Objectives Valvular heart disease (VHD) is a growing global health concern with increasing prevalence, particularly in aging populations. While surgical valve replacement (VRS) remains a definitive .....

Background Cardiac myxomas are the most common primary tumors of the heart, although they remain rare overall, particularly in elderly male patients. Left atrial myxomas typically present with nonspec...

Cardiovascular diseases remain the leading cause of mortality worldwide, with elderly patients experiencing the worst prognosis following ST-elevation myocardial infarction (STEMI). Traditional risk s...

AbstractBackground. Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, with its burden increasingly

The clinical and para-clinical status in patients undergoing CABG surgery changes after on-pump surgery. In addition, comorbidities of patients have a positive and significant effect on PaO₂, as well as gender, on cerebral oximetry, hemoglobin, and hematocrit values.

Introduction Inferior vena cava (IVC) filters are widely used to prevent pulmonary embolism (PE), particularly in patients with contraindications to anticoagulation or those experiencing recurrent thr...

This meta-analysis exclusively examines pulmonary valve replacement (PVR) outcomes in congenital heart disease (CHD) patients. CHD affects nearly 1% of live births globally, with a significant subset ...

Chronic kidney disease (CKD) presents a growing global challenge among aging populations. Effective self-care remains a cornerstone of disease management in elderly patients. This study investigated t...

Background Dynapenia and obesity have been independently shown to be associated with an increased risk of all-cause mortality. However, the association between dynapenic obesity [defined by waist circ...

Background Metabolic syndrome (MetS) is highly prevalent among individuals with type 2 diabetes and is characterized by a combination of specific clinical parameters including abnormal blood lipid lev...

Emotional stress leading to cortisol release is an important infertility factor in females. Increased cortisol levels can significantly affect tight junction proteins and dysregulate the implantation process. This study investigated the effect of ...

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In patients with suspected vasovagal syncope, a 15-min head-up tilt test protocol yielded similar diagnostic results to the conventional 20-min protocol. This shorter approach may improve patient com....

A summary of the patient's history and treatment process.

Background The European Society of Cardiology (ESC) recently endorsed low-dose colchicine for chronic coronary syndrome. However, its role in acute coronary syndrome (ACS) remains uncertain due to inc...

Tricuspid regurgitation (TR) is a significant valve disorder with limited data on management outcomes.

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Pain stands as one of the main factors related to human disability and suffering, with different classifications (e.g., acute/chronic, somatic/visceral, and mal...

Introduction Carbohydrate Antigen 125 (CA125) has emerged as a potential biomarker in patients with heart failure (HF). This meta-analysis comprehensively evaluates the association between CA125 levels and clinical outcomes across HF populations. Methods We conducted this study based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). We systematically searched PubMed, Scopus, Web of Science, and Embase libraries up to April 2025. We selected the original English-language investigations that reported the association between CA125 levels and clinical outcomes in cases with HF. The random-effects model and Hartung-Knapp-Sidik-Jonkman method were used to pool effect sizes and report summary statistics. The current review was registered in PROSPERO (CRD420251023141). Results A total of 20,458 cases were included from 29 studies, with an average age of 70.3 years, and 36.1% of cases were women. The average cut-off level was 37.78 U/mL, and 35 U/mL was mainly used as the CA125 cut-off level. A meta-analysis of nine studies that reported the risk of experiencing endpoint events (death or HF-related hospitalization) showed significantly higher risk (HR 2.23, 95% CI 1.69–2.93; p < 0.01; I2 = 75.0%) among the patients with higher CA125 levels compared to those with lower levels. The increased risk remained significant across the acute heart failure (AHF) (HR based on two studies: 1.88, 95% CI 1.54–2.30; p < 0.01; I2 = 39.6%) and chronic heart failure (CHF) (HR based on seven studies: 2.52, 95% CI 1.69–3.77; p < 0.01; I2 = 77.4%) subgroups. Furthermore, a correlation meta-analysis of 13 studies revealed a significant direct correlation between CA125 and pro-BNP levels (r = 0.42; 95% CI 0.30 to 0.54; p < 0.01; I2 = 96.9%). Conclusion The current review findings revealed CA125 as a significant prognostic factor of mortality and hospitalization risks in HF population. Furthermore, CA125 could be a non-invasive and operator-independent tool for evaluating disease severity and monitoring response to therapy. We suggested CA125 for monitoring various treatments in individuals with HF, specifically diuretic therapy. Further prospective studies are needed to determine the optimal cut-off for CA125 levels in HF.

Background Weight regain (WR) and insufficient weight loss (WL) occur in 20–25% of patients after bariatric surgery due to various factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have shown promise in promoting WL; however, evidence regarding their effectiveness in managing WL and preventing WR post-bariatric surgery remains limited. Objective This study aims to evaluate the role of GLP-1RAs in treating and preventing WR following bariatric surgery. Methods A systematic search was conducted across PubMed, Scopus, and Web of Science for studies assessing the impact of GLP-1RAs on WR after bariatric surgery. Results Our search identified 27 original studies, with 10 included in the meta-analysis involving 769 participants (392 treated with GLP-1RAs). The mean age was 44.05 years, with 30.47% male. The time interval from surgery to the initiation of GLP-1RAs treatment ranged from 1.5 to 86.7 months, with treatment durations between 4 and 12 months. The analysis showed significantly greater WL in the GLP-1RAs group compared to placebo (SMD = 0.82, 95% CI 0.23 to 1.42). Subgroup analysis for treatment durations ≤ 6 months indicated a higher WL in the GLP-1RAs group (SMD = 0.79, 95% CI 0.25 to 1.34). Adverse events were primarily gastrointestinal, with nausea significantly more frequently in the GLP-1RAs group (OR = 2.01, 95% CI 1.24 to 3.27). Conclusion GLP-1RAs effectively promote WL among participants experiencing WR after bariatric surgery. Initiating GLP-1RAs therapy shortly after surgery may help prevent WR. Further research is warranted to explore long-term outcomes and optimize treatment protocols for this patient population. Graphical Abstract

Pain is an unpleasant sensory and emotional sensation about actual or possible tissue damage that can cause remarkable health and economic problems. For pain re...