Vienna Airway Lab
@viennaairwaylab.bsky.social
Immunology | Allergology | Type 2 Inflammation | Chronic Rhinosinusitis
🌐 viairlab.com
📷 instagram.com/viairlab
🔬 Run by dedicated Lab Members 🇦🇹 🇬🇧 🇪🇹 🇸🇾 🇬🇷 🇨🇳🇪🇱 🏳️🌈
🌐 viairlab.com
📷 instagram.com/viairlab
🔬 Run by dedicated Lab Members 🇦🇹 🇬🇧 🇪🇹 🇸🇾 🇬🇷 🇨🇳🇪🇱 🏳️🌈
Pinned
Hello Bluesky!
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky
Have a productive day everyone 🤗
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky
Have a productive day everyone 🤗
Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting Eosinophil Extracellular Traps (EET) formation and release in Chronic rhinosinusitis with nasal polyps (CRSwNP)
#CRSwNP #inflammation #ROS #oxidativestress
🔗 ino.to/hBsxjbm
#CRSwNP #inflammation #ROS #oxidativestress
🔗 ino.to/hBsxjbm
November 25, 2025 at 7:17 AM
Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting Eosinophil Extracellular Traps (EET) formation and release in Chronic rhinosinusitis with nasal polyps (CRSwNP)
#CRSwNP #inflammation #ROS #oxidativestress
🔗 ino.to/hBsxjbm
#CRSwNP #inflammation #ROS #oxidativestress
🔗 ino.to/hBsxjbm
Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations
#Immunology #allergy #rhinitis #immunotherapy #asthma
🔗 ino.to/CKPDLAC
#Immunology #allergy #rhinitis #immunotherapy #asthma
🔗 ino.to/CKPDLAC
Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations
LAR patients who respond to AIT during the first year and are treated for two more years continue improving (less symptoms and medication intake) during the following seven years. AIT prevents the on...
ino.to
November 21, 2025 at 6:39 PM
Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations
#Immunology #allergy #rhinitis #immunotherapy #asthma
🔗 ino.to/CKPDLAC
#Immunology #allergy #rhinitis #immunotherapy #asthma
🔗 ino.to/CKPDLAC
Reposted by Vienna Airway Lab
As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
Tumour-reactive heterotypic CD8 T cell clusters from clinical samples
Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.
www.nature.com
November 19, 2025 at 7:32 PM
As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
#immunology
#science
#tumor
#immunotherapy
buff.ly/pETJPEH
Review highlights the role of NRF2 signalling in chronic obstructive pulmonary disease: regulation of #ferroptosis and therapeutic implications 💊
#Immunology #redox #NRF2 #COPD
🔗 ino.to/P4uko9Z
#Immunology #redox #NRF2 #COPD
🔗 ino.to/P4uko9Z
November 18, 2025 at 7:03 AM
Review highlights the role of NRF2 signalling in chronic obstructive pulmonary disease: regulation of #ferroptosis and therapeutic implications 💊
#Immunology #redox #NRF2 #COPD
🔗 ino.to/P4uko9Z
#Immunology #redox #NRF2 #COPD
🔗 ino.to/P4uko9Z
New research reveals a hidden link between systemic and gut immunity, showing that affinity-matured IgA in the gut can be generated from IgG1 cells, a pathway that could be key for designing effective mucosal vaccines.
#Immunology #vaccines
🔗 doi.org/10.1016/j.im...
#Immunology #vaccines
🔗 doi.org/10.1016/j.im...
November 18, 2025 at 6:56 AM
New research reveals a hidden link between systemic and gut immunity, showing that affinity-matured IgA in the gut can be generated from IgG1 cells, a pathway that could be key for designing effective mucosal vaccines.
#Immunology #vaccines
🔗 doi.org/10.1016/j.im...
#Immunology #vaccines
🔗 doi.org/10.1016/j.im...
Beyond its beautiful, segmented shape 🔬, the #neutrophil nucleus may be a key to understanding immune cell migration and gene regulation - but its full functional relevance remains unknown.
#Immunology #ImmunoSky #CellBiology
🔗 ino.to/bQiWo2g
#Immunology #ImmunoSky #CellBiology
🔗 ino.to/bQiWo2g
November 13, 2025 at 7:06 PM
Beyond its beautiful, segmented shape 🔬, the #neutrophil nucleus may be a key to understanding immune cell migration and gene regulation - but its full functional relevance remains unknown.
#Immunology #ImmunoSky #CellBiology
🔗 ino.to/bQiWo2g
#Immunology #ImmunoSky #CellBiology
🔗 ino.to/bQiWo2g
A new study finds that some patients on #dupilumab for chronic rhinosinusitis with nasal polyps are "super-responders", successfully maintaining disease control with a single dose 💊 just once every 12 weeks.
#CRSwNP #biologics #type2disease #Immunology
🔗 ino.to/WtzjQlV
#CRSwNP #biologics #type2disease #Immunology
🔗 ino.to/WtzjQlV
“Super‐Responders” to Dupilumab Treatment in Patients With Primary Diffuse Chronic Rhinosinusitis With Nasal Polyps
This study aimed to evaluate the feasibility of extending dupilumab dosing intervals in T2-CRSwNP by assessing how many patients maintain disease control with once-every-12-weeks (Q12W) dosing and co....
ino.to
November 13, 2025 at 6:47 PM
A new study finds that some patients on #dupilumab for chronic rhinosinusitis with nasal polyps are "super-responders", successfully maintaining disease control with a single dose 💊 just once every 12 weeks.
#CRSwNP #biologics #type2disease #Immunology
🔗 ino.to/WtzjQlV
#CRSwNP #biologics #type2disease #Immunology
🔗 ino.to/WtzjQlV
In severe asthma, type 2 cytokines (IL-5/IL-4) drive harmful eosinophil inflammation. A multi-omics study shows all-trans retinoic acid (ATRA) counteracts this and maintains eosinophil homeostasis, offering novel insights and therapeutic hopes.
#Immunology #asthma #type2
🔗 doi.org/10.1016/j.ja...
#Immunology #asthma #type2
🔗 doi.org/10.1016/j.ja...
November 11, 2025 at 8:24 AM
In severe asthma, type 2 cytokines (IL-5/IL-4) drive harmful eosinophil inflammation. A multi-omics study shows all-trans retinoic acid (ATRA) counteracts this and maintains eosinophil homeostasis, offering novel insights and therapeutic hopes.
#Immunology #asthma #type2
🔗 doi.org/10.1016/j.ja...
#Immunology #asthma #type2
🔗 doi.org/10.1016/j.ja...
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness ino.to/fg4HeLH
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness - Nature Immunology
Peanut oral immunotherapy reshapes T cell responses, suppressing allergy-associated type 2 helper T cells and boosting cytotoxic type 1 helper T cells, offering clues to long-term tolerance.
ino.to
November 6, 2025 at 8:26 PM
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness ino.to/fg4HeLH
New murine study reveals characteristics of mature IgE PCs and localizes long-lived IgE PCs in the spleen in addition to bone marrow.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00465-0
🔗 cell.com/immunity/fulltext/S1074-7613(25)00465-0
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario
et al. find that IgE-producing plasma cells mature, acquire survival adaptations,
and persist for extended periods of...
cell.com
November 3, 2025 at 6:28 AM
New murine study reveals characteristics of mature IgE PCs and localizes long-lived IgE PCs in the spleen in addition to bone marrow.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00465-0
🔗 cell.com/immunity/fulltext/S1074-7613(25)00465-0
Multi-omic profiling reveals age-related immune dynamics in healthy adults
#Immunology #omics
🔗 ino.to/r4DCCQW
#Immunology #omics
🔗 ino.to/r4DCCQW
Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature
This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...
ino.to
October 30, 2025 at 8:34 PM
Multi-omic profiling reveals age-related immune dynamics in healthy adults
#Immunology #omics
🔗 ino.to/r4DCCQW
#Immunology #omics
🔗 ino.to/r4DCCQW
📣 Join our webinar 🖥️ today to hear about biomarkers 🧬 of #NRF2 activation and their role in fighting chronic diseases 💊
@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox
🔗 www.antiox.it/webinars2025...
@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox
🔗 www.antiox.it/webinars2025...
October 28, 2025 at 6:19 AM
📣 Join our webinar 🖥️ today to hear about biomarkers 🧬 of #NRF2 activation and their role in fighting chronic diseases 💊
@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox
🔗 www.antiox.it/webinars2025...
@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox
🔗 www.antiox.it/webinars2025...
Reposted by Vienna Airway Lab
DOPAC, a microbial metabolite of quercetin, enhances CD8+ T cell-mediated anti-tumor immunity by activating NRF2-driven mitophagy, thereby improving T cell fitness and potentiating the response to immune checkpoint blockade @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
DOPAC, a microbial metabolite of quercetin, enhances CD8+ T cell-mediated anti-tumor
immunity by activating NRF2-driven mitophagy, thereby improving T cell fitness and
potentiating the response to imm...
www.cell.com
October 28, 2025 at 2:36 AM
DOPAC, a microbial metabolite of quercetin, enhances CD8+ T cell-mediated anti-tumor immunity by activating NRF2-driven mitophagy, thereby improving T cell fitness and potentiating the response to immune checkpoint blockade @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Vienna Airway Lab
Great energy at the COST Action BenBedPhar meeting in Istanbul! Researchers from across Europe discussed the latest on NRF2 and its translational potential in chronic diseases. Collaboration, science & progress at their best! 💡
#BenBedPhar #NRF2 #Science
#BenBedPhar #NRF2 #Science
October 20, 2025 at 7:34 AM
Great energy at the COST Action BenBedPhar meeting in Istanbul! Researchers from across Europe discussed the latest on NRF2 and its translational potential in chronic diseases. Collaboration, science & progress at their best! 💡
#BenBedPhar #NRF2 #Science
#BenBedPhar #NRF2 #Science
📣 Newsletter alert: Check out the latest and sadly the last newsletter 🗞️ by @benbedphar.bsky.social COST Action CA20121 on recent cutting-edge #NRF2 research 🔬. Don't miss it 🎉
#BenBedPhar #EU #COSTaction #OxidativeStress
🔗 benbedphar.org/issue-13-oct...
#BenBedPhar #EU #COSTaction #OxidativeStress
🔗 benbedphar.org/issue-13-oct...
Issue 13, October 2025 - BenBedPhar
NRF2 in COST Action 20121 Our quarterly newsletter attempts to provide our latest news and also aims at becoming a forum for analysis of relevant topics on the field of NRF2 and provide comments to so...
benbedphar.org
October 23, 2025 at 4:17 PM
📣 Newsletter alert: Check out the latest and sadly the last newsletter 🗞️ by @benbedphar.bsky.social COST Action CA20121 on recent cutting-edge #NRF2 research 🔬. Don't miss it 🎉
#BenBedPhar #EU #COSTaction #OxidativeStress
🔗 benbedphar.org/issue-13-oct...
#BenBedPhar #EU #COSTaction #OxidativeStress
🔗 benbedphar.org/issue-13-oct...
Reposted by Vienna Airway Lab
Eosinophil-derived IL-24 compromises epithelial integrity and aggravates airway remodeling in mouse models of allergic asthma @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 21, 2025 at 1:51 AM
Eosinophil-derived IL-24 compromises epithelial integrity and aggravates airway remodeling in mouse models of allergic asthma @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vienna Airway Lab
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular
mechanisms guiding their sustained functional adaptation remain unclear. Kolter and
Döring et al. show that local i...
www.cell.com
October 16, 2025 at 9:00 AM
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
📚 Our new review is out! @benbedphar.bsky.social WG3 dives deep into measuring #NRF2 activity across diseases and how to translate these biomarkers into clinical practice for better patient care.
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress
🔗 doi.org/10.1016/j.re...
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress
🔗 doi.org/10.1016/j.re...
October 14, 2025 at 7:46 AM
📚 Our new review is out! @benbedphar.bsky.social WG3 dives deep into measuring #NRF2 activity across diseases and how to translate these biomarkers into clinical practice for better patient care.
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress
🔗 doi.org/10.1016/j.re...
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress
🔗 doi.org/10.1016/j.re...
Great to be part of the United Airways Symposium in Linz!
I spoke about “Epithelium as the starting point of inflammation in the upper and lower respiratory tract.”
Thanks to Prof. Lamprecht and AstraZeneca for a well-organized and inspiring event.
#UnitedAirways #medsky #medunivienna
I spoke about “Epithelium as the starting point of inflammation in the upper and lower respiratory tract.”
Thanks to Prof. Lamprecht and AstraZeneca for a well-organized and inspiring event.
#UnitedAirways #medsky #medunivienna
October 13, 2025 at 6:23 AM
Great to be part of the United Airways Symposium in Linz!
I spoke about “Epithelium as the starting point of inflammation in the upper and lower respiratory tract.”
Thanks to Prof. Lamprecht and AstraZeneca for a well-organized and inspiring event.
#UnitedAirways #medsky #medunivienna
I spoke about “Epithelium as the starting point of inflammation in the upper and lower respiratory tract.”
Thanks to Prof. Lamprecht and AstraZeneca for a well-organized and inspiring event.
#UnitedAirways #medsky #medunivienna
A fantastic finale at Kadir Has Istanbul for the #BenBedPhar MC&Scientific Meeting. Delivered WG3 report, presented our new research, and chaired #NRF2 scientific session. Grateful for an incredible 4 years with this brilliant #COST Action community—a truly unique journey 🎉
@benbedphar.bsky.social
@benbedphar.bsky.social
October 11, 2025 at 2:10 PM
A fantastic finale at Kadir Has Istanbul for the #BenBedPhar MC&Scientific Meeting. Delivered WG3 report, presented our new research, and chaired #NRF2 scientific session. Grateful for an incredible 4 years with this brilliant #COST Action community—a truly unique journey 🎉
@benbedphar.bsky.social
@benbedphar.bsky.social
A 16-week #dupilumab 💊 regimen for young kids with eczema restored skin barrier and suppressed local Th2 inflammation 🔥, with machine learning pinpointing new redox-related treatment targets 🎉
#Immunology #biologics #type2immunity #redox #ML
🔗 ino.to/2rLyiTE
#Immunology #biologics #type2immunity #redox #ML
🔗 ino.to/2rLyiTE
Dupilumab in Children Under 6 Years With Moderate‐to‐Severe Atopic Dermatitis: A 16‐Week Real‐World Prospective Study on Efficacy, Safety, and Local‐Systemic Immune Responses
Sixteen-week dupilumab improved clinical outcomes in young children with AD, restoring skin barrier and suppressing local Th2 inflammation. However, persistent systemic inflammation suggests a need f...
ino.to
October 8, 2025 at 9:59 AM
A 16-week #dupilumab 💊 regimen for young kids with eczema restored skin barrier and suppressed local Th2 inflammation 🔥, with machine learning pinpointing new redox-related treatment targets 🎉
#Immunology #biologics #type2immunity #redox #ML
🔗 ino.to/2rLyiTE
#Immunology #biologics #type2immunity #redox #ML
🔗 ino.to/2rLyiTE
Reposted by Vienna Airway Lab
Thrilled to see immunological research recognized with this year’s #NobelPrize! ✨
Congratulations to the laureates, Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, for their discoveries on peripheral immune tolerance—a landmark achievement for #immunology!
www.nobelprize.org/prizes/medic...
Congratulations to the laureates, Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, for their discoveries on peripheral immune tolerance—a landmark achievement for #immunology!
www.nobelprize.org/prizes/medic...
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
www.nobelprize.org
October 6, 2025 at 12:00 PM
Thrilled to see immunological research recognized with this year’s #NobelPrize! ✨
Congratulations to the laureates, Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, for their discoveries on peripheral immune tolerance—a landmark achievement for #immunology!
www.nobelprize.org/prizes/medic...
Congratulations to the laureates, Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, for their discoveries on peripheral immune tolerance—a landmark achievement for #immunology!
www.nobelprize.org/prizes/medic...
To optimise treatment for chronic rhinosinusitis with polyps, precise diagnosis is key, as Western patients often have Type 2 inflammation (treated with #biologics) while Eastern patients more commonly have non-Type 2 inflammation (use of macrolide antibiotics).
#Immunology #CRSwNP
🔗 ino.to/MJfod3w
#Immunology #CRSwNP
🔗 ino.to/MJfod3w
Treatment Approach to Chronic Rhinosinusitis Based on Endotype: Difference Between East and West
Heterogeneity among CRSwNP patients in Western and Eastern countries leads to differences in management. Type 2 (T2) inflammation accounts for the majority of CRSwNP patients in Western countries, wh...
ino.to
October 6, 2025 at 7:02 AM
To optimise treatment for chronic rhinosinusitis with polyps, precise diagnosis is key, as Western patients often have Type 2 inflammation (treated with #biologics) while Eastern patients more commonly have non-Type 2 inflammation (use of macrolide antibiotics).
#Immunology #CRSwNP
🔗 ino.to/MJfod3w
#Immunology #CRSwNP
🔗 ino.to/MJfod3w
More highlights from the ENT Congress 🇦🇹
Our team contributed across many areas:
🔬 Christina on machine learning in CRS
🤧 Mo on allergies in the upper airway
🧬 Linda on oxidative stress & NRF2 signaling
💡 Sven in clinical dialogue & interactive sessions
#ENT #Allergy #Science #Medicine #Research
Our team contributed across many areas:
🔬 Christina on machine learning in CRS
🤧 Mo on allergies in the upper airway
🧬 Linda on oxidative stress & NRF2 signaling
💡 Sven in clinical dialogue & interactive sessions
#ENT #Allergy #Science #Medicine #Research
September 19, 2025 at 1:16 PM
🇦🇹 First highlight from the Austrian ENT Conference: Vienna Airway Lab!
✨ Tina Bartosik gave a talk in the Allergology session on “Indicating Biologicals – What Role Do Allergies Play?”
🏆 Sven Schneider was elected Chair of the Working Group on Rhinology and Skull Base Surgery.
#ENT #Immunosky
✨ Tina Bartosik gave a talk in the Allergology session on “Indicating Biologicals – What Role Do Allergies Play?”
🏆 Sven Schneider was elected Chair of the Working Group on Rhinology and Skull Base Surgery.
#ENT #Immunosky
September 18, 2025 at 9:38 AM
🇦🇹 First highlight from the Austrian ENT Conference: Vienna Airway Lab!
✨ Tina Bartosik gave a talk in the Allergology session on “Indicating Biologicals – What Role Do Allergies Play?”
🏆 Sven Schneider was elected Chair of the Working Group on Rhinology and Skull Base Surgery.
#ENT #Immunosky
✨ Tina Bartosik gave a talk in the Allergology session on “Indicating Biologicals – What Role Do Allergies Play?”
🏆 Sven Schneider was elected Chair of the Working Group on Rhinology and Skull Base Surgery.
#ENT #Immunosky