Annalaura Mastrangelo
@annalaura-m.bsky.social
390 followers 130 following 17 posts
Researcher at CNIC Madrid, member of award committee #FeMS. Passion for #Metabolomics, #Microbiome & #CVD, #Obesity #InsulinResistance #Immunometabolism #Biostatistics fascinated & travelholic
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annalaura-m.bsky.social
Just gave a seminar for the Master in Bioinformatics program at @uam.es sharing our work on ImP in #CVD and new #bioinformaticstools for #metabolomics data. It is always rewarding to share science with future researchers!
Reposted by Annalaura Mastrangelo
natureportfolio.nature.com
“We are closer than ever to the day when a diagnosis of Alzheimer’s disease stops being a death sentence — but only if we continue to support researchers and enable their ability to work with one another,” writes Bill Gates in a World View article for Nature Medicine. #medsky 🧪
Global collaboration is key to decoding Alzheimer’s disease
Recent progress on Alzheimer’s disease shows what we gain when scientists work together — and what the world loses when bad policies force them apart.
go.nature.com
Reposted by Annalaura Mastrangelo
sancholab.bsky.social
Fantástico resumen por @manuelansede.bsky.social
🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón €
🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab
🙏 @erc.europa.eu ERC-CoG ERC-POC
#CNIC_CARDIO

Open acess: www.nature.com/articles/s41...
Reposted by Annalaura Mastrangelo
sancholab.bsky.social
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
Reposted by Annalaura Mastrangelo
caixaresearch.bsky.social
Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis.

Descubre más de la mano de uno de los investigadores del equipo 👇🧬
sancholab.bsky.social
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
annalaura-m.bsky.social
Thank you to my co-author @iroblesv.bsky.social and
@sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!
annalaura-m.bsky.social
This discovery opens exciting new directions in the field, bridging the gut #microbiomesky, #immunosky & #cardiosky.
👀 And it all started with a simple #untargeted #metabolomics experiment!
annalaura-m.bsky.social
Take-home messages:
- ImP is elevated in early and active atherosclerosis in asymptomatic volunteers
- ImP induces atherosclerosis in atheroprone mice
- ImP signals via imidazoline 1 receptor (I1R)
- Blocking the ImP/I1R axis in myeloid cells halts disease progression.
annalaura-m.bsky.social
🌟Proud to share our latest research: "Imidazole propionate (ImP) is a driver therapeutic target in atherosclerosis" in
@nature.com A step toward early diagnosis & targeted therapy in cardiovascular care! #metabolites #impact #PersonalizedMedicine 👇🧵https://www.nature.com/articles/s41586-025-09263-w
Reposted by Annalaura Mastrangelo
metabomichael.bsky.social
Have you missed #MetSoc25? Join us for our Munich Metabolomics Meeting. We still have open seats and talk slots! Be fast, they will be taken soonish 😜 Register and submit your abstract under www.munichmetabolomics.com #metabolomics #lipidomics
metabomichael.bsky.social
#ASMS2025 is around the corner, #MetSoc2025 is coming up soon... And if you don't have enough or you might missing out on these two, please consider this year's Munich Metabolomics Meeting. Registration is now open. We have @pluskal-lab.org as wonderful keynote speaker www.munichmetabolomics.com
Munich Metabolomics Meeting
Save the Date! The Munich Metabolomics Meeting 2025 is coming up! Dates: 9-10.10.2025 Venue: TUM School of Life Sciences - Freising
www.munichmetabolomics.com
annalaura-m.bsky.social
Since 1869, Nature's journal has been delivering some of the coolest science out there. Big thanks to the editor George Caputa for sharing a behind-the-scenes look super insightful and inspiring! 🧠🔬🌍 #NatureJournal #BehindTheScenes
Reposted by Annalaura Mastrangelo
santoshlamichhane.bsky.social
There so much to learn what microbes are doing inside us. Glad to be part of this work, thanks to Pieter and the whole team.
Reposted by Annalaura Mastrangelo
pieterdorrestein.bsky.social
This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...
Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...
www.cell.com
Reposted by Annalaura Mastrangelo
mannlab.bsky.social
Check out ADAPT-MS: our flexible, scalable diagnostic framework that transforms discovery plasma proteomics directly into clinical decisions.Dynamic retraining enables single-sample diagnostics for any clinical question.
www.medrxiv.org/content/10.1...
Reposted by Annalaura Mastrangelo
natureportfolio.nature.com
A study in Nature Immunology uses a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppressed phases of systemic inflammation. go.nature.com/44bj71Y
This is figure 2, which shows single-cell characterization of the acute hyperinflammatory response to LPS administration.
Reposted by Annalaura Mastrangelo
erictopol.bsky.social
New @science.org
Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective
www.science.org/doi/10.1126/...
Reposted by Annalaura Mastrangelo
natureportfolio.nature.com
A Review in Nature Medicine summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field. go.nature.com/42LUmrU 🔒
This is figure 1, which shows illustrating mechanisms, metrics and modifiers through the example of IBD.
annalaura-m.bsky.social
Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero
annalaura-m.bsky.social
Insightful talk by Maria Mittelbrunn: T cells are key drivers of aging! Dysfunctional T cells trigger inflammaging, accelerating tissue senescence and age-related diseases. Today at the #ImmunoAthero meeting #TCellAging #Inflammaging
Reposted by Annalaura Mastrangelo
drjwdietrich.bsky.social
Interestingly, both subclinical #hypothyroidism and #thyrotoxicosis predict #MACE. The free thyroxine (FT4) concentration is more associated with the HR for cardiovascular events than thyrotropin (TSH) levels. Our observations yield an integrated model including psychosocial and somatic mechanisms.
An integrated model for the association between thyroid homeostasis and major cardiovascular events. In the dyshomeostatic type of thyrogenic arrhythmia elevated FT4 concentration, caused by primary thyrotoxicosis, increases the risk for severe arrhythmia as a major cause for cardiovascular mortality. The TSH concentration is reduced in this case, represented by the left, declining, branch of the U-shaped relation between TSH level and risk (A). In the allostatic type, mainly caused by type 2 allostatic load and genetic traits, the set point of thyroid homeostasis is raised, resulting in increased TSH and FT4 concentration and subsequently elevated risk for arrhythmia. This situation is mirrored in the right, rising, branch of the relation between TSH concentration and cardiovascular risk (B). In any case, elevated concentrations of T3, T4 and other T3-agonistic thyroid hormones increase the sensitivity to catecholamines and sympathetic signaling (via upregulated expression of beta1 and beta2 adrenoceptors), thereby contributing to reduced stress tolerance. SPINA-GT, “gain of thyroid,” i.e., thyroid’s secretory capacity.