Alfonso Santos Lopez
@asantoslopez.bsky.social
Evolution of antibiotic resistance. Ramón y Cajal Fellow at Universidad Autónoma de Madrid. https://amrevolution.es/
Pinned
New paper out! 🔈🔈📣📣
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.
Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻
www.biorxiv.org/content/10.1...
Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation
Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...
www.biorxiv.org
Our new manuscript is out! A bit of everything cool:
Plasmids ✅
Insertion Sequences ✅
AMR Evolution ✅
Microbial Communities ✅
Databases analyses ✅
Mathematical modeling ✅
See the scientific thread below of Jorge Sastre, who has brilliantly led this work with @palomarodera.bsky.social
Plasmids ✅
Insertion Sequences ✅
AMR Evolution ✅
Microbial Communities ✅
Databases analyses ✅
Mathematical modeling ✅
See the scientific thread below of Jorge Sastre, who has brilliantly led this work with @palomarodera.bsky.social
Reposted by Alfonso Santos Lopez
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
November 20, 2025 at 10:12 PM
What is the best strategy to win any contest?
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Eliminate your opponents of course.
Recently, my friend @fernpizza.bsky.social showed how plasmids compete intracellularly (check out his paper published in Science today!). With @baym.lol, we now know they can fight.
www.biorxiv.org/content/10.1...
Reposted by Alfonso Santos Lopez
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alfonso Santos Lopez
🚨 Excited to share our new paper is out! 🎉
We show how interactions within gut microbiomes allow certain antibiotic-resistant E. coli strains to persist even without antibiotics, helping explain how resistance is maintained in the human gut.
Now published in @natcomms.nature.com rdcu.be/eOf63
We show how interactions within gut microbiomes allow certain antibiotic-resistant E. coli strains to persist even without antibiotics, helping explain how resistance is maintained in the human gut.
Now published in @natcomms.nature.com rdcu.be/eOf63
Multi-layered ecological interactions determine growth of clinical antibiotic-resistant strains within human microbiomes
Nature Communications - The role of ecological factors in modulating the spread of antibiotic-resistance bacteria in the gut remains unclear. Here, the authors use anaerobic microcosms to study the...
rdcu.be
November 7, 2025 at 9:15 AM
🚨 Excited to share our new paper is out! 🎉
We show how interactions within gut microbiomes allow certain antibiotic-resistant E. coli strains to persist even without antibiotics, helping explain how resistance is maintained in the human gut.
Now published in @natcomms.nature.com rdcu.be/eOf63
We show how interactions within gut microbiomes allow certain antibiotic-resistant E. coli strains to persist even without antibiotics, helping explain how resistance is maintained in the human gut.
Now published in @natcomms.nature.com rdcu.be/eOf63
Do plasmids really move around that much? Well, maybe not always
Thrilled to have contributed to this story with two of my favourite microbiologists: @jrpenades.bsky.social & @sanmillan.bsky.social
This great work was led by Akshay Sabnis & @wfigueroac3.bsky.social
www.cell.com/cell-reports...
Thrilled to have contributed to this story with two of my favourite microbiologists: @jrpenades.bsky.social & @sanmillan.bsky.social
This great work was led by Akshay Sabnis & @wfigueroac3.bsky.social
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While
increased mobility can easily evolve by incorporating phage DNA into plasmids, this
is disadvantageous because it...
www.cell.com
October 22, 2025 at 5:47 PM
Do plasmids really move around that much? Well, maybe not always
Thrilled to have contributed to this story with two of my favourite microbiologists: @jrpenades.bsky.social & @sanmillan.bsky.social
This great work was led by Akshay Sabnis & @wfigueroac3.bsky.social
www.cell.com/cell-reports...
Thrilled to have contributed to this story with two of my favourite microbiologists: @jrpenades.bsky.social & @sanmillan.bsky.social
This great work was led by Akshay Sabnis & @wfigueroac3.bsky.social
www.cell.com/cell-reports...
Reposted by Alfonso Santos Lopez
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While
increased mobility can easily evolve by incorporating phage DNA into plasmids, this
is disadvantageous because it...
www.cell.com
October 22, 2025 at 1:12 PM
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Reposted by Alfonso Santos Lopez
✨New paper from @jrpenades.bsky.social and @sanmillan.bsky.social labs. We found that non-conjugative plasmids 🧬 tend to have low mobility to promote functional diversity ⚔️💊 in bacterial communities🦠🦠.
Brilliant work by Akshay, @asantoslopez.bsky.social and others.
www.cell.com/cell-reports...
Brilliant work by Akshay, @asantoslopez.bsky.social and others.
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While
increased mobility can easily evolve by incorporating phage DNA into plasmids, this
is disadvantageous because it...
www.cell.com
October 22, 2025 at 1:37 PM
✨New paper from @jrpenades.bsky.social and @sanmillan.bsky.social labs. We found that non-conjugative plasmids 🧬 tend to have low mobility to promote functional diversity ⚔️💊 in bacterial communities🦠🦠.
Brilliant work by Akshay, @asantoslopez.bsky.social and others.
www.cell.com/cell-reports...
Brilliant work by Akshay, @asantoslopez.bsky.social and others.
www.cell.com/cell-reports...
Reposted by Alfonso Santos Lopez
📢¡Oferta de trabajo en el CBM!
El grupo de David Ruano ofrece un contrato predoctoral para desarrollar un nuevo método diagnóstico del SIBO (Small Intestinal Bacterial Overgrowth).
Plazo hasta el 30 oct.
Info👇
www.cbm.uam.es/index.php/jo...
El grupo de David Ruano ofrece un contrato predoctoral para desarrollar un nuevo método diagnóstico del SIBO (Small Intestinal Bacterial Overgrowth).
Plazo hasta el 30 oct.
Info👇
www.cbm.uam.es/index.php/jo...
Predoctoral contract - Centro de Biología Molecular Severo Ochoa
Contract for the doctoral thesis project: «Development of a new diagnostic method for SIBO». Call We are looking for a student to join our research team (https://rebrand.ly/druanogallego) at the Sev...
www.cbm.uam.es
October 17, 2025 at 2:37 PM
📢¡Oferta de trabajo en el CBM!
El grupo de David Ruano ofrece un contrato predoctoral para desarrollar un nuevo método diagnóstico del SIBO (Small Intestinal Bacterial Overgrowth).
Plazo hasta el 30 oct.
Info👇
www.cbm.uam.es/index.php/jo...
El grupo de David Ruano ofrece un contrato predoctoral para desarrollar un nuevo método diagnóstico del SIBO (Small Intestinal Bacterial Overgrowth).
Plazo hasta el 30 oct.
Info👇
www.cbm.uam.es/index.php/jo...
Reposted by Alfonso Santos Lopez
🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
EVOMG-DN
EvoMG-DN is a European Doctoral Network funded by the Horizon Europe Marie Skłodowska-Curie Actions (MSCA), composed of 14 beneficiaries and associated partners from both academic and non-academic sectors.
www.evomg-dn.eu
October 15, 2025 at 7:02 AM
🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
Reposted by Alfonso Santos Lopez
Session 3 (Thr 09/10 in the afternoon) was dedicated to Microbes, microbiome and antibiotic resistance.
October 12, 2025 at 2:53 PM
Session 3 (Thr 09/10 in the afternoon) was dedicated to Microbes, microbiome and antibiotic resistance.
Reposted by Alfonso Santos Lopez
Nuestro compañero Álvaro San Millán (@sanmillan.bsky.social), investigador en el #CNB_CSIC ha recibido el Premio María Moliner, que reconoce la labor de quienes se inician en la dirección de tesis doctorales, destacando su compromiso en el acompañamiento del talento emergente.
¡Enhorabuena!👏
¡Enhorabuena!👏
🏆 El #CSIC entrega las Medallas Margarita Salas, Premios Tesis Relevante y Premios María Moliner
🔬 Con estos galardones, la institución reafirma su compromiso con la excelencia investigadora, el aprendizaje y la formación de nuevas generaciones
👉 https://f.mtr.cool/zledhiknbb
🔬 Con estos galardones, la institución reafirma su compromiso con la excelencia investigadora, el aprendizaje y la formación de nuevas generaciones
👉 https://f.mtr.cool/zledhiknbb
October 9, 2025 at 1:21 PM
Nuestro compañero Álvaro San Millán (@sanmillan.bsky.social), investigador en el #CNB_CSIC ha recibido el Premio María Moliner, que reconoce la labor de quienes se inician en la dirección de tesis doctorales, destacando su compromiso en el acompañamiento del talento emergente.
¡Enhorabuena!👏
¡Enhorabuena!👏
Reposted by Alfonso Santos Lopez
New preprint!
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Resistance mutation supply modulates the benefit of CRISPR immunity against virulent phages
Only a fraction of bacterial genomes encode CRISPR-Cas systems but the selective causes of this variation are unexplained. How naturally virulent bacteriophages (phages) select for CRISPR immunity has...
www.biorxiv.org
October 6, 2025 at 6:27 AM
New preprint!
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠
Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare!
An epic effort by Rosanna Wright
www.biorxiv.org/content/10.1...
Reposted by Alfonso Santos Lopez
Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predati...
doi.org
October 6, 2025 at 10:42 AM
Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...
If you like time travel & biology, this 🧵is for you👇
Reposted by Alfonso Santos Lopez
Published in Current Biology! P. aeruginosa can use its filamentous phage to inhibit competitors but high phage production is susceptible to cheater miniphage invasion. Subsequent phage tragedy of the commons can lower bacteria and phage fitness. Link: authors.elsevier.com/c/1lt5I3QW8S...
Preprint out! Bacteria w/ hyper-replicative filamentous phage lead to overnight emergence of cheater phages. Bacteria w/ both phages can outcompete wildtype, then rapidly lose phage via a phage Tragedy of the Commons
@shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...
@shellyscrib.bsky.social @vscooper.micropopbio.org www.biorxiv.org/content/10.1...
Filamentous cheater phages drive bacterial and phage populations to lower fitness
Many bacteria carry phage genome(s) in their chromosome (i.e., prophage), and this intertwines the fitness of the bacterium and the phage. Most Pseudomonas aeruginosa strains carry filamentous phages ...
www.biorxiv.org
October 2, 2025 at 3:54 PM
Published in Current Biology! P. aeruginosa can use its filamentous phage to inhibit competitors but high phage production is susceptible to cheater miniphage invasion. Subsequent phage tragedy of the commons can lower bacteria and phage fitness. Link: authors.elsevier.com/c/1lt5I3QW8S...
Reposted by Alfonso Santos Lopez
Reposted by Alfonso Santos Lopez
View from the lab now. Did I mention that we are recruiting faculty microbiologists?
www.linkedin.com/posts/vaughn...
www.linkedin.com/posts/vaughn...
September 29, 2025 at 2:43 PM
View from the lab now. Did I mention that we are recruiting faculty microbiologists?
www.linkedin.com/posts/vaughn...
www.linkedin.com/posts/vaughn...
Reposted by Alfonso Santos Lopez
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
September 25, 2025 at 9:29 PM
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
Reposted by Alfonso Santos Lopez
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine.
1) Fundamental researc...
www.linkedin.com
September 23, 2025 at 10:31 PM
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine.
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
1) MMG (my dept): fundamental research in med micro
2) Peds ID / I4Kids institute
3) Center for Vaccine Research
🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
Reposted by Alfonso Santos Lopez
We are hiring a PhD student! Are you fascinated by microbes and evolution? Come join us in Barcelona!
#WeAreHiring
📣 The #IBE_Barcelona is seeking a #PhD Student for the Evolutionary #Microbiology Lab.🔬🧫
⏳ Apply before September 30th and #JoinOurTeam!
#UnravellingEvolution #ConservingBiodiversity
✍ https://www.ibe.upf-csic.es/work-with-us/job-offers
📣 The #IBE_Barcelona is seeking a #PhD Student for the Evolutionary #Microbiology Lab.🔬🧫
⏳ Apply before September 30th and #JoinOurTeam!
#UnravellingEvolution #ConservingBiodiversity
✍ https://www.ibe.upf-csic.es/work-with-us/job-offers
September 10, 2025 at 8:39 AM
We are hiring a PhD student! Are you fascinated by microbes and evolution? Come join us in Barcelona!
Reposted by Alfonso Santos Lopez
Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution
By solving a previously unsolved biological question, the AI co-scientist predicted
a complex mechanism of gene transfer and generated hypotheses that opened new research
directions, illustrating AI's...
www.cell.com
September 9, 2025 at 5:23 PM
Our second paper with @tcostalab.bsky.social and GoogleDeepMind
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.
www.cell.com/cell/fulltex...
Reposted by Alfonso Santos Lopez
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
September 9, 2025 at 9:10 PM
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
Reposted by Alfonso Santos Lopez
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇
Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio
The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...
journals.asm.org
September 9, 2025 at 5:11 AM
Check out @julielebris.bsky.social’s thread on our latest manuscript describing phenotypic heterogeneity in capsule production in Klebsiella & Acinetobacter @klebclub.bsky.social
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
This work started when I was still in @pasteur.fr & got finished in @cbitoulouse.bsky.social
#microsky #phagesky
Reposted by Alfonso Santos Lopez
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 7, 2025 at 7:59 PM
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alfonso Santos Lopez
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.
https://f.mtr.cool/rnstpoiucs
https://f.mtr.cool/rnstpoiucs
August 26, 2025 at 7:01 AM
El próximo 5 de septiembre en nuestro #47congresosebbm tendrá lugar la entrega del Premio Fundación Lilly a la Mejor Tesis Doctoral en Bioquímica y Biología Molecular a Alberto Hipólito Carrillo por el trabajo de su tesis.
https://f.mtr.cool/rnstpoiucs
https://f.mtr.cool/rnstpoiucs
Reposted by Alfonso Santos Lopez
Extremely glad to see this out!!
Wonderful work by all the lab, especially @aliciapcv.bsky.social. Don't miss her thread!!
Wonderful work by all the lab, especially @aliciapcv.bsky.social. Don't miss her thread!!
This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14
Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens
Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...
rdcu.be
August 22, 2025 at 9:17 AM
Extremely glad to see this out!!
Wonderful work by all the lab, especially @aliciapcv.bsky.social. Don't miss her thread!!
Wonderful work by all the lab, especially @aliciapcv.bsky.social. Don't miss her thread!!
Reposted by Alfonso Santos Lopez
New prepint ‼️
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
August 15, 2025 at 1:07 PM
New prepint ‼️
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...
We studied how the 3 T6SSs of P. putida shape the rhizobiota of tomato plants. Spoiler alert: K2- and K3-T6SS do not kill E. coli, but they are functional in the rhizosphere. In collaboration with the lab of Prof. Marta Martin & Rafael Rivilla @uam.es
www.biorxiv.org/content/10.1...