Willi
@willigo09.bsky.social
Working on #SelfDrivingLabs at the Acceleration Consortium @ UofT. Former employee at dsm-firmenich working on self-driving labs for food applications. Interested in systems biology, microbial communities, ML/AI, software development, product management.
Pinned
Willi
@willigo09.bsky.social
· Nov 11
I created a #StarterPack for #SelfDrivingLabs. Please comment if you would like to be added: go.bsky.app/Jq7EKC2
Looking forward to the discussions!
Looking forward to the discussions!
Reposted by Willi
I do this ish for a living, I am an AI developer and researcher, and *I* don’t fully understand the security implications. What hope do regular users have?
www.windowscentral.com/microsoft/wi...
www.windowscentral.com/microsoft/wi...
Microsoft warns that Windows 11's agentic AI could install malware on your PC: "Only enable this feature if you understand the security implications"
Microsoft is pushing ahead with its plan to add agentic capabilities to Windows 11 but has issued an important security warning for anyone who is interested in trying it out.
www.windowscentral.com
November 18, 2025 at 8:30 PM
I do this ish for a living, I am an AI developer and researcher, and *I* don’t fully understand the security implications. What hope do regular users have?
www.windowscentral.com/microsoft/wi...
www.windowscentral.com/microsoft/wi...
Workflow orchestration of #SelfDrivingLabs was a hot topic at #Accelerate25. We now organize 2 dedicated workshops on this topic, more details can be found here: www.linkedin.com/posts/willig...
Please get in touch if you want to contribute and shape the future of self-driving labs!
Please get in touch if you want to contribute and shape the future of self-driving labs!
#selfdrivinglabs #accelerate25 #selfdrivinglabs | Willi Gottstein
“𝗪𝗵𝘆 𝗱𝗼 𝘄𝗲 𝗵𝗮𝘃𝗲 𝘀𝗼 𝗺𝗮𝗻𝘆 𝗼𝗿𝗰𝗵𝗲𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 𝘁𝗼𝗼𝗹𝘀? 𝗪𝗵𝘆 𝗮𝗿𝗲 𝗲𝗳𝗳𝗼𝗿𝘁𝘀 𝗳𝗿𝗮𝗴𝗺𝗲𝗻𝘁𝗲𝗱 𝘄𝗵𝗲𝗻 𝘄𝗲 𝗳𝗮𝗰𝗲 𝘁𝗵𝗲 𝘀𝗮𝗺𝗲 𝗰𝗵𝗮𝗹𝗹𝗲𝗻𝗴𝗲𝘀? 𝗜𝘀𝗻’𝘁 𝗶𝘁 𝘁𝗶𝗺𝗲 𝘁𝗼 𝗮𝗹𝗶𝗴𝗻 𝗼𝗻 𝗽𝗿𝗶𝗻𝗰𝗶𝗽𝗹𝗲𝘀 𝗮𝗻𝗱 𝘀𝘁𝗮𝗻𝗱𝗮𝗿𝗱𝘀 𝘁𝗵𝗮𝘁 𝗴𝗼𝘃𝗲𝗿𝗻 𝘄𝗼𝗿𝗸𝗳𝗹𝗼𝘄 𝗼𝗿𝗰𝗵𝗲𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 #𝗦𝗲𝗹𝗳...
www.linkedin.com
November 18, 2025 at 9:18 PM
Workflow orchestration of #SelfDrivingLabs was a hot topic at #Accelerate25. We now organize 2 dedicated workshops on this topic, more details can be found here: www.linkedin.com/posts/willig...
Please get in touch if you want to contribute and shape the future of self-driving labs!
Please get in touch if you want to contribute and shape the future of self-driving labs!
Reposted by Willi
For Python package management I use a mixture of pixi, uv and conda depending on the task I'm doing.
I wrote up a long form post about the history of these tools, why each one exists, and why I settled on these choices in my workflow.
jacobtomlinson.dev/posts/2025/p...
I wrote up a long form post about the history of these tools, why each one exists, and why I settled on these choices in my workflow.
jacobtomlinson.dev/posts/2025/p...
Python package managers: uv vs pixi?
When I talk to people about Python package management in 2025 I see the following tools in active use; uv, pixi, pip, conda, mamba, micromamba and poetry. There may be others, but I don’t hear much ab...
jacobtomlinson.dev
November 18, 2025 at 12:56 PM
For Python package management I use a mixture of pixi, uv and conda depending on the task I'm doing.
I wrote up a long form post about the history of these tools, why each one exists, and why I settled on these choices in my workflow.
jacobtomlinson.dev/posts/2025/p...
I wrote up a long form post about the history of these tools, why each one exists, and why I settled on these choices in my workflow.
jacobtomlinson.dev/posts/2025/p...
Reposted by Willi
TIL that pyproject.toml might require one #Python version, but what you actually get also depends on the Python version(s) you have installed.
November 18, 2025 at 6:35 PM
TIL that pyproject.toml might require one #Python version, but what you actually get also depends on the Python version(s) you have installed.
Reposted by Willi
The Netherlands is to invest up to €1 billion in cycling infrastructure to connect hundreds of thousands of new homes nationwide.
Read more: zagdaily.com/trends/dutch...
Read more: zagdaily.com/trends/dutch...
November 17, 2025 at 5:24 PM
The Netherlands is to invest up to €1 billion in cycling infrastructure to connect hundreds of thousands of new homes nationwide.
Read more: zagdaily.com/trends/dutch...
Read more: zagdaily.com/trends/dutch...
Reposted by Willi
I’m genuinely curious about this. The numbers in the blog are quite impressive.
Has anyone tried it and would like to share their $200 experience?
Has anyone tried it and would like to share their $200 experience?
Today, we're announcing Kosmos, our newest AI Scientist, available today. Kosmos makes fully autonomous scientific discoveries at scale by analyzing datasets and literature, and is the most powerful agent for science so far. Beta users estimate that Kosmos does 6 months of work in a single day.
November 17, 2025 at 4:11 PM
I’m genuinely curious about this. The numbers in the blog are quite impressive.
Has anyone tried it and would like to share their $200 experience?
Has anyone tried it and would like to share their $200 experience?
Reposted by Willi
Integrative Biology at UT is hiring an Evolutionary Biologist! Happy to answer any questions about the position/dept/UT. Come join us!
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
Decoding Nature’s Networks
The Department of Integrative Biology at The University of Texas at Austin
integrativebio.utexas.edu
November 17, 2025 at 3:52 PM
Integrative Biology at UT is hiring an Evolutionary Biologist! Happy to answer any questions about the position/dept/UT. Come join us!
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
integrativebio.utexas.edu
cns.utexas.edu
apply.interfolio.com/177547
Reposted by Willi
I've got a bad feeling about the upcoming flu season, given the fact that there are a bunch of subtypes at this party with the potential to wreak varying amounts of havoc. So I broke it all down here.
open.substack.com/pub/rasmusse...
open.substack.com/pub/rasmusse...
The Real Subtypes of the 2025 Flu Season
Have you ever been to a party where you sensed the messiness before it happened?
open.substack.com
November 17, 2025 at 2:54 PM
I've got a bad feeling about the upcoming flu season, given the fact that there are a bunch of subtypes at this party with the potential to wreak varying amounts of havoc. So I broke it all down here.
open.substack.com/pub/rasmusse...
open.substack.com/pub/rasmusse...
Reposted by Willi
A Software Framework for Physics- and AI-Driven Homogeneous Catalyst Design and Reactivity Optimization | ChemRxiv - doi.org/10.26434/che... #compchem
A Software Framework for Physics- and AI-Driven Homogeneous Catalyst Design and Reactivity Optimization
Identifying molecular catalysts that simultaneously exhibit high selectivity, high turnover frequency, and robust stability remains a major challenge in homogeneous catalysis. Traditionally, catalyst ...
doi.org
November 17, 2025 at 8:59 AM
A Software Framework for Physics- and AI-Driven Homogeneous Catalyst Design and Reactivity Optimization | ChemRxiv - doi.org/10.26434/che... #compchem
Reposted by Willi
Listened to this podcast yesterday with Nobel Laureate physicist Gerard 't Hooft and it's a masterclass in vibe metaphysics www.youtube.com/watch?v=gsSJ... - an hour and a half of him saying the universe must be deterministic cuz he wants it to be
The Nobel Laureate Who (Also) Says Quantum Theory Is "Totally Wrong"
YouTube video by Curt Jaimungal
www.youtube.com
November 16, 2025 at 8:50 AM
Listened to this podcast yesterday with Nobel Laureate physicist Gerard 't Hooft and it's a masterclass in vibe metaphysics www.youtube.com/watch?v=gsSJ... - an hour and a half of him saying the universe must be deterministic cuz he wants it to be
Reposted by Willi
This seems to be the original paper: arxiv.org/abs/2301.08243
(I’ve coauthored with Mike Rabbat which makes me have a collaboration distance of 2 from LeCun, that’s pretty sweet)
(I’ve coauthored with Mike Rabbat which makes me have a collaboration distance of 2 from LeCun, that’s pretty sweet)
Self-Supervised Learning from Images with a Joint-Embedding Predictive Architecture
This paper demonstrates an approach for learning highly semantic image representations without relying on hand-crafted data-augmentations. We introduce the Image-based Joint-Embedding Predictive Archi...
arxiv.org
November 17, 2025 at 1:18 AM
This seems to be the original paper: arxiv.org/abs/2301.08243
(I’ve coauthored with Mike Rabbat which makes me have a collaboration distance of 2 from LeCun, that’s pretty sweet)
(I’ve coauthored with Mike Rabbat which makes me have a collaboration distance of 2 from LeCun, that’s pretty sweet)
Reposted by Willi
Among news of Yann LeCun leaving Meta, I learned about his JEPA architecture and world models. This looks like a detailed write up from an engineer at Google: rohitbandaru.github.io/blog/JEPA-De...
Rohit Bandaru | Deep Dive into Yann LeCun’s JEPA
ML blog.
rohitbandaru.github.io
November 17, 2025 at 1:18 AM
Among news of Yann LeCun leaving Meta, I learned about his JEPA architecture and world models. This looks like a detailed write up from an engineer at Google: rohitbandaru.github.io/blog/JEPA-De...
Reposted by Willi
Merck is accepting applications for its 2026 Future Talent Program - these are internships and co-ops in a variety of areas including drug discovery, vaccines, clinical trials, biostatistics, epidemiology, HEOR, data science, regulatory affairs, and more
#chemsky 🧪⚗️
jobs.merck.com/us/en/search...
#chemsky 🧪⚗️
jobs.merck.com/us/en/search...
Your job search results | Merck Careers
jobs.merck.com
September 18, 2025 at 3:05 PM
Merck is accepting applications for its 2026 Future Talent Program - these are internships and co-ops in a variety of areas including drug discovery, vaccines, clinical trials, biostatistics, epidemiology, HEOR, data science, regulatory affairs, and more
#chemsky 🧪⚗️
jobs.merck.com/us/en/search...
#chemsky 🧪⚗️
jobs.merck.com/us/en/search...
Reposted by Willi
We built GenoPHI: a machine learning workflow that predicts phage-host interactions at strain level. This could help rapidly select phages to treat drug-resistant bacterial infections or for microbiome engineering without exhaustive lab testing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 16, 2025 at 11:16 PM
We built GenoPHI: a machine learning workflow that predicts phage-host interactions at strain level. This could help rapidly select phages to treat drug-resistant bacterial infections or for microbiome engineering without exhaustive lab testing.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Willi
OUR APPROACH: Interpretable genomic features + ML to predict interactions. Phylogeny-agnostic feature construction so it works for novel phages and bacteria. We trained and tested across 5 public datasets (128,357 interactions total) and validated with high-throughput phenotyping + RB-TnSeq.
November 16, 2025 at 11:16 PM
OUR APPROACH: Interpretable genomic features + ML to predict interactions. Phylogeny-agnostic feature construction so it works for novel phages and bacteria. We trained and tested across 5 public datasets (128,357 interactions total) and validated with high-throughput phenotyping + RB-TnSeq.
Reposted by Willi
THE CHALLENGE: Bacteria and phages are incredibly diverse. Experimentally testing each phage against a new bacterial target isn't feasible. But finding the right phage quickly could be life-saving, especially for drug-resistant infections where treatment options are limited.
November 16, 2025 at 11:16 PM
THE CHALLENGE: Bacteria and phages are incredibly diverse. Experimentally testing each phage against a new bacterial target isn't feasible. But finding the right phage quickly could be life-saving, especially for drug-resistant infections where treatment options are limited.
Reposted by Willi
LeCun: “I’ve been not making friends in various corners of Silicon Valley, including at Meta, saying that within three to five years, this [world models, not LLMs] will be the dominant model for AI architectures, and nobody in their right mind would use LLMs of the type that we have today."
He’s Been Right About AI for 40 Years. Now He Thinks Everyone Is Wrong.
Yann LeCun invented many fundamental components of modern AI. Now he’s convinced most in his field have been led astray by the siren song of large language models.
www.wsj.com
November 15, 2025 at 12:01 PM
LeCun: “I’ve been not making friends in various corners of Silicon Valley, including at Meta, saying that within three to five years, this [world models, not LLMs] will be the dominant model for AI architectures, and nobody in their right mind would use LLMs of the type that we have today."
Reposted by Willi
Trying to measure coding productivity is, and always will be, a fool's errand.
Why? Because I can go for a walk then take a shower and have an idea, then write a single line of code that fixes everything I was working on.
Immense productivity, but by most metrics I didn't do anything at all.
Why? Because I can go for a walk then take a shower and have an idea, then write a single line of code that fixes everything I was working on.
Immense productivity, but by most metrics I didn't do anything at all.
November 16, 2025 at 4:10 PM
Trying to measure coding productivity is, and always will be, a fool's errand.
Why? Because I can go for a walk then take a shower and have an idea, then write a single line of code that fixes everything I was working on.
Immense productivity, but by most metrics I didn't do anything at all.
Why? Because I can go for a walk then take a shower and have an idea, then write a single line of code that fixes everything I was working on.
Immense productivity, but by most metrics I didn't do anything at all.
Reposted by Willi
Robots have been getting really dynamic and capable this year while no one was looking
November 16, 2025 at 2:53 AM
Robots have been getting really dynamic and capable this year while no one was looking
Reposted by Willi
<rant> A periodic reminder that Sprints, Backlogs, Daily Scrums, Scrum Boards, Scrum Masters, Product Owners, Points, Velocity, PIs, etc., have NOTHING AT ALL to do with "Agile." Agility comes from working small, delivering frequently for feedback from actual customers, and adapting based on
1/3
1/3
November 15, 2025 at 7:00 PM
<rant> A periodic reminder that Sprints, Backlogs, Daily Scrums, Scrum Boards, Scrum Masters, Product Owners, Points, Velocity, PIs, etc., have NOTHING AT ALL to do with "Agile." Agility comes from working small, delivering frequently for feedback from actual customers, and adapting based on
1/3
1/3
Reposted by Willi
I am so excited to share our project with you! We find prokaryotic proteases activate toxic enzymes and pores as a modular strategy in phage defense. We studied four fascinating protease-toxin pairs that are abundant across bacterial genomes:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Proteolytic activation of diverse antiviral defense modules in prokaryotes
Linked protease–effector modules are widespread in prokaryotic antiviral defense, yet the mechanisms of most remain poorly understood. Here we show that four of the most prevalent modules—metallo-β-la...
www.biorxiv.org
November 15, 2025 at 11:49 PM
I am so excited to share our project with you! We find prokaryotic proteases activate toxic enzymes and pores as a modular strategy in phage defense. We studied four fascinating protease-toxin pairs that are abundant across bacterial genomes:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Willi
Medical Republic: 'Fibromyalgia finally gets a genetic fingerprint'
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
Fibromyalgia finally gets a genetic fingerprint - Medical Republic
A massive global study links the chronic pain condition to 26 genes associated with brain signalling, marking a turning point in understanding its biological roots.
www.medicalrepublic.com.au
November 13, 2025 at 2:28 PM
Medical Republic: 'Fibromyalgia finally gets a genetic fingerprint'
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
'Additionally, certain risk loci overlapped with long covid (BPTF) and ME/CFS (OLFM4, RABGAP1L/GPR52), two poorly characterised disorders, albeit with different lead variants.'
www.medicalrepublic.com.au/fibromyalgia...
Reposted by Willi
📅 Join us on Tue, Nov 18 (10–11 AM EST) for our final AC seminar of the semester. Tim Cernak of University of Michigan will present “Combinatorial explosion: from atom-bond arrangements to exotic diseases”🚀
Attend in person @utoronto.ca or online: airtable.com/appYBjHgttvB...
Attend in person @utoronto.ca or online: airtable.com/appYBjHgttvB...
November 14, 2025 at 3:13 PM
📅 Join us on Tue, Nov 18 (10–11 AM EST) for our final AC seminar of the semester. Tim Cernak of University of Michigan will present “Combinatorial explosion: from atom-bond arrangements to exotic diseases”🚀
Attend in person @utoronto.ca or online: airtable.com/appYBjHgttvB...
Attend in person @utoronto.ca or online: airtable.com/appYBjHgttvB...
Reposted by Willi
Explainable AI is often assumed to build trust. A study of sonographers estimating gestational age found AI predictions improved accuracy, but explanations did not. In fact, explanations made some clinicians perform worse, highlighting user variability.
#MedSky #MLSky
#MedSky #MLSky
The human factor in explainable artificial intelligence: clinician variability in trust, reliance, and performance - npj Digital Medicine
npj Digital Medicine - The human factor in explainable artificial intelligence: clinician variability in trust, reliance, and performance
www.nature.com
November 14, 2025 at 5:10 PM
Reposted by Willi
Artificial intelligence is flying high. Nature asked leading innovators what they think will happen next.
go.nature.com/3WWokpq
go.nature.com/3WWokpq
The future of AI
Artificial intelligence is flying high. Nature asked leading innovators what they think will happen next.
go.nature.com
November 14, 2025 at 2:36 PM
Artificial intelligence is flying high. Nature asked leading innovators what they think will happen next.
go.nature.com/3WWokpq
go.nature.com/3WWokpq