Cristian Pattaro
@cpattaro.bsky.social
210 followers 230 following 180 posts
Biostatistics. Genetics. Epidemiology. Group leader of Biostats & Epi @ Eurac Research
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Reposted by Cristian Pattaro
tuuliel.bsky.social
We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...
Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center
Find a career with New York Genome Center
jobs.silkroad.com
Reposted by Cristian Pattaro
pottj.bsky.social
📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish)
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.
cpattaro.bsky.social
Very nice application of factor analysis #stats
Reposted by Cristian Pattaro
biorxiv-genetic.bsky.social
SAFE-LD: A novel method for the estimation of linkage disequilibrium from summary statistics https://www.biorxiv.org/content/10.1101/2025.09.29.679154v1
Reposted by Cristian Pattaro
andganna.bsky.social
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.

Our new study in Nature Genetics including 9 disease and 7 biobanks shows:

• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better
Reposted by Cristian Pattaro
sashagusevposts.bsky.social
I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:
Beneath the surface of the sum
When genetic interactions matter and when they don't
open.substack.com
Reposted by Cristian Pattaro
llobrienlab.bsky.social
For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.
Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.
Reposted by Cristian Pattaro
hos-asa.bsky.social
#OTD 1876 Edith Abbott b (d 28 Jul 1957) ASA Fellow 1945. One of the 1st F deans in the US, she pioneered statistical methods applied to policy development for welfare, education & protections for immigrants, working women & children
Reposted by Cristian Pattaro
cpattaro.bsky.social
We often try to put rare genetic diseases & common diseases into context wrt some genetic finding. Here, a helpful review on how rare variants may alter common disease risk & viceversa, how common disease genetic background influence rare/genetic diseases
www.sciencedirect.com/science/arti...
The rare-to-common disease journey: a winding road to new therapies
The study of genetic variants that cause rare diseases has been a central strategy of genetic research for the last century, but the contribution of r…
www.sciencedirect.com
Reposted by Cristian Pattaro
yun-s-song.bsky.social
We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)
Reposted by Cristian Pattaro
meghanazad.bsky.social
A Genetic Atlas of the Mammary Gland 🧬🤱🐭

New research from @geula.bsky.social & team shows shifts in gene activity across pregnancy → lactation → weaning.

This new 'atlas' provides new avenues for studying lactation disorders and breast cancer.

academic.oup.com/nar/article/...