Lightnews — Scholar-powered news

Reposted by Adrien Leger

Immagina BioTechnology @immagina.bsky.social · Aug 28

Excited to welcome ‪@adrienleger.bsky.social from‪ @nanoporetech.com to our RNA Symposium! 🎤 His talk will focus on how nanopore direct RNA sequencing can reveal multiple RNA modifications at once. Secure your spot at our symposium now 👉 zurl.co/mrhKq
#RNA #ribosome #nanopore

1 2

Reposted by Adrien Leger

Mike Clark @michaelbclark.bsky.social · Aug 12

Our paper using Oxford #Nanopore direct RNA sequencing to identify m6A modifications on RNA isoforms in human brain is now out in Science Advances. 🧪
www.science.org/doi/10.1126/...

Isoform-level profiling of m6A epitranscriptomic signatures in human brain

Direct RNA-seq in brain reveals RNA isoform and region-specific m6A modifications, highlighting their role in gene regulation.

www.science.org

1 18 40

Adrien Leger @adrienleger.bsky.social · Jun 2

🚨 We’re hiring ! 🚨
Join our cutting-edge research team as a molecular biologist at @nanoporetech.com HQ in Oxford.
Perfect for a fresh PhD or MSc with a couple of years’ experience. Work at the interface of chemistry, molecular/synthetic biology and AI

👉 ejnh.fa.em2.oraclecloud.com/hcmUI/Candid...

4 4

Reposted by Adrien Leger

Akshat Rathi @akshatrathi.bsky.social · May 27

The world prefers its energy more in the form of electricity than anything else.

5 20 85

Reposted by Adrien Leger

Oxford Nanopore @nanoporetech.com · May 21

At London Calling, Rosemary Sinclair Dokos and Lakmal Jayasinghe shared how we’re doubling down on what matters: delivering a future-ready platform with proven performance across DNA, RNA, and now proteins. Click here to discover what’s new – and why it matters: nanoporetech.com/news/london-...

6 5

Reposted by Adrien Leger

David Eccles 🌻🇵🇸7x🩹🛡️ @gringene.org · May 22

#NanoporeConf Lakmal Jayasinghe

ONT is the *only* sequencing technology that detects RNA modifications directly. They're now up to 8 modifications that can be detected simultaneously.

[This is something I think ONT should be shouting from the rooftops every day]

RNA barcoding is in beta testing.

image showing RNA modification landscape of human ribosomal RNAs for 18S and 28S rRNA; patterns of different modifications are shown throughout the entirety of the sequence. A validation of synthetic constructs demonstrates RNA modification detection accuracies of 95-99%.

1 9 24

Reposted by Adrien Leger

Mike Vella @vellamike.bsky.social · May 22

New HAC models are 1.4Q more accurate - a 25% error reduction

2 2

Reposted by Adrien Leger

Mike Vella @vellamike.bsky.social · May 22

Big improvements in modification calling accuracy - 6mA increases from Q16 to Q24

2 2

Reposted by Adrien Leger

Mike Vella @vellamike.bsky.social · May 22

Dorado v1.0.0 introduces dramatic improvement to modified base calling speed

2 1

Reposted by Adrien Leger

Mike Vella @vellamike.bsky.social · May 22

Base calling obeys scaling laws in deep learning - a Q28 base caller using standard chemistry is now available on demand.

1 1 2

Reposted by Adrien Leger

Oxford Nanopore @nanoporetech.com · May 21

Oxford Nanopore sequencing will be ubiquitous for multiomics….and the next step is proteomics.

First panel-based proteomics assays, before driving towards full protein sensing in the future. #nanoporeconf

2 14 29

Reposted by Adrien Leger

Marcus Stoiber @stoibs11.bsky.social · May 21

More details on new RNA modified bases detectable with @nanoporetech.com sequencing. #NanoporeConf

3 4

Reposted by Adrien Leger

Marcus Stoiber @stoibs11.bsky.social · May 21

Dorado 1.0 🚀release with new RNA modified base models for 2’Ome as well as improvement of all DNA and RNA modified base models including massive improvement in 6mA for open chromatin prediction! Also a lot more non-mods related features😆! #NanoporeConf

github.com/nanoporetech...

2 2

Reposted by Adrien Leger

Marcus Stoiber @stoibs11.bsky.social · May 21

Dorado 1.0 🚀release with new RNA modified base models for 2’Ome as well as improvement of all DNA and RNA modified base models including massive improvement in 6mA for open chromatin prediction! Also a lot more non-mods related features😆! #NanoporeConf

github.com/nanoporetech...

1 2 7

Reposted by Adrien Leger

Oxford Nanopore @nanoporetech.com · May 21

With significant ML advances, Dorado & MinKNOW now power built-in accurate variant calling, default methylation detection & short fragment mode. Adaptive sampling & T2T assemblies are production-ready — enabling faster, richer, more meaningful insights.

2 5

Reposted by Adrien Leger

Chris Seymour @iiseymour.bsky.social · May 21

Dorado is 1.0! 🎉

LC25 release adds v5.2 DNA/RNA models with a new suite of mod models that are higher accuracy, lower FP rates, and significantly faster.

- Introducing dorado variant 👀
- HAC error rate is down over 25%.
- New 2’Ome mod models
- Hopper & Blackwell SUP speed ups

#Nanoporeconf

8 18

Reposted by Adrien Leger

Oxford Nanopore @nanoporetech.com · May 21

Your speakers for London Calling 2025! #NanoporeConf

1 5

Reposted by Adrien Leger

Matt Loose @minomatt.bsky.social · May 21

Really pleased that this paper is out - academic.oup.com/neuro-oncolo... thanks to all our collaborators far and wide who have helped and of course @nanoporetech.com

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis

academic.oup.com

3 13 23

Reposted by Adrien Leger

Marcus Stoiber @stoibs11.bsky.social · May 21

Excited for another London Calling! Incredible updates coming over the next two days! #NanoporeConf @nanoporetech.com

1 1 7

Reposted by Adrien Leger

yanqiangli.bsky.social @yanqiangli.bsky.social · Feb 21

I am quite interesting in this Nm modification. As we detected Nm in rRNA as well as mRNA using Nanopore RNA002 version. www.cell.com/molecular-ce...

2′-O-methylation at internal sites on mRNA promotes mRNA stability

Li et al. develop a machine learning approach to measure the stoichiometry of 2′-O-methylation at internal sites of mRNA using nanopore RNA sequencing data. FBL-mediated Nm modifications, when connect...

www.cell.com

1 3

Reposted by Adrien Leger