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Reposted by Alfonso Santos Lopez

Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 1h

Nuestro compañero Álvaro San Millán (@sanmillan.bsky.social), investigador en el #CNB_CSIC ha recibido el Premio María Moliner, que reconoce la labor de quienes se inician en la dirección de tesis doctorales, destacando su compromiso en el acompañamiento del talento emergente.

¡Enhorabuena!👏

CSIC @csic.es · 6h

🏆 El #CSIC entrega las Medallas Margarita Salas, Premios Tesis Relevante y Premios María Moliner

🔬 Con estos galardones, la institución reafirma su compromiso con la excelencia investigadora, el aprendizaje y la formación de nuevas generaciones

👉 https://f.mtr.cool/zledhiknbb

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Reposted by Alfonso Santos Lopez

Michael Brockhurst @brockhurstlab.bsky.social · 3d

New preprint!

Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠

Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!

An epic effort by Rosanna Wright

www.biorxiv.org/content/10.1...

Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages

Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...

www.biorxiv.org

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Reposted by Alfonso Santos Lopez

Adrian Cazares @cazares-adr.bsky.social · 3d

Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics

We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...

If you like time travel & biology, this 🧵is for you👇

Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance

Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...

doi.org

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Alfonso Santos Lopez @asantoslopez.bsky.social · 6d

I love this paper. Congrats!!

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Reposted by Alfonso Santos Lopez

Nanami Kubota @nanamikubota.bsky.social · 6d

Published in Current Biology! P. aeruginosa can use its filamentous phage to inhibit competitors but high phage production is susceptible to cheater miniphage invasion. Subsequent phage tragedy of the commons can lower bacteria and phage fitness. Link: authors.elsevier.com/c/1lt5I3QW8S...

Nanami Kubota @nanamikubota.bsky.social · Apr 2

Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons
@shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...

Filamentous cheater phages drive bacterial and phage populations to lower fitness

Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...

www.biorxiv.org

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Reposted by Alfonso Santos Lopez

Michael Baym @baym.lol · 7d

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Reposted by Alfonso Santos Lopez

Vaughn Cooper @vscooper.micropopbio.org · 9d

View from the lab now. Did I mention that we are recruiting faculty microbiologists?

www.linkedin.com/posts/vaughn...

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Alfonso Santos Lopez @asantoslopez.bsky.social · 10d

This is awesome! Congrats!

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Reposted by Alfonso Santos Lopez

Zamin Iqbal @zaminiqbal.bsky.social · 13d

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n

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Reposted by Alfonso Santos Lopez

Vaughn Cooper @vscooper.micropopbio.org · 15d

🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...

Faculty Professor Associate - Full-Time | Vaughn Cooper

We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...

www.linkedin.com

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Reposted by Alfonso Santos Lopez

Macarena Toll-Riera @mtoll8.bsky.social · 29d

We are hiring a PhD student! Are you fascinated by microbes and evolution? Come join us in Barcelona!

Institut de Biologia Evolutiva (IBE) @ibe-barcelona.bsky.social · 29d

#WeAreHiring

📣 The #IBE_Barcelona is seeking a #PhD Student for the Evolutionary #Microbiology Lab.🔬🧫

⏳ Apply before September 30th and #JoinOurTeam!

#UnravellingEvolution #ConservingBiodiversity

✍ https://www.ibe.upf-csic.es/work-with-us/job-offers

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Reposted by Alfonso Santos Lopez

José R Penadés @jrpenades.bsky.social · 29d

Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...

AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution

By solving a previously unsolved biological question, the AI co-scientist predicted a complex mechanism of gene transfer and generated hypotheses that opened new research directions, illustrating AI's...

www.cell.com

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Reposted by Alfonso Santos Lopez

Lingchen He 何灵尘 @lingchenhe.bsky.social · 29d

We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social

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Reposted by Alfonso Santos Lopez

Olaya Rendueles @olayarendueles.bsky.social · Sep 9

Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social

This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky

Julie Le Bris @julielebris.bsky.social · Sep 5

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio

The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

journals.asm.org

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Reposted by Alfonso Santos Lopez

Johan Jakobsson @jakobssonlab.bsky.social · Sep 7

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.

www.biorxiv.org/content/10.1...

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease

Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...

www.biorxiv.org

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Alfonso Santos Lopez @asantoslopez.bsky.social · Aug 30

Ole ole!

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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · Aug 26

El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.

https://f.mtr.cool/rnstpoiucs

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Reposted by Alfonso Santos Lopez

Jorge Sastre Domínguez @jorgesastred.bsky.social · Aug 22

Extremely glad to see this out!!

Wonderful work by all the lab, especially @aliciapcv.bsky.social. Don't miss her thread!!

Alicia Calvo-Villamañán @aliciapcv.bsky.social · Aug 20

This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

rdcu.be

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Reposted by Alfonso Santos Lopez

Patricia Bernal @pbernalt6ss.bsky.social · Aug 15

New prepint ‼️

We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es

www.biorxiv.org/content/10.1...

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Alfonso Santos Lopez @asantoslopez.bsky.social · Aug 13

#TEsky #microsky #plasmidsky #AMRsky

Alfonso Santos Lopez @asantoslopez.bsky.social · Aug 13

This manuscript is the result of a wonderful collaborative effort with the one and only @sanmillan.bsky.social and his brilliant team.
I’m especially proud — it’s the second paper from my lab, with many students involved, and collaborating with friends is always a joy.

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Alfonso Santos Lopez @asantoslopez.bsky.social · Aug 13

Our new manuscript is out! A bit of everything cool:

Plasmids ✅
Insertion Sequences ✅
AMR Evolution ✅
Microbial Communities ✅
Databases analyses ✅
Mathematical modeling ✅

See the scientific thread below of Jorge Sastre, who has brilliantly led this work with @palomarodera.bsky.social

Jorge Sastre Domínguez @jorgesastred.bsky.social · Aug 13

New paper out! 🔈🔈📣📣

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.

Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻

www.biorxiv.org/content/10.1...

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

www.biorxiv.org

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Reposted by Alfonso Santos Lopez

Alvaro San Millan @sanmillan.bsky.social · Aug 4

Oxygen levels can affect how resistance genes work, impacting antibiotic efficacy. This can be relevant for the most used ones: for example, resistance to fosfomycin varies with oxygen.

Learn more in our latest paper 👉 bit.ly/3T8sdpp a work led by @jaescudero.bsky.social

#AntibioticResistance

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Reposted by Alfonso Santos Lopez

Craig MacLean @craigmaclean.bsky.social · Jul 29

New pre-print from my lab!
Plasmids link antibiotic resistance and phage defense.

E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage

www.biorxiv.org/content/10.1....

Plasmids link antibiotic resistance genes and phage defense systems in E. coli

Phage therapy has been proposed as an alternative to antibiotics to treat resistant infections. However, we have a limited understanding of how antibiotic resistance genes (ARGs) associate with bacter...

www.biorxiv.org

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Reposted by Alfonso Santos Lopez

Ana Elena Pérez-Cobas @anaelenaperezcobas.bsky.social · Apr 29

New mini-review on the respiratory microbiome and its contribution to human health from biotechnology 🫁🦠
@tmcoque.bsky.social @microbiotech.bsky.social
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

The Respiratory Tract Microbiome and Human Health

The respiratory tract microbiome (RTM) trains the immune system and protects against infections. Changes in the RTM are linked to various respiratory diseases. High-throughput methodologies and compu...

enviromicro-journals.onlinelibrary.wiley.com

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