banner
adrover.bsky.social
Jose M. Adrover
@adrover.bsky.social
280 followers 640 following 23 posts
Studying the cancer-cardiovascular disease interplay, with a focus on how cancer reprograms the hematopoietic and immune systems, at the Francis Crick Institute in London http://www.adroverlab.com
www.adroverlab.com
Posts Media Videos Starter Packs
Reposted by Jose M. Adrover
obenaufa.bsky.social
Anna Obenauf @obenaufa.bsky.social · 29d
🔥Trio Fatale: Neutrophils, NETs and Necrosis
👉 authors.elsevier.com/a/1lk-k3qNrU...

We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau

Congrats!
7 31
Reposted by Jose M. Adrover
haoyin.bsky.social
Hao Yin @haoyin.bsky.social · Sep 7
A new model of #TumorNecrosis👹

Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis

a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
3 12
Reposted by Jose M. Adrover
jem.org
Journal of Experimental Medicine @jem.org · Aug 18
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/...

#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
2 3
Reposted by Jose M. Adrover
jem.org
Journal of Experimental Medicine @jem.org · Aug 11
#Cancer patients display an elevated burden of #CardiovascularDisease. This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...
2 6
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Aug 12
Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social

rupress.org/jem/article/...
Heart of the matter: Neutrophils, cancer, and cardiovascular disease | Journal of Experimental Medicine | Rockefeller University Press
Cancer and cardiovascular disease are the leading causes of death worldwide. Cancer patients display an abnormally elevated burden of cardiovascular diseas
rupress.org
1 6 10
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Aug 4
Thanks to Cancer Discovery for highlighting our manuscript with such a nice summary!

Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis
Major Finding: A Ly6GhighLy6Clow subset of neutrophils drives pleomorphic necrosis by forming intravascular neutrophil extracellular traps (NET).Concept: Tumor cells adjacent to neutrophil-induced nec...
aacrjournals.org
3
Reposted by Jose M. Adrover
cdi-einstein.bsky.social
Cancer Dormancy Institute @ Einstein @cdi-einstein.bsky.social · Aug 4
@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening
jaguirreghisolab.bsky.social
Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
2 4
Reposted by Jose M. Adrover
nature.com
Nature @nature.com · Jul 23
Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis

go.nature.com/4lzilSb
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
go.nature.com
8 25
Reposted by Jose M. Adrover
ajbrenes.com
Alejandro Brenes @ajbrenes.com · Jul 27
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
3 18 64
Reposted by Jose M. Adrover
jhu-bdps.bsky.social
JHU Bloomberg Distinguished Professorships @jhu-bdps.bsky.social · Jul 23
A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.
megeblad.bsky.social
Mikala Egeblad @megeblad.bsky.social · Jul 17
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
3 5
Reposted by Jose M. Adrover
megeblad.bsky.social
Mikala Egeblad @megeblad.bsky.social · Jul 17
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
10 39
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
This project started when I joined the @megeblad.bsky.social lab at @cshlnews.bsky.social, and continued at @hopkinsmedicine.bsky.social and at
@crick.ac.uk, with help from many colleagues along the way! It has been an absolute pleasure to work with Mikala and the rest of the team! (13/13)
1 2
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
We show, therefore, that tumour necrosis is not a passive phenomenon, but an active phenomenon that we can target by targeting neutrophils or their NET formation ability. And by reducing tumour necrosis we can reduce metastatic spread. (12/13)
1 1 6
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
There, they form NETs and enter a feedforward loop with platelets that ultimately leads to the blockage of blood flow and subsequent necrosis of downstream tumour regions. This induces cancer cells around these necrotic regions to change and become more metastatic. (11/13)
1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
In summary, we found that the tumour changes the haematopoietic compartment and drives the production of vascular-restricted neutrophils. Then, neutrophils leave the bone marrow and enter the bloodstream, eventually reaching the tumour vasculature. (10/13)
1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
These neutrophils form NETs more efficiently than normal neutrophils, interact more with platelets, and, intriguingly, cannot extravasate and are stuck in the vasculature. We called them vascular-restricted neutrophils (vrPMNs). (9/13)
1 3
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
But why are neutrophils forming NETs in the vasculature? We found that the tumour communicates with the bone marrow and changes myelopoiesis to produce a novel neutrophil subpopulation. (8/13)
1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
Using spatial transcriptomics, we found that tumour necrosis increased metastasis because cancer cells in peri-necrotic areas gained pro-metastatic traits in a TGFb-driven manner. (7/13)
1 1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
We found that the process was driven by NETs. When we block NETs genetically or pharmacologically, tumour necrosis is greatly reduced. This, interestingly, also reduced metastatic spread. (6/13)
1 1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
These aggregates were blocking blood flow in the tumour, and that caused the necrosis of downstream tumour regions. (5/13)
1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
Interestingly, around necrotic regions we found vessels that contained intraluminal aggregates of neutrophils, NETs and platelets. (4/13)
1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
We found that the architecture of necrosis was peculiar and intricate in different tumour models (we call it “pleomorphic necrosis”), and these regions were covered by neutrophils and NETs. (3/13)
1 1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
Tumour necrosis is associated with a bad prognosis across the board of cancer types, including in breast cancer. But it was thought to be a passive phenomenon due to cancer growth outpacing nutrient supply. (2/13)
1
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jul 17
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
3 25 61
adrover.bsky.social
Jose M. Adrover @adrover.bsky.social · Jun 27
Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here: adroverlab.com/open-positio...
Open call for a Postdoctoral Fellow - Cancer Macroenvironment Lab
Open postdoctoral position at the Cancer Macroenvironment Lab led by Dr. Adrover at the Francis Crick Institute in London
adroverlab.com
2