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Anne Chevallereau

@annechevallereau.bsky.social

1.1K followers 360 following 46 posts

Group leader @CNRS, @MMSB (Lyon, France) studying how viruses interact and evolve with other MGE and with their host #bacterial_immunity #sociovirology #phages #Pseudomonas.

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Anne Chevallereau @annechevallereau.bsky.social · Aug 7

📝New preprint!

We investigated how spatial structure affects cooperation between phages, combining mathematical modelling and experiments.

A short thread 🧶

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Aug 7

The ambivalent effect of spatial structure on the spread of cooperative anti-CRISPR phages https://www.biorxiv.org/content/10.1101/2025.08.06.668856v1

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Reposted by Anne Chevallereau

CNRS Biologie @cnrsbiologie.bsky.social · 1d

#ResultatScientifique 🔎| Le complexe CST protège l’ADN en réparant les cassures même après dégradation partielle, limitant ainsi les mutations dangereuses 🧬
✍️ @zhouxu.bsky.social
📕 @CellGenomics | buff.ly/84geAXj

Le complexe CST, un acteur inattendu de la réparation de l’ADN

Réparer l’ADN endommagé est un processus essentiel à l’intégrité du génome, qui peut être dérégulé dans les cancers.

www.insb.cnrs.fr

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Reposted by Anne Chevallereau

Vaughn Cooper @vscooper.micropopbio.org · 6d

DYK most P. aeruginosa carry filamentous phage(s) that don't need to kill the cell to reproduce?

We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE.

"Filamentous cheater phages drive bacterial and phage populations to lower fitness"

🔗 authors.elsevier.com/c/1lt5I3QW8S...

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Reposted by Anne Chevallereau

CNRS Rhône Auvergne @cnrs-rhoneauvergne.bsky.social · 7d

#Évènement🎟️|
Lancement de la 3️⃣ème saison des #ÉchappéesInattendues du @cnrs.fr avec la conférence immersive de Jean-Michel Jault, biologiste au @mmsb-lyon.bsky.social sur l’antibiorésistance 🧫 des bactéries 🦠 pour la #FDS2025

📅 11 octobre
🕢 à 17h30
✔️ sur inscription : bit.ly/confmmsb

#FDSAURA

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Reposted by Anne Chevallereau

Martial Marbouty @mmarbout.bsky.social · 19d

You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range.
@rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social

www.nature.com/articles/s41...

Phages with a broad host range are common across ecosystems - Nature Microbiology

Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.

www.nature.com

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Reposted by Anne Chevallereau

Agathe couturier @agathe-couturier.bsky.social · 21d

Exclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes.

@nfrk92.bsky.social
@narjournal.bsky.social

academic.oup.com/nar/article/...

Exclusion systems preserve host cell homeostasis and fitness, ensuring successful dissemination of conjugative plasmids and associated resistance genes

Abstract. Plasmid conjugation is a major driver of antibiotic resistance dissemination in bacteria. In addition to genes required for transfer and maintena

academic.oup.com

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Reposted by Anne Chevallereau

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 22d

YprA family helicases provide the missing link between diverse prokaryotic immune systems https://www.biorxiv.org/content/10.1101/2025.09.15.676423v1

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Reposted by Anne Chevallereau

Alice Maestri @alicemaestri.bsky.social · 26d

We're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded.

Link to the job emploi.pasteur.fr/offre-de-emp...
Thx for sharing!

INSTITUT PASTEUR - Technicien de recherche Microbiologie H/F

emploi.pasteur.fr

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Anne Chevallereau @annechevallereau.bsky.social · 28d

Best cake ever!
Thanks to my wonderful team 😍

Anne Chevallereau @annechevallereau.bsky.social · Sep 8

Hilarious ! Death by conjugation is very common in French 😂

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Reposted by Anne Chevallereau

Zamin Iqbal @zaminiqbal.bsky.social · Sep 7

For anyone who has used pling for comparing plasmids using rearrangement distances ("how many structural events apart are these plasmids"), here's how to tweak parameters, and integrate it with typing info, and the host phylogeny
www.biorxiv.org/content/10.1...
github.com/iqbal-lab-or...

Clustering of plasmid genomes for genomic epidemiology by using rearrangement distances, with pling

Integration of plasmids into genomic epidemiology is challenging, because there are no clearly defined evolving-units (equivalent to species), and because plasmids appear to evolve as much by structur...

www.biorxiv.org

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Reposted by Anne Chevallereau

Eduardo Rocha @epcrocha.bsky.social · Sep 3

At last ! A tool specifically for phage-plasmid hunters. Check tyPPing by @karinailchenko.bsky.social and @eugenpfeifer.bsky.social

Karina Ilchenko @karinailchenko.bsky.social · Sep 3

🚨 New preprint! 🧬

𝐏𝐡𝐚𝐠𝐞-𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 (𝐏-𝐏𝐬) are fascinating elements: both 𝐭𝐞𝐦𝐩𝐞𝐫𝐚𝐭𝐞 𝐩𝐡𝐚𝐠𝐞𝐬 and 𝐩𝐥𝐚𝐬𝐦𝐢𝐝𝐬 ➡️ tricky to detect.

We present 𝐭𝐲𝐏𝐏𝐢𝐧𝐠 — the first 𝐢𝐝𝐞𝐧𝐭𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐜𝐥𝐚𝐬𝐬𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐭𝐨𝐨𝐥 🛠️designed specifically for P-Ps:
✅ Accurate
✅ Sensitive
✅ Easy to use

📖 www.biorxiv.org/content/10.1...

Efficient detection and typing of phage-plasmids

Phage-plasmids are temperate phages that replicate as plasmids during lysogeny. Despite their high diversity, they carry genes similar to phages and plasmids. This leads to gene exchanges, and to the ...

www.biorxiv.org

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Reposted by Anne Chevallereau

Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Sep 6

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters

Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.

www.science.org

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Reposted by Anne Chevallereau

Julie Le Bris @julielebris.bsky.social · Sep 5

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio

The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

journals.asm.org

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Anne Chevallereau @annechevallereau.bsky.social · Sep 5

Thank you Ellinor! 💜

Anne Chevallereau @annechevallereau.bsky.social · Sep 5

Happy to see our paper out!

Functional assessment of anti-phage defence systems in their native clinical E. coli host
royalsocietypublishing.org/doi/10.1098/...

Thread in previous post 👇

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Reposted by Anne Chevallereau

Benoit Pons @benoitjpons.bsky.social · Sep 4

How do bacteria choose what type of defences to use against phages? We explored that question in the last paper I worked on as a postdoc at the Uni of Exeter @uniofexeteresi.bsky.social with Stineke van Houte, Stefano Pagliara and Edze Westra (not on Bluesky)
doi.org/10.1098/rstb...

Phage provoke growth delays and SOS response induction despite CRISPR-Cas protection | Philosophical Transactions of the Royal Society B: Biological Sciences

Bacteria evolve resistance against their phage foes with a wide range of resistance strategies whose costs and benefits depend on the level of protection they confer and on the costs for maintainance....

doi.org

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Anne Chevallereau @annechevallereau.bsky.social · Sep 4

Thank you to everyone who’s supported this journey so far — collaborators, students, mentors, friends - and to funding programs that have made this adventure possible !

We’re just getting started — more curiosity, more chaos (the good kind), and way more science to come! 💥💡

Anne Chevallereau @annechevallereau.bsky.social · Sep 4

🎉🧪 The MEEP lab @mmsb.cnrs.fr celebrates its first anniversary!

A year of experiments, caffeine-fueled late nights, and nerdy excitement. 🚀🔬

I'm very grateful to the team of amazing #WomenInScience who joined this incredible journey
@josie-e.bsky.social
Clarisse Plantady and Elodie Kenck.

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Reposted by Anne Chevallereau

Josie Elliott @josie-e.bsky.social · Sep 4

Can CRISPR-Cas systems target any phage? Yes, no, it depends? What does it depend on? The second paper from my PhD came out today in a special issue of Phil Trans B on the ecology and evolution of bacterial immune systems
doi.org/10.1098/rstb...

Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system in Pseudomonas aeruginosa is nutrient dependent | Philosophical Transactions of the Royal Society B: Biological Sciences

CRISPR-Cas systems can provide adaptive, heritable immunity to their prokaryotic hosts against invading genetic material such as phages. It is clear that the importance of acquiring CRISPR-Cas immunit...

doi.org

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Reposted by Anne Chevallereau

CNRS Biologie @cnrsbiologie.bsky.social · Sep 4

#ResultatScientifique🔎| Des scientifiques ont révélé comment le plasmide pOXA-48 rend les bactéries ultra-résistantes aux antibiotiques 🦠
🤝 @cnrs.fr @mmsb-lyon.bsky.social @cnrs-rhoneauvergne.bsky.social
✍️ @sbigot.bsky.social
📕 @natcomms.nature.com | buff.ly/u3Cy4Db

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Reposted by Anne Chevallereau

Kaitlin Schaal @evokait.bsky.social · Sep 3

Plasmids can be lost from a bacterial community even under positive environmental selection: doi.org/10.1101/2025...

Species interactions determine plasmid persistence in a 3-member bacterial community

Microbial communities are shaped by complex forces, including interspecies interactions and the effects of mobile genetic elements such as plasmids. How these forces interact to affect community respo...

doi.org

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Reposted by Anne Chevallereau

Jan-Willem Veening @veeninglab.com · Sep 3

Cool preprint by Mathieu Berge @polardlab.bsky.social showing that the Spr1630 toxin (RipA) toxin targets the replication sliding-clamp (DnaN) and that this induces competence in Streptococcus pneumoniae. www.biorxiv.org/content/10.1...

A toxin/antitoxin system targeting the replication sliding-clamp induces competence in Streptococcus pneumoniae.

Streptococcus pneumoniae is a pathogenic bacterium capable of entering a cellular differentiation state, called competence, which enables it to acquire new genetic functions by natural transformation,...

www.biorxiv.org

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Reposted by Anne Chevallereau

CNRS @cnrs.fr · Sep 2

#CNRSnews 📰 As antibiotic resistant bacteria are proliferating, causing millions of deaths worldwide, scientists are turning to a century-old, neglected solution: that of using bacteriophage viruses, which only attack bacteria

CNRS News

Few weapons are available to fight antibiotic-resistant bacteria, which continue to cause millions of deaths. However, scientists are currently resuscitating a century-old solution, bacteriophages,

news.cnrs.fr

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Anne Chevallereau @annechevallereau.bsky.social · Aug 25

@mmsb-lyon.bsky.social

Reposted by Anne Chevallereau

Guzzo lab - Lyon @mguzzo.bsky.social · Aug 24

Check out the first preprint from our lab describing a direct molecular cross-talk between (p)ppGpp and c-di-GMP nucleotide messengers! Great work from first-author Corentin Jaboulay who was a postdoc in our lab, and great collaborations! @mmsb-lyon.bsky.social @cnrsbiologie.bsky.social

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · Aug 24

Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition https://www.biorxiv.org/content/10.1101/2025.08.22.671821v1

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