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brian_delisle

@bpdelisle.bsky.social

1.4K followers 2.1K following 110 posts

Prof of Physiology; Heart Disease; Cardiac EP; LQTS; Ion Channels; Biophysics; Chronobiology; Reviewer 2; He, him, his; Opinions/retweets/likes are my own https://orcid.org/0000-0002-2146-327X

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brian_delisle @bpdelisle.bsky.social · Nov 16

🌙 Ever wondered how artificial light at night affects your #autonomic nerves and #heart? New #circadian research with @bethaschroder.bsky.social reveals some surprising sex-specific effects on cardiovascular health in mice 🐭 #ChronoBiology #HeartHealth #shiftwork

www.nature.com/articles/s42...

Dim light at night unmasks sex-specific differences in circadian and autonomic regulation of cardiovascular physiology - Communications Biology

Restricted feeding to the dim light at night restores disrupted day-night autonomic and cardiovascular rhythms but not activity in male and female mice.

www.nature.com

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brian_delisle @bpdelisle.bsky.social · Sep 9

Congrats!!!! You are doing amazing work - generating new knowledge!

brian_delisle @bpdelisle.bsky.social · Aug 10

Congratulations Abhilash- You are doing great research and doing so much hard work! Didn’t you just do a 2-day circadian collection earlier this week?

brian_delisle @bpdelisle.bsky.social · Jul 19

🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....

brian_delisle @bpdelisle.bsky.social · Jul 18

🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy
👉 journals.physiology.org/doi/full/10....

Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway | American Journal of Physiology-Cell Physiology | American Physiological Society

Aberrant autophagy mediated by AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51 like kinase 1 (ULK1) pathway (a canonical autophagy pathway) plays important roles in dia...

journals.physiology.org

brian_delisle @bpdelisle.bsky.social · Jul 18

🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology

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brian_delisle @bpdelisle.bsky.social · Jul 16

🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky

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brian_delisle @bpdelisle.bsky.social · Jul 16

🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle

Reposted by brian_delisle

Hao Yin @haoyin.bsky.social · Jun 7

Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis

Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)

Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓

bioRxiv 2025
www.biorxiv.org/content/10.1...

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The Physiological Society @physoc.bsky.social · May 29

📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias.

📝 Submit by 2 June ⬇️

Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias

Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us

buff.ly

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Karyn @kaesser.bsky.social · May 11

Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia

Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological functions. They reveal cance...

www.cell.com

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Reposted by brian_delisle

Ken Campbell @cardiaccampbell.bsky.social · May 10

Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins.

Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...

Graphical abstract - cell mechanics, histology and western blots.

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Reposted by brian_delisle

Maria Paz Fernandez @mariadelapax.bsky.social · May 7

We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors.

You can read the full study here:

PLOS Biology @plosbiology.org · May 7

Sexual dimorphism in the #Drosophila #circadian pacemaker. @aishwaryaramak6.bsky.social @mariadelapax.bsky.social &co show that female flies are more resilient to disruptions in circadian rhythms caused by changes in the PDF pathway or pacemaker cell clock speed @plosbiology.org 🧪 plos.io/4kbWuzg

Left: PDF expressing neurons upon CRISPR-Cas9 knockout of Pdf. Double staining of an adult female brain with RFP (magenta) and PDF (blue). Image credits: Eva Scholz-Carlson. Right: Speeding up the clock in M-cells leads to sexually dimorphic phenotypes. Representative actograms of controls (Pdf-Gal4 and UAS-DBTs) and experimental (Pdf > DBTs) females (top) and males (bottom) plotted for five days of LD followed by 10 days of DD.

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Mary Feeney @mkfeeney.bsky.social · Apr 24

For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵

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Yamuna Krishnan @krishnanyamuna.bsky.social · Apr 24

Please read this.

Mary Feeney @mkfeeney.bsky.social · Apr 24

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Ali D. Güler @aguler.bsky.social · Dec 18

GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15

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APS Publications @apspublications.bsky.social · Apr 3

#FreeToRead 👀

CONGRATULATIONS!

An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.

➡️doi.org/10.1152/ajph...

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Reposted by brian_delisle

The Journal of Physiology @jphysiol.bsky.social · Apr 1

David J Paterson of @oxforddpag.bsky.social & Kalyanam Shivkumar of @uclaupdates.bsky.social present this preface #Editorial for our latest special issue 'Cardiac Neurobiology: Concepts to Clinic' which is dedicated to Jeffrey L. Ardell (1952–2025)

📜 physoc.onlinelibrary.wiley.com/doi/full/10....

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htw @heniek-htw.bsky.social · Apr 2

Diet-induced obesity dampens temporal oscillation of hepatic mitochondrial lipids

Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver
www.sciencedirect.com/science/arti...

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APS Publications @apspublications.bsky.social · Apr 1

🔓Editorial From Timothy Musch et al.

“APS Initiatives and Milestones: a Year in Review and a Look Ahead”

➡️doi.org/10.1152/phys...

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brian_delisle @bpdelisle.bsky.social · Mar 30

🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1...
#Physiology #Science #Circadian #Asthma

Reposted by brian_delisle

Jeff Greene @jeffgreene.bsky.social · Mar 29

Unsurprisingly, @tressiemcphd.bsky.social is spot-on in this analysis: “A.I.’s most revolutionary potential is helping experts apply their expertise better and faster. But for that to work, there has to be experts.”
www.nytimes.com/2025/03/29/o...

Opinion | Actually, A.I. Is Pretty Mid (Gift Article)

A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.

www.nytimes.com

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htw @heniek-htw.bsky.social · Mar 30

Common hallmarks and potential mechanisms linking cancer, circadian rhythms, and aging.

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htw @heniek-htw.bsky.social · Mar 29

•Night shift work is associated with increased inflammation
•HDL-C levels are decreased among night shift workers
•Night shift workers have prolonged heart rate-corrected QT intervals
•HDL-C & QTc are promising indicators of CVD risk among night shift workers
www.sciencedirect.com/science/arti...

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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · Mar 29

For a presentation I am giving, I made a wordcloud of the titles of the NIH grants that were canceled. It is clear about the unscientific goals of this administration

a word cloud of the titles of canceled NIH grants with gender and minority being that largest words

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brian_delisle @bpdelisle.bsky.social · Mar 29

🚨🆕🔬Three meals, same calories, different metabolism 🧬 Dörner et al show that our bodies shift from🔥carbs in the morning to fat by dinner- Glucose handling dips 📉 but metabolic resilience rises📈 w/ triglyceride use 👉 journals.physiology.org/doi/abs/10.1...
#Physiology #Science #Circadian #Metabolism

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