Ben Lehner
@benlehner.bsky.social
1.6K followers
780 following
15 posts
Solve Biology
Head of Generative Genomics, Wellcome Sanger Institute, Cambridge, UK
Systems + Synthetic Biology, CRG, Barcelona
http://barcelonacollaboratorium.com http://allox.bio https://www.sanger.ac.uk/programme/generative-and-synthetic-genomics/
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Reposted by Ben Lehner
Guillaume Diss
@guillaumediss.bsky.social
· Aug 25
Alexandra Bendel
@alexbendel.bsky.social
· Aug 25
The genetic architecture of the human bZIP family
Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...
www.biorxiv.org
Ben Lehner
@benlehner.bsky.social
· Aug 1
Under which circumstances do genomic neural networks learn motifs and their interactions?
The use of neural networks to model genomic data in sequence-to-function scenarios has soared over the last decade. There remains much debate about whether these models are interpretable, either inher...
www.biorxiv.org
Ben Lehner
@benlehner.bsky.social
· Jul 31
Allosteric and Energetic Remodeling by Protein Domain Extensions
Many functions of proteins are performed by independently folding structural units called domains. The structures of domains are conserved during evolution but they are not identical. For example, the...
www.biorxiv.org
Reposted by Ben Lehner
Ben Lehner
@benlehner.bsky.social
· Jun 25
Allostery is a widespread cause of loss-of-function variant pathogenicity
Allosteric communication between non-contacting sites in proteins plays a fundamental role in biological regulation and drug action. While allosteric gain-of-function variants are known drivers of onc...
biorxiv.org
Reposted by Ben Lehner
Jonathan Frazer
@jonnyfrazer.bsky.social
· May 26
Charlie Pugh
@cwjpugh.bsky.social
· May 26
From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models
Generative models trained on natural sequences are increasingly used to predict the effects of genetic variation, enabling progress in therapeutic design, disease risk prediction, and synthetic biolog...
www.biorxiv.org
Reposted by Ben Lehner
Doug Fowler
@dougfowler.bsky.social
· May 15
Atlas of Variant Effects 2030 Roadmap: resolving human variants of uncertain significance
At the Clinical Atlas of Variant Effects meeting (CLAVE meeting, July 2024, Pittsburgh USA), we developed recommendations for a draft atlas that can be realized by 2030, with a focus on empowering gen...
zenodo.org
Reposted by Ben Lehner
Reposted by Ben Lehner
Reposted by Ben Lehner
Reposted by Ben Lehner
Leopold Parts
@leopoldparts.bsky.social
· Jan 31
Postdoctoral Fellow | Generative and Synthetic Genomics
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
Reposted by Ben Lehner
Leopold Parts
@leopoldparts.bsky.social
· Jan 31
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
www.science.org
Ben Lehner
@benlehner.bsky.social
· Jan 19