Synthetic receptors are a powerful approach for engineering cell-based therapies that can sense and respond to their environment. Here cytokine receptor domains have been repurposed to develop enginee...

Nature Biotechnology - Children with rare genetic diseases get CRISPR Cures center

The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...

Key PointsCD70 is an upregulated cell surface antigen and a promising therapeutic target in high-risk myeloma tumors.Structure-optimized CD27-based CAR-Ts

Yu et al. developed a programmable RNA acetylation system using dCas13–eNAT10 to specifically install N4-acetylcytidine on target RNAs in cells and in vivo, enabling functional studies of RNA acetylat...

Chimeric antigen receptor (CAR) T cell activities can be remotely controlled to provide spatiotemporal precision of CAR T cell activity and improve the safety of cellular immunotherapies. This Review discusses physical and chemogenetic stimuli and the combination of stimuli-responsive nanotechnologies with immuno-engineering to design controllable CAR T cell therapies.

Drug combination targeting lax airways is nearing an FDA submission

Background: Chimeric antigen receptor (CAR) T-cell therapies are highly efficacious for several different hematologic cancers. However, for most CAR T targets it is observed that low surface antigen d...

Nature - Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.