University of Oxford seeks Research Associate to study extracellular vesicles and biomarkers in Parkinson’s disease using blood samples and iPSC based models.

Nature Reviews Neurology, Published online: 05 August 2025; doi:10.1038/s41582-025-01129-zNew evidence supports trans-synaptic propagation of tau pathology in the neurodegenerative disease progressive supranuclear palsy.

YouTube video by Dementia Researcher

The templated spread of tau aggregates in tauopathies has been attributed to neuron-to- neuron spread, but microglia have also been implicated through mouse studies. Here we examine in detail the upta...

Human neurodegenerative conditions such as Parkinson’s and Alzheimer’s Disease are characterized by the formation and deposition of toxic protein species which exacerbate neuronal dysfunction, impacti...

Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

In this episode of the Dementia Researcher podcast, host Dr Amanda Heslegrave leads an insightful discussion on one of the most promising developments in dementia diagnostics: blood-based biomarker...

The real fun of being a neuroscientist, and maybe the key to asking and answering new questions, is to think big and take intellectual risks.

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing & Alzheimer’s using iPSC models, genomics & molecular biology

The UK DRI at UCL is recruiting a lab manager to oversee daily operations and contribute to pioneering neuro-glia-immune research in ageing & neurodegeneration

While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

Nature Structural & Molecular Biology, Published online: 05 May 2025; doi:10.1038/s41594-025-01534-4Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a framework for specific deubiquitinase inhibition.