Wilson Lab
@wilsonlab.bsky.social
Ribosomes & Translation Regulation; Antibiotics & Resistance Mechanisms; Structural Biology & Cryo-EM; University of Hamburg.
Reposted by Wilson Lab
My quote of the day
For every complex problem there is an answer that is clear, simple, and wrong.
H. L. Mencken
For every complex problem there is an answer that is clear, simple, and wrong.
H. L. Mencken
November 24, 2025 at 11:41 AM
My quote of the day
For every complex problem there is an answer that is clear, simple, and wrong.
H. L. Mencken
For every complex problem there is an answer that is clear, simple, and wrong.
H. L. Mencken
Reposted by Wilson Lab
📣Publication alert!
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
Colliding ribosomes signal cellular stress
LMU researchers uncover the mechanism by which ribosomes raise alarms in the cell.
www.lmu.de
November 25, 2025 at 8:52 AM
📣Publication alert!
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
Reposted by Wilson Lab
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
ZAK activation at the collided ribosome - Nature
The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.
www.nature.com
November 24, 2025 at 9:12 PM
Check out our latest work on how collided ribosomes activate the MAP3K ZAK! 💫
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
www.nature.com/articles/s41...
A fun collaboration with @beckmannlab.bsky.social @doubleshuang.bsky.social
Reposted by Wilson Lab
Evolutionary Flexibility of Ribosome Biogenesis in Bacteria | Molecular Biology and Evolution | Oxford Academic https://academic.oup.com/mbe/article/42/11/msaf288/8340222?login=false
Evolutionary Flexibility of Ribosome Biogenesis in Bacteria
Abstract. Ribosomes are essential for protein synthesis and require ribosome biogenesis factors for assembly. To uncover the evolutionary diversity of ribo
dx.doi.org
November 24, 2025 at 10:45 AM
Evolutionary Flexibility of Ribosome Biogenesis in Bacteria | Molecular Biology and Evolution | Oxford Academic https://academic.oup.com/mbe/article/42/11/msaf288/8340222?login=false
Reposted by Wilson Lab
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
November 23, 2025 at 3:47 PM
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
Reposted by Wilson Lab
Bacteriologists - save the date for the next BacNet meeting in September 2026 #BacNet26 organised by @lalouxlab.bsky.social
Bacterial networks #BacNet26 in September 2026 will be chaired by @lalouxlab.bsky.social and co-chaired by @s-lab.bsky.social with @coralietesseur.bsky.social
Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
Sneak peak on invited speakers and preliminary program:
meetings.embo.org/event/26-bac...
November 20, 2025 at 8:58 AM
Bacteriologists - save the date for the next BacNet meeting in September 2026 #BacNet26 organised by @lalouxlab.bsky.social
Reposted by Wilson Lab
Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
November 19, 2025 at 3:17 PM
Are you looking to establish yourself as a scientific group leader? BRIC is recruiting 1-2 junior group leaders to join our research centre in the heart of Copenhagen.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
See more at www.bric.ku.dk
Please repost and get in touch if you are curious.
Reposted by Wilson Lab
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
November 18, 2025 at 8:56 AM
Two M. tuberculosis RelE toxins don’t cut mRNA, they slice 16S rRNA itself, shutting down translation in a totally unexpected way, new study reveals.
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
A big leap in understanding TB’s survival tricks and new angles for therapies.
📖 shorturl.at/Z8MVX
✍️ @genevauxpierre.bsky.social & coll.
#MicroSky
Reposted by Wilson Lab
Excited about Kolya Aleksashin's new work, enabling preparation of active in vitro translation systems from primary human cells and difficult-to-edit cells (fibroblasts and cardiomyocytes). This opens new opportunities to probe mechanisms of translation regulation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Overcoming the eIF2α Brake in Human Cell-Derived Translation Systems
Cell-free translation from human cells is a powerful platform for studying mammalian gene expression and building synthetic biology tools, but productivity is often curtailed by inhibitory phosphoryla...
www.biorxiv.org
November 18, 2025 at 6:29 PM
Excited about Kolya Aleksashin's new work, enabling preparation of active in vitro translation systems from primary human cells and difficult-to-edit cells (fibroblasts and cardiomyocytes). This opens new opportunities to probe mechanisms of translation regulation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Wilson Lab
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Termination of the integrated stress response
Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...
www.science.org
November 13, 2025 at 7:05 PM
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...
Reposted by Wilson Lab
🎉Thrilled to share that our lab has been awarded an ERC Synergy Grant @erc.europa.eu! Excited for amazing collaborations with the Pertschy (Uni Graz), Henras (CBI Toulouse), and Woodson (Johns Hopkins) labs.
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
November 7, 2025 at 1:50 PM
🎉Thrilled to share that our lab has been awarded an ERC Synergy Grant @erc.europa.eu! Excited for amazing collaborations with the Pertschy (Uni Graz), Henras (CBI Toulouse), and Woodson (Johns Hopkins) labs.
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
#ERCSyG #GeneCenter #LMU #UniGraz #CNRS #JohnsHopkins
Reposted by Wilson Lab
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
codon usage
About the Conference
Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...
sites.google.com
November 5, 2025 at 10:55 PM
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
Reposted by Wilson Lab
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
November 5, 2025 at 1:18 AM
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
Reposted by Wilson Lab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Wilson Lab
#GetTheMessage - Did you know? After 300+ days in the hospital, Baby KJ went home—sitting up, waving, and growing. His parents were once told to consider end-of-life care. Now they're watching him thrive, thanks to mRNA technology.
www.chop.edu/news/worlds-...
www.chop.edu/news/worlds-...
World's First Patient Treated with Personalized CRISPR Gene Editing Therapy at Children’s Hospital of Philadelphia
Landmark study from CHOP and Penn Medicine showcases the power of customized gene editing therapy to treat patient with rare metabolic disease.
www.chop.edu
October 30, 2025 at 4:00 AM
#GetTheMessage - Did you know? After 300+ days in the hospital, Baby KJ went home—sitting up, waving, and growing. His parents were once told to consider end-of-life care. Now they're watching him thrive, thanks to mRNA technology.
www.chop.edu/news/worlds-...
www.chop.edu/news/worlds-...
It was a fantastic mini-ribosome meeting with great science, lots of historical anecdotes and speeches as well as Swedish singing. Nice to catch up with old friends and make new ones! Special thanks to Suparna, Maria Selmer and Magnus Johansson for the organization!
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
October 30, 2025 at 1:32 PM
It was a fantastic mini-ribosome meeting with great science, lots of historical anecdotes and speeches as well as Swedish singing. Nice to catch up with old friends and make new ones! Special thanks to Suparna, Maria Selmer and Magnus Johansson for the organization!
Reposted by Wilson Lab
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
October 30, 2025 at 10:13 AM
Sweden: celebrating structural biology & protein synthesis! Saluting Anders Liljas & Måns Ehrenberg for years of shaping discoveries and service to the Nobel committee. Friends and colleagues gathering to discuss transformative advances and how to push the boundaries next.
Reposted by Wilson Lab
EF-G variants (fusA mutants) slow down ribosome translocation only when the ribosome is bound by an aminoglycoside => the antibiotic isn’t displaced, but translation on that ribosome is effectively stalled 🦠 rdcu.be/eNt96
Selective silencing of antibiotic-tethered ribosomes as a resistance mechanism against aminoglycosides
Nature Communications - Mutations in elongation factor G protect bacteria from aminoglycoside antibiotics through unknown mechanisms. Here, the authors show that the mutations selectively slow the...
rdcu.be
October 30, 2025 at 1:10 PM
EF-G variants (fusA mutants) slow down ribosome translocation only when the ribosome is bound by an aminoglycoside => the antibiotic isn’t displaced, but translation on that ribosome is effectively stalled 🦠 rdcu.be/eNt96
Reposted by Wilson Lab
25 years on from publishing the structure of the bacterial 30S ribosomal subunit, alumni, collaborators & friends of Venki Ramakrishnan’s group joined us for a symposium celebrating the legacy of this work.
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
October 29, 2025 at 12:11 PM
25 years on from publishing the structure of the bacterial 30S ribosomal subunit, alumni, collaborators & friends of Venki Ramakrishnan’s group joined us for a symposium celebrating the legacy of this work.
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
Read about the event and find photos here: www2.mrc-lmb.cam.ac.uk/25-years-of-...
#LMBNews
Reposted by Wilson Lab
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
October 29, 2025 at 5:22 PM
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
Reposted by Wilson Lab
Finally out in print! Long time project with @olexandr.bsky.social and the PHENIX group. Refinement of X-ray and CryoEM structures, using Machine Learned Potentials as the back end to help fitting. This fulfills the old dream of doing QM refinement, but very very cheap www.nature.com/articles/s41...
AQuaRef: machine learning accelerated quantum refinement of protein structures - Nature Communications
AQuaRef employs machine learning to refine protein structures from cryo-EM and X-ray data in Phenix. It achieves quantum-level precision, improving model geometry and fit to the data while reducing ov...
www.nature.com
October 23, 2025 at 3:20 PM
Finally out in print! Long time project with @olexandr.bsky.social and the PHENIX group. Refinement of X-ray and CryoEM structures, using Machine Learned Potentials as the back end to help fitting. This fulfills the old dream of doing QM refinement, but very very cheap www.nature.com/articles/s41...
Reposted by Wilson Lab
End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC https://www.biorxiv.org/content/10.1101/2025.10.17.682689v1
October 20, 2025 at 1:47 PM
End-to-end automation of repeat-target cryo-EM structure determination in CryoSPARC https://www.biorxiv.org/content/10.1101/2025.10.17.682689v1