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Reposted by Anand Vaidya

American Journal of Hypertension @amjhypertension.bsky.social · 5d

#WeekendReads from the Advance Articles section

Time to retire Aldosterone Suppression Testing?

academic.oup.com/ajh/advance-...

Is It Time to Retire Aldosterone Suppression Testing?

Abstract. Primary aldosteronism (PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving nonsuppressibility of aldost

academic.oup.com

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Anand Vaidya @anandvaidya17.bsky.social · Sep 7

academic.oup.com/ajh/advance-...

Is it time to retire confirmatory testing for primary aldosteronism?

Abstract. Primary aldosteronism(PA) is the most common endocrine hypertension. For decades, PA diagnosis has required proving non-suppressibility of aldost

academic.oup.com

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Anand Vaidya @anandvaidya17.bsky.social · Sep 7

Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process

academic.oup.com/ejendo/artic...

Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism

AbstractBackground. The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary ald

academic.oup.com

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Anand Vaidya @anandvaidya17.bsky.social · Sep 7

To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension.

www.jacc.org/doi/10.1016/...

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Reposted by Anand Vaidya

JAMA @jama.com · Sep 1

Adrenal insufficiency is a syndrome of cortisol deficiency.

This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis.

ja.ma/3HKk9Jr

An illustration from JAMA's review on adrenal insufficiency, dated June 16, 2025, showing normal and impaired hypothalamic-pituitary-adrenal axis physiology with mechanisms leading to adrenal insufficiency.

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Anand Vaidya @anandvaidya17.bsky.social · Sep 1

Yes!

American Journal of Hypertension @amjhypertension.bsky.social · Aug 31

#WeekendReads from #EditorsChoice

Can you have normal looking adrenal glands with primary aldosteronism?

🔗 academic.oup.com/ajh/article/... 🔓

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism

AbstractBackground. Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (

academic.oup.com

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Reposted by Anand Vaidya

Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · Aug 29

Don't miss the preprint from:
@alice.soragnilab.com
@michaelyehmd.bsky.social
@anandvaidya17.bsky.social
@nicolebechmann.bsky.social

🏥
@uthealthsa.bsky.social
@dgsomucla.bsky.social
@harvardmed.bsky.social
@mdanderson.bsky.social
@tudresden.bsky.social

www.biorxiv.org/content/10.1...

Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas

Pheochromocytomas and paragangliomas (PPGLs) are rare chromaffin cell-derived neuroendocrine tumors of sympathetic (catecholamine-producing) or parasympathetic (nonsecretory) origin, frequently driven...

www.biorxiv.org

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Reposted by Anand Vaidya

Jia Luo, MD @jia-luo.bsky.social · Aug 8

🩺 In NEJM, our interactive case on a common CC - evaluation of a patient with new pulmonary symptoms www.nejm.org/doi/full/10....

Congrats to star fellow Dr Joanne I. Hsu for leading & wonderful to learn from expert multi-D colleagues @anandvaidya17.bsky.social @harvardmed.bsky.social @nejm.org

NEJM.org @nejm.org · Jul 28

A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL

Interactive Medical Case
A Case of Crackles

An illustration of the patient coughing in bed and her husband caring for her

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Reposted by Anand Vaidya

NEJM.org @nejm.org · Jul 28

A 59-year-old woman presented to the emergency department with a 1-week history of profound fatigue, nonproductive cough, confusion, and decreased oral intake. The night before presentation, she began to have chills and night sweats. Learn more and test your skills: nej.md/4mcUHuL

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Reposted by Anand Vaidya

Adina Turcu @adinaturcu.bsky.social · Aug 28

#ENDO2026 Welcomes Your Ideas | Our annual meeting will take place in Chicago, IL, June 13–16, and I’m inviting YOU to shape the program💡Submit your symposium proposal or session suggestion by Tuesday, September 2: bit.ly/4flCMjl
#endocrinology @TheEndoSociety

ENDO 2026 Session Submissions

ENDO wouldn’t be possible without the insight and expertise of the Endocrine community. Your ideas are essential to building a dynamic, forward-thinking program that reflects the full breadth of our f...

bit.ly

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Reposted by Anand Vaidya

Josh Leisring @joshleisring.bsky.social · Jul 28

1/ Even outside of AVS the intra-individual variability of plasma aldo is important. Another study with the same message. www.ahajournals.org/doi/10.1161/...

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Reposted by Anand Vaidya

American Journal of Hypertension @amjhypertension.bsky.social · Jul 24

#ThrowbackThursday

Variability of Aldosterone concentration while performing AVS

academic.oup.com/ajh/article/...

#Free #EditorsCHoice

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Anand Vaidya @anandvaidya17.bsky.social · Jul 20

Subclinical Primary Aldosteronism and MACE

www.ahajournals.org/doi/10.1161/...

Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study | Circulation

BACKGROUND: Primary aldosteronism (PA), an overt form of renin-independent aldosterone production, leads to a disproportionately high rate of major adverse cardiovascular events (MACEs). Mounting evid...

www.ahajournals.org

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Anand Vaidya @anandvaidya17.bsky.social · Jul 18

You were right the first time!

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Anand Vaidya @anandvaidya17.bsky.social · Jul 17

www.acpjournals.org/doi/10.7326/... Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 178, No 7

www.acpjournals.org

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Anand Vaidya @anandvaidya17.bsky.social · Jul 15

New Primary Aldosteronism Guidelines - simpler, streamlined, and hopefully more pragmatic
academic.oup.com/jcem/advance...

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Anand Vaidya @anandvaidya17.bsky.social · Jul 3

The Impact of Modern Industrialized Dietary Sodium Intake on the Plasma Proteome

academic.oup.com/ajh/advance-...

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Anand Vaidya @anandvaidya17.bsky.social · Jun 21

A pragmatic approach to evaluate for ADRENAL INSUFFICIENCY

Thanks to @irinabancos.bsky.social and Jay Findling for lending their expertise!

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Anand Vaidya @anandvaidya17.bsky.social · Jun 16

Adrenal Insufficiency

JAMA @jama.com · Jun 16

Adrenal insufficiency is a syndrome of cortisol deficiency.

This Review summarizes the pathophysiology of adrenal insufficiency and approaches to diagnosis, treatment, and prevention of adrenal crisis.

https://ja.ma/43Zy2ui

Figure 1. Pathophysiology of Adrenal Insufficiency

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Anand Vaidya @anandvaidya17.bsky.social · May 17

For the minority of ppl with purely unilateral disease, RFA transcutaneous or EUS is a great option. But for all the rest, I suspect ASI will be the game changer. Medical “aldosteronectomy”

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Anand Vaidya @anandvaidya17.bsky.social · May 6

and this SR/MA that makes the point: www.ahajournals.org/doi/10.1161/...

Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis | Hypertension

Background: Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear. Methods: We searched Medline, EMBASE, and the Cochrane Central Register o...

www.ahajournals.org

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Anand Vaidya @anandvaidya17.bsky.social · May 6

would suggest the following approach that obviates need for "confirmatory" testing
www.nejm.org/doi/full/10....

Targeting a Hormonal Cause of Hypertension | NEJM

This interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnost...

www.nejm.org

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Anand Vaidya @anandvaidya17.bsky.social · May 6

yes, same. as seen in this study: www.acpjournals.org/doi/abs/10.7...

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Anand Vaidya @anandvaidya17.bsky.social · May 6

Beautiful study. Stop the madness.
Low-renin hypertension is by far and away some manifestation of primary aldosteronism pathophysiology. Even if you get caught up in names and definitions and can't accept this, it responds beautifully to MR antagonist therapy, so just do the right thing.

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · May 6

In the @annalsofim.bsky.social

www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team

Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)

#NephSky #EndoSky

Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0

Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...

www.acpjournals.org

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Reposted by Anand Vaidya

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · May 6

In the @annalsofim.bsky.social

www.acpjournals.org/doi/10.7326/... from @ucalgarymed.bsky.social team

Saline suppression test not useful in confirming primary #aldosteronism - go straight to AVS if planning Sx (and ramp up MRA to target renin if Medical management)

#NephSky #EndoSky

Confirmatory Testing for Primary Aldosteronism: A Study of Diagnostic Test Accuracy: Annals of Internal Medicine: Vol 0, No 0

Background: Confirmatory testing to verify the diagnosis of primary aldosteronism (PA) in patients who have an abnormal screening result is of uncertain benefit. Objective: To perform a blinded assess...

www.acpjournals.org

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