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Reposted by Abdel Mazouzi

Max-Planck-Gesellschaft @maxplanck.de · 21d

Open Call for Expressions of Interest: become a Max Planck Director & redefine what’s possible in science! We offer scientific independence, long-term stable funding & exceptional infrastructure. Lead your own department & open new frontiers of research. Apply by 31 Oct 2025 → www.mpg.de/directors

Directors

The Max Planck Society offers Directors a unique platform for groundbreaking research and leadership in diverse scientific fields.

www.mpg.de

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Reposted by Abdel Mazouzi

Sarah Moser @sarahmoser.bsky.social · 24d

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Histone Recycling Promotes PARP Inhibitor Resistance

Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...

aacrjournals.org

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Reposted by Abdel Mazouzi

IMP @impvienna.bsky.social · 29d

Sarah Moser ( @sarahmoser.bsky.social) from the lab of Jos Jonkers, Netherlands Cancer Institute (@nkinl.bsky.social) & Oncode Institute (@oncodeinstitute.bsky.social). 👏🏾 5/

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IMP @impvienna.bsky.social · 29d

Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025!

🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...

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Abdel Mazouzi @amazouzi.bsky.social · Sep 4

Congrats Andre!

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Reposted by Abdel Mazouzi

The Groth lab @grothlab.bsky.social · Aug 28

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

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Reposted by Abdel Mazouzi

Netherlands Cancer Institute @nkinl.bsky.social · Aug 22

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/...

#fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

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Reposted by Abdel Mazouzi

Nature @nature.com · Aug 18

Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance

go.nature.com/45vRWhd

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

go.nature.com

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Reposted by Abdel Mazouzi

Francesca Mattiroli @fmattiroli.bsky.social · Aug 16

Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out!
Congratulations!! and happy we could contribute a tiny bit.

Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.

Sarah Moser @sarahmoser.bsky.social · Aug 13

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

www.nature.com

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Reposted by Abdel Mazouzi

Sarah Moser @sarahmoser.bsky.social · Aug 13

This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.

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Reposted by Abdel Mazouzi

Sarah Moser @sarahmoser.bsky.social · Aug 13

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

www.nature.com

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Reposted by Abdel Mazouzi

Craig Kaplan @triggerloop.bsky.social · Aug 13

Extremely cool!

Sarah Moser @sarahmoser.bsky.social · Aug 13

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

www.nature.com

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Abdel Mazouzi @amazouzi.bsky.social · Aug 14

Thank you for sharing!

Reposted by Abdel Mazouzi

Barbara Marte @barbmarte.bsky.social · Aug 14

new out in Nature yesterday www.nature.com/articles/s41...

NASP modulates histone turnover to drive PARP inhibitor resistance - Nature

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

www.nature.com

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Abdel Mazouzi @amazouzi.bsky.social · Aug 13

Here is the link to get the PDF of our paper in case you don’t have access to Nature: rdcu.be/eAChv

NASP modulates histone turnover to drive PARP inhibitor resistance

Nature - PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

rdcu.be

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Abdel Mazouzi @amazouzi.bsky.social · Aug 13

Thanks Sabrina!

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Abdel Mazouzi @amazouzi.bsky.social · Aug 13

Thanks Andre!

Abdel Mazouzi @amazouzi.bsky.social · Aug 13

I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.

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Di Jiang @dijiang319.bsky.social · Jul 8

@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/...
@rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.

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Danielle Bianchi @daaninthelab.bsky.social · Jul 4

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression

Zinc finger proteins (ZNFs) are the largest family of transcription factors, yet how they activate gene expression remains unclear. In this study, we identified Zincore, a protein complex consisting o...

www.science.org

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Netherlands Cancer Institute @nkinl.bsky.social · Jun 27

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research.

Congrats Thijn! 🎉 @thijnbrummel.bsky.social

Full article ➡️ bit.ly/40p4KnK

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puckknipscheer.bsky.social @puckknipscheer.bsky.social · Jun 13

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

RNA transcripts regulate G-quadruplex landscapes through G-loop formation

G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...

www.science.org

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Ryohei Thomas Nakano (Hokudai) @luckystrike1984.bsky.social · Jun 6

Hey my fellow Germans! I wasn't aware, but there is an AvH-JSPP postdoc fellowship, dedicated to German citizens aiming to do their postdoc in Japan. It covers salary + travel to Japan + startup for your life in Japan. Let me know if you are interested!
www.humboldt-foundation.de/en/apply/spo...

JSPS Research Fellowship

The Japan Society for the Promotion of Science (JSPS) Research Fellowship supports you as a highly qualified postdoc from Germany in conducting your research in Japan – regardless of discipline.

www.humboldt-foundation.de

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Abdel Mazouzi @amazouzi.bsky.social · Jun 2

Great news from The ERC : erc.europa.eu/news-events/...:

Abdel Mazouzi @amazouzi.bsky.social · Mar 21

Really cool story highlighting one of the most beautiful genetic suppression interactions between SRBD1 and condensin II! #CoolScience
www.linkedin.com/feed/update/...

SRBD1, a highly conserved gene required for chromosome individualization | Jonne Raaijmakers

Excited to share our latest publication in Cell Reports! Our study reveals the critical role of SRBD1, a highly conserved and previously enigmatic essential…

www.linkedin.com

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