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Aysu Okbay @aysuo.bsky.social · May 20

PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social

bioRxivpreprint @biorxivpreprint.bsky.social · May 19

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1

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Varun Warrier @vw1234.bsky.social · May 14

New review on the genetics of schizophrenia, depression, and bipolar disorder.

www.nature.com/articles/s41...

Genomics of schizophrenia, bipolar disorder and major depressive disorder

Nature Reviews Genetics - Genomic advances have enhanced our understanding of schizophrenia, bipolar disorder and major depressive disorder, revealing genetic architectures and risk mechanisms...

www.nature.com

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Reposted by Alex Strudwick Young

Matt Loose @minomatt.bsky.social · May 9

UK Genome Science meeting - Newcastle. 9th - 11th July 2025. Great speakers. Great community.
Early bird registration-16th May
Abstract submission-23rd May
Registration close-26th June
If you want that sweet sweet early bird deal - get going quick!
www.genomescience.org.uk

Genome Science UK 2025

Newcastle University

www.genomescience.org.uk

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Rafael Ahlskog @rafaelahlskog.bsky.social · Apr 25

Some really interesting contrasts in our new "assumption-free heritability" preprint: papers.ssrn.com/sol3/papers....

Nature, nurture, and socioeconomic outcomes: New evidence from sib pairs and molecular genetic data

A consequence of Mendel's First Law is that siblings' genetic relatedness varies randomly (with a mean of 50% and a standard deviation of ~4%). We use molecular

papers.ssrn.com

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Uku Vainik @ukuvainik.bsky.social · May 8

Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!

Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1

@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social

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Alex Strudwick Young @alextisyoung.bsky.social · May 8

Great work on estimating heritability using sibling relatedness variation (estimated using my software package snipar). Surprisingly low h2 for education and high h2 for IQ (with large SE). Give it a read!

Uku Vainik @ukuvainik.bsky.social · May 8

Siblings are not always 50% genetically similar! The difference may vary from 40 to 60%!

Our preprint uses this difference via sibling regression to estimate "assumption-free heritability" of socio-cognitive traits /1

@eivindy.bsky.social @rafaelahlskog.bsky.social @renemottus.bsky.social

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Alex Strudwick Young @alextisyoung.bsky.social · Apr 28

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

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Aysu Okbay @aysuo.bsky.social · Apr 29

A great opportunity to work with @alextisyoung.bsky.social if you're interested in methods development!

Alex Strudwick Young @alextisyoung.bsky.social · Apr 28

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

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Andrea Ganna @andganna.bsky.social · Apr 28

🚨 EBI has just lunched a new portal to calculate genetic scores from individual-level genetic data.

Check it out 👇. It is very cool!

geneticscores.org

It is linked with the @pgscatalog.bsky.social

This was supported by INTERVENE

GeneticScores.org

GeneticScores.org provides tools and data to help AI developers and human health researchers make better polygenic scores

geneticscores.org

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Reposted by Alex Strudwick Young

Molly Przeworski @mollyprz.bsky.social · Apr 24

Posting on behalf of Shamil Sunyaev: Eimear(Vice Chair) and I (Chair) are organizing the 2025 Gordon Research Conference (GRC) on Human Genetics and Genomics, which will be held on July 6-11, 2025 in beautiful University of Southern Maine, Portland, Maine.

2025 Human Genetics and Genomics Conference GRC

The 2025 Gordon Research Conference on Human Genetics and Genomics will be held in Portland, Maine. Apply today to reserve your spot.

www.grc.org

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Alex Strudwick Young @alextisyoung.bsky.social · Apr 28

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

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Rosa Ritunnano @rritunnano.bsky.social · Dec 20

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

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Alex Strudwick Young @alextisyoung.bsky.social · Dec 17

Yeah isn't this exactly what one would expect and similar to things like bmi?

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Aaron Quinlan (he/him) @aaronquinlan.bsky.social · Dec 14

Our UU colleague Wes Sundquist won the 2024 Breakthrough of the year! His long-term research into the structure and function of HIV’s capsid protein has led to the development lenacapavir, a game-changing new treatment that is extremely effective at preventing HIV.
www.science.org/content/arti...

Science’s 2024 Breakthrough of the Year: Opening the door to a new era of HIV prevention

A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

www.science.org

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Shai Carmi @shaicarmi.bsky.social · Dec 6

www.medrxiv.org/content/10.1...

Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals

Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from p...

www.medrxiv.org

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Erich M. Schwarz @erichmschwarz.bsky.social · Dec 6

After 5 years, our team has a new telomere-to-telomere gap-free reference genome for C. elegans. We published our first results in 2019; I thought we'd have our loose ends wrapped up by spring 2020. That prediction was ... slightly off.
But here's the genome now!
www.biorxiv.org/content/10.1...

CGC1, a new reference genome for Caenorhabditis elegans

The original 100.3 Mb reference genome for Caenorhabditis elegans , generated from the wild-type laboratory strain N2, has been crucial for analysis of C. elegans since 1998 and has been considered co...

www.biorxiv.org

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Kieran Campbell @kieranrcampbell.bsky.social · Nov 27

Tumour mutational burden: clinical utility, challenges and emerging improvements

Tumour mutational burden: clinical utility, challenges and emerging improvements - Nature Reviews Clinical Oncology

Tumour mutational burden (TMB), reflecting the number of mutations present in the DNA of a tumour, is a biologically appealing biomarker of a response to immune-checkpoint inhibitors (ICIs). Nonethele...

www.nature.com

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Alex Strudwick Young @alextisyoung.bsky.social · Nov 22

I see. Well yes but it might be tricky because inherited variants would tend to have smaller effect sizes than de novos independently of assortment.

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Alex Strudwick Young @alextisyoung.bsky.social · Nov 21

I'm not sure why assortment would affect this?

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Alex Strudwick Young @alextisyoung.bsky.social · Nov 21

When there is assortment, common and rare variant contributions will become correlated and this needs to be taken into account when analyzing either.

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Alex Strudwick Young @alextisyoung.bsky.social · Nov 21

This paper provides the first direct evidence of this by showing a surprisingly large correlation between the common variant education polygenic score and a rare variant burden score.

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Alex Strudwick Young @alextisyoung.bsky.social · Nov 21

It's possible that this is because the parents' genetics affect the offspring through the env but it could be assortment: parents with lower education polygenic scores based on common variants are more likely to mate with individuals with rare variants that cause neurodevelopmental conditions.

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Alex Strudwick Young @alextisyoung.bsky.social · Nov 21

Great to see this paper out in Nature today!

One aspect that I worked on was the curious result that the education polygenic score predicts neurodevelopmental conditions but this prediction disappears within family.

Emilie Wigdor @emiliewigdor.bsky.social · Nov 20

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣

Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

a couple of cartoon characters standing next to each other with one wearing a purple earring

Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring

media.tenor.com

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Emilie Wigdor @emiliewigdor.bsky.social · Nov 20

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣

Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

a couple of cartoon characters standing next to each other with one wearing a purple earring

Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring

media.tenor.com

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Kevin Mitchell @wiringthebrain.bsky.social · Nov 18

Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals #icanhazpdf? www.nature.com/articles/s41...

Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals - Nature Human Behaviour

In 394,005 UK individuals with exome sequencing data, Wu et al. find 56 neuroticism-associated genes (18 novel) and quantify the heritability explained by rare coding variants, highlighting the associ...

www.nature.com

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