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004g.bsky.social
@004g.bsky.social
36 followers 710 following 6 posts
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Reposted
allyouneedislungs.bsky.social
A year of coughing led to Eve’s lung cancer diagnosis.

Her cough was dismissed more than once - until further tests revealed stage 4 EGFR+ #lungcancer.

Eve lives in the NE with her husband & 2 daughters. She loves yoga, Zumba, & travelling - ‘laughter with family & friends keeps me going’ #LCSM
November 4, 2025 at 7:50 AM
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allyouneedislungs.bsky.social
It’s 1 November - the start of Lung Cancer Awareness Month and the launch of the third year of #AllYouNeedIsLungs! 💟

We’re sharing over 30 real voices this year - all ages & backgrounds who want others to recognise the signs sooner.

Because lung cancer doesn’t have one face. #LCSM
November 1, 2025 at 8:05 AM
Reposted
biorxiv-cancer.bsky.social
ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target https://www.biorxiv.org/content/10.1101/2025.09.23.678089v1
September 23, 2025 at 10:49 PM
Reposted
rjdlab.bsky.social
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
www.nature.com
July 29, 2025 at 2:56 PM
Reposted
purpleliissa.bsky.social
Always happy to advocate for Lung Cancer! Proud to be a 10 year Stage IV survivor! 🤍#LungCancerAwareness #LiveLung
#LLadvocacy25 #LCSM
July 21, 2025 at 1:42 PM
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cri-utsw.bsky.social
Momentous day for CRI @rjdlab.bsky.social postdoc & UTSW Neonatologist @walterwchen.bsky.social 🎉 recipient of a 2025 @bwfund.bsky.social Career Award for Medical Scientists! 👏👏 He will continue his #relentlessdiscovery studying uncharacterized organellar proteins 🧪 ⬇️ cri.utsw.edu/deberardinis...
DeBerardinis Lab postdoc awarded prestigious Burroughs Wellcome Fund Career Award for Medical Scientists - Children's Medical Center Research Institute (CRI) | Dallas Texas
UTSW Neonatologist Walter W. Chen to receive $700,000 in funding to continue studying uncharacterized organellar proteins, their connections to disease When his twin daughters were born prematurely, W...
cri.utsw.edu
June 18, 2025 at 3:16 PM
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alkpositiveuk.bsky.social
🫁 “We’ve got to stop saying ‘smoking-related disease’ & start saying ‘risk factors include smoking’… because there are others.”

Prof Matt Evison on #lungcancer risk, & early diagnosis in @gatewayc.bsky.social’s brilliant #GPsTalkCancer podcast.

#LCSM

podcasts.apple.com/gb/podcast/g...
June 12, 2025 at 11:55 AM
Reposted
natrevgenet.nature.com
New online! Cell-type deconvolution methods for spatial transcriptomics
Cell-type deconvolution methods for spatial transcriptomics
Nature Reviews Genetics, Published online: 14 May 2025; doi:10.1038/s41576-025-00845-yCell-type deconvolution methods are often needed to analyse spatial transcriptomic data to recover cell-type distributions. In this Review, the authors describe the process of cell-type deconvolution, contrast the tools available and highlight important considerations for which tool to use.
www.nature.com
May 14, 2025 at 5:46 PM
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helenbranswell.bsky.social
The #NIH will no longer allow researchers working on its grants have sub-awards in other countries, a common practice that allows US scientists to investigate questions that cannot be studied in this country. @mmolteni.bsky.social reports. www.statnews.com/2025/05/01/n...
NIH halts funding for new projects with foreign collaborators, citing national security concerns
NIH announced it will no longer allow subawards to foreign institutions, as part of a national security-minded overhaul to how it manages research funding
www.statnews.com
May 2, 2025 at 12:25 AM
Reposted
albertvilella.bsky.social
Ranking of Variant Effect Predictor (VEP) in-silico tools from a recently published review, based on Relative performance with rate on MAVE data)
1. CPT-1 (Broad Institute)
2. AlphaMissense (Google DeepMind and cols.)
3. ESCOTT (Sorbonne/INSERM France)
April 16, 2025 at 9:41 AM
Reposted
nejm.org
A woman with a history of metastatic small-cell lung cancer and Cushing’s syndrome was found to have reduced skin thickness, a possible result of antianabolic effects of excess cortisol. Methods of measuring skin thickness are shown in videos. Full case details: nej.md/3DDah23

#MedSky #DermSky
Images in Clinical Medicine Thin Skin in Cushing’s Syndrome Panels A and B: Photos from the examination of the patient's skin.
March 18, 2025 at 1:36 PM
Reposted
jia-luo.bsky.social
📚 Thank you Drs Prince, Chijioke, and Bubendorf for your Editorial on our work on "lung adenocarcinomas with mucinous features" in Ann of Oncology, highlighting the importance of better characterizing this NSCLC subtype & its translational implications

www.annalsofoncology.org/article/S092... #lcsm
Title page of "Unravelling lung adenocarcinoma with mucinous histology and its translational implications", Annals of Oncology Editorial
March 16, 2025 at 7:40 PM
Reposted
rjdlab.bsky.social
1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
www.science.org
March 15, 2025 at 5:27 PM
Reposted
cri-utsw.bsky.social
🦓 #RareDiseaseDay2025: members of CRI's Genetic & Metabolic Disease Program don stripes for disorders affecting fewer than 200K ppl in the U.S., such as inborn errors of #metabolism & #Cancer. Diagnosing “zebras” is hearing hoofbeats & thinking zebra not horse. 🧪 #relentlessdiscovery #RareDiseaseDay
February 28, 2025 at 6:39 PM
004g.bsky.social
February 26, 2025 at 3:33 AM
Reposted
jimd-editors.bsky.social
Cell trafficking disorders represent the largest group of complex molecule diseases. However, they are still poorly recognized as a unified diagnostic entity and are often viewed as unrelated individual diseases by non-metabolic specialists.

👉 doi.org/10.1002/jimd...
February 23, 2025 at 2:14 PM
Reposted
faubert.bsky.social
1/For over a decade, we’ve been studying tumor metabolism in patients with non-small cell lung cancer

This long-term commitment allowed us to connect tumor metabolic features to patient outcomes

We found that 13C glucose contribution to the TCA cycle predicts overall survival in NSCLC
elizsmckenna.bsky.social Elizabeth McKenna @elizsmckenna.bsky.social · Feb 17
Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
February 17, 2025 at 8:20 PM
Reposted
jia-luo.bsky.social
🌟 In Nature Reviews Clinical Oncology,

we examine the *overwhelming* evidence for classifying NUT carcinoma as a subtype of squamous lung cancer and squamous head and neck cancer

🫁 🗣️ rdcu.be/d8uni @natrevclinoncol.bsky.social #medsky #oncsky #meded #lcsm #lungcancer

🧵 Highlights:
Jia Luo 1,2 , Justin A. Bishop3, Steven G. DuBois4, Glenn J. Hanna1,2, Lynette M. Sholl 5, Edward B. Stelow6,Lester D. R. Thompson7, Geoffrey I. Shapiro 1,2 & Christopher A. French 5 Abstract In the past two decades, treatment for non-small-cell lung cancers(NSCLCs) and head and neck squamous cell carcinoma (HNSCC) hasadvanced considerably, owing largely to the characterization of distinctoncological subtypes, the development of targeted therapies for eachsubtype and the advent of immunotherapy. Data emerging over thepast two decades suggest that NUT carcinoma, a highly aggressivemalignancy driven by a NUT fusion oncoprotein and arising in the lungs,head and neck, and rarely in other sites, is a squamous cell carcinoma(SCC) based on transcriptional, histopathological, cell-of-origin andmolecular characteristics. NUT carcinoma has an estimated incidenceof 1,400 cases per year in the United States, surpassing that of somerare NSCLC and HNSCC subtypes. However, NUT carcinoma is currentlynot recognized as an SCC of the lungs or head and neck. The orphanclassification of NUT carcinoma as a distinct entity leads to a lack ofawareness of this malignancy among oncologists and surgeons, despiteearly diagnosis being crucial for this cancer type with a median survivalof only ~6.5 months. Consequently, NUT carcinoma is underdiagnosedand often misdiagnosed, resulting in limited research and progress indeveloping effective treatments in one of the most aggressive formsof lung and head and neck cancer. With a growing number of targetedagents that can potentially be used to treat NUT carcinoma, improvedrecognition through reclassification and inclusion of NUT carcinomaas a squamous NSCLC or an HNSCC when arising in these locations willaccelerate the development of effective therapies for this disease. Thus,in the Perspective, we propose such a reclassification of NUT carcinomaas an SCC and discuss the supporting evidence.
February 4, 2025 at 12:20 PM
Reposted
physaliacourses.bsky.social
🚨 SPATIAL OMICS IN R/BIOCONDUCTOR with @stemang.bsky.social and @lgmartelotto.bsky.social 🌍

🗓️ 19-21 May 2025 | 💻 Online

Explore imaging vs. sequencing, experimental design, and data analysis in spatial omics. Gain hands-on skills with R/Bioconductor
www.physalia-courses.org/courses-work...
January 22, 2025 at 8:39 AM
Reposted
sashagusevposts.bsky.social
I wrote about the ongoing debates over genomic data sharing and the use of such data for "abhorrent science", including some perspective papers that came out last month. A few key points: 🧵
On abhorrent science and the weaponization of genomic data
How to balance open data sharing and public responsibility
open.substack.com
January 12, 2025 at 7:11 PM
Reposted
davidcookemd.bsky.social
Defining high-quality wedge resections for small #NSCLC! Expert input & Delphi process, we developed consensus in 5 areas: preop, technique, lymph nodes, margins, & pathology. A leap forward in thoracic oncology! #LungCancer #LCSM #CancerSky #SurgSky #OncSky

www.sciencedirect.com/science/arti...
Thoracic Surgery Outcomes Research Network (ThORN) Consensus Document on Defining a High Quality Wedge Resection for Early Stage Lung Cancer
With the publication of CALGB 140503, an increase in wedge resections for small, peripheral non-small cell lung cancer is expected; however, a relativ…
www.sciencedirect.com
January 13, 2025 at 1:17 AM
Reposted
alkpositiveuk.bsky.social
Weight gain on #ALK #lungcancer TKIs—something many experience but isn’t often talked about. This editorial explores why it happens, the impact (especially with alectinib), and whether treatments like GLP-1 meds or drug monitoring could help. #LCSM

ascopubs.org/doi/10.1200/...
ALK Tyrosine Kinase Inhibitors Induced Weight Gain: More Refined Definition of Weight Gain, Glucagon-Like Peptide-1 Agonist Treatment, and Therapeutic Drug Monitoring of <i>ALK+</i> Non–Small Cell Lun...
ascopubs.org
January 12, 2025 at 10:30 PM
Reposted
faubert.bsky.social
My lab and I were ecstatic to be funded by the VFoundation and Astrazeneca.

Learning it was also sponsored by Hockey Fights Cancer was extra special to my Canadian, hockey-obsessed self.

Experiencing the Winter Classic? A dream come true.

www.nhl.com/news/univers...
Faubert honored at Winter Classic for cancer research | NHL.com
University of Chicago professor receives V Scholar Award for work on lung cancer
www.nhl.com
January 8, 2025 at 12:07 AM
Reposted
allyouneedislungs.bsky.social
Valerie was diagnosed with Stage 4 EGFR+ #lungcancer in 2023. It’s changed her life, but she now appreciates each day. ‘Take 1 scan at a time. Remember your loved ones will process things in their way, but there’s still room for joy & adventure.’ #LCSM

www.allyouneedislungs.org.uk/volunteers-v...
Valerie, a mum of two, is living with Stage 4 lung cancer — ALL YOU NEED IS LUNGS
Valerie continues to embrace life and adventure with Stage 4 EGFR+ lung cancer
www.allyouneedislungs.org.uk
December 16, 2024 at 7:55 AM
004g.bsky.social
But it still has those cute eyes...
December 11, 2024 at 4:07 AM