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Reposted by Carlos Moreno-Yruela

Real Sociedad Española de Química (RSEQ) @rseq-quimica.bsky.social · 28d

🎉 ¡Orgullo RSEQ! Nuestros socios @casadevallcarla.bsky.social,
@nikinikki87.bsky.social y @carlosmyruela.bsky.social han sido galardonados con una prestigiosa #ERCStartingGrant 2025🔬 Enhorabuena!!!!!

📖 rseq.org/tres-miembro...

@urv.cat
@lcbm-epfl.bsky.social
@iciq.org @icfo.eu

Tres miembros de la RSEQ han conseguido una ERC... – RSEQ

Los miembros de la RSEQ: Carla Casadevall, Nicoletta Liguori y Carlos Moreno Yruela consiguen una ERC Starting Grant en la convocatoria 2025.

rseq.org

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Sep 5

I am really excited that #CHEMTUBIO will be funded through an @erc.europa.eu Starting Grant!
This funding will kickstart my lab next year and help us unveil the mechanisms and therapeutic implications of erasers of microtubule modifications.
Stay tuned!

European Research Council (ERC) @erc.europa.eu · Sep 4

📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope

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Reposted by Carlos Moreno-Yruela

BIST-Barcelona Institute of Science and Technology @bist.eu · Sep 4

Six #BISTcommunity early-career researchers have secured prestigious ERC grants 👏

These awards highlight the ability of BIST Community centres to attract and nurture outstanding young international talent.

@crg.eu @icfo.eu @iciq.org @ibecbarcelona.eu

👉http://bit.ly/486ENOq

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · May 24

Pint of Science was again a great success in Lausanne, with >500 people attending our events!
Kudos to co-coordinators @miriamlisci.bsky.social and @juliensluneau.bsky.social, and to the fantastic team of 19 volunteers at the bars 🥳!

#PINT25 #scicomm

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Reposted by Carlos Moreno-Yruela

Alexandra Teslenko @alexateslenko.bsky.social · May 22

If you always wanted to know the kinetics of how the Polycomb enzymes modify chromatin, we are thrilled to share our work!!! 🎉📄🧬🔬

Thank you, @beatfierz.bsky.social for all the guidance as well as the @lcbm-epfl.bsky.social group members for all the support!
doi.org/10.1126/scia...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

doi.org

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Reposted by Carlos Moreno-Yruela

LCBM @lcbm-epfl.bsky.social · May 22

Check out our new study of chromatin ubiquitylation. @alexateslenko.bsky.social visualized directly at single molecule scale how vPRC1 ubiquitylates neighboring nucleosomes. These results suggest potential mechanism on how H2Aub domains are established. 👇👇👇
www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

www.science.org

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Apr 24

The program for Pint of Science Lausanne 🧪 is ready!
pintofscience.ch/events/lausa...

This year we have again three venues covering topics from aging to robotic surgery or sustainable agriculture

Come join us on the 19th, 20th and 21st of May 🥳

#PintCH #scicomm @pintofscience.ch

Lausanne

Explore Pint of Science Switzerland events in Lausanne

pintofscience.ch

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 19

What started as the M.Sc. projects of Michaela Benová and Athanasios Tsiris, seeking potent and selective inhibition of #HDAC11, turned into a great collaboration between the labs of @christianaolsen.bsky.social and Christian Heinis led by @danieladankova.bsky.social.

Big congratulations, Daniela!

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 19

Very happy to see this story out in #JACS_Au!

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
pubs.acs.org/doi/10.1021/...

#ChemBio #chemsky #HDAC

Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11

Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...

pubs.acs.org

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Reposted by Carlos Moreno-Yruela

Marcus Buschbeck and Lab @marcusbuschbeck.bsky.social · Feb 12

!THREE OPPORTUNITIES TO JOIN US!

We are looking for 3 (!!!) PhD students interested in:
How Metabolism affects Genome Regulation.

Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow.

More info:
2 x experimental: www.nuclear-dn.eu
1 x computational: www.hubmol.eu

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Reposted by Carlos Moreno-Yruela

Maric Lab @hmariclab.bsky.social · Jan 28

🚨 Excited to share our work @elife.bsky.social doi.org/10.7554/eLife.98827.2 on targeting Hepatitis B virus #HBV 🦠 capsid aggregation by designed molecules! #DrugDiscovery #ChemBio

Thanks V Khayenko C Makbul @clemensschulte.bsky.social & @boettchercryoem.bsky.social for stunning #CryoEM visuals!

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

Thanks, Christian!

Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

@naturecomms.bsky.social

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

Thank you as well to @snsf-ch.bsky.social and IRFD for funding my postdoc at EPFL, to the @swisschemistry.bsky.social foundation and La Caixa Foundation for supporting Polina and Esther, and other funding from @snsf-ch.bsky.social, EPFL and the Dubochet Center for Imaging.
(8/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

This would not have been possible without the excellent (and very efficient!) contributions of Babatunde Ekundayo and Polina Foteva (who just defended her MSc thesis 🥳), of Dongchun Ni, Esther Calviño and Henning Stahlberg, or without the truly supportive guidance of @beatfierz.bsky.social.
(7/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

The contacts of the catalytic domain with DNA, on the other hand, are responsible for maintaining #H3K36ac selectivity.
Mutating a key interacting loop helps release the enzyme from the nucleosome and become much more active on #H3K18ac substrates 🤯.
(6/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

The multivalent interactions of the nucleosome-binding domain are important for both activities, especially to find #chromatin substrates in an environment full of nucleic acids.
Interestingly, this domain is only present in insects and most vertebrates.
(5/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

By comparing structures trapped at each substrate position we could rationalize its activity and intrinsic selectivity 🔍.
#SIRT7 binding is optimal for targeting #H3K36ac, and it can only access #H3K18ac through partial disengagement from the nucleosome and DNA bending.
(4/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

Babatunde Ekundayo generated beautiful high-resolution structures, where we identified:
- A unique N-terminal nucleosome-binding domain, which places the #SIRT7 catalytic domain by the H3 tail exit site
- Extensive contacts with the two DNA gyres!
(3/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

We produced nucleosomes with a thiourea mechanism-based handle (MTU) at the H3K18 and H3K36 preferred substrate positions, through histone semi-synthesis and reconstitution in vitro.
This allowed us to stabilize specific enzyme:substrate complexes efficiently for #cryoEM.
(2/8)

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Feb 4

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates.
We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇
www.nature.com/articles/s41...
(1/8) #ChemBio #ChemSky

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Carlos Moreno-Yruela @carlosmyruela.bsky.social · Jan 25

Hi Dorien, I would love to be added to this started pack!

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Reposted by Carlos Moreno-Yruela

eLife @elife.bsky.social · Jan 25

Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules. #CryoEm
https://elifesciences.org/articles/105335?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights

High-resolution structural imaging using customised magnetic beads.

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Reposted by Carlos Moreno-Yruela

Eric Topol @erictopol.bsky.social · Jan 24

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...

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Reposted by Carlos Moreno-Yruela

Nature @nature.com · Jan 24

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X

https://go.nature.com/42tH8Ai

Bluesky’s science takeover: 70% of Nature poll respondents use platform

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

go.nature.com

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