@amandagwee.bsky.social
Gen paed, ID physician, clinical pharmacologist. Researcher, interest in optimising antimicrobial use in kids. Views my own
Thanks Josh! It was really Peltola’s RCT of short course first gen cephalosporins for septic arthritis that started this practice in kids! pubmed.ncbi.nlm.nih.gov/19323633/
Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis - PubMed
Large doses of well-absorbed antimicrobials for <2 weeks (initially administered intravenously) and only 1 joint aspiration are sufficient for treatment of most cases of childhood septic arthritis, re...
pubmed.ncbi.nlm.nih.gov
April 22, 2025 at 10:38 AM
Thanks Josh! It was really Peltola’s RCT of short course first gen cephalosporins for septic arthritis that started this practice in kids! pubmed.ncbi.nlm.nih.gov/19323633/
Reposted
Lots of work on this in kids. @amandagwee.bsky.social the BOSS on this topic & @alisonboast.bsky.social her badass sidekick!
pubmed.ncbi.nlm.nih.gov/32412727/
pubmed.ncbi.nlm.nih.gov/32412727/
Twice- and Thrice-daily Cephalexin Dosing for Staphylococcus aureus Infections in Children - PubMed
Our study proposes a BID and TID cephalexin dosing regimen that can be prospectively evaluated. Through reducing the dose frequency of this widely prescribed antibiotic, we can reduce the medication b...
pubmed.ncbi.nlm.nih.gov
April 22, 2025 at 8:41 AM
Lots of work on this in kids. @amandagwee.bsky.social the BOSS on this topic & @alisonboast.bsky.social her badass sidekick!
pubmed.ncbi.nlm.nih.gov/32412727/
pubmed.ncbi.nlm.nih.gov/32412727/
But crushed DRT is a promising alternative oral treatment option pubmed.ncbi.nlm.nih.gov/39475156/ #idsky #amssky #pedsID
Crushed posaconazole delayed-release tablets for antifungal prophylaxis and treatment in children - PubMed
Crushed posaconazole DRT administered via EFT may be used as a method of attaining therapeutic posaconazole concentrations in children for antifungal prophylaxis and treatment.
pubmed.ncbi.nlm.nih.gov
March 28, 2025 at 9:35 AM
But crushed DRT is a promising alternative oral treatment option pubmed.ncbi.nlm.nih.gov/39475156/ #idsky #amssky #pedsID
This follows our review of posa dosing in kids showing poor attainment of prophylaxis target with oral suspension (≥0.7mg/l, 12-78%) despite high doses of 14–23mg/kg/d (max 1.2g/d). DRT achieved levels ≥0.7µg/mL in 58-94% with doses of 4–12 mg/kg/d (max 300 mg/d) pubmed.ncbi.nlm.nih.gov/38637310/
Posaconazole in paediatric malignancy and haematopoietic stem cell transplant: dosing to achieve therapeutic concentration - PubMed
The required posaconazole dose in immunocompromised children varies depending on the formulation. The IV infusion had the highest attainment of therapeutic concentration followed by the DRT and powder...
pubmed.ncbi.nlm.nih.gov
March 28, 2025 at 9:30 AM
This follows our review of posa dosing in kids showing poor attainment of prophylaxis target with oral suspension (≥0.7mg/l, 12-78%) despite high doses of 14–23mg/kg/d (max 1.2g/d). DRT achieved levels ≥0.7µg/mL in 58-94% with doses of 4–12 mg/kg/d (max 300 mg/d) pubmed.ncbi.nlm.nih.gov/38637310/
@joshosowicki.bsky.social - thoughts?
February 13, 2025 at 11:32 AM
@joshosowicki.bsky.social - thoughts?
Reposted
📚 Our findings, along with our earlier study showing that #BCGvaccine increased risk of symptomatic [but not severe] #COVID-19, suggest that BCG vaccination does not enhance immunity to #SARSCoV2 or COVID-19 vaccines 🌍✨ #IDsky #Immunosky www.sciencedirect.com/science/arti...
BCG vaccination of healthcare workers for protection against COVID-19: 12-month outcomes from an international randomised controlled trial
Bacille Calmette-Guérin (BCG) vaccine has immunomodulatory effects that may provide protection against unrelated infectious diseases. We aimed to dete…
www.sciencedirect.com
February 4, 2025 at 5:33 AM
📚 Our findings, along with our earlier study showing that #BCGvaccine increased risk of symptomatic [but not severe] #COVID-19, suggest that BCG vaccination does not enhance immunity to #SARSCoV2 or COVID-19 vaccines 🌍✨ #IDsky #Immunosky www.sciencedirect.com/science/arti...
Reposted
Look at that - @bradspellberg.bsky.social gently triggering world war CRO vs CTX!
BD or OD???
@alisonboast.bsky.social @amandagwee.bsky.social
pubmed.ncbi.nlm.nih.gov/39377581/
BD or OD???
@alisonboast.bsky.social @amandagwee.bsky.social
pubmed.ncbi.nlm.nih.gov/39377581/
Population pharmacokinetic modeling of ceftriaxone in cerebrospinal fluid in children: should we be using once- or twice-daily dosing for meningitis? - PubMed
Guidelines for bacterial meningitis in children recommend intravenous ceftriaxone 50 mg/kg (max 2 g) twice daily (BD) or 100 mg/kg (max 4 g) once daily (OD), leaving the decision regarding the dose fr...
pubmed.ncbi.nlm.nih.gov
January 18, 2025 at 3:39 AM
Look at that - @bradspellberg.bsky.social gently triggering world war CRO vs CTX!
BD or OD???
@alisonboast.bsky.social @amandagwee.bsky.social
pubmed.ncbi.nlm.nih.gov/39377581/
BD or OD???
@alisonboast.bsky.social @amandagwee.bsky.social
pubmed.ncbi.nlm.nih.gov/39377581/
Reposted
Reviews of antimicrobial dosing:
1. Anti-fungals: doi.org/10.1093/ofid...
2. All-antimicrobials: ccforum.biomedcentral.com/articles/10....
Systematic Reviews:
1. Definitions of ECMO infections: www.ajicjournal.org/article/S019...
2. Use of ppx antibiotics: journals.lww.com/asaiojournal...
1. Anti-fungals: doi.org/10.1093/ofid...
2. All-antimicrobials: ccforum.biomedcentral.com/articles/10....
Systematic Reviews:
1. Definitions of ECMO infections: www.ajicjournal.org/article/S019...
2. Use of ppx antibiotics: journals.lww.com/asaiojournal...
Antifungals in Patients With Extracorporeal Membrane Oxygenation: Clinical Implications
This review summarizes antifungal use in ECMO patients, exploring specific substances, dosing, TDM and ECMO-related factors from a clinical point of view.
doi.org
December 23, 2024 at 8:32 PM
Reviews of antimicrobial dosing:
1. Anti-fungals: doi.org/10.1093/ofid...
2. All-antimicrobials: ccforum.biomedcentral.com/articles/10....
Systematic Reviews:
1. Definitions of ECMO infections: www.ajicjournal.org/article/S019...
2. Use of ppx antibiotics: journals.lww.com/asaiojournal...
1. Anti-fungals: doi.org/10.1093/ofid...
2. All-antimicrobials: ccforum.biomedcentral.com/articles/10....
Systematic Reviews:
1. Definitions of ECMO infections: www.ajicjournal.org/article/S019...
2. Use of ppx antibiotics: journals.lww.com/asaiojournal...