Michaela Novotná
@michaelanovotna.bsky.social
130 followers
290 following
5 posts
PhD student in @balikovalab.bsky.social at @czechacademy.bsky.social of Sciences, BIOCEV, @charlesuni.cuni.cz in Prague
💊 antibiotics 💎 ribosome
🧫 resistance 🧬 ABC-Fs
🦠 staph ❄️ cryo-em
@mbuavcr.bsky.social
@sciencecharles.bsky.social
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Reposted by Michaela Novotná
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Chi-Min Ho
@cmholab.bsky.social
· Aug 18
Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug
Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...
rdcu.be
Fanny DEMAY
@titefanny.bsky.social
· Aug 13
ABCF protein-mediated resistance shapes bacterial responses to antibiotics based on their type and concentration | mBio
Bacteria adapt to diverse stimuli mainly through transcriptional changes that regulate adaptive protein factors. Here, we show that responses to protein synthesis-inhibiting antibiotics are fine-tuned by antibiotic resistance ABCF proteins at the ...
doi.org
Reposted by Michaela Novotná
Wilson Lab
@wilsonlab.bsky.social
· Jul 14
A Natural Depsipeptide Antibiotic that Targets the E site of the Bacterial Ribosome
A significant challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds. Although natural products produced by fungi and bacteria, particularly actinomycetes,...
www.researchsquare.com
Reposted by Michaela Novotná
Reposted by Michaela Novotná
cryoEM papers
@cryoempapers.bsky.social
· Jun 10
Reposted by Michaela Novotná
cryoEM papers
@cryoempapers.bsky.social
· Jul 12
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Will Wan
@williamnwan.bsky.social
· Jul 8
A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries
Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…
www.sciencedirect.com
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Wilson Lab
@wilsonlab.bsky.social
· Jun 19
Mechanism of release factor–mediated peptidyl-tRNA hydrolysis on the ribosome
Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factor...
www.science.org
Reposted by Michaela Novotná
Reposted by Michaela Novotná
Merve Yigit
@merveyigit.bsky.social
· May 26
Sendoel Lab
@sendoellab.bsky.social
· May 26
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
www.biorxiv.org
Reposted by Michaela Novotná
Liam Faller
@liamfaller.bsky.social
· May 8
Detecting ribosome collisions with differential rRNA fragment analysis in ribosome profiling data
Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp
academic.oup.com
Reposted by Michaela Novotná
Wilson Lab
@wilsonlab.bsky.social
· May 7
The structure of the Vibrio natriegens 70S ribosome in complex with the proline-rich antimicrobial peptide Bac5(1–17)
Abstract. Proline-rich antimicrobial peptides (PrAMPs) are produced as part of the innate immune response of animals, insects, and plants. The well-charact
academic.oup.com