Anne Kühnel
@akuehnel.bsky.social
480 followers 550 following 11 posts
Neuroscientist working on computational psychiatry @neuromadlab in Bonn
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Reposted by Anne Kühnel
helencbarron.bsky.social
** We have up to TWO funded PhD positions available in our lab!! Apply below to find new ways to enhance memory👇 Pls retweet **

Deadline: 2nd December

1. Cross-species closed-loopTMR: tinyurl.com/bddu4tp6

2. TUS and TMR in humans:
tinyurl.com/jjws5ctj

Happy to chat to interested applicants.
Enhancing memory using cross-species closed-loop Targeted Memory Reactivation | mrcbndu
tinyurl.com
Reposted by Anne Kühnel
mariame.bsky.social
Second day of the conference of Experimental endocrinology in Freising! 🥨

Really enjoyed the talk by Henrik Oster on circadian appetite regulation which gave a lot of food for thought: should I really give this dessert in the evening a go? 💭
Reposted by Anne Kühnel
Reposted by Anne Kühnel
Reposted by Anne Kühnel
sirileknes.bsky.social
Please RT
2 new positions in the lab as postdoc & PhD!

Interested in stress, pain, or reward? This project has it all!

We are a friendly but ambitious group. Oslo is a capital city on the fjord & bordered by forest, great urban & outdoors opportunities: 💃 ⛷️ 🚣 🎭 🎶

www.jobbnorge.no/en/available...
Postdoctoral Research Fellowship (286516) | University of Oslo
Job title: Postdoctoral Research Fellowship (286516), Employer: University of Oslo, Deadline: Wednesday, October 15, 2025
www.jobbnorge.no
Reposted by Anne Kühnel
rssmith.bsky.social
Big congrats to Marishka on this. I know how much time and effort went into it. Really happy to see it out! For those interested, she replicated prior longitudinal results using an approach-avoidance conflict task and showed how model parameters afforded out-of-sample clinical prediction.
cpsyjournal.bsky.social
New paper in CPsy - 'Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders' from Marishka Mehta and the group of @rssmith.bsky.social
doi.org/10.5334/cpsy...
Computational Mechanisms of Approach-Avoidance Conflict Predictively Differentiate Between Affective and Substance Use Disorders | Computational Psychiatry
doi.org
Reposted by Anne Kühnel
Reposted by Anne Kühnel
dhernaus.bsky.social
In our new paper 📖🔥, we conducted a pooled analysis (n=443; 5 studies) to test if state affect (momentary mood) or trait dispositions (approach/avoidance) predict cortisol reactivity beyond biological & contextual factors. (1/4)

#neuroscience #Neuroskyence #cogpsyc #AffectSci #psychscisky
Unpacking cortisol stress reactivity: Associations with psychological state and trait data in a pooled data sample
Prior research suggests that cortisol responses to acute stress induction paradigms (i.e., “cortisol stress reactivity”) likely arise from complex int…
www.sciencedirect.com
akuehnel.bsky.social
We recently reported higher variability of reinforcement learning in obesity and BED, but what about neural representations? In our new preprint, we show higher variability in NAcc responses to reward cues in obesity and disinhibited eating www.medrxiv.org/content/10.1... w/ @nbkroemer.bsky.social
Reposted by Anne Kühnel
nbkroemer.bsky.social
When we encounter the same reward repeatedly, we show variable responses; is this just noise?
In our new preprint, we replicate the association of BMI and disinhibited eating with variability of NAcc signals to reward. #neuroskyence 🩺
W/ @akuehnel.bsky.social
www.medrxiv.org/content/10.1...
The figure depicts the study rationale and procedures. We anticipated differences in reward sensitivity across groups varying in symptoms of binge eating, specifically in the variability. Patients with binge eating disorder (BED) have a higher variability in food wanting ratings during the effort allocation task in the behavioral session. Participants with a higher body mass index (BMI) show elevated variability of anticipatory cue responses in the nucleus accumbens (NAcc).
Reposted by Anne Kühnel
Reposted by Anne Kühnel
nicolecrust.bsky.social
Continuing the general thread, Peter Dyan does a very nice summary of Berridge's liking/wanting distinction, the evidence for it, and how it links to RL and interoception here (21:30):

www.youtube.com/watch?v=vLA7...
Peter Dayan: The Marriage of Natural and Engineered Reinforcement Learning
YouTube video by Reinforcement Learning Conference
www.youtube.com
Reposted by Anne Kühnel
glassybrain.bsky.social
One of the last projects of my PhD looking into insular functional segregation in depression is finally out as a preprint 🙏👇 Have a look and let us know what you think! #neuroskyence
nbkroemer.bsky.social
New preprint...and this one is truly EPIC 🚨.

Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Graphical summary of the analysis pipeline Decreased similarity within the anterior insula cortex drives group differences between patients with MDD and healthy control participants. This difference is illustrated by shift functions and compared to control regions in the temporal cortex. Patients with depression can be robustly classified based on functional connectivity profiles, and the accuracy improves with increasing symptom severity.
Reposted by Anne Kühnel
nbkroemer.bsky.social
If you are interested in using functional neuroimaging and neuromodulation to improve key symptoms of depression, we are still looking for PhD students:

Official ad (in German, B2 level or better is required): karriereamukb.de/jobs/doktora...
Reposted by Anne Kühnel
nbkroemer.bsky.social
New preprint...and this one is truly EPIC 🚨.

Using a large group of patients with depression and healthy controls (N>800), we show differences in the functional segregation of insular subnetworks. And we can use it to classify!
Led by @glassybrain.bsky.social #neuroskyence 🩺
osf.io/preprints/ps...
Graphical summary of the analysis pipeline Decreased similarity within the anterior insula cortex drives group differences between patients with MDD and healthy control participants. This difference is illustrated by shift functions and compared to control regions in the temporal cortex. Patients with depression can be robustly classified based on functional connectivity profiles, and the accuracy improves with increasing symptom severity.
Reposted by Anne Kühnel
Reposted by Anne Kühnel
w-joel-schneider.bsky.social
Now on CRAN, ggdiagram is a #ggplot2 extension that draws diagrams programmatically in #Rstats. Allows for precise control in how objects, labels, and equations are placed in relation to each other.
wjschne.github.io/ggdiagram/ar...
An arrow with a LaTeX equation Trigonometric functions and a unit circle A bivariate change model with structured residuals A hierarchical model of cognitive abilities
Reposted by Anne Kühnel
johalgermissen.bsky.social
Very happy to share my first preprint from @oxexppsy.bsky.social @oxneuro.bsky.social ! We (me + co-first authors @lilweb.bsky.social @mirunarascu.bsky.social + PI @mkflugge.bsky.social + many others) used transcranial focused ultrasound stimulation (TUS/tFUS/LIFU) of the human amygdala ... (1/15)
Reposted by Anne Kühnel
biorxiv-neursci.bsky.social
Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network-level activity https://www.biorxiv.org/content/10.1101/2025.08.14.670358v1
Reposted by Anne Kühnel
psychopy.org
🚀 We’re creating a PsychoPy Cheat Sheet to help students get started fast!

If you could give a new user one tip for their first 30 minutes with PsychoPy, what would it be?

We’d love your ideas! (They might even join our PsychoPy tips in the app 😉 )

💡👇
Reposted by Anne Kühnel
nbkroemer.bsky.social
While our official job ad is on the way, we are seeking PhD students to join @neuromadlab.bsky.social for projects running in Bonn.

The candidate will lead projects on body-brain interactions using brain stimulation to improve core symptoms of depression: www.neuromadlab.org/jobs #neurojobs
Image of a job ad preview.
Reposted by Anne Kühnel
ondrejzika.bsky.social
This paper is now published in Computational Psychiatry :)

cpsyjournal.org/articles/10....
Reposted by Anne Kühnel
nbkroemer.bsky.social
📣Call for applications

We are recruiting the 2nd cohort of PhD students for the international research training group on women's mental health. If you care about translational pharmacoimaging work integrating hormonal states, please apply #neurojobs
jobs.medizin.uni-tuebingen.de/Job/6598/PhD...
PhD Researcher (f/m/d) Women’s Mental Health
jobs.medizin.uni-tuebingen.de
Reposted by Anne Kühnel
cmc-lab.bsky.social
Wanna know about *internal* reinforcement learning? We'll show you seemingly random switches during perceptual multistability is a form informational foraging, is task-modulated & how RL explain them all! Poster B71, Wed 2-5pm, talk to @neuroprinciplist.bsky.social 2025.ccneuro.org/poster/?id=8...
Poster Presentation
2025.ccneuro.org