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Reposted by Angelo D’Alessandro

Christian Frezza @frezzalab.bsky.social · 14d

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

www.nature.com/articles/s41...

Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

www.nature.com

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Angelo D’Alessandro @dalessandrolab.bsky.social · 16d

Elegant work from Kirk Hansen’s lab @cuanschutz.bsky.social Transglutaminase 2 (likely from RBCs) contributes to forming fibrin beta cross-links, even in the absence of FXIII. TG2 increases in plasma in trauma patients with higher injury severity score.

ashpublications.org/blood/articl...

Tissue transglutaminase drives fibrin β-chain cross-linking: a novel fibrin modification observed in trauma patients

Key Points. Trauma patient plasma clots feature entirely novel fibrin β-chain crosslinking not evident in healthy controlsFibrin β-chain crosslinks evident

ashpublications.org

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Reposted by Angelo D’Alessandro

Christian Frezza @frezzalab.bsky.social · 19d

BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states

doi.org/10.1038/s422...

BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states - Nature Metabolism

Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately a...

doi.org

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Angelo D’Alessandro @dalessandrolab.bsky.social · 25d

Patients with SCD transfused with blood stored >30 days have higher iron, cytokines, hemolysis, hypoxia and inflammation markers compared to recipients of RBCs stored <10 days. Metabolites in the bag impact in vivo metabolism (hypoxanthine —> urate). Kudos to Matt Karafin for this clinical trial

Journal of Clinical Investigation @jci.org · 25d

RBC units can be stored in the refrigerator for up to 42 days, but it’s unclear how extended storage affects recipients.

@dalessandrolab.bsky.social & team compare short- and long-stored RBC transfusions in patients with sickle cell disease 👇

buff.ly/CWjcWGc

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Angelo D’Alessandro @dalessandrolab.bsky.social · Sep 5

Congratulations!

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Angelo D’Alessandro @dalessandrolab.bsky.social · Sep 5

Another great one from the @cjoneslab.bsky.social !

Courtney Jones @cjoneslab.bsky.social · Sep 4

Excited to share a new publications led by Dr. Cristiana O'Brien showing that circulating lipids levels can be used to predict chemotherapy response in AML patients.
doi.org/10.1182/bloo...

Angelo D’Alessandro @dalessandrolab.bsky.social · Sep 4

Blood donors, like 67% of adult Americans, drink a lot of coffee. However, caffeine may reduce quality of stored RBCs by (i) inhibiting G6PD (~40%); (ii) antagonizing ADORA2b. Likely relevant beyond blood transfusion!

Paper: haematologica.org/haematologic...

news.cuanschutz.edu/news-stories...

Study Reveals Caffeine May Undermine Blood Transfusion Effectiveness

news.cuanschutz.edu

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Reposted by Angelo D’Alessandro

Christian Frezza @frezzalab.bsky.social · Sep 1

Evidence that mitochondria in macrophages are destroyed by microautophagy
www.nature.com/articles/s41...

Evidence that mitochondria in macrophages are destroyed by microautophagy - Nature Communications

Mitophagy, the selective degradation of mitochondria, has been thought to occur via macroautophagy. Here, the authors present data indicating that microautophagy also mediates mitophagy in macrophages...

www.nature.com

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Reposted by Angelo D’Alessandro

Oli Clarke @olibclarke.bsky.social · Aug 30

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

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Angelo D’Alessandro @dalessandrolab.bsky.social · Aug 14

Great job Pavel and team! Thanks for the inclusion

Journal of Clinical Investigation @jci.org · Aug 14

Behind the scenes: first author Guadalupe Roja-Sanchez pipetting away!

Angelo D’Alessandro @dalessandrolab.bsky.social · Aug 14

As always, this is a team effort, led by Daniel Stephenson, Greg Keele @grkeele.bsky.social and Grier Page @rti.bsky.social, experts in ferroptosis @brentstockwell.bsky.social - blood storage and transfusion medicine - from the Zimring lab at UVA, Vitalant Research Institute, UCSF

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Angelo D’Alessandro @dalessandrolab.bsky.social · Aug 14

Iron-loaded Red Blood Cells undergo a lipid peroxidation process akin to ferroptosis during storage in the blood bank. We now show that they also harbor a functional GPX4, and common SNPs, genetic or pharmacological manipulation impact transfusion outcomes www.sciencedirect.com/science/arti...

GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells

Red blood cell (RBC) membrane lipid peroxidation during blood bank storage profoundly impacts transfusion efficacy; however, the genetic determinants …

www.sciencedirect.com

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Reposted by Angelo D’Alessandro

Jesse G Meyer PhD @j-my-sci.bsky.social · Aug 2

Stop 👏 building 👏 python/R👏 packages!

we show that well described methods in academic papers can serve as the specification for an LLM to create methods on demand. This can serve to reduce package maintenance while ensuring accessibility in any programming language

arxiv.org/abs/2507.22324

From Articles to Code: On-Demand Generation of Core Algorithms from Scientific Publications

Maintaining software packages imposes significant costs due to dependency management, bug fixes, and versioning. We show that rich method descriptions in scientific publications can serve as standalon...

arxiv.org

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Angelo D’Alessandro @dalessandrolab.bsky.social · Jul 30

Great work James, Mercedes and teams!

Nature @nature.com · Jul 30

Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse

go.nature.com/41iIdJR

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu

Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

go.nature.com

Reposted by Angelo D’Alessandro

University of Colorado Anschutz @cuanschutz.bsky.social · Jul 30

Researchers at #CUAnschutz, @einsteinmededu.bsky.social and @utrechtuniversity.bsky.social have found the first direct evidence that common respiratory infections, including #COVID-19, can awaken dormant #breastcancer cells that have spread to the lungs, setting the stage for new metastatic tumors.

Respiratory Viruses Can Wake Up Breast Cancer Cells in Lungs

news.cuanschutz.edu

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Angelo D’Alessandro @dalessandrolab.bsky.social · Jul 18

Really cool! Heme catabolism and biliverdin/bilirubin steps are NADPH dependent, and G6PD deficiency may protect from malaria. I wonder if/how the two stories line up

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Angelo D’Alessandro @dalessandrolab.bsky.social · Jul 16

Really cool!

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Angelo D’Alessandro @dalessandrolab.bsky.social · Jul 8

Does it track with hemoglobin levels? HBB C93 and glutathione seem to track at a 1:1 ratio in humans and mice.
They used 13C 15N-glycine in vivo, it would be interesting to see how GSH synthesis rates track with de novo heme synthesis

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Reposted by Angelo D’Alessandro

Gary Siuzdak @siuzdak.bsky.social · Jun 17

A free version just posted—courtesy of #Nature.
Lipidomics (via #XCMS / #METLIN) reveals α-tocopherol (vitamin E) as a key player in ferroptosis resistance in cancer.

t.co/HMJSLuTAnM

#Lipidomics #CancerResearch #Ferroptosis #VitaminE

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Angelo D’Alessandro @dalessandrolab.bsky.social · Jun 14

So nice to finally associate a face and person to the names and papers, especially when it turns out to be such a lovely company! Thank you for the evening!

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Reposted by Angelo D’Alessandro

Nikolai Slavov @slavov-n.bsky.social · Jun 7

Single-cell RNA sequencing data are often used as indirect estimates of protein abundance in single cells.

Instead, I think the goal should be to use the consistent discrepancies to understand regulatory mechanisms.

www.biorxiv.org/content/10.1...

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Angelo D’Alessandro @dalessandrolab.bsky.social · Jun 4

Always great to catch up with friends and colleagues around the world, while sharing the latest stories with the transfusion medicine community at #ISBTMILAN!

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Reposted by Angelo D’Alessandro

Vijay G. Sankaran @bloodgenes.bsky.social · Jun 4

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...

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Reposted by Angelo D’Alessandro

Kevin Drew @ksdrew.bsky.social · May 29

Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes.

www.embopress.org/doi/full/10....

hu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments | Molecular Systems Biology

imageimagehu.MAP3.0 integrates mass spectrometry experiments to identify human protein complexes. Using this resource, this study characterizes covariation of complexes, identifies mutually exclusive ...

www.embopress.org

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Angelo D’Alessandro @dalessandrolab.bsky.social · May 15

Love it!

Eric Topol @erictopol.bsky.social · May 15

Astrocytes have long been conceived as passive support player cells in the brain. But today @science.org (via 3 reports) they got a big upgrade for their active role in neuromodulation and control of brain function
www.science.org/doi/10.1126/...

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