/10.64898/2025.12.10.693424v1
Reposted by Konstantin Sparrer
Reposted by Konstantin Sparrer
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 7, 2025 at 6:30 PM
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Konstantin Sparrer
Helmholtz-Geschäftsführerin Sabine Helling-Moegen im Interview mit Deutschlandfunk Nova zur Attraktivität des Wissenschaftsstandorts Deutschland www.deutschlandfunknova.de/beitrag/brai...
Brain-Drain in den USA: Mehr Forschende kommen nach Deutschland
Brain-Drain in den USA: Mehr Forschende kommen nach Deutschland
www.deutschlandfunknova.de
December 9, 2025 at 7:24 AM
Helmholtz-Geschäftsführerin Sabine Helling-Moegen im Interview mit Deutschlandfunk Nova zur Attraktivität des Wissenschaftsstandorts Deutschland www.deutschlandfunknova.de/beitrag/brai...
Reposted by Konstantin Sparrer
Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
December 2, 2025 at 4:00 PM
Multiple large natural experiments have documented Shingles vaccine is linked with ~20-25% reduced risk of dementia and Alzheimer's disease. A new report today adds to that and extends the to slowing the progression of dementia @cellcellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Konstantin Sparrer
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Also join us on December 4th, 2025, at 2:00 PM (CET) for an inspiring talk on Publishing at PLOS Biology by Melissa Vázquez Hernández. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Also join us on December 4th, 2025, at 2:00 PM (CET) for an inspiring talk on Publishing at PLOS Biology by Melissa Vázquez Hernández. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
November 26, 2025 at 12:49 PM
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Also join us on December 4th, 2025, at 2:00 PM (CET) for an inspiring talk on Publishing at PLOS Biology by Melissa Vázquez Hernández. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Also join us on December 4th, 2025, at 2:00 PM (CET) for an inspiring talk on Publishing at PLOS Biology by Melissa Vázquez Hernández. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Reposted by Konstantin Sparrer
Highly recommended for late PhDs and Postdocs👇 #LoveVirology
ViroCareer Compass – Navigating Your Career in Virology
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Arbeitskreis Achieve | Arbeitskreis der Gesellschaft für Virologie
achieve.g-f-v.org
November 21, 2025 at 12:44 PM
Highly recommended for late PhDs and Postdocs👇 #LoveVirology
Reposted by Konstantin Sparrer
The 2026 edition of the ACHIEVE mentoring program open to final year PhD students, postdoctoral researchers, and veterinary/medical doctors has just launched. You will benefit from 1-year individual mentoring by established PIs,
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November 7, 2025 at 10:26 AM
The 2026 edition of the ACHIEVE mentoring program open to final year PhD students, postdoctoral researchers, and veterinary/medical doctors has just launched. You will benefit from 1-year individual mentoring by established PIs,
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1/2
Reposted by Konstantin Sparrer
ViroCareer Compass – Navigating Your Career in Virology
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Arbeitskreis Achieve | Arbeitskreis der Gesellschaft für Virologie
achieve.g-f-v.org
November 20, 2025 at 2:19 PM
ViroCareer Compass – Navigating Your Career in Virology
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Shape your career at the 6th #ACHIEVE Workshop of the #GfV! Explore academia, industry & diagnostics, strengthen your CV, get hands-on tips for your first grant
📅 16–17 Mar 2026 | Heidelberg | Late PhD, postdocs & MDs
📝 Apply: achieve.g-f-v.org
Reposted by Konstantin Sparrer
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
October 29, 2025 at 8:39 AM
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on November 4th, 2025, at 2:00 PM (CET) for an inspiring talk on “BSL-4” by PD Dr. Thomas Hoenen. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Reposted by Konstantin Sparrer
Let me be very clear. It is not enough that RFK Jr. was forced to admit today that no causal relationship between Tylenol and autism has been shown.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
October 29, 2025 at 7:01 PM
Let me be very clear. It is not enough that RFK Jr. was forced to admit today that no causal relationship between Tylenol and autism has been shown.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
We know that while disinformation spreads like wildfire on social media, corrections most often die on the vine.
Reposted by Konstantin Sparrer
🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 28, 2025 at 4:04 PM
🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
Reposted by Konstantin Sparrer
Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis https://www.biorxiv.org/content/10.1101/2025.10.28.685013v1
October 29, 2025 at 4:17 AM
Respiratory viruses activate autophagy via the IFN-STAT1/STAT5B-SOCS1 axis https://www.biorxiv.org/content/10.1101/2025.10.28.685013v1
Reposted by Konstantin Sparrer
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
October 1, 2025 at 7:08 AM
🔬 Upcoming Expert Insights Seminar by ACHIEVE
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Join us on October 7th, 2025, at 2:00 PM (CET) for an inspiring talk on “AlphaFold & HerpesFolds” by Dr. Timothy Soh. Register here to join via Zoom: achieve.g-f-v.org/seminar-seri...
Reposted by Konstantin Sparrer
🦠 Abstract submission for the 35th Annual Meeting of the Society for Virology is open!
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Abstract submission
virology-meeting.de
October 22, 2025 at 7:34 AM
🦠 Abstract submission for the 35th Annual Meeting of the Society for Virology is open!
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Share your research with the virology community and help shape the scientific dialogue next year in Heidelberg.
🕐 Deadline: Jan 4, 2026
🔗 virology-meeting.de/programme-ab...
#GfV2026 #virology #virologymeeting
Reposted by Konstantin Sparrer
Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
October 18, 2025 at 5:05 PM
Excited to be co-organizing this @embo.org Workshop on #Pathogen #Immunity and #Signalling next June 8-12 2026 in Leiden! 🥳🥳🥳 #Savethedate
Reposted by Konstantin Sparrer
Nach einem Zoster (Gürtelrose) besteht ein erhöhtes Risiko für Demenz.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
October 14, 2025 at 8:06 PM
Nach einem Zoster (Gürtelrose) besteht ein erhöhtes Risiko für Demenz.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
Die Impfung gegen Zoster verringert das Demenzrisiko signifikant.
Die Shingrix-Impfung ist für alle ab 60 Jahre und ab 50 Jahre mit Begleiterkrankungen empfohlen.
Reposted by Konstantin Sparrer
🎉 Exciting news: my PhD project @daothilab.bsky.social has been published in #PLoS Pathogens! I investigated how the #hepatitis E virus ORF2 protein counteracts antiviral responses, contributing to persistent viral replication. A huge thank you to all collaborators! 🙏🏻
🔗 share.google/WwIT43Su3KOP...
🔗 share.google/WwIT43Su3KOP...
The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistent replication in cell culture
Author summary Hepatitis E virus (HEV) is an important yet often underestimated pathogen. Depending on the genotype, HEV infections can progress to chronicity, but the underlying mechanisms remain poo...
share.google
October 8, 2025 at 6:31 AM
🎉 Exciting news: my PhD project @daothilab.bsky.social has been published in #PLoS Pathogens! I investigated how the #hepatitis E virus ORF2 protein counteracts antiviral responses, contributing to persistent viral replication. A huge thank you to all collaborators! 🙏🏻
🔗 share.google/WwIT43Su3KOP...
🔗 share.google/WwIT43Su3KOP...
Reposted by Konstantin Sparrer
Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...
www.biorxiv.org
October 2, 2025 at 6:10 PM
Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...