banner
LightNews
achemsynbio.bsky.social
Abhishek Chatterjee
@achemsynbio.bsky.social
2.1K followers 1.1K following 59 posts
Professor @BostonCollege Chemical Biology, Synthetic Biology, Directed Evolution, Expanding the genetic code https://sites.google.com/a/bc.edu/thechatterjeelab/home https://scholar.google.com/citations?user=zeSNxNcAAAAJ&hl=en
sites.google.com
Posts Media Videos Starter Packs
Pinned
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · Dec 1
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing!
V1: go.bsky.app/3P5i7nJ
V2: go.bsky.app/Cr4ej7
12 32 81
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · 6d
Thanks, André!
1
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · 7d
Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5
Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics
Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...
rdcu.be
4 22
Reposted by Abhishek Chatterjee
johntngo.bsky.social
John Ngo @johntngo.bsky.social · 17d
🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
6 97 220
Reposted by Abhishek Chatterjee
jeremybaskin.bsky.social
Jeremy Baskin @jeremybaskin.bsky.social · Aug 25
Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs
Cornell University, Chemistry and Chemical Biology
Job #AJO30338, WDR-00054776 Assistant Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New York, US
academicjobsonline.org
1 52 49
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · Aug 21
Thrilled to see this in print! Co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yields novel backbone modifications. One step closer to novel genetically encoded biopolymers!
cgemcci.bsky.social
C-GEM, the NSF Center for Genetically Encoded Materials @cgemcci.bsky.social · Aug 21
✨New in Nat Chem Biol: Site-selective protein editing by backbone extension acyl rearrangements
bit.ly/4oKQ251

Congrats @roeleah.bsky.social, Izzi, Carly, Taylor, Bhavana, @nxhamlish.bsky.social, Arjun, Diondra, Zhongqi, @achemsynbio.bsky.social, Matt, Scott, Alanna, and collaborators!
#NSFfunded
Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology
A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...
www.nature.com
1 5
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · Aug 8
Continuous evolution in E. coli using an orthogonal replisome www.science.org/doi/10.1126/...
An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli
Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions....
www.science.org
1 5
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · Aug 6
Cool technology from the @chembiobryan.bsky.social lab for high-throughput discovery of protein binders
natmethods.nature.com
Nature Methods @natmethods.nature.com · Aug 6
PANCS-Binders (phage-assisted noncontinuous selection of protein binders) screens multiple high-diversity protein libraries against a panel of dozens of targets for high-throughput binder discovery. @chembiobryan.bsky.social @mstyles-chembiol.bsky.social

www.nature.com/articles/s41...
3
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · Aug 2
Congratulations, Rita!
1
Reposted by Abhishek Chatterjee
kjohnsson.bsky.social
Kai Johnsson @kjohnsson.bsky.social · Jul 3
Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
www.nature.com
2 76 170
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · Jun 7
Congratulations, Simon!
Reposted by Abhishek Chatterjee
nature.com
Nature @nature.com · May 30
The further a researcher or inventor moves from their previous work, the less cited their latest work will be

https://go.nature.com/44VjEW9
Shifting research focus comes with the risk of reduced impact
An analysis of millions of scientific papers and patents shows that the further a researcher or inventor moves from their previous work, the less cited their latest work will be.
go.nature.com
5 24 67
Reposted by Abhishek Chatterjee
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · May 24
David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...
Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company
YouTube video by Amanpour and Company
youtu.be
1 100 240
Reposted by Abhishek Chatterjee
jeremymberg.bsky.social
Jeremy Berg @jeremymberg.bsky.social · May 23
I am a big believe of doing your own research and checking facts and sources.

BUT THE BIG PROBLEM IS THAT A POST FROM SOME DUDE ON THE INTERNET SHOULD NOT BE WEIGHTED THE SAME AS INFORMATION FROM SOMEONE WHO HAS SPENT DECADES STUDYING AN ISSUE.
6 37 180
Reposted by Abhishek Chatterjee
cenmag.bsky.social
C&EN (Chemical & Engineering News) @cenmag.bsky.social · May 22
Chemists Stuart Schreiber of Harvard University and Arena BioWorks and Peter Schultz of @scripps.edu will split the 2025 Welch Award in Chemistry for their work in the field of chemical biology. cen.acs.org/people/award... #chemsky🧪
2025 Welch Award honors chemical biologists
Recipients Schreiber and Schultz will each receive $500K prize for work on chemical probes, unnatural amino acids, and new therapeutics
cen.acs.org
1 11 55
Reposted by Abhishek Chatterjee
mclem.org
Michael Clemens @mclem.org · May 21
They're terminating OPT.

Today the nominee to head USCIS stated directly: he will end Optional Practical Training, the single largest channel for high-skill immigrants to work in the US.

6 weeks ago I warned about this & summarized the research on impacts of this drastic action—> @piie.com
Skilled immigration on the chopping block? Effects of eliminating "Optional Practical Training" in the US
The White House has taken numerous steps to sharply reduce the number of immigrant workers, with or without legal status, in the US economy. These policies, so far, typically target immigrants with le...
www.piie.com
2 360 640
Reposted by Abhishek Chatterjee
huiqingzhou.bsky.social
Huiqing Zhou @huiqingzhou.bsky.social · May 16
Happy to share a paper from our group on "MapID-tRNA-seq" for confidently identifying modifications by RT mutation signatures in human tRNAs. This method will enable future discoveries of modifications' occurrence and functions in tRNA biology and diseases. www.cell.com/cell-chemica...
MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA
tRNA chemical modifications play critical roles in biology and diseases. Tepe et al. report MapID-tRNA-seq to map m1A, m3C, and multiple bulky modifications in tRNAs from HEK293T and breast cancer-rel...
www.cell.com
1 4 20
Reposted by Abhishek Chatterjee
standupforscience.bsky.social
Stand Up for Science! @standupforscience.bsky.social · May 10
HAPPY 75th, NSF!

We’re celebrating this milestone by highlighting some of NSF’s most transformative accomplishments—innovations that have shaped our world and continue to drive progress in health, technology, the environment, and beyond.

Read on 🧵(1/11):
A chocolate cake with red and white decorations and lit candles shaped as the number 75. Bold text reads: ‘The NSF Turns 75 Today. What has it done over the past 7 decades?’ The background is a celebratory red with a spray-paint texture.
8 410 800
Reposted by Abhishek Chatterjee
davidimiller.bsky.social
Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · May 4
🧪 Though a doubling of NSF's budget might seem far-fetched, that's exactly what Congress said what's needed to maintain national competitiveness in science & tech.

From the bipartisan CHIPS and Science Act of 2022:
CHIPS and Science authorization for FY26 = $17.8B White House skinny budget = $3.9B
2 95 190
Reposted by Abhishek Chatterjee
biorxiv-synthbio.bsky.social
bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · May 2
Escherichia coli with a 57-codon genetic code https://www.biorxiv.org/content/10.1101/2025.05.02.651837v1
9 15
Reposted by Abhishek Chatterjee
maxkozlov.bsky.social
Max Kozlov @maxkozlov.bsky.social · May 2
BREAKING: Reports that Trump would try to cut NIH's budget by 40% have come true.

The request released moments ago would:
- Cut $18 BILLION to NIH's $47b budget
- Eliminate NIMHD, NCCIH, FIC
- Collapse ICs into five 'focus areas'

There's also a long screed about NIH's deficiencies.
10 120 150
achemsynbio.bsky.social
Abhishek Chatterjee @achemsynbio.bsky.social · May 1
Very nice work @kunjapur.bsky.social. Congratulations to the team!
1 1
Reposted by Abhishek Chatterjee
theonion.com
The Onion @theonion.com · Apr 28
Badass Surgeon Puts On Fingerless Latex Gloves Before Operating
Badass Surgeon Puts On Fingerless Latex Gloves Before Operating
91 720 7.2K
Reposted by Abhishek Chatterjee
jeremybaskin.bsky.social
Jeremy Baskin @jeremybaskin.bsky.social · Apr 26
So excited for the annual student-organized Chemistry-Biology Interface symposium today! Amazing lineup including @hsulab.bsky.social @achemsynbio.bsky.social, Sloan Devlin (Harvard), & Nick Agard (Genentech) + stellar Cornell student and faculty speakers. Looking forward to some great science!
3 16
Reposted by Abhishek Chatterjee
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 11
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.

chemsymposia.com
Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
chemsymposia.com
8 110 200