Conrad Nieduszynski
@conradn.bsky.social
Research scientist; chromosome biology; DNA replication; genomics; nanopore sequencing
Group leader at Earlham Institute, Norwich
https://www.earlham.ac.uk/profile/conrad-nieduszynski
https://tinyurl.com/kvmdxdp8
ORDID: 0000-0003-2001-076X
Group leader at Earlham Institute, Norwich
https://www.earlham.ac.uk/profile/conrad-nieduszynski
https://tinyurl.com/kvmdxdp8
ORDID: 0000-0003-2001-076X
Pinned
We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5
Reposted by Conrad Nieduszynski
📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project.
This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes
📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...
This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes
📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...
Postdoctoral Researcher (Dr Miguel Montez) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Wellcome Trust project led by Dr Miguel Montez and hosted within the Dodd Group at the John Innes Centre.
www.jic.ac.uk
November 13, 2025 at 8:34 AM
📣 Looking for a 3-Year Postdoc @johninnescentre.bsky.social to join my Wellcome project.
This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes
📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...
This is a highly interdisciplinary project that explores chromatin dynamics in 🌱 plant responses across timescales, from circadian rhythms to seasonal changes
📅 Closes on 10 Dec.
www.jic.ac.uk/vacancies/36...
Reposted by Conrad Nieduszynski
ICYMI: New Online! Discovery of a human gene encoding a cyclin-dependent kinase
Discovery of a human gene encoding a cyclin-dependent kinase
Nature Reviews Molecular Cell Biology, Published online: 05 November 2025; doi:10.1038/s41580-025-00926-0A study showing that human cells encode a functional cyclin-dependent kinase, thereby demonstrating that cell-cycle regulation is conserved across eukaryotes.
bit.ly
November 8, 2025 at 3:54 PM
ICYMI: New Online! Discovery of a human gene encoding a cyclin-dependent kinase
Reposted by Conrad Nieduszynski
We have a fully funded and exciting opportunity for a PhD project led by @conradn.bsky.social and the Biofoundry group to advance synthetic genomics @earlhaminst.bsky.social
PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes.
buff.ly/l3dTmAf
#synbio
buff.ly/l3dTmAf
#synbio
Engineering stable synthetic chromosomes
4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD
buff.ly
October 29, 2025 at 5:07 PM
We have a fully funded and exciting opportunity for a PhD project led by @conradn.bsky.social and the Biofoundry group to advance synthetic genomics @earlhaminst.bsky.social
We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5
November 5, 2025 at 1:57 PM
We have a 4 year fully-funded PhD opportunity to join our group @earlhaminst.bsky.social on an Eng Bio project: Engineering stable synthetic chromosomes. Jointly with the BioFoundry and @cgrandel.bsky.social. Read more about the project shorturl.at/GZMbB and about our research shorturl.at/HR6p5
Reposted by Conrad Nieduszynski
PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes.
buff.ly/l3dTmAf
#synbio
buff.ly/l3dTmAf
#synbio
Engineering stable synthetic chromosomes
4-year Norwich Research Park Biosciences Doctoral Training Partnership (NRPDTP) PhD
buff.ly
October 29, 2025 at 2:06 PM
PHD: Building on recent research to develop the first "designer" eukaryotic chromosome, this fully-funded #PhDproject with @conradn.bsky.social and @cgrandel.bsky.social will clarify and test the design principles for stable maintenance of fully synthetic chromosomes.
buff.ly/l3dTmAf
#synbio
buff.ly/l3dTmAf
#synbio
Reposted by Conrad Nieduszynski
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes www.nature.com/articles/s41... 🧬🖥️🧪 github.com/HaploTeam/10...
October 15, 2025 at 5:55 PM
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes www.nature.com/articles/s41... 🧬🖥️🧪 github.com/HaploTeam/10...
Congratulations Aykut & Alper!
Congratulations to Aykut Shen, one of my first PhD students, who has successfully passed his viva yesterday. Many thanks to examiners @conradn.bsky.social and @adamcribbs.bsky.social and co-supervisor/collaborator. @whaerty.bsky.social. @nrpdtp.bsky.social @biouea.bsky.social
October 15, 2025 at 4:57 PM
Congratulations Aykut & Alper!
Reposted by Conrad Nieduszynski
📣 Applications have just opened for our 2026 #PhD programme as part of the @nrpdtp.bsky.social and @aries-dtp.bsky.social!
Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich.
buff.ly/327FNrX
#genomics #findaphd #AcademicSky
Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich.
buff.ly/327FNrX
#genomics #findaphd #AcademicSky
October 13, 2025 at 8:23 AM
📣 Applications have just opened for our 2026 #PhD programme as part of the @nrpdtp.bsky.social and @aries-dtp.bsky.social!
Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich.
buff.ly/327FNrX
#genomics #findaphd #AcademicSky
Begin your academic career with the expert scientists, technology, and facilities at the Earlham Institute in Norwich.
buff.ly/327FNrX
#genomics #findaphd #AcademicSky
Reposted by Conrad Nieduszynski
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership
This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C...
biodtp.norwichresearchpark.ac.uk
October 12, 2025 at 7:43 PM
New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr
Reposted by Conrad Nieduszynski
Fantastic to welcome researchers for another Norwich #Nanopore Day at the Earlham Institute - bringing together the research community using @nanoporetech.com! 🧬
September 18, 2025 at 3:05 PM
Fantastic to welcome researchers for another Norwich #Nanopore Day at the Earlham Institute - bringing together the research community using @nanoporetech.com! 🧬
Reposted by Conrad Nieduszynski
📣 We're pleased to open applications for a new Group Leader in Artificial Intelligence (#AI) in Biology.
Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics.
🗓️ Applications close: 24 Oct
➡️ buff.ly/YRz3YLe
#machinelearning
Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics.
🗓️ Applications close: 24 Oct
➡️ buff.ly/YRz3YLe
#machinelearning
Group Leader: Artificial Intelligence (AI) in Biology
buff.ly
September 29, 2025 at 9:01 AM
📣 We're pleased to open applications for a new Group Leader in Artificial Intelligence (#AI) in Biology.
Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics.
🗓️ Applications close: 24 Oct
➡️ buff.ly/YRz3YLe
#machinelearning
Join our collaborative and inter-disciplinary research environment, exploring the natural world through the lens of #genomics.
🗓️ Applications close: 24 Oct
➡️ buff.ly/YRz3YLe
#machinelearning
Reposted by Conrad Nieduszynski
Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Strand- and replication timing-dependent functions of DNA polymerase η in human DNA replication and mutagenesis.
Efficient eukaryotic DNA replication relies on the coordinated actions of replicative and error-prone polymerases, with the latter providing flexibility at the cost of mutagenesis. DNA polymerase η (P...
www.biorxiv.org
September 12, 2025 at 8:46 AM
Our preprint on Pol-η usage during genome replication has been uploaded. It addresses the biased use of Pol-η in the lagging strand and late-replicating regions, which may be correlated with cancer mutagenesis.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Conrad Nieduszynski
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells
Nature Communications - Determining how replication forks move across the human genome is critical for the effective use of agents that target replication stress. Here, the authors present...
rdcu.be
September 1, 2025 at 10:04 AM
Checkout our latest research in @natcomms.nature.com
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
Reposted by Conrad Nieduszynski
how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)
Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The adaptive molecular landscape of reprogrammed telomeric sequences
Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...
www.biorxiv.org
July 3, 2025 at 10:46 AM
how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)
Reposted by Conrad Nieduszynski
@davideanne.bsky.social showing off our new protocol with the Opentrons 👏🏼🤖 @earlhaminst.bsky.social
July 22, 2025 at 1:49 PM
@davideanne.bsky.social showing off our new protocol with the Opentrons 👏🏼🤖 @earlhaminst.bsky.social
Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.
July 20, 2025 at 6:19 PM
Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.
Reposted by Conrad Nieduszynski
Next week at #Yeast2025 Dr Sathish Thiyagarajan will be presenting work from the @conradn.bsky.social group at the Earlham Institute using #nanopore #sequencing to identify pause sites in DNA replication.
📄 Plenary session 4
🗓️ Wednesday, 23 July 2025
🕤 9:30am - 11:00am
📄 Plenary session 4
🗓️ Wednesday, 23 July 2025
🕤 9:30am - 11:00am
Single-molecule identification of replication fork pause sites around highly transcribed genomic loci using nanopore sequencing
buff.ly
July 18, 2025 at 11:02 AM
Next week at #Yeast2025 Dr Sathish Thiyagarajan will be presenting work from the @conradn.bsky.social group at the Earlham Institute using #nanopore #sequencing to identify pause sites in DNA replication.
📄 Plenary session 4
🗓️ Wednesday, 23 July 2025
🕤 9:30am - 11:00am
📄 Plenary session 4
🗓️ Wednesday, 23 July 2025
🕤 9:30am - 11:00am
Reposted by Conrad Nieduszynski
Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
From cooperation to conflicts – a complicated relationship between transcription and replication.
A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated…
www.sciencedirect.com
July 17, 2025 at 2:59 PM
Our new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Conrad Nieduszynski
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic
academic.oup.com
July 10, 2025 at 2:55 PM
It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...
Reposted by Conrad Nieduszynski
📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
June 9, 2025 at 1:02 PM
📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
Reposted by Conrad Nieduszynski
💬 "These technologies have the power to remove breeding bottlenecks that have stymied development of new and improved #crops."
A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.
A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.
Scientists look to biotechnology to improve crop resilience and nutritional value
A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome…
buff.ly
June 12, 2025 at 7:01 AM
💬 "These technologies have the power to remove breeding bottlenecks that have stymied development of new and improved #crops."
A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.
A new project - funded by a £8.5M from @aria-research.bsky.social - will leverage advances in #engineeringbiology to establish #synthetic #plant chromosome technologies.
Reposted by Conrad Nieduszynski
Modern agriculture faces significant challenges, from climate change to soil degradation and food security.
Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.
Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.
Scientists look to biotechnology to improve crop resilience and nutritional value
A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome…
buff.ly
June 8, 2025 at 10:01 AM
Modern agriculture faces significant challenges, from climate change to soil degradation and food security.
Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.
Scientists at the Earlham Institute are part of a new multi-million project developing #synthetic #plant #chromosome technologies to speed up the introduction of novel traits to plants.
Reposted by Conrad Nieduszynski
Here ends our foray into rDNA variation in model organisms—w/ Christine Queitsch, Bonnie Brewer, and many others. Especially Ashley Hall and Elizabeth Morton.
tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans).
But outside those ranges? Some things happen.
1/3
tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans).
But outside those ranges? Some things happen.
1/3
June 4, 2025 at 5:40 PM
Here ends our foray into rDNA variation in model organisms—w/ Christine Queitsch, Bonnie Brewer, and many others. Especially Ashley Hall and Elizabeth Morton.
tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans).
But outside those ranges? Some things happen.
1/3
tl;dr: In natural ranges of rDNA copy number, phenotypes are rare (yeast + C. elegans).
But outside those ranges? Some things happen.
1/3
Very excited to be part of this project and to continue working with our longstanding collaborator, the amazing Yizhi (Patrick) Cai from @uommib.bsky.social
🆕 Scientists at the Earlham Institute, @uommib.bsky.social, and @johninnescentre.bsky.social are partnering to develop #synthetic plant chromosome technologies, to rapidly design and deliver beneficial traits to crops, as part of a new £8.5m @aria-research.bsky.social project.
➡️ buff.ly/n80muy0
➡️ buff.ly/n80muy0
Scientists look to biotechnology to improve crop resilience and nutritional value
A new project - funded by a £8.5M grant from the UK Government’s Advanced Research and Invention Agency (ARIA) - will leverage advances in engineering biology to establish synthetic plant chromosome (...
buff.ly
June 2, 2025 at 11:46 AM
Very excited to be part of this project and to continue working with our longstanding collaborator, the amazing Yizhi (Patrick) Cai from @uommib.bsky.social
Reposted by Conrad Nieduszynski
Great to welcome @adrianramsay.bsky.social MP for Waveney Valley, to the Earlham Institute and Norwich Research Park today.
Thank you Norwich Research Park & @nnuh.bsky.social for showing me around their impressive institutes today. Great to discuss their wide-ranging work including on microbiological research, public health improvement & new diagnostic techniques
@earlhaminst.bsky.social @quadraminstitute.bsky.social
@earlhaminst.bsky.social @quadraminstitute.bsky.social
May 23, 2025 at 5:08 PM
Great to welcome @adrianramsay.bsky.social MP for Waveney Valley, to the Earlham Institute and Norwich Research Park today.