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athemis.bsky.athemis.de
Alexander Minges
@athemis.bsky.athemis.de
49 followers 170 following 2 posts
Former structural biologist turned data steward. Cyclist and cat owner/servant. Mastodon: @[email protected]
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Reposted by Alexander Minges
maltegersch.bsky.social
Malte Gersch @maltegersch.bsky.social · May 5
Super happy to share that our work on the specific inhibition of USP30 - a clinical stage Parkinson's drug target - is now online at NSMB www.nature.com/articles/s41... Have a read if you fancy chimeric protein engineering or a framework for DUB ligandability. Huge congratulations to Nafizul & team!
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology
Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framew...
www.nature.com
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athemis.bsky.athemis.de
Alexander Minges @athemis.bsky.athemis.de · Mar 18
Grateful for the fantastic #Dataverse upload event of the @crc1430.bsky.social. Many inspiring discussions and a huge pile of datasets for me to work through the next days. Thanks to all participants!
Seminar room with group tables and wall screen reading "Dataverse". Buffet with salads, fruit and wraps.
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Reposted by Alexander Minges
crc1430.bsky.social
CRC 1430 @crc1430.bsky.social · Mar 10
🚀 We’re proud to celebrate Gina Simon, a @crc1430.bsky.social PhD researcher in @hellerschmiedlab.bsky.social at @unidue-zmb.bsky.social, who received the Data Champion Award! Gina shares how eLabFTW streamlines research and boosts efficiency.
#DataChampion #eLabFTW
www.uni-due.de/rds/en/datac...
Data Champion: Gina Simon
www.uni-due.de
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athemis.bsky.athemis.de
Alexander Minges @athemis.bsky.athemis.de · Mar 6
Currently using servers from www.netcup.com/en
They offer web hosting (US and European server locations) as well.
Your partner for web hosting, servers, domains | netcup
Web hosting, servers, domains, e-mails, security, management services - simply everything for your successful internet presence.
www.netcup.com
Reposted by Alexander Minges
science.org
Science Magazine @science.org · Feb 25
Tomatoes lose their bitterness and toxicity as they ripen thanks to DNA demethylation, the hormone ethylene, and key transcription factors, finds a new #ScienceAdvances study. scim.ag/4bfdr8u
Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network
A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.
scim.ag
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Reposted by Alexander Minges
actacrystd.iucr.org
Structural Biology @actacrystd.iucr.org · Feb 24
Many crystal structure analyses that previously required experimental phase evaluation can now be solved by AlphaFold-guided MR. In effect, this and related MR approaches are de novo phasing methods. #MolecularReplacement #MachineLearning doi.org/10.1107/S205...
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Reposted by Alexander Minges
pdbeurope.bsky.social
Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · Feb 17
Interested in developing a dataset for a Large Language Models (LLMs) project?

Register for March 5:
www.ebi.ac.uk/training/eve...

Webinar by Melanie Vollmar
(ARISE Fellow working with @pdbeurope.bsky.social team)

From @training.ebi.embl.org's series on:
LLM & Bioinformatics
Developing a dataset for LLM projects -
Developing a dataset for LLM projects -
www.ebi.ac.uk
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Reposted by Alexander Minges
rki.de
Robert Koch-Institut @rki.de · Feb 12
🚀 Die Gesundheitsberichterstattung #GBE am #RKI stellt regelmäßig Daten zu nichtübertragbaren Krankheiten und ihren Einflussfaktoren auf #GitHub und #Zenodo bereit: maschinenlesbar, offen, frei verwendbar.

🔗 www.gbe.rki.de/DE/Startseit...

#OpenData #Gesundheit #Transparenz #PublicHealth
Transparenz durch Open Data RKI stellt Daten zur freien Nachnutzung bereit
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Reposted by Alexander Minges
thetiredscientist.bsky.social
The Tired Scientist @thetiredscientist.bsky.social · Jan 25
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Reposted by Alexander Minges
landerlab.bsky.social
Lander Lab @landerlab.bsky.social · Jan 22
Just because it's a homo-oligomer, don't assume it's symmetric! @benjabsnt.bsky.social & collaborators used cryo-EM to study the transthyretin (TTR) tetramer (55 kDa), shedding light on its misfolding pathways linked to amyloid disease. Now in peer-reviewed form: www.nature.com/articles/s41...
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Reposted by Alexander Minges
becklab.bsky.social
Beck Laboratory @becklab.bsky.social · Jan 17
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
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Reposted by Alexander Minges
pdbeurope.bsky.social
Protein Data Bank in Europe (PDBe) @pdbeurope.bsky.social · Jan 17
PDB-IHM (formerly PDB-Dev) is for integrative structures.

Intergrative structures = from multiple experimental & computational methods.
Since mid-2024 assigned PDB ids & DOIs.

Access via wwPDB archive or
PDB-IHM - pdb-ihm.org

👉 https://www.wwpdb.org/news/news?year=2025#677880ea44a8c95814022eb9
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Reposted by Alexander Minges
daviddesancho.bsky.social
David De Sancho @daviddesancho.bsky.social · Jan 16
This is just out and already looks like textbook material
#MustRead
lindorfflarsen.bsky.social
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Jan 16
How do proteins mis-fold?

Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with MD simulations to study the transition state for amyloid fibril growth

doi.org/10.1038/s415...
Figure from the paper that illustrates the approach of probing the transition state for amyloid growth by experiments and simulations
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