Bryan Lenneman
@brlenneman.bsky.social
Instructor @ Massachusetts General Brigham & Harvard Medical School | Phage & microbiome engineering | He/him | Views my own
Reposted by Bryan Lenneman
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
November 20, 2025 at 8:40 PM
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages.
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms.
A thread 1/8
Reposted by Bryan Lenneman
Why attend the @shigellameeting.bsky.social in 6 months you ask? (🧵) 🦠 🧫 🔬 #Microsky #IDsky
What a question and a grand request,
To muse on why scientists should travel for a pest!
Forget lonely lab benches and the pipette's cold song,
There are better pursuits for which researchers long.
What a question and a grand request,
To muse on why scientists should travel for a pest!
Forget lonely lab benches and the pipette's cold song,
There are better pursuits for which researchers long.
October 21, 2025 at 3:39 PM
Why attend the @shigellameeting.bsky.social in 6 months you ask? (🧵) 🦠 🧫 🔬 #Microsky #IDsky
What a question and a grand request,
To muse on why scientists should travel for a pest!
Forget lonely lab benches and the pipette's cold song,
There are better pursuits for which researchers long.
What a question and a grand request,
To muse on why scientists should travel for a pest!
Forget lonely lab benches and the pipette's cold song,
There are better pursuits for which researchers long.
Reposted by Bryan Lenneman
Exciting to see the Standardized #Organoid Modeling Center is opening to help standardize protocols, provide tools and resources, and connect the research community at the national level after being in development for a few years
www.nih.gov/som
www.nih.gov/som
NIH Standardized Organoid Modeling (SOM) Center
The Standardized Organoid Modeling (SOM) Center will be the nation’s first fully integrated platform dedicated to developing standardized organoid-based New Approach Methodologies (NAMs).
www.nih.gov
September 25, 2025 at 8:34 PM
Exciting to see the Standardized #Organoid Modeling Center is opening to help standardize protocols, provide tools and resources, and connect the research community at the national level after being in development for a few years
www.nih.gov/som
www.nih.gov/som
Reposted by Bryan Lenneman
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home
www.shigella2026.conferences-pasteur.org/home
September 19, 2025 at 1:12 AM
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky
www.shigella2026.conferences-pasteur.org/home
www.shigella2026.conferences-pasteur.org/home
Reposted by Bryan Lenneman
Come and join us in Paris 2026 to talk all about Shigella!
September 18, 2025 at 12:46 PM
Come and join us in Paris 2026 to talk all about Shigella!
Had a wonderful time at #phages2025. Cool venue, exciting science, and inspiring people!
August 8, 2025 at 10:39 PM
Had a wonderful time at #phages2025. Cool venue, exciting science, and inspiring people!
Reposted by Bryan Lenneman
I also put together an extra ColabFold formatted database of nearly 130M phage proteins that can be used to make better viral protein structure predictions github.com/gbouras13/co...
GitHub - gbouras13/colabfoldv: Augmented Local MSA Generation for Phage and Viral Proteins using the ColabFold Framework
Augmented Local MSA Generation for Phage and Viral Proteins using the ColabFold Framework - gbouras13/colabfoldv
github.com
August 8, 2025 at 7:14 AM
I also put together an extra ColabFold formatted database of nearly 130M phage proteins that can be used to make better viral protein structure predictions github.com/gbouras13/co...
Reposted by Bryan Lenneman
Our MISC clinical trial results, just published!
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
July 30, 2025 at 8:30 PM
Our MISC clinical trial results, just published!
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
“Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome”
massgeneralbrigham.org/en/about/newsr…#COVIDID
@ScienceTM
@biotium.bsky.social
Reposted by Bryan Lenneman
Really looking forward to the First #Shigella International Meeting to be held in Paris, France, April 2026! The meeting website is almost ready. Please follow @shigellameeting.bsky.social for more information and updates! #Microsky 🦠 🧫 🔬
Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04
Shigella, the first international meeting
coming-soon.embo.org
July 25, 2025 at 4:53 PM
Really looking forward to the First #Shigella International Meeting to be held in Paris, France, April 2026! The meeting website is almost ready. Please follow @shigellameeting.bsky.social for more information and updates! #Microsky 🦠 🧫 🔬
Reposted by Bryan Lenneman
Delighted to be part of this collaboration with the Raman Lab at @uwmadison.bsky.social:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts
Understanding core and conditional gene essentiality is crucial for decoding genotype-phenotype relationships in organisms. We present phage high-thro…
www.sciencedirect.com
July 22, 2025 at 4:39 PM
Delighted to be part of this collaboration with the Raman Lab at @uwmadison.bsky.social:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Bryan Lenneman
TAILΦR Milestone! Dosed our first patient with
@bwtrautner.bsky.social in an academic-led clinical trial (NCT06559618). The phages were discovered, manufactured, tested, FDA approved and now administered in one location by one team, an end-to-end miracle we hope will counter the AMR crisis. Dream!
@bwtrautner.bsky.social in an academic-led clinical trial (NCT06559618). The phages were discovered, manufactured, tested, FDA approved and now administered in one location by one team, an end-to-end miracle we hope will counter the AMR crisis. Dream!
June 6, 2025 at 9:57 AM
TAILΦR Milestone! Dosed our first patient with
@bwtrautner.bsky.social in an academic-led clinical trial (NCT06559618). The phages were discovered, manufactured, tested, FDA approved and now administered in one location by one team, an end-to-end miracle we hope will counter the AMR crisis. Dream!
@bwtrautner.bsky.social in an academic-led clinical trial (NCT06559618). The phages were discovered, manufactured, tested, FDA approved and now administered in one location by one team, an end-to-end miracle we hope will counter the AMR crisis. Dream!
Reposted by Bryan Lenneman
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.
Out @natgenet.nature.com:
rdcu.be/eqGgf
Out @natgenet.nature.com:
rdcu.be/eqGgf
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
June 12, 2025 at 2:14 PM
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.
Out @natgenet.nature.com:
rdcu.be/eqGgf
Out @natgenet.nature.com:
rdcu.be/eqGgf
Reposted by Bryan Lenneman
The human body is chock full of phages, from the skin to the gut. What role does the phageome have in health and disease? Watch Microbial Minutes for the story! www.youtube.com/watch?v=5PyM...
The Phageome’s Role in Health and Disease
YouTube video by American Society for Microbiology
www.youtube.com
June 10, 2025 at 11:27 AM
The human body is chock full of phages, from the skin to the gut. What role does the phageome have in health and disease? Watch Microbial Minutes for the story! www.youtube.com/watch?v=5PyM...
Reposted by Bryan Lenneman
🚨 Extensively drug-resistant #Shigella is increasing in #LosAngeles. PLWH and GBMSM are disproportionately affected.
We have seen several of these, very difficult to treat.
Antibiogram shows 📈 resistance, susceptibility testing is 🔑.
#IDsky #Medsky #EMSky #AMR #XDR
🔗: t.e2ma.net/webview/3apx...
We have seen several of these, very difficult to treat.
Antibiogram shows 📈 resistance, susceptibility testing is 🔑.
#IDsky #Medsky #EMSky #AMR #XDR
🔗: t.e2ma.net/webview/3apx...
June 6, 2025 at 10:07 AM
🚨 Extensively drug-resistant #Shigella is increasing in #LosAngeles. PLWH and GBMSM are disproportionately affected.
We have seen several of these, very difficult to treat.
Antibiogram shows 📈 resistance, susceptibility testing is 🔑.
#IDsky #Medsky #EMSky #AMR #XDR
🔗: t.e2ma.net/webview/3apx...
We have seen several of these, very difficult to treat.
Antibiogram shows 📈 resistance, susceptibility testing is 🔑.
#IDsky #Medsky #EMSky #AMR #XDR
🔗: t.e2ma.net/webview/3apx...
Reposted by Bryan Lenneman
📢 Attention all phage-interested: the WHO has just release its first report on phages!
This report highlights key insights from expert consultations, webinars, and a dedicated workshop in Tbilisi, Georgia.
Read report here ➡️ www.who.int/europe/publi...
This report highlights key insights from expert consultations, webinars, and a dedicated workshop in Tbilisi, Georgia.
Read report here ➡️ www.who.int/europe/publi...
Building the evidence for the use of bacteriophage therapy
Publicaciones de la Organización Mundial de la Salud
www.who.int
May 27, 2025 at 9:29 AM
📢 Attention all phage-interested: the WHO has just release its first report on phages!
This report highlights key insights from expert consultations, webinars, and a dedicated workshop in Tbilisi, Georgia.
Read report here ➡️ www.who.int/europe/publi...
This report highlights key insights from expert consultations, webinars, and a dedicated workshop in Tbilisi, Georgia.
Read report here ➡️ www.who.int/europe/publi...
Reposted by Bryan Lenneman
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Bryan Lenneman
#SuperBug #Shigella #Diarrhea #LA #LosAngeles #California #StomachFlu #XDR #Bacteria #Sonnei
Researchers have tracked down a worrying new strain of Shigella bacteria in the area—one that can resist almost every antibiotic thrown at it.
Abridged (shortened) article thread ⬇️ 4 min
Researchers have tracked down a worrying new strain of Shigella bacteria in the area—one that can resist almost every antibiotic thrown at it.
Abridged (shortened) article thread ⬇️ 4 min
'Alarming': A Dangerous Diarrhea-Causing Superbug Is Spreading in Los Angeles
An novel and extensively drug-resistant strain of Shigella sonnei has emerged and is likely still actively spreading in the U.S., scientists warn.
gizmodo.com
December 22, 2024 at 8:12 AM
#SuperBug #Shigella #Diarrhea #LA #LosAngeles #California #StomachFlu #XDR #Bacteria #Sonnei
Researchers have tracked down a worrying new strain of Shigella bacteria in the area—one that can resist almost every antibiotic thrown at it.
Abridged (shortened) article thread ⬇️ 4 min
Researchers have tracked down a worrying new strain of Shigella bacteria in the area—one that can resist almost every antibiotic thrown at it.
Abridged (shortened) article thread ⬇️ 4 min
Reposted by Bryan Lenneman
#USUHS Summer Scholars Program is accepting applications for #high-schoolers and #undergrads to gain #research experience. #Paid internship for 8-10 weeks, options for #mentors across campus, including my lab 😀
Other #career development activities included, links below! 🧫🦠🧪🧬🔬
Other #career development activities included, links below! 🧫🦠🧪🧬🔬
November 22, 2024 at 1:01 PM
#USUHS Summer Scholars Program is accepting applications for #high-schoolers and #undergrads to gain #research experience. #Paid internship for 8-10 weeks, options for #mentors across campus, including my lab 😀
Other #career development activities included, links below! 🧫🦠🧪🧬🔬
Other #career development activities included, links below! 🧫🦠🧪🧬🔬