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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

We are excited about the potential for anti-CD70 CAR-Ts to make a difference for high-risk #myeloma patients

Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

Special shout-out to our Junior Specialist Sanjana Prudhvi, who designed our Visual Abstract. We are lucky to work with such an amazing team, including everyone in the Wiita Lab @ucsfcancer.bsky.social and our collaborators. (10/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

Finally, we developed a proof-of-principle dual-targeting CAR against both BCMA and CD70 as a potential strategy to avoid antigen escape–mediated resistance in #HRMM (9/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

We also evaluated epigenetic regulation of CD70 in #myeloma, using a machine learning model to predict and then test key transcriptional regulators of surface expression (8/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

While all anti-CD70 CARs demonstrated clear efficacy against myeloma cell line xenograft models in vivo, the CD27-based CAR showed remarkable >80-fold expansion‼️ versus scFv-based CARs, suggesting a highly favorable phenotype for clinical translation (7/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

We then used the crystal structure of CD70 bound to its natural receptor CD27 to develop a structure-guided, optimized CD27-based CAR to compare to standard “scFv” based CAR, using frameworks containing either CD28 or 4-1BB costim domains. (6/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

Analysis of paired tumor RNA sequencing data from
‪@themmrf.bsky.social‬ CoMMpass study, cell surface #proteomics, and flow cytometry revealed CD70 was present on primary #myeloma. CD70 transcript was strongly enriched in high risk genotypes t(4;14), gain 1q, and loss 1p (5/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

...Samir Parekh at Icahn Mount Sinai, Stieglitz lab and the myeloma clinical group @ucsfcancer.bsky.social . Major support from Myeloma Solutions Fund, NIH NCI, and
UCSF Living Therapeutics Initiative (4/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

This work was co-led by myself, Adila Izgutdina, and
@bonellpatinoe.bsky.social under mentorship of @apwiita.bsky.social, + collab w/ Ben Barwick and Larry Boise @winshipcancer.emory.edu, ‪@jdlicht.bsky.social,
‪@shanmugamlab.bsky.sociall, @kortemmelab.bsky.social, and... (3/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

In this work we show CD70 is a novel CAR target enriched in #HRMM. We used structure-guided design to optimize a CD27-based anti-CD70 CAR-T that outperforms scFv-based CAR-Ts in preclinical efficacy studies. (2/10)

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Aug 25

Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...

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Reposted by Corynn Kasap MD PhD

Bonell Patiño E @bonellpatinoe.bsky.social · Aug 18

Thrilled to share our new paper in Blood! We show that CD70 is upregulated in high-risk MM, and that a CD27-based anti-CD70 CAR-T design achieves >80-fold improved expansion in vivo. So honored to co–lead this work with @corynnkasap.bsky.social, Adila Izgutdina under
@apwiita.bsky.social mentorship

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Reposted by Corynn Kasap MD PhD

Dr Susan Johnson @susanjoh.bsky.social · Mar 8

We did a thing. @standupforscience.bsky.social

Scott Budman @scottbudman.bsky.social · Mar 7

#New: Huge crowd gathers for #StandUpForScience2025 rally in San Francisco:

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Reposted by Corynn Kasap MD PhD

callaslilies.bsky.social @callaslilies.bsky.social · Mar 8

It was so much work but worth it! San Francisco really showed up!
@standupforscience.bsky.social

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Reposted by Corynn Kasap MD PhD

Michael E. Mann @michaelemann.bsky.social · Mar 7

“Out of the lab and into the streets, researchers and doctors rally for science against Trump cuts” by @borenbears.bsky.social for @apnews.com. Read more here:

apnews.com/article/scie...

Out of the lab and into the streets, researchers and doctors rally for science against Trump cuts

Researchers, doctors, their patients and supporters are venturing out of labs, hospitals and offices across the country to stand up to what they call an attack on life-saving science by the Trump admi...

apnews.com

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Reposted by Corynn Kasap MD PhD

apwiita.bsky.social @apwiita.bsky.social · Mar 7

STAND UP FOR SCIENCE!✊🏽💪

Great turnout in #SanFrancisco to defend science from political attacks. Funding science is what actually makes America great vehicle for economic growth, advances in innovation, American leadership, upward mobility for Americans, and overall benefit to humanity.

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Mar 7

Beautiful day and amazing turnout to hear keynote speaker and Nobel laureate Carolyn Bertozzi speak in San Francisco at today’s protest in defense of federal science funding #StandUpForScience2025 #StandUpForScience

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Reposted by Corynn Kasap MD PhD

Katie Wilkinson @drkwilkinson.bsky.social · Mar 7

Nobel Prize winner @carolynbertozzi.bskyverified.social talking about how important science is and how we are in danger of losing decades worth of investment in science. Highlighting the danger to programs that gave her her start in science targeted for DEI & the cost of losing them

Attendees at SF Stand Up for Science with signs

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Reposted by Corynn Kasap MD PhD

Science Magazine @science.org · Mar 7

Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4

Thousands gather across U.S. in Stand Up for Science events

Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration

scim.ag

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Reposted by Corynn Kasap MD PhD

Ardem Patapoutian @ardemp.bskyverified.social · Mar 7

I was bot involved in making any of the posters behind me but I agree with all of them.

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Reposted by Corynn Kasap MD PhD

Alexandra Witze @alexwitze.bsky.social · Mar 7

#StandUpForScience Denver

A Capitol building with pro-science signs

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Reposted by Corynn Kasap MD PhD

Scott Budman @scottbudman.bsky.social · Mar 7

#New: Huge crowd gathers for #StandUpForScience2025 rally in San Francisco:

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Reposted by Corynn Kasap MD PhD

Haezyll @haezyll.bsky.social · Mar 7

San Francisco really showed up for #standupforscience2025!! Making me proud, Bay Area.
🥼🌁🌍

Scott Budman @scottbudman.bsky.social · Mar 7

#New: Huge crowd gathers for #StandUpForScience2025 rally in San Francisco:

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Mar 7

So happy to see so many people who want to support the fight to preserve science funding at today’s #StandUpForScience in SF @standupforscience.bsky.social

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Corynn Kasap MD PhD @corynnkasap.bsky.social · Mar 7

Amazing turnout at today’s #StandUpForScience in San Francisco

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