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Petr Cejka @cejkalab.bsky.social · 18d

Switzerland

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Petr Cejka @cejkalab.bsky.social · 18d

Trip to Greina plateau, northern Ticino

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Petr Cejka @cejkalab.bsky.social · Aug 31

Last hike in August with first snow

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Reposted by Petr Cejka

Daniel Durocher @durocher1.bsky.social · Aug 28

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

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Petr Cejka @cejkalab.bsky.social · May 31

Hiking in Switzerland today, Val Poschiavo

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Petr Cejka @cejkalab.bsky.social · May 5

Please see our latest paper on the role of EXO1 in meiosis: "EXO1 promotes the meiotic MLH1-MLH3 endonuclease through conserved interactions with MLH1, MSH4 and DNA". Congratulations to both first authors, Megha Roy and Aurore Sanchez and thanks to all our collaborators!

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Petr Cejka @cejkalab.bsky.social · May 1

Southern Alps today

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Reposted by Petr Cejka

Andrew Deans @genomestability.bsky.social · Apr 29

🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks
www.pnas.org/doi/abs/10.1...

ATM priming and end resection–coupled phosphorylation of MRE11 is important for fork protection and replication restart | PNAS

The MRE11/RAD50/NBS1 (MRN) complex plays multiple roles in the maintenance of genome stability. MRN is associated with replication forks to preserv...

www.pnas.org

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Petr Cejka @cejkalab.bsky.social · Apr 11

Nice weekend everyone from sunny Bellinzona

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Petr Cejka @cejkalab.bsky.social · Apr 10

Great news, thank you

Swiss National Science Foundation (SNSF) @snsf.ch · Apr 10

The SNSF welcomes #Switzerland’s retroactive association to #HorizonEurope from 1 Jan 2025, enabling researchers to join nearly all calls following the Federal Council’s approval of the EU Programmes Agreement.

Find out more here ➡️

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Reposted by Petr Cejka

stapleslab.bsky.social @stapleslab.bsky.social · Apr 9

New preprint from the lab, revealing new roles for IFI16 during replication stress. Great collab with @unterholznerlab.bsky.social and @cejkalab.bsky.social

www.biorxiv.org/content/10.1...

IFI16 senses and protects stalled replication forks

Replication stress is a key driver of DNA damage and genome instability. Replication stress-induced fork remodelling generates a new DNA end that is vulnerable to the action of nucleases, and which is...

www.biorxiv.org

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Petr Cejka @cejkalab.bsky.social · Apr 5

Spring is here. Valleys and lakesides are green, and snow is melting fast in the mountains.

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Reposted by Petr Cejka

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Apr 4

ICYMI - New #Review on #DNARepair

In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways.

🔗 go.nature.com/4iSKphQ

Mechanisms and regulation of DNA end resection in the maintenance of genome stability - Nature Reviews Molecular Cell Biology

DNA end resection is crucial for most DNA double-strand break repair pathways. This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-transla...

go.nature.com

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Petr Cejka @cejkalab.bsky.social · Mar 31

Are they related?

Petr Cejka @cejkalab.bsky.social · Mar 26

An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...

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Petr Cejka @cejkalab.bsky.social · Mar 25

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

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Reposted by Petr Cejka

Lopes_Lab @lopeslab.bsky.social · Mar 17

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

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Reposted by Petr Cejka

Hopfner Lab @hopfnerlab.bsky.social · Mar 17

Happy to share our latest pre-print!
We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨
www.biorxiv.org/content/10.1...

Structural basis for DNA double-strand break sensing by human MRE11-RAD50-NBS1 and its TRF2 complex

The MRE11-RAD50-NBS1 (MRN) complex is a central, multifunctional factor in the detection, signaling and nucleolytic processing of DNA double-strand breaks (DSBs). To clarify how human MRN binds generi...

www.biorxiv.org

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Petr Cejka @cejkalab.bsky.social · Mar 17

Looks like an amazing achievement - looking forward to reading it!!!

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Reposted by Petr Cejka

Agnel Sfeir @agnelsfeir.bsky.social · Mar 5

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

Mechanisms of Mitochondrial DNA Mutation and Repair

events.faseb.org

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Petr Cejka @cejkalab.bsky.social · Feb 28

Very sad to read about the science funding situation in the US at the moment. I am waiting for some funding decisions in the coming weeks, but I will likely have opening(s) in my lab in Switzerland in the coming weeks (PhD student/postdoc). As a PhD candidate, you need to have a Master's degree.

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Petr Cejka @cejkalab.bsky.social · Feb 28

What a sad situation. I am waiting for some funding decisions on my end, and may have opening (s), so please let them know

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Petr Cejka @cejkalab.bsky.social · Feb 24

Understandable, but so unfair - sorry….

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Petr Cejka @cejkalab.bsky.social · Feb 20

Congratulations!!!!

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Petr Cejka @cejkalab.bsky.social · Feb 19

Or cold room, after protein purification (when it fails…)

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