LightNews LightNews
baebeaboo.bsky.social
@baebeaboo.bsky.social
1 followers 40 following 0 posts
Posts Replies Media Videos
Reposted
siegenthalerlab.bsky.social
🧪 #DevBio
biologists.bsky.social The Company of Biologists @biologists.bsky.social · Nov 27
Wenli Fan et al. leverage conditional mouse knockouts to explore the link between placental problems and congenital heart defects, showing that SLC25A1 regulates trophoblast differentiation and placental development to safeguard embryonic heart formation. 🐭🫀 https://bit.ly/4g372OU #DevBio
Working model of the impact of Slc25a1 deficiency on placental and embryonic cardiac development. In the normal placenta (left), SLC25A1 facilitates the transport of citrate from mitochondria to the cytoplasm. Citrate is converted into acetyl-CoA, which is essential for maintaining H3K27ac and promoting the differentiation of trophoblast cells. Trophoblast cells secrete PSG proteins, supporting normal placental and embryonic heart development. In the absence of Slc25a1 (right), citrate cannot be transported from mitochondria to the cytoplasm, resulting in a reduction in acetyl-CoA levels. This leads to reduced deposition of H3K27ac at the promoter and enhancer regions of key factors involved in trophoblast differentiation and Psg genes, thereby affecting the expression levels of these genes and causing abnormal placental development, which in turn leads to conotruncal defects and thinner ventricular walls in mouse embryonic hearts.
November 27, 2024 at 3:32 PM
Reposted
chemjobber.bsky.social
chemsky 🧪⚗️
chemistryworld.com Chemistry World @chemistryworld.com · Nov 27
One thing @chemjobber.bsky.social appreciates about the commercial chemical manufacturing world is that it uses the standard ‘retest date’, rather than the food-related term ‘expiration date’.
www.chemistryworld.com/opinion/how-...
How long are medicines good for?
Stability data is necessary but tedious work
www.chemistryworld.com
November 27, 2024 at 4:17 PM
Reposted
hanata87ha.bsky.social
悠真くんとﾊﾙﾏｻボンプ😴
November 27, 2024 at 10:38 AM
Reposted
dreameffectss.bsky.social
Kalim in various types of turbans 🥰🥰
#TWST #TwistedWonderland #ツイステファンアート #ツイステ #twstファンアート
October 22, 2024 at 6:52 PM
Reposted
ekuapiyo.bsky.social
稲妻風男子×マフィアパロ！！

Inazuma Anemo boys ×Mafia

#Genshinlmpact #原神  #scaramouche #wanderer #heizou #Kazuha
October 18, 2024 at 11:54 AM
Reposted
nasani.bsky.social
October 20, 2024 at 6:33 AM
Reposted
ichi-1saku.bsky.social
#原神絵描きさんと繋がりたい
#絵描きさんと繋がりたい
RT中心に巡回致します❤️
October 17, 2024 at 2:49 PM
Reposted
scalzi.com
Caught the comet.
Comet Tsuchinshan-ATLAS, hovering over my neighbor's house.
October 21, 2024 at 1:01 AM
Reposted
tpwrtrmnky.bsky.social
"For mature audiences" not as in "legally allowed to see a boob" but "can see a fictional character do a bad thing and not immediately go on a crusade against the author"
October 21, 2024 at 9:02 PM