Stephanie
@stephy.bsky.social
Is chemical synthesis one of the most time-consuming steps in drug development? 🤔
Onepot.AI has launched with $13 million in funding to use artificial intelligence and robotics to automate one of the most time-consuming steps in drug development: chemical synthesis. cen.acs.org/business/sta... #chemsky 🧪
Molecule-maker Onepot.AI launches with $13 million
With an AI engine named Phil and a robotic platform, the start-up cuts down on synthesis turnaround
cen.acs.org
November 25, 2025 at 4:29 PM
Is chemical synthesis one of the most time-consuming steps in drug development? 🤔
Reposted by Stephanie
13 million seems rather little for a really hard problem.
Look, I'll take it on. We build AI models. We have tons of retrosynthetic expertise. We mess around with liquid handling robots.
But I wouldn't touch this for less than about 1.3 billion. This is a hard problem. Very, very, very hard.
Look, I'll take it on. We build AI models. We have tons of retrosynthetic expertise. We mess around with liquid handling robots.
But I wouldn't touch this for less than about 1.3 billion. This is a hard problem. Very, very, very hard.
Onepot.AI has launched with $13 million in funding to use artificial intelligence and robotics to automate one of the most time-consuming steps in drug development: chemical synthesis. cen.acs.org/business/sta... #chemsky 🧪
Molecule-maker Onepot.AI launches with $13 million
With an AI engine named Phil and a robotic platform, the start-up cuts down on synthesis turnaround
cen.acs.org
November 25, 2025 at 1:30 PM
13 million seems rather little for a really hard problem.
Look, I'll take it on. We build AI models. We have tons of retrosynthetic expertise. We mess around with liquid handling robots.
But I wouldn't touch this for less than about 1.3 billion. This is a hard problem. Very, very, very hard.
Look, I'll take it on. We build AI models. We have tons of retrosynthetic expertise. We mess around with liquid handling robots.
But I wouldn't touch this for less than about 1.3 billion. This is a hard problem. Very, very, very hard.
FDA 'Priority Voucher' Program Comes Under Congressional Scrutiny www.medpagetoday.com/publichealth...
FDA 'Priority Voucher' Program Comes Under Congressional Scrutiny
Sanders, Pallone say the program raises 'significant concerns' that it will enable corruption
www.medpagetoday.com
November 25, 2025 at 12:24 PM
FDA 'Priority Voucher' Program Comes Under Congressional Scrutiny www.medpagetoday.com/publichealth...
Cockroaches
The "DOGE is gone" articles are clickbait but this one gets it closer to the truth: DOGE is not gone, it just claims to have "no centralized leadership" anymore -- in other words, its leadership is hiding in an attempt to avoid blame.
DOGE no longer has ‘centralized leadership’ under White House tech team, personnel head says
The team that was altered to house DOGE — formerly the U.S. Digital Service — is also still doing its own technology work across agencies.
www.nextgov.com
November 25, 2025 at 3:15 AM
Cockroaches
Reposted by Stephanie
The "DOGE is gone" articles are clickbait but this one gets it closer to the truth: DOGE is not gone, it just claims to have "no centralized leadership" anymore -- in other words, its leadership is hiding in an attempt to avoid blame.
DOGE no longer has ‘centralized leadership’ under White House tech team, personnel head says
The team that was altered to house DOGE — formerly the U.S. Digital Service — is also still doing its own technology work across agencies.
www.nextgov.com
November 25, 2025 at 3:09 AM
The "DOGE is gone" articles are clickbait but this one gets it closer to the truth: DOGE is not gone, it just claims to have "no centralized leadership" anymore -- in other words, its leadership is hiding in an attempt to avoid blame.
@sararah.bsky.social does anyone ever come into the store and ask you this
November 25, 2025 at 2:45 AM
@sararah.bsky.social does anyone ever come into the store and ask you this
A few times this year, I thought about getting a PharmD - it could help with my current career path, and working as a retail pharmacist seemed like a more stable alternative career. But I wonder how many of these openings are due to burnout...
Projected job openings in occupations typically requiring a graduate-level degree, 2024–34 www.bls.gov/opub/ted/202...
November 25, 2025 at 2:16 AM
A few times this year, I thought about getting a PharmD - it could help with my current career path, and working as a retail pharmacist seemed like a more stable alternative career. But I wonder how many of these openings are due to burnout...
Reposted by Stephanie
I did not have ‘Rubber duck museum moves to Canada because of tariffs and trade war’ on my 2025 bingo card. www.cbc.ca/news/canada/...
This American rubber duck museum is moving to B.C. due to tariffs, drop in tourism | CBC News
Quirky Point Roberts-based Rubber Duck Museum is coming to Tsawwassen Mills mall in B.C. after increasing tariffs and decreasing tourism have made business in the U.S. exclave unsustainable.
www.cbc.ca
November 25, 2025 at 1:36 AM
I did not have ‘Rubber duck museum moves to Canada because of tariffs and trade war’ on my 2025 bingo card. www.cbc.ca/news/canada/...
"Prasad’s message delivers a sharp critique of CBER research, but lacks specific citations to support his claims, which include accusations that the center is minimizing or downplaying safety concerns, is dishonest in its research conduct, and a poor steward of taxpayer funds."
CBER Poised for Research Shakeup As Prasad Makes Unproven Claims About ‘Polluted Science’
In an email to staff filled with unsupported accusations about the quality of the center’s research, CBER Director Vinay Prasad said no resources or time should be spent on ongoing projects started be...
insights.citeline.com
November 25, 2025 at 2:00 AM
"Prasad’s message delivers a sharp critique of CBER research, but lacks specific citations to support his claims, which include accusations that the center is minimizing or downplaying safety concerns, is dishonest in its research conduct, and a poor steward of taxpayer funds."
Reposted by Stephanie
As @gregggonsalves.bsky.social said, here is the main winner in the forced departure of Carl Dieffenbach.
November 24, 2025 at 11:59 AM
As @gregggonsalves.bsky.social said, here is the main winner in the forced departure of Carl Dieffenbach.
Reposted by Stephanie
Fifteen Years
xkcd.com
November 24, 2025 at 10:57 PM
Reposted by Stephanie
I will say this plainly: the Department of Education’s exclusion of nursing as a professional degree is a direct attack on the people who hold our health care system together, and it’s an attack shaped by race, class, and power. It is unacceptable.
www.newsweek.com/nursing-not-...
www.newsweek.com/nursing-not-...
Nursing is no longer counted as a 'professional degree' by Trump admin
The Department of Education has excluded nursing as a "professional degree" program as it implements various changes to student loans.
www.newsweek.com
November 24, 2025 at 10:07 PM
I will say this plainly: the Department of Education’s exclusion of nursing as a professional degree is a direct attack on the people who hold our health care system together, and it’s an attack shaped by race, class, and power. It is unacceptable.
www.newsweek.com/nursing-not-...
www.newsweek.com/nursing-not-...
Reposted by Stephanie
Remember Andrew Wakefield?
Here he is with his friend RFK Jr. in 2020.
Wakefield is the guy behind the fraudulent, retracted MMR–autism study. He lost his medical license for subjecting autistic children to unnecessary invasive procedures.
Now, with Kennedy in power, he’s getting a second act.
Here he is with his friend RFK Jr. in 2020.
Wakefield is the guy behind the fraudulent, retracted MMR–autism study. He lost his medical license for subjecting autistic children to unnecessary invasive procedures.
Now, with Kennedy in power, he’s getting a second act.
November 24, 2025 at 4:36 PM
Remember Andrew Wakefield?
Here he is with his friend RFK Jr. in 2020.
Wakefield is the guy behind the fraudulent, retracted MMR–autism study. He lost his medical license for subjecting autistic children to unnecessary invasive procedures.
Now, with Kennedy in power, he’s getting a second act.
Here he is with his friend RFK Jr. in 2020.
Wakefield is the guy behind the fraudulent, retracted MMR–autism study. He lost his medical license for subjecting autistic children to unnecessary invasive procedures.
Now, with Kennedy in power, he’s getting a second act.
Reposted by Stephanie
The next time someone gives me an urgent, high priority task…
October 21, 2023 at 11:42 PM
The next time someone gives me an urgent, high priority task…
Reposted by Stephanie
Looks like RFK Jr. Stadium now
November 24, 2025 at 1:45 PM
Looks like RFK Jr. Stadium now
Reposted by Stephanie
The combination of diminished staff capacity and immense pressure to use new, but unvalidated, AI tools to replace it “could jeopardize FDA’s gold standard review process, leaving ... further uncertainty about whether FDA-approved drugs work and are effective." - @reshmagar.bsky.social
US FDA Cancer Office Keeps Hemorrhaging Staff, Most Land At Industry
Merck, Lilly, and Johnson & Johnson are some of the pharma companies who have snagged the many staff leaving the FDA’s oncology positions. The Pink Sheet estimates CDER’s oncology division is operatin...
insights.citeline.com
November 24, 2025 at 2:09 PM
The combination of diminished staff capacity and immense pressure to use new, but unvalidated, AI tools to replace it “could jeopardize FDA’s gold standard review process, leaving ... further uncertainty about whether FDA-approved drugs work and are effective." - @reshmagar.bsky.social
Reposted by Stephanie
These are the people that study mad cow disease (BSE) which leads to Creuztfeldt-Jakob Disease in humans (don't google if you don't want to freak yourself out), or the Chronic Wasting Disease deer have in the US.
It's insane to stop research on these conditions.
It's insane to stop research on these conditions.
During the government shutdown, CDC's National Center for Emerging and Zoonotic Infectious Diseases Prion and Public Health Office staff were illegally RIFed, and the group is at risk of being eliminated permanently
www.cidrap.umn.edu/chronic-wast...
www.cidrap.umn.edu/chronic-wast...
While no one was watching: Tenuous status of CDC prion unit, risk of CWD to people worry scientists
www.cidrap.umn.edu
November 24, 2025 at 11:22 AM
These are the people that study mad cow disease (BSE) which leads to Creuztfeldt-Jakob Disease in humans (don't google if you don't want to freak yourself out), or the Chronic Wasting Disease deer have in the US.
It's insane to stop research on these conditions.
It's insane to stop research on these conditions.
Reposted by Stephanie
Smokers, do you think you can just stop? Nuh-uh.
CDC: it takes most people 8–11 tries before they can quit.
FDA: in 2018 55% of adult smokers tried to quit. Only 8% were successful in quitting for 6-12 mos.
Guess how many smoking deaths every year?
480,000
And 41,000 more from secondhand smoke
CDC: it takes most people 8–11 tries before they can quit.
FDA: in 2018 55% of adult smokers tried to quit. Only 8% were successful in quitting for 6-12 mos.
Guess how many smoking deaths every year?
480,000
And 41,000 more from secondhand smoke
With more actors, pop stars and other celebrities spotted unapologetically smoking, the cultural taboo against it shows signs of ebbing.
Celebrities Are Making Smoking Cigarettes Cool Again
Cigarettes are resurfacing in pop music and movies, raising fears that a yearslong decline in smoking rates could reverse.
on.wsj.com
November 24, 2025 at 3:49 AM
Smokers, do you think you can just stop? Nuh-uh.
CDC: it takes most people 8–11 tries before they can quit.
FDA: in 2018 55% of adult smokers tried to quit. Only 8% were successful in quitting for 6-12 mos.
Guess how many smoking deaths every year?
480,000
And 41,000 more from secondhand smoke
CDC: it takes most people 8–11 tries before they can quit.
FDA: in 2018 55% of adult smokers tried to quit. Only 8% were successful in quitting for 6-12 mos.
Guess how many smoking deaths every year?
480,000
And 41,000 more from secondhand smoke
Reposted by Stephanie
And if you prefer your dogs smarter than you and functioning as a personal trainer that makes sure you go for a run by eating the house if you don’t, there are also Heelers someone dumped in an orchard.
November 24, 2025 at 3:40 AM
And if you prefer your dogs smarter than you and functioning as a personal trainer that makes sure you go for a run by eating the house if you don’t, there are also Heelers someone dumped in an orchard.
CATTLE DOG ALERT
And if you prefer your dogs smarter than you and functioning as a personal trainer that makes sure you go for a run by eating the house if you don’t, there are also Heelers someone dumped in an orchard.
November 24, 2025 at 4:14 AM
CATTLE DOG ALERT
Reposted by Stephanie
There were dead deer all over Montgomery County, MD this summer, right outside Washington, DC. No one was testing them for CWD or, usually, even disposing of the carcasses to ensure the prions didn't infect something else.
During the government shutdown, CDC's National Center for Emerging and Zoonotic Infectious Diseases Prion and Public Health Office staff were illegally RIFed, and the group is at risk of being eliminated permanently
www.cidrap.umn.edu/chronic-wast...
www.cidrap.umn.edu/chronic-wast...
While no one was watching: Tenuous status of CDC prion unit, risk of CWD to people worry scientists
www.cidrap.umn.edu
November 24, 2025 at 12:51 AM
There were dead deer all over Montgomery County, MD this summer, right outside Washington, DC. No one was testing them for CWD or, usually, even disposing of the carcasses to ensure the prions didn't infect something else.
Setting aside the question of whether or not we are ready to phase out the use of animals in research (spoiler: we are not), there is an ethical way to do this. Abruptly shutting down research programs means that many animals are going to be euthanized! www.science.org/content/arti...
Exclusive: CDC to end all monkey research
Studies related to HIV and other infectious diseases will be phased out, sources say; fate of the agency's animals remains unclear
www.science.org
November 24, 2025 at 1:01 AM
Setting aside the question of whether or not we are ready to phase out the use of animals in research (spoiler: we are not), there is an ethical way to do this. Abruptly shutting down research programs means that many animals are going to be euthanized! www.science.org/content/arti...
During the government shutdown, CDC's National Center for Emerging and Zoonotic Infectious Diseases Prion and Public Health Office staff were illegally RIFed, and the group is at risk of being eliminated permanently
www.cidrap.umn.edu/chronic-wast...
www.cidrap.umn.edu/chronic-wast...
While no one was watching: Tenuous status of CDC prion unit, risk of CWD to people worry scientists
www.cidrap.umn.edu
November 24, 2025 at 12:38 AM
During the government shutdown, CDC's National Center for Emerging and Zoonotic Infectious Diseases Prion and Public Health Office staff were illegally RIFed, and the group is at risk of being eliminated permanently
www.cidrap.umn.edu/chronic-wast...
www.cidrap.umn.edu/chronic-wast...
Reposted by Stephanie
I did something like this when I was teaching upper-division classes. But I asked students what it got right and what it got wrong.
November 23, 2025 at 9:33 PM
I did something like this when I was teaching upper-division classes. But I asked students what it got right and what it got wrong.
Reposted by Stephanie
Gatekeeping by demanding expensive technology or approaches is the ancient tactic of the rich laboratory.
My favorite from an @hhmi.org scientist: “the great thing about optogenetics is it keeps the riff raff out of the field.”
Heard an established successful neuroscientist dismissing junior scientists as "people at the bottom" 🤦♀️
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
You folks with lots of research funds & power: young scientists more than ever need our respect and support even if you don't agree with their ideas and approaches
#sfn2025
November 23, 2025 at 6:30 PM
Gatekeeping by demanding expensive technology or approaches is the ancient tactic of the rich laboratory.