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Národní institut virologie a bakteriologie @nivbcz.bsky.social · Aug 29

Dvě vědkyně z @mbuavcr.bsky.social - Natalia Slonská a Lucie Najmanová, se zúčastnily soutěže Věda fotogenická, kterou pořádá @akademievedcr.bsky.social. Do soutěže přihlásily snímky, které propojují krásu květu fuchsie se světem půdních bakterií Streptomyces coelicolor.

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Lucas Farnung @lucas.farnunglab.com · 12d

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Aug 31

Structural insights into YheS-mediated release of SecM-arrested ribosome. www.biorxiv.org/content/10.1... 🦠 #ribosome #rnasky

Structural insights into YheS-mediated release of SecM-arrested ribosome.

ATPase-binding cassette subfamily F (ABCF) proteins interact with the ribosome to resolve translation defects near the peptidyl-transferase center, induced by ribosome-targeting antibiotics or "hard-t...

www.biorxiv.org

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Sergey Melnikov @sergeymelnikov.bsky.social · Jun 19

Here, we show that bacterial ribosomes—often viewed as conserved drug targets—actually vary across species due to extensive sequence variation in their drug-binding residues. In some cases, this divergence may lead to intrinsic drug resistance in certain bacterial clades: doi.org/10.1016/j.ce...

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Michaela Novotná @michaelanovotna.bsky.social · Aug 13

Happy to share a new paper from our lab with my little contribution! 🥳🥳🥳
We show that antibiotic resistance ABC-F proteins fine-tune responses to ribosome-binding antibiotics. Thanks to ABC-Fs, bacteria can differentiate between antibiotic classes and even concentrations for a tailored response. 🦠💊⬇️

Fanny DEMAY @titefanny.bsky.social · Aug 13

New ABCF article from @balikovalab.bsky.social group!

Even though ABCF proteins have the same shape and act on the ribosome E-site, they have very different role in bacteria physiology level.

What an interesting topic!🤩

doi.org/10.1128/mbio...

ABCF protein-mediated resistance shapes bacterial responses to antibiotics based on their type and concentration | mBio

Bacteria adapt to diverse stimuli mainly through transcriptional changes that regulate adaptive protein factors. Here, we show that responses to protein synthesis-inhibiting antibiotics are fine-tuned by antibiotic resistance ABCF proteins at the ...

doi.org

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Fanny DEMAY @titefanny.bsky.social · Aug 13

New ABCF article from @balikovalab.bsky.social group!

Even though ABCF proteins have the same shape and act on the ribosome E-site, they have very different role in bacteria physiology level.

What an interesting topic!🤩

doi.org/10.1128/mbio...

ABCF protein-mediated resistance shapes bacterial responses to antibiotics based on their type and concentration | mBio

Bacteria adapt to diverse stimuli mainly through transcriptional changes that regulate adaptive protein factors. Here, we show that responses to protein synthesis-inhibiting antibiotics are fine-tuned by antibiotic resistance ABCF proteins at the ...

doi.org

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Jul 27

#rnasky #microsky

George O'Toole (he/him/his) @geiselbiofilm.bsky.social · Jul 21

Editor's Pick: Shen, Ye et al. review recent literature on the role of bacterial ribosome heterogeneity on facilitating rapid response to stress.
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Jul 17

''natural human tRNAAla variants generate mistranslation leading to defects in protein production that depend on the nature of the amino acid replacement.'' #rnasky Natural human tRNAAla anticodon variants mistranslate the genetic code
m.rnajournal.cshlp.org/content/earl...

RNA | Mobile

m.rnajournal.cshlp.org

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Wilson Lab @wilsonlab.bsky.social · Jul 14

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… www.researchsquare.com/article/rs-6...

A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial Ribosome

A significant challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds. Although natural products produced by fungi and bacteria, particularly actinomycetes,...

www.researchsquare.com

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Jul 10

Insights on how ribosomal RNA modification distant from drug binding site can still affect drug binding, in mycobacterium 🦠 #rnasky #ribosome #microsky

cryoEM papers @cryoempapers.bsky.social · Jul 9

Distant ribose 2'-O-methylation of 23S rRNA helix 69 pre-orders the capreomycin drug binding pocket at the ribosome subunit interface pubmed.ncbi.nlm.nih.gov/40626557/ #cryoem

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Fanny DEMAY @titefanny.bsky.social · Jun 29

Bye Bye "Ribosome2025", Pacific Grove, California!🌁🌊
It was a very nice conference with beautiful science and amazing people!!🤩👌

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Wiep Klaas Smits (ExpBac/CMAT) @smitslab.bsky.social · Jun 26

Paper alert: www.sciencedirect.com/science/arti...? Proud that we brought together researchers, clinicians and patient/carers to convey our point that it is important to bring novel treatments for bacterial pathogens to patients *also* if they are not on the WHO Bacterial Priority Pathogen list.

Clostridioides difficile should be considered a bacterial priority pathogen

www.sciencedirect.com

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Fanny DEMAY @titefanny.bsky.social · Jun 23

Happy to attend this new "Ribosome Conference" in California, Pacific Grove. Beautiful venue and amazing science !!
#Ribo2025 #ribosome

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Wilson Lab @wilsonlab.bsky.social · Jun 19

Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome www.science.org/doi/10.1126/...

Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome

Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factor...

www.science.org

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Fanny DEMAY @titefanny.bsky.social · May 22

Super projet! Dommage que je ne rentre pas encore en France☺️

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · May 21

Marie Curie fellowship, post-doc hosting oppotunity in my lab. MSCA Post-doctoral Fellowship at IBPC Paris on RNA modifications in bacteria (FRANCE) 🦠💫 euraxess.ec.europa.eu/jobs/hosting...

euraxess.ec.europa.eu

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EMBL Events @events.embl.org · May 7

Does your research revolve around protein synthesis? 👨‍🔬

Then submit your abstract by 1 June for a chance to be one of over 50 selected short talk speakers and share your findings at #EMBLProtein!

💻 https://s.embl.org/trc24-01-bl

#proteinsynthesis #molecularbiology #translationbiology #mrna

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Rémi Fronzes @fronzeslab.bsky.social · May 7

www.radiofrance.fr/franceinter/...

La recherche américaine en labo français

Le président de la République s’est adressé hier aux chercheurs américains auxquels l’Europe propose refuge. J’ai mis la main sur le témoignage d’une jeune chercheuse américaine, fraîchement débarquée...

www.radiofrance.fr

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Gal Haimovich ☣ 🧪🔬🎗 @grnfluoresceblg.bsky.social · Apr 24

Ok what?
#RNASky #RNABiology 🧪

Tim @timisstuck.bsky.social · Apr 23

I think that’s enough drinks for you, Molecular Biology! Pack up!

“Translation initiation from all 64 codons in E. coli”

academic.oup.com/nar/article/...

Measurements of translation initiation from all 64 codons in E. coli

Abstract. Our understanding of translation underpins our capacity to engineer living systems. The canonical start codon (AUG) and a few near-cognates (GUG,

academic.oup.com

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RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS @aribio.bsky.social · May 5

Bonjour, un poste d´IE (biochimie/BM) en mobilité interne (NOEMI) est disponible au Laboratoire de Biologie Structurale de la Cellule (bioc.ip-paris.fr), École polytechnique, Palaiseau.

Rejoignez-nous!!!

emploi.cnrs.fr/Offres/MOBIN...

Merci de faire circuler l´information!

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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Apr 10

Small RNA pairing in coding sequences can locally slow translation elongation from Storz lab www.cell.com/molecular-ce... #microsky #rnasky

Modulation of protein activity by small RNA base pairing internal to coding sequences

Thongdee et al. reveal that regulatory RNA pairing internal to coding sequences can lead to locally slowed translation elongation and increased enzymatic activity, likely through effects on co-transla...

www.cell.com

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Michaela Novotná @michaelanovotna.bsky.social · Mar 23

Huge thanks, I feel very honored, and congratulations to the other winners!
Publication will hopefully follow soon, stay tuned! 🤘
Presented work done with @balikovalab.bsky.social & @innislab.bsky.social

structbiocssb.bsky.social @structbiocssb.bsky.social · Mar 23

Congratulation to authors of best student posters Veronika Klapšťová, Jakub Hrubý and Martin Sitte and best student talks Klára Kohoutová and Michaela Novotná @michaelanovotna.bsky.social

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structbiocssb.bsky.social @structbiocssb.bsky.social · Mar 23

Congratulation to authors of best student posters Veronika Klapšťová, Jakub Hrubý and Martin Sitte and best student talks Klára Kohoutová and Michaela Novotná @michaelanovotna.bsky.social

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Gerry Wright @gdwantibiotics.bsky.social · Mar 26

The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Nature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...

rdcu.be

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Frances Yap @ribo1214.bsky.social · Feb 18

🚨The triennial Ribosome Conference will be held June 22-June 27, 2025 in Pacific Grove, California. Registration is open - hope to see many #Ribosome #RNA aficionados there. #RNASky #AcademicSky 🧪 rna.ucsc.edu/rnacenter/ri...

Ribosomes2025 Program

The Ribosome Conference is held every three years and brings together researchers working on all aspects of the ribosome, from structure and function to its role in disease and use as a drug target.

rna.ucsc.edu

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