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Reposted by David A. Delgadillo

C&EN (Chemical & Engineering News) @cenmag.bsky.social · 1d

The 2025 #NobelPrize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.” Stay tuned for the full story to come! cen.acs.org/people/nobel...

#ChemNobel #Chem #Chemistry #chemsky 🧪

The 2025 chemistry Nobel goes to MOFs

Susumu Kitagawa, Richard Robson and Omar M. Yaghi win the prize for developing metal–organic frameworks

cen.acs.org

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David A. Delgadillo @daverdude.bsky.social · 12d

When was the NSF-GRFP eligibility change implemented? #chemsky

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Chemistry World @chemistryworld.com · 18d

A new electron diffraction technique could make it easier to study molecules that need to remain solvated at all times.

New electron diffraction strategy could make it easier to study solvated organic microcrystals

The approach combines carbon liquid cells and rapid data acquisition to study solvated molecules at room temperature

www.chemistryworld.com

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Reposted by David A. Delgadillo

Harry M. Williams @harrywilliams.bsky.social · 21d

❄️ NEW PRE-PRINT ❄️ Happy to see our latest work online. Here we present a super simple solution to the preferred orientation problem in single particle cryo-EM: the use of ultrasonic excitation during vitrification! Details in the 🧵 below... #cryoEM #structuralbiology

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 21d

Overcoming Preferred Orientation in Cryo-EM With Ultrasonic Excitation During Vitrification https://www.biorxiv.org/content/10.1101/2025.09.14.676144v1

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Reposted by David A. Delgadillo

R. David Britt @rdavbritt.bsky.social · Aug 30

is the dimer core of the H-cluster of FeFe hydrogenase formed by rSAM chemistry in HydE?

pubs.acs.org/doi/full/10....

The Radical S-Adenosyl-l-methionine Enzyme HydE Forms an Fe(I)Fe(I) Dimer En Route to the [FeFe] Hydrogenase H-Cluster

[FeFe] hydrogenases are highly efficient metalloenzymes that catalyze hydrogen conversion via a sophisticated active site cofactor known as the H-cluster. Biosynthesis of its [2Fe]H subcluster, which ...

pubs.acs.org

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David A. Delgadillo @daverdude.bsky.social · Aug 28

Trying to do more with less 🙂‍↕️

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Reposted by David A. Delgadillo

Chemjobber @chemjobber.bsky.social · Aug 20

ACS Council approves the petition to establish the Committee on the Advancement of LGBTQ+ Chemists, 86% to 14%.

#chemsky 🧪⚗️ #acsfall2025

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Reposted by David A. Delgadillo

Timothy Caulfield @caulfieldtim.bsky.social · Aug 14

Scientists’ role in defending democracy www.science.org/doi/10.1126/...

Let's all support this vital need: the ability to tell the truth. 💪

"Those in the science community who are willing & able to be more visible can step up. Acting together will be more impactful than going it alone."

Scientists’ role in defending democracy

The United States’ democratic leadership, commitment to freedom of expression, and investment in the pursuit of knowledge have long enabled its preeminence in science and technology. Yet today we are ...

www.science.org

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Reposted by David A. Delgadillo

Eric Topol @erictopol.bsky.social · Aug 14

Defending US democracy: the role of scientists
@science.org
www.science.org/doi/10.1126/...

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Scott Bagley @bagphos.bsky.social · Aug 8

#ChemSky #ACSFall2025 Huge thank you to Prof. Isaiah Speight, Prof. Kensha Clark, and Prof. Davita Watkins for organizing this amazing lineup of impressive speakers. Hosted by organicdivision.org POLY and INOR. Thank you to ACS President Dr. Phillips for elevating this to a Presidential Symposium

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C&EN (Chemical & Engineering News) @cenmag.bsky.social · Aug 2

@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪

Jennifer Doudna is named 2026 Priestley Medalist

The award recognizes the biochemist for discoveries on ribozyme function and CRISPR gene editing, and international science leadership

cen.acs.org

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Reposted by David A. Delgadillo

CCDC Cambridge @ccdc.cam.ac.uk · Jul 22

Natural products (NPs) play a crucial role in medicine, inspiring over 50% of the drugs on the market.

🔎In this work, the team used an 'arrayED' workflow, that enabled high-throughput screening for crystalline NPs amenable to microcrystal electron diffraction (microED).

🔗 ccdc-info.com/3GP4yb2

Promotional graphic with the ball and stick structure of CSD entry FACNUX.

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Reposted by David A. Delgadillo

Dmitry Eremin @dmeremin.bsky.social · Jul 30

Check out the stunning cover featuring recent paper from @hoseanelson.bsky.social Lab, led by our one and only @daverdude.bsky.social! He discovered an entire class of natural products using microED powered by arrayED

@caltech.edu @caltechcce.bsky.social @uclacb.bsky.social

Journal of the American Chemical Society (JACS) @jacs.acspublications.org · Jul 30

On the front cover of this week's issue: "Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites"

Read it here 🔗: buff.ly/F6E8Ygs

#ChemSky #JACS

JACS Front Cover - Week of July 28, 2025

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Journal of the American Chemical Society (JACS) @jacs.acspublications.org · Jul 30

On the front cover of this week's issue: "Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites"

Read it here 🔗: buff.ly/F6E8Ygs

#ChemSky #JACS

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Reposted by David A. Delgadillo

cryoEM papers @cryoempapers.bsky.social · Jul 29

Combining MicroED and native mass spectrometry for structural discovery of enzyme-small molecule complexes pubmed.ncbi.nlm.nih.gov/40720654/ #cryoem

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Reposted by David A. Delgadillo

Mark Levin @levinchem.bsky.social · Jul 17

Today in @science.org, @mikusp.bsky.social reports a method to replace the C2 of pyridines with N, affording pyridazines.

The change from electronically consonant (pyridine) to dissonant (pyridazine) opens retrosyntheses not typically available to the latter.

www.science.org/doi/10.1126/...

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Reposted by David A. Delgadillo

Maite Colinas @maitecolinas.bsky.social · Jul 16

Next one out from @oconnorlab.bsky.social department in @natchembio.nature.com. Work led by my office mate Allwin McDonald on the epimerisation of monoterpenoid indole alkaloids in Kratom!
#PlantSci
#NatProd

rdcu.be/ewvtP

Enzymatic epimerization of monoterpene indole alkaloids in kratom

Nature Chemical Biology - Monoterpene indole alkaloids are formed via a 3S stereoselective condensation between secologanin and tryptamine. Here the authors uncover the mechanism of epimerization...

rdcu.be

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Reposted by David A. Delgadillo

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Jul 11

Check out this amazing new work from @sattelylab.bsky.social along with collaborator and @stanford-chemh.bsky.social Institute Scholar @pollyfordyce.bsky.social !

www.nature.com/articles/s41...

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature

An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

www.nature.com

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Reposted by David A. Delgadillo

Science Magazine @science.org · Jul 3

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation.

Learn more in this week's issue: scim.ag/44uRorm

This illustration shows the interface of the kinase NEK7 (light blue) and the E3 ubiquitin ligase substrate receptor cereblon (teal). The interaction is facilitated by the small molecule MRT-3486 (orange).

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David A. Delgadillo @daverdude.bsky.social · Jun 25

I was first introduced to the potential of electron diffraction through the Pipeline back in 2018…full circle moment #chemsky

Derek Lowe @dereklowe.bsky.social · Jun 24

Using a faster workflow for micro-electron diffraction discovery of new natural products. They’re hiding out there!

Tiny Crystals from Small Extracts

www.science.org

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David A. Delgadillo @daverdude.bsky.social · Jun 3

There's been a rich connection between electron diffraction and the nature of the chemical bond over the years. Here, we've shown how you can leverage electron diffraction to discover and characterize novel natural products.
@caltechcce.bsky.social @uclacb.bsky.social
pubs.acs.org/doi/10.1021/...

Microcrystal Electron Diffraction-Guided Discovery of Fungal Metabolites

Nature remains a vast repository of complex and functional metabolites whose structural characterization continues to drive innovations in pharmaceuticals, agrochemicals, and materials science. The cr...

pubs.acs.org

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Reposted by David A. Delgadillo

Natural Product Reports @natprodreports.rsc.org · May 28

🔓Don't miss this #OpenAccess Highlight from @nadineziemert.bsky.social‬, Ludek Sehnal & co @unicampoficial.bsky.social‬ & @unituebingen.bsky.social‬ covering genomic insights to drug discovery of Antarctic bacterial natural products #natprod #secmet

Check it out here🔽
pubs.rsc.org/en/content/a...

Antarctic bacterial natural products: from genomic insights to drug discovery

Covering: up to the end of 2024 Microbial life dominates the extreme continent Antarctica, playing a pivotal role in ecosystem functioning and serving as a reservoir of specialized metabolites known…

pubs.rsc.org

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Reposted by David A. Delgadillo

cryoEM papers @cryoempapers.bsky.social · May 23

α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery? pubmed.ncbi.nlm.nih.gov/40401103/ #cryoem

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Reposted by David A. Delgadillo

Alex Crits-Christoph @acritschristoph.bsky.social · May 23

Self-supervised learning of molecular representations from millions of tandem mass spectra using DreaMS

www.nature.com/articles/s41...

Self-supervised learning of molecular representations from millions of tandem mass spectra using DreaMS - Nature Biotechnology

A transformer model is used to construct the DreaMS Atlas—a molecular network of 201 million MS/MS spectra.

www.nature.com

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