ccgoetzke
@ccgoetzke.bsky.social
Pediatrician & Clinician Scientist @Charité Berlin and @DRFZ
Interested in rheumatology and immunology
Interested in rheumatology and immunology
Reposted by ccgoetzke
SARS-CoV2 infection in subset of children linked to EBV reactivation. “establish a connection between SARS-CoV-2 infection and COVID-19 sequelae in children, ..triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation.” #virology www.nature.com/articles/s41...
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 13, 2025 at 1:05 PM
SARS-CoV2 infection in subset of children linked to EBV reactivation. “establish a connection between SARS-CoV-2 infection and COVID-19 sequelae in children, ..triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation.” #virology www.nature.com/articles/s41...
Reposted by ccgoetzke
TGFβ overproduction in MIS-C impairs T cell cytotoxicity, leading to EBV reactivation and hyperinflammation. Blocking TGFβ restores immune function, linking SARS-CoV-2 to post-infectious sequelae. #EBV #COVID19 #Immunology
Nature (open access): www.nature.com/articles/s41...
Nature (open access): www.nature.com/articles/s41...
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 14, 2025 at 12:09 AM
TGFβ overproduction in MIS-C impairs T cell cytotoxicity, leading to EBV reactivation and hyperinflammation. Blocking TGFβ restores immune function, linking SARS-CoV-2 to post-infectious sequelae. #EBV #COVID19 #Immunology
Nature (open access): www.nature.com/articles/s41...
Nature (open access): www.nature.com/articles/s41...
Reposted by ccgoetzke
Scientists found that children with MIS-C after COVID-19 have high TGFβ levels, which weaken T cells and reactivate Epstein-Barr virus.
Blocking TGFβ restores immune function, linking EBV to MIS-C inflammation.
www.nature.com/articles/s41...
Blocking TGFβ restores immune function, linking EBV to MIS-C inflammation.
www.nature.com/articles/s41...
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 12, 2025 at 4:56 PM
Scientists found that children with MIS-C after COVID-19 have high TGFβ levels, which weaken T cells and reactivate Epstein-Barr virus.
Blocking TGFβ restores immune function, linking EBV to MIS-C inflammation.
www.nature.com/articles/s41...
Blocking TGFβ restores immune function, linking EBV to MIS-C inflammation.
www.nature.com/articles/s41...
Reposted by ccgoetzke
Exciting to see this story out — showing that children with MIS-C have high levels of TGFβ, which weakens T cells and reactivates EBV. Blocking TGFβ reversed this effect, making this a potential treatment option!
Proud to have contributed our part!
Proud to have contributed our part!
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 14, 2025 at 10:36 AM
Exciting to see this story out — showing that children with MIS-C have high levels of TGFβ, which weakens T cells and reactivates EBV. Blocking TGFβ reversed this effect, making this a potential treatment option!
Proud to have contributed our part!
Proud to have contributed our part!
Reposted by ccgoetzke
Impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation in SARS-CoV-2 MIS-C
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
March 12, 2025 at 6:47 PM
Impaired T cell cytotoxicity triggered by TGFβ overproduction leads to EBV reactivation and subsequent hyperinflammation in SARS-CoV-2 MIS-C
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by ccgoetzke
SARS-CoV-2, MIS-C, and EBV!
Unexpected mechanism behind this puzzling disease!
Kids with MIS-C show weakened T cell responses due to high TGFβ levels, allowing EBV to reactivate and drive inflammation
Blocking TGFβ reverses these effects—a potential treatment path!
www.nature.com/articles/s41...
Unexpected mechanism behind this puzzling disease!
Kids with MIS-C show weakened T cell responses due to high TGFβ levels, allowing EBV to reactivate and drive inflammation
Blocking TGFβ reverses these effects—a potential treatment path!
www.nature.com/articles/s41...
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 14, 2025 at 3:16 AM
SARS-CoV-2, MIS-C, and EBV!
Unexpected mechanism behind this puzzling disease!
Kids with MIS-C show weakened T cell responses due to high TGFβ levels, allowing EBV to reactivate and drive inflammation
Blocking TGFβ reverses these effects—a potential treatment path!
www.nature.com/articles/s41...
Unexpected mechanism behind this puzzling disease!
Kids with MIS-C show weakened T cell responses due to high TGFβ levels, allowing EBV to reactivate and drive inflammation
Blocking TGFβ reverses these effects—a potential treatment path!
www.nature.com/articles/s41...
Reposted by ccgoetzke
Reposted by ccgoetzke
Nature research paper: TGFβ links EBV to multisystem inflammatory syndrome in children
https://go.nature.com/43HJ4pu
https://go.nature.com/43HJ4pu
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
go.nature.com
March 17, 2025 at 11:43 AM
Nature research paper: TGFβ links EBV to multisystem inflammatory syndrome in children
https://go.nature.com/43HJ4pu
https://go.nature.com/43HJ4pu
Reposted by ccgoetzke
Exiting publication in Nature by DRFZ researchers: Congratulations!
Original publication: bit.ly/3Fn63Mt
News DRFZ: bit.ly/4kJ1AUq
Original publication: bit.ly/3Fn63Mt
News DRFZ: bit.ly/4kJ1AUq
Our latest study in @nature.com reveals how #TGFβ drives Epstein-Barr Virus (#EBV) reactivation in multisystem inflammatory syndrome in #children (#MISC, #PIMS) following #COVID19.
@drfzberlin.bsky.social @mashreghilab.bsky.social
🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6
@drfzberlin.bsky.social @mashreghilab.bsky.social
🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6
Nature
Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest ...
nature.com
March 12, 2025 at 4:28 PM
Exiting publication in Nature by DRFZ researchers: Congratulations!
Original publication: bit.ly/3Fn63Mt
News DRFZ: bit.ly/4kJ1AUq
Original publication: bit.ly/3Fn63Mt
News DRFZ: bit.ly/4kJ1AUq
Reposted by ccgoetzke
‼️ Cause of post-#COVID inflammatory shock in children identified: Reactivation of the Epstein-Barr virus appears to cause the rare condition #MISC. The findings, uncovered by a team from #CharitéBerlin & @drfzberlin.bsky.social, have now been published in @nature.com
www.charite.de/en/service/p...
www.charite.de/en/service/p...
Press reports: Charité – Universitätsmedizin Berlin
Press release of the Charité – Universitätsmedizin Berlin
www.charite.de
March 12, 2025 at 4:34 PM
‼️ Cause of post-#COVID inflammatory shock in children identified: Reactivation of the Epstein-Barr virus appears to cause the rare condition #MISC. The findings, uncovered by a team from #CharitéBerlin & @drfzberlin.bsky.social, have now been published in @nature.com
www.charite.de/en/service/p...
www.charite.de/en/service/p...
Reposted by ccgoetzke
Reposted by ccgoetzke
How does SARS-CoV-2 lead to the multisystem inflammatory syndrome in children, a rare, potentially fatal condition?
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 12, 2025 at 4:39 PM
How does SARS-CoV-2 lead to the multisystem inflammatory syndrome in children, a rare, potentially fatal condition?
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
Reposted by ccgoetzke
Our latest study in @nature.com reveals how #TGFβ drives Epstein-Barr Virus (#EBV) reactivation in multisystem inflammatory syndrome in #children (#MISC, #PIMS) following #COVID19.
@drfzberlin.bsky.social @mashreghilab.bsky.social
🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6
@drfzberlin.bsky.social @mashreghilab.bsky.social
🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6
Nature
Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest ...
nature.com
March 12, 2025 at 4:18 PM
Our latest study in @nature.com reveals how #TGFβ drives Epstein-Barr Virus (#EBV) reactivation in multisystem inflammatory syndrome in #children (#MISC, #PIMS) following #COVID19.
@drfzberlin.bsky.social @mashreghilab.bsky.social
🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6
@drfzberlin.bsky.social @mashreghilab.bsky.social
🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6
Reposted by ccgoetzke
Bimodal single-cell RNA-seq data reveals four distinct modalities, uncovering genes tied to splicing, transcription & degradation rates.
academic.oup.com/nargab/artic...
academic.oup.com/nargab/artic...
Exploring transcription modalities from bimodal, single-cell RNA sequencing data
Abstract. There is a growing interest in generating bimodal, single-cell RNA sequencing (RNA-seq) data for studying biological pathways. These data are pre
academic.oup.com
December 20, 2024 at 11:58 AM
Bimodal single-cell RNA-seq data reveals four distinct modalities, uncovering genes tied to splicing, transcription & degradation rates.
academic.oup.com/nargab/artic...
academic.oup.com/nargab/artic...