Alessandro Nascimento
@asnascimento.bsky.social
1.5K followers 2.8K following 65 posts
Associate Professor @ University of Sao Paulo. Structural biologist. Protein crystallographer. Interested in protein-ligand interactions and modeling
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Reposted by Alessandro Nascimento
danielmedic.bsky.social
Bioinformaticists need a set of Greek theater masks. 🧪 🧬 🖥️
Reposted by Alessandro Nascimento
krishnanyamuna.bsky.social
My hero.
kojamf.bsky.social
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
Reposted by Alessandro Nascimento
Reposted by Alessandro Nascimento
aixbiobot.bsky.social
SimpleFold: Folding Proteins is Simpler than You Think [new]
Folding Proteins is Simpler than You Think
...by using a flow-matching objective and general-purpose transformers, achieving competitive results without complex domain-specific components.
SimpleFold: Folding Proteins is Simpler than You Think Figure 1 Figure 2 Figure 3
Reposted by Alessandro Nascimento
franknoe.bsky.social
Postdoc position available in the BioEmu team at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK. Looking for candidates with backgrounds in #MachineLearning #AI Biophysics or Bioinformatics

jobs.careers.microsoft.com/global/en/jo...
Reposted by Alessandro Nascimento
phdcomics.com
The Plans
**My new book is out! 👉GreatBigUniverse.net
asnascimento.bsky.social
I missed that… thanks for highlighting this difference!

I also wonder how different it would be the comparison with ipSAE min/max from Boltz2 with Boltz1/AF3.

I wish I had some GPUs to test it myself….
asnascimento.bsky.social
And it is worth mentioning that this preprint showed that AF3 ipSAE was found to be the best predictor for experimental success for de novo designed binders:

www.biorxiv.org/content/10.1...
Reposted by Alessandro Nascimento
mphendricks.bsky.social
Come be my colleague! Whitman College is searching for a tenure-track biochemist to join the chemistry department and help with the biochem/biophysics/molbio program. My chemistry colleagues are the absolute best—please consider applying! Apps due in 1 week.

apply.interfolio.com/171535
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
Reposted by Alessandro Nascimento
mgalvosas.bsky.social
Chocolate intake is associated with the number of Nobel Prize recipients.

Source NEJM : www.nejm.org/doi/full/10....
asnascimento.bsky.social
Happy programmer’s day!
github.com
To all the builders, creators, and problem-solvers: Happy #ProgrammersDay! 🎉
Reposted by Alessandro Nascimento
kevinkaichuang.bsky.social
If you're an undergrad and want to intern with me, this is where you need to apply!
msftresearch.bsky.social
The Microsoft Research Undergraduate Internship Program offers 12-week internships in our Redmond, NYC, or New England labs for rising juniors and seniors who are passionate about technology. Apply by October 6: msft.it/6015scgSJ
Reposted by Alessandro Nascimento
pwk2024.bsky.social
Opportunity for Medicinal #DrugDesign Lead at Isomorphic Labs (London UK) closing: 26-Sep-2025 #MedChem #SynChem #DrugDiscovery #UKChemJobs #ChemJobs #chemsky 🧪
job-boards.greenhouse.io/isomorphicla...
Medicinal Drug Design Lead
London
job-boards.greenhouse.io
Reposted by Alessandro Nascimento
simon-e-lewis.bsky.social
Come and be our colleague at @bathchem.bsky.social - we are recruiting to a (permanent) faculty position in AI/Machine Learning for Drug Discovery #chemjobs #facultychemjobs DEADLINE 30th Sep - For details see: www.bath.ac.uk/jobs/Vacancy...
AP13001 Lecturer in AI/ML applied to Drug discovery - Jobs at Bath
Lecturer
www.bath.ac.uk
Reposted by Alessandro Nascimento
Reposted by Alessandro Nascimento
rolanddunbrack.bsky.social
In 2019, we published a clustering & nomenclature of beta turns in proteins & found 18 unique types. The code was in python2. I've just rewritten it in python3, because it might still be useful to people.

The paper & code:

journals.plos.org/ploscompbiol...

github.com/DunbrackLab/...
Reposted by Alessandro Nascimento
thematterlab.bsky.social
Ever wondered how to get organic chemists to synthesize the molecules you designed with your newest generative AI model?

Please check out our latest article: “The elephant in the lab: Synthesizability in generative small-molecule design”.

🐘 Link to preprint: chemrxiv.org/engage/chemr...
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Reposted by Alessandro Nascimento
merz.bsky.social
I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions.

Descriptions and links in the following two posts.
Reposted by Alessandro Nascimento
picardtips.bsky.social
Picard management tip: When you've gotten enough sleep, an impossible task becomes an interesting challenge.