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Reposted by Prof Amanda J Farrin

Sarah Alderson @imp-sci-saraha.bsky.social · Jun 6

Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social

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Marion Campbell @marionkcampbell.bsky.social · Jun 2

A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7

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Marion Campbell @marionkcampbell.bsky.social · Jun 16

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120

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UK CTU Network @ukcrc-ctu.org.uk · Mar 20

🚀 Exciting News! 🚀

Interested in or leading a clinical trial?

Want to be the best Chief Investigator you can be?

This updated course is for you!

tinyurl.com/HTBAGCI

#ClinicalTrials #CITraining

@leedsctru.bsky.social @amandafarrin.bsky.social

Flyer advertising a training course on How to be a great chief investigator for clinical trials. Find out more via the following link https://tinyurl.com/HTBAGCI

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Prof Amanda J Farrin @amandafarrin.bsky.social · Mar 12

Phew: ResearchFish submitted again for another year ✅️

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Marion Campbell @marionkcampbell.bsky.social · Mar 10

A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7
#MethodologyMonday #113

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Prof Amanda J Farrin @amandafarrin.bsky.social · Feb 13

📢 Delighted our CHART trial is now OPEN to recruitment

Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉

🙏 @nihr.bsky.social for funding

PenARC (NIHR ARC South West Peninsula) @penarc.bsky.social · Feb 13

PenARC & @arc-yharc.bsky.social researchers are working in partnership with older people with #heartfailure and #frailty to increase their independence.

> Learn more: tinyurl.com/4xt8f7en

@nihrarcs.bsky.social @exeter.ac.uk @universityofleeds.bsky.social @livunipress.bsky.social @nihr.bsky.social

NIHR APPLIED RESEARCH COLLABORATION SOUTH WEST PENINSULA.
Two older men smile as they walk through a park.

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Katie Gillies @katiegillies.bsky.social · Feb 12

Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials.

forms.office.com/e/fkeLD8HbMA

Please complete &RT

@ukctunetwork.bsky.social

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Bethan Copsey @bethancopsey.bsky.social · Jan 31

Consider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist
bmjopen.bmj.com/content/14/1...

Enhancing the reporting quality of rehabilitation interventions through an extension of the Template for Intervention Description and Replication (TIDieR): the TIDieR-Rehab checklist and supplementary...

Background Rehabilitation is a complex biopsychosocial process in which multidisciplinary professionals work in collaboration with a person and their family, with the shared objective of enhancing the...

bmjopen.bmj.com

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Prof Amanda J Farrin @amandafarrin.bsky.social · Feb 3

Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂

FReSH START @freshstart-uk.bsky.social · Jan 13

FReSH START is a research project aiming to develop a therapy intervention for adults who self-harm. We are now running a clinical trial to see if the therapy we developed is effective and if it improves people's quality of life. #introduction #mentalhealthresearch #selfharm #NIHR

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Katie Gillies @katiegillies.bsky.social · Jan 21

Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA

Microsoft Forms

forms.office.com

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Katie Gillies @katiegillies.bsky.social · Jan 21

Do you work on clinical trials?

We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials

Please share across your networks

Microsoft Forms

tinyurl.com

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Marion Campbell @marionkcampbell.bsky.social · Jan 28

Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!

American Statistical Association History of Statistics @hos-asa.bsky.social · Jan 28

#OTD 28 Jan 1809 Louis-Dominique-Jules Gavarret b (d 30 Aug 1890) An early proponent of the 'statistical method' in medicine, his 1840 book 'Principes de Statistique Médicale' was among the first to describe statistical principles for rigorous clinical trial conduct. /10 🧵

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Marion Campbell @marionkcampbell.bsky.social · Jan 27

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8
#MethodologyMonday #109

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Prof Amanda J Farrin @amandafarrin.bsky.social · Jan 22

Welcome to bluesky @complexleedsctru.bsky.social 🎉

Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇

CTRU Complex Interventions @complexleedsctru.bsky.social · Jan 22

There's only 2 days left to sign up for our Masterclass in the Design and Conduct of Complex Intervention Evaluations!

Limited spaces are left! Register here - t.co/V6Q7p51feu

Prof Amanda J Farrin @amandafarrin.bsky.social · Jan 9

We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February.

Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social

Register now to reserve your place. Deadline 24 Jan.
Link below 👇

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Darren Dahly @statsepi.bsky.social · Jan 14

We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!

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Prof Sheena Cruickshank @sheencr.bsky.social · Jan 12

I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪

Who’s quitting academia? Data reveal gender gaps in surprising fields

Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

www.nature.com

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Prof Amanda J Farrin @amandafarrin.bsky.social · Jan 11

Snow day

#Yorkshire
#Langsett

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Marion Campbell @marionkcampbell.bsky.social · Jan 8

Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊
www.bmj.com/content/388/...

Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration

This article presents the CONSORT (consolidated standards of reporting trials) extension for cluster randomised crossover trials. A cluster randomised crossover trial involves randomisation of groups ...

www.bmj.com

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Prof Amanda J Farrin @amandafarrin.bsky.social · Jan 9

We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February.

Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social

Register now to reserve your place. Deadline 24 Jan.
Link below 👇

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Prof Amanda J Farrin @amandafarrin.bsky.social · Jan 5

Just a wee bit of snow in Yorkshire 🥶❄️

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Tim Morris @timpmorris.bsky.social · Jan 3

🤢 horrifying piece of work, which we’ll see idiots quoting.
For goodness sake @jclinepi.bsky.social

Journal of Clinical Epidemiology @jclinepi.bsky.social · Jan 3

Treatment Effects in Pharmacological Clinical Randomized Controlled Trials are Mainly Due to Placebo - @jclinepi.bsky.social www.jclinepi.com/article/S089...

Treatment Effects in Pharmacological Clinical Randomized Controlled Trials are Mainly Due to Placebo

The placebo response in clinical trials has four components: regression to the mean (RTM), measurement artefacts, natural tendency (NT) of the disease, and the genuine placebo effect. Our objective is to determine what contributes to the size of the placebo-effect in clinical trials by meta-regressions of randomized placebo-controlled clinical trials.

www.jclinepi.com