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Reposted by Wilson Lab

Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 1d

Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications

tRNA-modifying enzymes in bacterial stress adaptation | Open Biology

Transfer RNAs (tRNAs) and their modifications are central to bacterial translation and physiology, yet their roles in stress adaptation remain underexplored. While extensively studied in eukaryotes, a...

doi.org

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Reposted by Wilson Lab

Briggs Group @briggsgroup.bsky.social · 4d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Reposted by Wilson Lab

David Kuster @rnadavid.bsky.social · 5d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Reposted by Wilson Lab

Susan Shao @sshaolab.bsky.social · 7d

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Reposted by Wilson Lab

Dmitri Ermolenko @ermolenkolab.bsky.social · 6d

We combine our yeast genetics experiments with the massive body of literature data to make a case for 40S scanning of 5’UTRs of by 1D diffusion (finalised version): m.rnajournal.cshlp.org/content/31/1...

RNA | Mobile

https://m.rnajournal.cshlp.org/content/31/10/…

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Reposted by Wilson Lab

Jamie Cate @jhdcate.bsky.social · 5d

Giant DNA viruses taking on translation factors!
www.biorxiv.org/content/10.1...

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

www.biorxiv.org

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Wilson Lab @wilsonlab.bsky.social · 6d

www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Reposted by Wilson Lab

Haselbach Lab @haselbachlab.bsky.social · 13d

Finally! This was really missing.

RCSB Protein Data Bank @rcsbpdb.bsky.social · 13d

wwPDB has introducing the first 3DEM Model-Map percentile slider (based on Q-score) to validation reports

Introducing the first 3DEM Model-Map percentile slider to the wwPDB validation report

Introducing the latest wwPDB Percentile slider based on the Q-score model-map validation metric

www.rcsb.org

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Wilson Lab @wilsonlab.bsky.social · 16d

Deep-mining the archaeal proteome for antibiotics www.nature.com/articles/s41...

Deep-mining the archaeal proteome for antibiotics - Nature Microbiology

A deep-learning algorithm unravels a collection of archaeasins, peptides from the archaeal proteome with potential antimicrobial activity and implications for the development of next-generation antibiotics

www.nature.com

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Reposted by Wilson Lab

David Balchin @davidbalchin.bsky.social · 20d

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

www.nature.com

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Reposted by Wilson Lab

Universität zu Köln @unicologne.bsky.social · 27d

The team of Prof. Dr Niels Gehring @volkerboehm.bsky.social records a comprehensive database that records systematically which genes and gene variants are directly affected by "Nonsense-mediated mRNA Decay" which opens up new avenues for RNA and genome research.
The database ➡️ nmdrht.uni-koeln.de

NMDRHT v1.2

nmdrht.uni-koeln.de

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Reposted by Wilson Lab

Jack Bravo @jpkbravo.bsky.social · 25d

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social!

Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus.

Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

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Reposted by Wilson Lab

cryoEM papers @cryoempapers.bsky.social · 25d

Confidence-guided cryo-EM map optimisation with LocScale-2.0 www.biorxiv.org/content/10.1101/2025.09.11.674726v1 #cryoem

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Wilson Lab @wilsonlab.bsky.social · 24d

Evolution of drug-binding residues in eukaryotic ribosomes…. pubmed.ncbi.nlm.nih.gov/40944914/

Evolution of drug-binding residues in eukaryotic ribosomes - PubMed

Drugs that target eukaryotic ribosomes are becoming increasingly important as research tools and potential therapies against cancer and pathogenic eukaryotes. However, in the absence of comparative st...

pubmed.ncbi.nlm.nih.gov

Reposted by Wilson Lab

Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 28d

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

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Reposted by Wilson Lab

Ryan Estrada @ryanestrada.com · Sep 6

Just a reminder to check for your name in this list of books that OpenAI trained from. If your name is there, they probably owe you several thousand dollars.

OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.

Search LibGen, the Pirated-Books Database That Meta Used to Train AI

Millions of books and scientific papers are captured in the collection’s current iteration.

www.theatlantic.com

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Reposted by Wilson Lab

FMI science @fmiscience.bsky.social · Sep 8

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

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Reposted by Wilson Lab

ASM @asm.org · Sep 10

Julian Davies was a renowned scientist who made crucial strides in the study of antibiotics & antibiotic resistance. Honor his legacy at the Julian Davies Memorial Symposium on Oct. 10, hosted by the University of British Columbia. Register by Sept. 15 to attend via Zoom or in person! asm.social/2Af

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Reposted by Wilson Lab

Marie Winz @mariewinz.bsky.social · Sep 9

Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.

bioRxivpreprint @biorxivpreprint.bsky.social · Sep 6

Jlp2 is an RQC complex-independent release factor acting on aberrant peptidyl-tRNA, protecting cells against translation elongation stress https://www.biorxiv.org/content/10.1101/2025.09.04.673968v1

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Reposted by Wilson Lab

Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Aug 30

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI #microsky #rnasky 🦠 www.biorxiv.org/content/10.1...

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI

Ribosomal RNA (rRNA) modifications are important for ribosome function and can influence bacterial susceptibility to ribosome-targeting antibiotics. The universally conserved 16S rRNA nucleotide C1402...

www.biorxiv.org

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Reposted by Wilson Lab

Raphael Laurenceau @raphael-microb.bsky.social · Aug 28

OMG this is it?! The final piece in the puzzle?!😲 tRNAs are the key, because archaic tRNAs sit at the core of all ribosomes. If aminoacyl-tRNAs could form on early Earth, you have a plausible route for the first self-replicators, the bridge from chemistry to biology
www.nature.com/articles/d41...

Origins of life: the molecules that could have unlocked peptide synthesis

For life to emerge on Earth, peptides must first have formed without the aid of enzymes — but how? Reactions of sulfur-containing molecules might have been key.

www.nature.com

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Reposted by Wilson Lab

Niladri Sinha @2primehydroxyl.bsky.social · Aug 21

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

The Sinha Lab

The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.

sinha.biochem.utah.edu

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Wilson Lab @wilsonlab.bsky.social · Aug 22

Congrats Niladri! Looking forward to following your work in the next years!!

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Reposted by Wilson Lab

Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · Aug 20

📄 New paper: 3DEM Structure Map Validation Recommendations

Two new metrics assess model-to-map fitness in cryo-EM:
🔹 Q_relative_all → compares avg Q-score across PDB/EMDB
🔹 Q_relative_resolution → compares within similar resolution

#3DEM #CryoEM #wwPDB

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Reposted by Wilson Lab

Heather Feaga @heatherfeaga.bsky.social · Aug 19

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social
journals.asm.org/doi/10.1128/...

Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio

Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...

journals.asm.org

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